uge1 (SPBC365.14c)


Gene Standard Nameuge1 Characterisation Statuspublished
Systematic IDSPBC365.14c Feature Typeprotein coding
Synonymsgal10 Name Description
ProductUDP-glucose 4-epimerase Uge1 Product Size355aa, 39.23 kDa
Genomic Location Chromosome II, 2523067-2521123 (1945nt); CDS:2522925-2521623 (1303nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
UDP-glucose 4-epimerase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
galactose catabolic process via UDP-galactose3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased mating efficiencyuge1Δ272
resistance to tamoxifenuge1Δ61
sensitive to 4-nitroquinoline N-oxideuge1Δ159
sensitive to 5-fluorouraciluge1Δ273
sensitive to camptothecinuge1Δ228
sensitive to clotrimazoleuge1Δ107
sensitive to cobaltuge1Δ57
sensitive to micafunginuge1Δ119
sensitive to tacrolimusuge1Δ81
sensitive to terbinafineuge1Δ103
sensitive to thiabendazoleuge1Δ264
slow vegetative cell population growthuge1Δ357
viable vegetative cell populationuge1Δ3837

Cell Phenotype

Term NameGenotypesCount
inviable stubby vegetative celluge1Δ17
viable stubby vegetative celluge1Δ75
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2523067..2522923, 2522855..2522793, 2522624..2521123
Intron2522922..2522856, 2522792..2522625
5' UTR2523067..2522926PMID:21511999
3' UTR2521622..2521123PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF16363 Pfam IPR016040 NAD(P)-binding domain 10 334 3
PTHR10366 HMMPANTHER 8 346 7
PTHR10366:SF433 HMMPANTHER 8 346 2
3.90.25.10 Gene3D NAD(P)-binding domain 189 241 3
3.90.25.10 Gene3D NAD(P)-binding domain 274 346 3
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 5 188 100
SSF51735 SuperFamily IPR016040 NAD(P)-binding domain 7 344 88
TIGR01179 TIGRFAM IPR005886 UDP-glucose 4-epimerase GalE 9 343 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.52 Da
Charge 3.50
Codon Adaptation Index 0.48
Isoelectric point 7.08
Molecular weight 39.23 kDa
Number of residues 355
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for uge1 (SPBC365.14c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
88741during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
87425during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
81624during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
84229during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
87471during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
34980.4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
24438.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
metabolic disorders143
carbohydrate metabolism disorders11
galactosemia3
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in bacteria1001
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC365.14c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withdot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
negative genetic interaction withvps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
negative genetic interaction withSPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withint6eIF3e subunit Int6 Negative GeneticPMID:22681890
negative genetic interaction withtps1alpha,alpha-trehalose-phosphate synthase [UDP-forming] Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withatg6autophagy associated beclin family protein Atg6 Negative GeneticPMID:22681890
negative genetic interaction withvps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
negative genetic interaction withsck2serine/threonine protein kinase Sck2 Negative GeneticPMID:24463365
negative genetic interaction withmpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
negative genetic interaction withpyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:22681890
negative genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withhif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
positive genetic interaction withsts5RNB-like protein Positive GeneticPMID:22681890
positive genetic interaction withlub1WD repeat protein Lub1 Positive GeneticPMID:22681890
synthetic growth defect withdis2serine/threonine protein phosphatase PP1, Dis2 Synthetic Growth DefectPMID:21965289
synthetic growth defect withght2hexose transmembrane transporter Ght2 Synthetic Growth DefectPMID:23254763
External References
Database Identifier Description
NBRP SPBC365.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC365.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC365.14c BioGRID Interaction Datasets
Expression Viewer SPBC365.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC365.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC365.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC365.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC365.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC365.14c Transcriptome Viewer (Bähler Lab)
GEO SPBC365.14c GEO profiles
PInt SPBC365.14c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC365.14c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC365.14c Fission yeast phenotypic data & analysis
Cyclebase SPBC365.14c.1 Cell Cycle Data
SPD / RIKEN22/22F08Orfeome Localization Data
UniProtKB/SwissProtQ9Y7X5UDP-glucose 4-epimerase uge1
ModBaseQ9Y7X5Database of comparative protein structure models
STRINGQ9Y7X5Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596043UDP-glucose 4-epimerase Uge1
RefSeq mRNANM_001021953972h- UDP-glucose 4-epimerase Uge1 (uge1), mRNA
MetaCycPWY-3821D-galactose degradation III
MetaCycPWY-6317D-galactose degradation I (Leloir pathway)
MetaCycPWY-6397Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
MetaCycPWY-6527Stachyose degradation
MetaCycPWY-7328Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis
MetaCycPWY-7344UDP-D-galactose biosynthesis
KEGG00052+5.1.3.2Galactose metabolism
KEGG00520+5.1.3.2Amino sugar and nucleotide sugar metabolism
UniPathwayUPA00214Carbohydrate metabolism; galactose metabolism

Literature for uge1

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016