pic1 (SPBC336.15)

Gene Standard Namepic1 Characterisation Statuspublished
Systematic IDSPBC336.15 Feature Typeprotein coding
SynonymsSPBC685.01 Name Description
Productkinetochore protein, INCENP ortholog Pic1 Product Size1018aa, 114.48 kDa
Genomic Location Chromosome II, 2769046-2772538 (3493nt); CDS:2769271-2772370 (3100nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding887
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitotic cytokinesis104
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid segregation187
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
chromosome passenger complex4
Annotation ExtensionEvidenceWith/FromReference
condensed nuclear chromosome inner kinetochore10
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle271
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationpic1Δ1455
resistance to hydrogen peroxidepic1Δ75
sensitive to cadmiumpic1Δ249
sensitive to caffeine during vegetative growthpic1Δ110
sensitive to hydrogen peroxidepic1Δ155

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cyclepic1Δ894
inviable after spore germination with elongated germ tubepic1Δ164
Target Of
FYPO affected by mutation in ark1 aurora-B kinase Ark1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2769046..2769428, 2769472..2772538
5' UTR2769046..2769270PMID:21511999
CDS2769271..2769428, 2769472..2772370
3' UTR2772371..2772538PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03941 Pfam IPR005635 Inner centromere protein, ARK-binding domain 921 978 1
PTHR13142:SF1 HMMPANTHER 875 1018 1
PTHR13142 HMMPANTHER 875 1018 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.45 Da
Charge 44.50
Codon Adaptation Index 0.39
Isoelectric point 10.22
Molecular weight 114.48 kDa
Number of residues 1018
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for pic1 (SPBC336.15)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
521.54during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
337during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.89during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
gene structure may be incorrect15
Taxonomic Conservation
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC336.15 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withark1aurora-B kinase Ark1 Two-hybridPMID:11950927
affinity captured byclp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
affinity capturesark1aurora-B kinase Ark1 Affinity Capture-WesternPMID:17301288
affinity capturesbir1survivin, Bir1 Affinity Capture-WesternPMID:17301288
modified bylkh1dual specificity protein kinase Lkh1 Biochemical ActivityPMID:26167880
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC336.15 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic lethal withmde4microtubule-site clamp monopolin complex subunit Mde4 Synthetic LethalityPMID:22264609
synthetic lethal withswi6HP1 family chromodomain protein Swi6 Synthetic LethalityPMID:22264609
overexpression rescuesbir1survivin, Bir1 Dosage RescuePMID:16199877
synthetic growth defect withswi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:17322402
rescued by overexpression ofark1aurora-B kinase Ark1 Dosage RescuePMID:11950927
External References
Database Identifier Description
NBRP SPBC336.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC336.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC336.15 BioGRID Interaction Datasets
Expression Viewer SPBC336.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC336.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC336.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC336.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC336.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC336.15 Transcriptome Viewer (Bähler Lab)
GEO SPBC336.15 GEO profiles
PInt SPBC336.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC336.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC336.15 Fission yeast phenotypic data & analysis
Cyclebase SPBC336.15.1 Cell Cycle Data
SPD / RIKEN47/47G12Orfeome Localization Data
UniProtKB/SwissProtQ1MTN3Inner centromere protein-related protein pic1
ModBaseQ1MTN3Database of comparative protein structure models
STRINGQ1MTN3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596135INCENP, Pic1
RefSeq mRNANM_001022053972h- INCENP, Pic1 (pic1), mRNA
European Nucleotide ArchiveCAB58167.1ENA Protein Mapping
UniParcUPI000006C889UniProt Archive

Literature for pic1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016