uge1 (SPBC365.14c)

Gene Standard Nameuge1 Characterisation Statuspublished
Systematic IDSPBC365.14c Feature Typeprotein coding
Synonymsgal10 Name Description
ProductUDP-glucose 4-epimerase Uge1 Product Size355aa, 39.23 kDa
Genomic Location Chromosome II, 2523067-2521123 (1945nt); CDS:2522925-2521623 (1303nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
coenzyme binding87
Annotation ExtensionEvidenceWith/FromReference
UDP-glucose 4-epimerase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
galactose catabolic process via UDP-galactose4
Annotation ExtensionEvidenceWith/FromReference
protein galactosylation11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased mating efficiencyuge1ΔNull247
sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000003uge1ΔNull
sensitive to camptothecin214
expressivity FYPO_EXT:0000003uge1ΔNull
sensitive to clotrimazole105
expressivity FYPO_EXT:0000003uge1ΔNull
sensitive to cobalt56
expressivity FYPO_EXT:0000002uge1ΔNull
sensitive to micafunginuge1ΔNull116
sensitive to tacrolimus81
expressivity FYPO_EXT:0000001uge1ΔNull
sensitive to terbinafine102
expressivity FYPO_EXT:0000003uge1ΔNull
sensitive to thiabendazoleuge1ΔNull185
viable vegetative cell populationuge1ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
inviable stubby vegetative cell11
penetrance FYPO_EXT:0000003uge1ΔNull
viable stubby vegetative cell70
penetrance FYPO_EXT:0000001uge1ΔNull
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01370 Pfam IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain 9 271 5
PF13950 Pfam IPR025308 UDP-glucose 4-epimerase C-terminal domain 285 346 2
PTHR10366:SF39 HMMPANTHER IPR005886 UDP-glucose 4-epimerase GalE 1 346 2
PTHR10366 HMMPANTHER 1 346 7 Gene3D IPR016040 NAD(P)-binding domain 5 188 100 Gene3D 189 241 3 Gene3D 274 346 3
SSF51735 SuperFamily 7 344 88
TIGR01179 tigrfam IPR005886 UDP-glucose 4-epimerase GalE 9 343 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.52 Da
Charge 3.50
Isoelectric point 7.08
Molecular weight 39.23 kDa
Number of residues 355
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
88741during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
87425during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
81624during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
84229during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
34980.4during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
87471during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
24438.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.4during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
conserved in metazoa3432
conserved in vertebrates3407

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:22681890
sts5RNB-like protein Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
tps1alpha,alpha-trehalose-phosphate synthase Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Negative GeneticPMID:24463365
SPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
vps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
dis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Synthetic Growth DefectPMID:21965289
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
pyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
ght2hexose transmembrane transporter Ght2 Synthetic Growth DefectPMID:23254763
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC365.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC365.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC365.14c BioGRID Interaction Datasets
Expression Viewer SPBC365.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC365.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC365.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC365.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC365.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC365.14c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC365.14c Cell Cycle Data
GEO SPBC365.14c GEO profiles
PInt SPBC365.14c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC365.14c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC365.14c Fission yeast phenotypic data & analysis
SPD / RIKEN22/22F08Orfeome Localization Data
UniProtKB/SwissProtQ9Y7X5UDP-glucose 4-epimerase uge1
ModBaseQ9Y7X5Database of comparative protein structure models
STRINGQ9Y7X5Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596043UDP-glucose 4-epimerase Uge1
RefSeq mRNANM_001021953972h- UDP-glucose 4-epimerase Uge1 (uge1), mRNA
European Nucleotide ArchiveCAB44766.1ENA Protein Mapping
MetaCycPWY-3821Galactose degradation III
MetaCycPWY-6317Galactose degradation I (Leloir pathway)
MetaCycPWY-6397Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
MetaCycPWY-6527Stachyose degradation
MetaCycPWY-7328Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis
MetaCycPWY-7344UDP-D-galactose biosynthesis
KEGG_Enzyme00052+ metabolism
KEGG_Enzyme00520+ sugar and nucleotide sugar metabolism
UniParcUPI0000069D49UniProt Archive
UniPathwayUPA00214Carbohydrate metabolism; galactose metabolism

Literature for uge1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015