pmr1 (SPBC31E1.02c)

Gene Standard Namepmr1 Characterisation Statuspublished
Systematic IDSPBC31E1.02c Feature Typeprotein coding
Synonymscps5, pgak2 Name Description
ProductP-type ATPase, calcium transporting Pmr1 Product Size899aa, 98.36 kDa
Genomic Location Chromosome II, 243731-239838 (3894nt); CDS:243069-240370 (2700nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
calcium ion binding44
Annotation ExtensionEvidenceWith/FromReference
calcium-transporting ATPase activity6
Annotation ExtensionEvidenceWith/FromReference
manganese ion binding9
Annotation ExtensionEvidenceWith/FromReference
manganese-transporting ATPase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
calcium ion transmembrane transport14
Annotation ExtensionEvidenceWith/FromReference
manganese ion transmembrane transport4
Annotation ExtensionEvidenceWith/FromReference
positive regulation of calcium-mediated signaling6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum595
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane205
Annotation ExtensionEvidenceWith/FromReference
integral component of endoplasmic reticulum membrane68
Annotation ExtensionEvidenceWith/FromReference
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth at high temperaturecps5-138 (400->opal)Not specified151
normal growth on glucose carbon sourcepmr1ΔNull189
normal growth on sorbitolcps5-138 (400->opal)Not specified17
normal vegetative cell population growth ratepmr1ΔNull57
sensitive to cadmium246
expressivity FYPO_EXT:0000002pmr1ΔNull
sensitive to calcium starvationcps5-138 (400->opal)Not specified3
sensitive to cell wall-degrading enzymescps5-138 (400->opal)Not specified42
sensitive to cyclosporin Acps5-138 (400->opal)Not specified5
sensitive to hydrogen peroxide137
expressivity FYPO_EXT:0000003pmr1ΔNull
sensitive to hydroxyureapmr1ΔNull518
sensitive to low osmolaritycps5-138 (400->opal)Not specified2
sensitive to salt stress86
expressivity FYPO_EXT:0000003pmr1ΔNull
sensitive to UV during vegetative growthpmr1ΔNull133
viable vegetative cell populationpmr1+ (wild type)Overexpression3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal cytokinetic cell separation resulting in septated cellcps5-138 (400->opal)Not specified7
decreased 1,3-beta-D-glucan synthase activitycps5-138 (400->opal)Not specified4
decreased cell wall galactomannan levelcps5-138 (400->opal)Not specified3
decreased protein glycosylationcps5-138 (400->opal)Not specified7
dispersed actin cortical patch localizationcps5-138 (400->opal)Not specified25
expressivity FYPO_EXT:0000003cps5-138 (400->opal)Not specified
galactomannan absent from cell wallcps5-138 (400->opal)Not specified1
increased 1,3-beta-D-glucan synthase activitycps5-138 (400->opal)Not specified5
increased cell wall alpha-glucan level during cellular response to calcium starvationcps5-138 (400->opal)Not specified1
increased septum thicknesscps5-138 (400->opal)Not specified18
lemon-shaped cellcps5-138 (400->opal)Not specified10
normal DNA contentpmr1ΔNull21
viable vegetative cell with normal cell morphologypmr1+ (wild type)Overexpression3092
viable vegetative cell, abnormal cell shape, normal cell size215
penetrance FYPO_EXT:0000001, expressivity FYPO_EXT:0000003pmr1ΔNull
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00702 Pfam IPR023214 HAD-like domain 323 639 9
PF00690 Pfam IPR004014 Cation-transporting P-type ATPase, N-terminal 7 75 6
PF00122 Pfam IPR008250 P-type ATPase, A domain 86 319 14
PF00689 Pfam IPR006068 Cation-transporting P-type ATPase, C-terminal 710 880 3
SM00831 SMART IPR004014 Cation-transporting P-type ATPase, N-terminal 4 80 5
TMhelix TMHMM 826 845 959
TMhelix TMHMM 248 265 959
TMhelix TMHMM 78 100 959
TMhelix TMHMM 855 874 959
TMhelix TMHMM 757 779 959
TMhelix TMHMM 280 302 959
TMhelix TMHMM 686 708 959
PS00154 Prosite Patterns IPR018303 P-type ATPase, phosphorylation site 329 335 14
PTHR24093 HMMPANTHER 1 892 5
PTHR24093:SF217 HMMPANTHER IPR006413 P-type ATPase, subfamily IIA, PMR1-type 1 892 1
1.20.1110.10 Gene3D IPR023298 P-type ATPase, transmembrane domain 59 115 5
1.20.1110.10 Gene3D IPR023298 P-type ATPase, transmembrane domain 594 884 5
1.20.1110.10 Gene3D IPR023298 P-type ATPase, transmembrane domain 158 507 5
SSF56784 SuperFamily IPR023214 HAD-like domain 476 728 41
SSF56784 SuperFamily IPR023214 HAD-like domain 325 345 41
SSF81660 SuperFamily IPR023299 P-type ATPase, cytoplasmic domain N 333 528 11
0049473 SuperFamily 675 884 14
0049473 SuperFamily 228 321 14
0049473 SuperFamily 6 118 14
0049471 SuperFamily 117 223 14
PR00119 PRINTS IPR001757 P-type ATPase 165 179 14
PR00119 PRINTS IPR001757 P-type ATPase 538 548 14
PR00119 PRINTS IPR001757 P-type ATPase 625 644 14
PR00119 PRINTS IPR001757 P-type ATPase 649 661 14
PR00119 PRINTS IPR001757 P-type ATPase 327 341 14
PR00119 PRINTS IPR001757 P-type ATPase 516 527 14
PR00120 PRINTS IPR001757 P-type ATPase 625 641 4
PR00120 PRINTS IPR001757 P-type ATPase 486 504 4
PR00120 PRINTS IPR001757 P-type ATPase 657 682 4
PR00120 PRINTS IPR001757 P-type ATPase 597 613 4
TIGR01494 tigrfam IPR001757 P-type ATPase 222 348 14
TIGR01494 tigrfam IPR001757 P-type ATPase 596 710 14
TIGR01494 tigrfam IPR001757 P-type ATPase 87 210 14
TIGR01522 tigrfam IPR006413 P-type ATPase, subfamily IIA, PMR1-type 2 885 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 109.41 Da
Charge -3.50
Isoelectric point 6.04
Molecular weight 98.36 kDa
Number of residues 899

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS892 1670
present during cellular response to thiabendazole, mitotic M phaseS892
Annotation ExtensionEvidenceResidueReference
experimental evidence S892 PMID:24763107
present during mitotic M phase experimental evidence S892 PMID:21712547
present during cellular response to thiabendazole IDA S892 PMID:18257517
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
IDA PMID:19547744
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
12667during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
12676during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
10921during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
12143during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
12141during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
3414.34during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
3765.91during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.9during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Disease Association
Hailey-Hailey disease1
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
pmc1mediator complex subunit Pmc1 Dosage RescuePMID:19168988
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Synthetic Growth DefectPMID:18931302
set1histone lysine methyltransferase Set1 Negative GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
SPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
gls2glucosidase II alpha subunit Gls2 Synthetic Growth DefectPMID:18931302
cta5Ca2+/Mn2+ transporting P-type ATPase P5 type Cta5 Synthetic Growth DefectPMID:19168988
Dosage Rescue
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
myp2myosin II heavy chain Myo3 Negative GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
SPCC1672.11cP-type ATPase P5 type (predicted) Synthetic Growth DefectPMID:19168988
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
yam8stretch-activated calcium channel Yam8 Synthetic Growth DefectPMID:18931302
ryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
nse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:18931302
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic EnhancementPMID:15470240
pdt1Nramp family manganese ion transmembrane transporter Phenotypic EnhancementPMID:14723709
Dosage Rescue
SPAC24H6.13DUF221 family protein implicated in Golgi to plasma membrane transport (predicted) Synthetic Growth DefectPMID:18931302
spa2GTPase activating protein Spa2 (predicted) Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
SPAPB2B4.04cvacuolar calcium transporting P-type ATPase P2 type, Pmc1 Synthetic LethalityPMID:15470240
Dosage Rescue
vps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
ubp2ubiquitin C-terminal hydrolase Ubp2 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
alg6glucosyltransferase Alg6 Synthetic Growth DefectPMID:18931302
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC31E1.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC31E1.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC31E1.02c BioGRID Interaction Datasets
Expression Viewer SPBC31E1.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC31E1.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC31E1.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC31E1.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC31E1.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC31E1.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC31E1.02c Cell Cycle Data
GEO SPBC31E1.02c GEO profiles
PInt SPBC31E1.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC31E1.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC31E1.02c Fission yeast phenotypic data & analysis
IntEnz3.6.3.8Integrated relational Enzyme database
Rhea3.6.3.8Annotated reactions database
SPD / RIKEN33/33H08Orfeome Localization Data
UniProtKB/SwissProtO59868Calcium-transporting ATPase 1
ModBaseO59868Database of comparative protein structure models
STRINGO59868Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595098P-type ATPase, calcium transporting Pmr1
RefSeq mRNANM_001021005972h- P-type ATPase, calcium transporting Pmr1 (pmr1), mRNA
European Nucleotide ArchiveAAC16669.1ENA Protein Mapping
European Nucleotide ArchiveCAB39136.1ENA Protein Mapping
UniParcUPI000006C86CUniProt Archive

Literature for pmr1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015