pic1 (SPBC336.15)

Gene Standard Namepic1 ChromosomeII
Systematic IDSPBC336.15 Gene Start2769046
SynonymsSPBC685.01 Gene End2772538
ProductINCENP, Pic1 Gene Length3493
Feature Typeprotein coding CDS Start2769271
Name Description CDS End2772370
Characterisation Statuspublished CDS Length3100

Ensembl Gene Location
  1. cdc10
  2. SPBC336.13c
  3. SPNCRNA.1547
  4. SPNCRNA.1548
  5. ppk26
  6. SPBTRNALEU.08
  7. pic1
  8. exo5
  9. SPBC685.03
  10. aps2
  11. gpi15
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000096sensitive to cadmiumCell growth assaypic1delta (deletion)deletionPECO:0000012PMID:18684775
FYPO:0002061inviable vegetative cell populationMicroscopypic1delta (deletion)deletionPMID:20473289
GO Molecular Function

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIark1PMID:11950927
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000070mitotic sister chromatid segregationIGIbir1PMID:16199877
IMPbir1PMID:16199877
GO:0000910cytokinesisIGIark1PMID:11950927
GO:0071276cellular response to cadmium ionIMPPMID:18684775
GO:0071585detoxification of cadmium ionIMPPMID:18684775
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000939condensed chromosome inner kinetochoreTASPMID:11950927
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmIEAUniProtKB:KW-0963GO_REF:0000037
GO:0005819spindleIDAPMID:16823372
GO:0032133chromosome passenger complexNASGO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127690462769428
227694722772538

References

Region Start End Reference
three_prime_UTR27723712772538PMID:21511999
five_prime_UTR27690462769270PMID:21511999
three_prime_UTR27723712772538PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF03941 IPR005635 Pfam Inner centromere protein, ARK-binding domain 921 980 1
PTHR13142:SF0 hmmpanther 2 1018 1
PTHR13142 hmmpanther 2 1018 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.45 Da
Charge 44.50
Isoelectric point 10.22
Molecular weight 114.48 kDa
Number of residues 1018
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide521.54PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.2PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.89PMID:23101633
Warning
DescriptionQualifierReference
gene structure may be incorrect
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
bir1survivin, Bir1 Dosage RescuePMID:16199877
swi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:17322402
Synthetic LethalityPMID:22264609
ark1aurora-B kinase Ark1 Dosage RescuePMID:11950927
mde4monopolin-like complex subunit Mde4 Synthetic LethalityPMID:22264609
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
bir1survivin, Bir1 Affinity Capture-WesternPMID:17301288
ark1aurora-B kinase Ark1 Two-hybridPMID:11950927
Affinity Capture-WesternPMID:17301288
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External References
Database Identifier Description
NBRP SPBC336.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC336.15 Retrieval of eukaryotic orthologs
BioGrid SPBC336.15 BioGRID Interaction Datasets
Bähler Lab SPBC336.15 Cell Cycle Expression Profile
Bähler Lab SPBC336.15 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC336.15 Pheromone response/mating expression profiles
Bähler Lab SPBC336.15 Environmental stress expression profiles
Bähler Lab SPBC336.15 Bähler Lab Transcriptome Viewer
Cyclebase SPBC336.15 Cell Cycle Data
PInt SPBC336.15 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC336.15 Entrez Gene
EntrezGene2540250INCENP, Pic1
Uniprot_genenamePIC1
WikiGene2540250INCENP, Pic1
SPD / RIKEN47/47G12Orfeome Localization Data
UniProtKB/SwissProtQ1MTN3Inner centromere protein-related protein pic1
ModBaseQ1MTN3Database of comparative protein structure models
Pfam Protein DomainsQ1MTN3Pfam Domain Arrangement
RefSeq PeptideNP_596135INCENP, Pic1
RefSeq mRNANM_001022053972h- INCENP, Pic1 (pic1), mRNA
European Nucleotide ArchiveCAB58167ENA Protein Mapping
UniParcUPI000006C889UniProt Archive

Literature for pic1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013