crs1 (SPBC2G2.09c)

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Gene Ontology:
- Biological Process
- Cellular Component
Phenotype:
- Single-allele:
  - Population
  - Cell
- Multi-allele:
  - Cell
Target Of
Transcript
Protein Features
Sequence
Gene Expression
Misc
Warning
Taxonomic Conservation
Interactions:
- Genetic
External References
Literature

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Gene Standard Name	crs1	Characterisation Status	published
Systematic ID	SPBC2G2.09c	Feature Type	protein coding
Synonyms	mug17	Name Description	Meiotically Upregulated Gene, Cyclin-like protein Regulated via Splicing
Product	meiosis specific cyclin Crs1	Product Size	300aa, 34.29 kDa
Genomic Location	Chromosome II, 3453406-3452323 (1084nt); CDS:3453406-3452323 (1084nt)

GO Biological Process

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Term Name

Count

meiotic cell cycle

234

Annotation Extension	Evidence	With/From	Reference
	NAS		GO_REF:0000051

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0051321	meiotic cell cycle	NAS		GO_REF:0000051	234

GO Cellular Component

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Term Name

Count

cytosol

2298

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

nucleus

2690

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0005829	cytosol	IDA		PMID:16823372	2298
GO:0005634	nucleus	IDA		PMID:16823372	2690

FYPO Single-Allele Phenotypes

Gene Deletion Viability: Viable

Population Phenotype

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Term Name

Genotypes

Count

viable vegetative cell population

crs1Δ

3862

Term ID	Term Name	Evidence	Genotype	Condition	Reference	Count
FYPO:0002060	viable vegetative cell population	3862
	Microscopy	crs1Δ	Null	PECO:0000137, PECO:0000005	PMID:23697806
	Cell growth assay	crs1Δ	Null		PMID:16615890
	Microscopy	crs1Δ	Null		PMID:20473289

Cell Phenotype

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Term Name

Genotypes

Count

abnormal sporulation resulting in formation of ascus with fewer than four spores

crs1Δ

viable vegetative cell with normal cell morphology

crs1Δ

3103

Term ID	Term Name	Evidence	Genotype	Condition	Reference	Count
FYPO:0003066	abnormal sporulation resulting in formation of ascus with fewer than four spores	82
	Microscopy	crs1Δ	Null		PMID:16303567
FYPO:0002177	viable vegetative cell with normal cell morphology	3103
penetrance FYPO_EXT:0000001	Microscopy	crs1Δ	Null	PECO:0000005, PECO:0000137	PMID:23697806

FYPO Multi-allele Phenotypes

Cell Phenotype

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Term Name

Genotypes

abnormal spindle pole body morphology during meiosis II

crs1Δ, rem1Δ

abnormal sporulation resulting in formation of ascus with fewer than four spores

puc1Δ, rem1Δ, cig1Δ, crs1Δ, cig2Δ

abnormal sporulation resulting in formation of ascus with more than four spores

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

puc1Δ, cig1Δ, crs1Δ, cig2Δ

puc1Δ, rem1Δ, cig1Δ, crs1Δ, cig2Δ

abnormal sporulation resulting in formation of ascus with single large spore

puc1Δ, cig1Δ, crs1Δ, cig2Δ

abnormal sporulation resulting in formation of azygotic ascus with more than four spores

crs1Δ, rem1Δ

abnormal sporulation resulting in formation of two-spore ascus

puc1Δ, cig1Δ, crs1Δ, cig2Δ

abolished premeiotic DNA replication during azygotic meiotic cell cycle

puc1Δ, rem1Δ, cig1Δ, crs1Δ, cig2Δ

inviable spore

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

puc1Δ, cig1Δ, crs1Δ, cig2Δ

puc1Δ, rem1Δ, cig1Δ, crs1Δ, cig2Δ

normal meiosis

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

crs1Δ, rem1Δ

Term ID	Term Name	Evidence	Genotype	Condition	Reference
FYPO:0004608	abnormal spindle pole body morphology during meiosis II
	Microscopy	crs1	crs1Δ	Null		PMID:25891897
rem1	rem1Δ	Null
FYPO:0003066	abnormal sporulation resulting in formation of ascus with fewer than four spores
penetrance 81.3	Microscopy	puc1	puc1Δ	Null		PMID:25891897
rem1	rem1Δ	Null
cig1	cig1Δ	Null
crs1	crs1Δ	Null
cig2	cig2Δ	Null
FYPO:0003263	abnormal sporulation resulting in formation of ascus with more than four spores
penetrance 11.6	Microscopy	puc1	puc1Δ	Null		PMID:25891897
rem1	rem1Δ	Null
cig1	cig1Δ	Null
crs1	crs1Δ	Null
cig2	cig2Δ	Null
penetrance 36	Microscopy	puc1 cig1 crs1 cig2	puc1Δ cig1Δ crs1Δ cig2Δ	Null Null Null Null		PMID:25891897
penetrance 60	Microscopy	cig2 puc1 rem1 cdc2 cdc2 crs1 cig1 cdc13	cig2Δ puc1Δ rem1Δ cdc2Δ cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator) crs1Δ cig1Δ cdc13Δ	Null Null Null Null Overexpression Null Null Null		PMID:25891897
FYPO:0004077	abnormal sporulation resulting in formation of ascus with single large spore
penetrance 10	Microscopy	puc1	puc1Δ	Null		PMID:25891897
cig1	cig1Δ	Null
crs1	crs1Δ	Null
cig2	cig2Δ	Null
FYPO:0004760	abnormal sporulation resulting in formation of azygotic ascus with more than four spores
penetrance 28	Microscopy	crs1	crs1Δ	Null		PMID:25891897
rem1	rem1Δ	Null
FYPO:0000681	abnormal sporulation resulting in formation of two-spore ascus
penetrance 20	Microscopy	puc1	puc1Δ	Null		PMID:25891897
cig1	cig1Δ	Null
crs1	crs1Δ	Null
cig2	cig2Δ	Null
FYPO:0004800	abolished premeiotic DNA replication during azygotic meiotic cell cycle
penetrance 80	Flow cytometry data	puc1	puc1Δ	Null	PECO:0000223	PMID:25891897
rem1	rem1Δ	Null
cig1	cig1Δ	Null
crs1	crs1Δ	Null
cig2	cig2Δ	Null
FYPO:0002151	inviable spore
penetrance 25	Cell growth assay	cig2	cig2Δ	Null		PMID:25891897
puc1	puc1Δ	Null
rem1	rem1Δ	Null
cdc2	cdc2Δ	Null
cdc2	cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator)	Overexpression
crs1	crs1Δ	Null
cig1	cig1Δ	Null
cdc13	cdc13Δ	Null
penetrance 69	Cell growth assay	puc1 cig1 crs1 cig2	puc1Δ cig1Δ crs1Δ cig2Δ	Null Null Null Null		PMID:25891897
penetrance 94.5	Cell growth assay	puc1 rem1 cig1 crs1 cig2	puc1Δ rem1Δ cig1Δ crs1Δ cig2Δ	Null Null Null Null Null		PMID:25891897
FYPO:0000478	normal meiosis
	Flow cytometry data	cig2	cig2Δ	Null	PECO:0000223	PMID:25891897
puc1	puc1Δ	Null
rem1	rem1Δ	Null
cdc2	cdc2Δ	Null
cdc2	cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator)	Overexpression
crs1	crs1Δ	Null
cig1	cig1Δ	Null
cdc13	cdc13Δ	Null
	Microscopy	crs1 rem1	crs1Δ rem1Δ	Null Null	PECO:0000223	PMID:25891897

Target Of

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Ontology	Relationship	Gene	Product
FYPO	affected by mutation in	iss10	Mmi1-driven selective elimination factor Iss10
FYPO	affected by mutation in	mei4	meiotic forkhead transcription factor Mei4
FYPO	affected by mutation in	mmi1	nucleus specific RNA binding exosome specificity factor Mmi1
FYPO	affected by mutation in	red1	RNA elimination defective protein Red1
FYPO	affected by mutation in	red5	human ZC3H3 homolog

Ontology	Relationship	Gene	Product	Reference
FYPO	affected by mutation in	iss10	Mmi1-driven selective elimination factor Iss10	PMID:24713849
FYPO	affected by mutation in	mei4	meiotic forkhead transcription factor Mei4	PMID:26670050
FYPO	affected by mutation in	mmi1	nucleus specific RNA binding exosome specificity factor Mmi1	PMID:16823445
FYPO	affected by mutation in	mmi1	nucleus specific RNA binding exosome specificity factor Mmi1	PMID:26670050
FYPO	affected by mutation in	red1	RNA elimination defective protein Red1	PMID:21317872
FYPO	affected by mutation in	red1	RNA elimination defective protein Red1	PMID:24713849
FYPO	affected by mutation in	red5	human ZC3H3 homolog	PMID:23658229

Transcript

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Transcript Structure

Region	Coordinates	Reference
Exons	3453406..3453119, 3453077..3452918, 3452877..3452822, 3452769..3452589, 3452540..3452323
Intron	3453118..3453078, 3452917..3452878, 3452821..3452770, 3452588..3452541
mRNA	3453406..3452323
CDS	3453406..3453119, 3453077..3452918, 3452877..3452822, 3452769..3452589, 3452540..3452323

Protein Features

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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID	Database	InterPro	Description	Start	End	Count
PF00134	Pfam	IPR006671	Cyclin, N-terminal	60	183	11
SM00385	SMART	IPR013763	Cyclin-like	88	176	13
PTHR10177	HMMPANTHER			102	255	6
PTHR10177:SF181	HMMPANTHER			102	255	1
1.10.472.10	Gene3D	IPR013763	Cyclin-like	84	182	13
SSF47954	SuperFamily	IPR013763	Cyclin-like	61	182	15

View domain organization at Pfam

Term ID	Term Name	Reference	Count
PBO:0000553	cyclin

Protein Properties

Ave. residue weight	114.29 Da
Charge	-3.00
Codon Adaptation Index	0.46
Isoelectric point	5.66
Molecular weight	34.29 kDa
Number of residues	300

Sequence

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Gene Expression

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Qualitative Gene Expression

Description	Level	Evidence	Reference
RNA level	increased during GO:0051321	experimental evidence	PMID:PMPB:0

Quantitative Gene Expression

View graphical display of gene expression data for crs1 (SPBC2G2.09c)

RNA Level

Molecules/Cell (average)	Extension	Condition	Scale	Evidence	Reference
0.11	during GO:0072690	PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633
0.19	during cell quiescence following G1 arrest due to nitrogen limitation	PECO:0000127, PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633

Misc

Description	Qualifier	Reference	Count
meiosis-specific splicing		PMID:15893732	14

Warning

Description	Qualifier	Reference	Count
gene structure updated		PMID:15893732	435

Taxonomic Conservation

Description	Qualifier	Reference	Count
orthologs cannot be distinguished			121
conserved in eukaryotes			4516
conserved in eukaryotes only			2525

Orthologs

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Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC2G2.09c into the Query Builder
View these interactions in esyN View network in esyN

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	Gene	Product	Evidence	Reference
enhances phenotype of	puc1	cyclin Puc1	Phenotypic Enhancement	PMID:25891897
enhances phenotype of	rem1	meiosis-specific cyclin Rem1	Phenotypic Enhancement	PMID:25891897
enhances phenotype of	cig2	G1/S-specific B-type cyclin Cig2	Phenotypic Enhancement	PMID:25891897
enhances phenotype of	cig1	cyclin Cig1	Phenotypic Enhancement	PMID:25891897
negative genetic interaction with	sts5	RNB-like protein	Negative Genetic	PMID:22681890

External References

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Database	Identifier	Description
NBRP	SPBC2G2.09c	Fission yeast strain database, National BioResource Project (Japan)
YOGY	SPBC2G2.09c	Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid	SPBC2G2.09c	BioGRID Interaction Datasets
Expression Viewer	SPBC2G2.09c	Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer	SPBC2G2.09c	Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer	SPBC2G2.09c	Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer	SPBC2G2.09c	Environmental stress expression profiles (Bähler Lab)
Pomb(A)	SPBC2G2.09c	Polyadenylation Viewer (Gullerova lab)
pombeTV	SPBC2G2.09c	Transcriptome Viewer (Bähler Lab)
GEO	SPBC2G2.09c	GEO profiles
PInt	SPBC2G2.09c	Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas	SPBC2G2.09c	Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO	SPBC2G2.09c	Fission yeast phenotypic data & analysis
Cyclebase	SPBC2G2.09c.1	Cell Cycle Data
SPD / RIKEN	10/10F06	Orfeome Localization Data
UniProtKB/SwissProt	O43008	Meiosis-specific cyclin crs1
ModBase	O43008	Database of comparative protein structure models
STRING	O43008	Network display of known and predicted interactions and functional associations
RefSeq Peptide	NP_596438	meiosis specific cyclin Crs1
RefSeq mRNA	NM_001022357	972h- meiosis specific cyclin Crs1 (crs1), mRNA
European Nucleotide Archive	CAA17889.3	ENA Protein Mapping
UniParc	UPI000228F4E4	UniProt Archive

Literature for crs1

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Release Version: PomBase:30_62 - 30 Jan 2017