spc24 (SPBC336.08)

Gene Standard Namespc24 ChromosomeII
Systematic IDSPBC336.08 Gene Start2755392
Synonyms Gene End2759388
Productspindle pole body protein Spc24 Gene Length3997
Feature Typeprotein coding CDS Start2755505
Name Description CDS End2756278
Characterisation Statuspublished CDS Length774

Ensembl Gene Location
  1. rnh1
  2. SPNCRNA.1546
  3. sfc3
  4. spc24
  5. rrn7
  6. tif512
  7. vps52
  8. cdc10
  9. SPBC336.13c
  10. SPNCRNA.1547
  11. SPNCRNA.1548
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001489inviable vegetative cellMicroscopyspc24delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIspc25PMID:15728720
IPIndc80PMID:15728720
GO:0042803protein homodimerization activityIPIspc24PMID:15728720
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000070mitotic sister chromatid segregationICGO:0000778GO_REF:0000001
GO:0051455attachment of spindle microtubules to kinetochore involved in homologous chromosome segregationIDAPMID:15728720
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000778condensed nuclear chromosome kinetochoreIDAPMID:11266451
IDAPMID:15728720
GO:0005829cytosolIDAPMID:16823372
GO:0031262Ndc80 complexTASPMID:15728720
GO:0031617NMS complexIDAPMID:16079914
GO:0044732mitotic spindle pole bodyIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127553922755658
227557062756041
327561722759388

References

Region Start End Reference
three_prime_UTR27562792759388PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF08286 IPR013252 Pfam Kinetochore-Ndc80 subunit Spc24 82 191 1
SSF143026 SuperFamily 133 192 1
Coil ncoils Rabaptin coiled-coil domain 94 129 974

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReference
SO:0001080coiled_coil

Protein Properties

Ave. residue weight 116.36 Da
Charge -7.50
Isoelectric point 4.72
Molecular weight 23.04 kDa
Number of residues 198
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.3PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.54PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
mis12kinetochore protein Mis12 Affinity Capture-MSPMID:16079914
spc7kinetochore protein Spc7 Affinity Capture-MSPMID:15371542
Affinity Capture-MSPMID:16079914
spc25kinetochore protein Spc25 Affinity Capture-MSPMID:15371542
Two-hybridPMID:15728720
ndc80spindle pole body protein Ndc80 Affinity Capture-MSPMID:15371542
Affinity Capture-WesternPMID:15728720
Two-hybrid
nuf2spindle pole body protein Nuf2 Affinity Capture-MSPMID:15371542
Affinity Capture-MSPMID:16079914
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External References
Database Identifier Description
NBRP SPBC336.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC336.08 Retrieval of eukaryotic orthologs
BioGrid SPBC336.08 BioGRID Interaction Datasets
Bähler Lab SPBC336.08 Cell Cycle Expression Profile
Bähler Lab SPBC336.08 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC336.08 Pheromone response/mating expression profiles
Bähler Lab SPBC336.08 Environmental stress expression profiles
Bähler Lab SPBC336.08 Bähler Lab Transcriptome Viewer
Cyclebase SPBC336.08 Cell Cycle Data
PInt SPBC336.08 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC336.08 Entrez Gene
SPD / RIKEN09/09F02Orfeome Localization Data
WikiGene2540238spindle pole body protein Spc24
Uniprot_genenameSPC24
EntrezGene2540238spindle pole body protein Spc24
UniProtKB/SwissProtQ9UST6Kinetochore protein spc24
ModBaseQ9UST6Database of comparative protein structure models
Pfam Protein DomainsQ9UST6Pfam Domain Arrangement
RefSeq PeptideNP_596128spindle pole body protein Spc24
RefSeq PeptideNP_596130translation elongation factor eIF5A
RefSeq mRNANM_001022046972h- spindle pole body protein Spc24 (spc24), mRNA
RefSeq mRNANM_001022048972h- translation elongation factor eIF5A (tif512), mRNA
European Nucleotide ArchiveCAB58160ENA Protein Mapping
SPD / RIKEN09/09F02Orfeome Localization Data

Literature for spc24
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013