uge1 (SPBC365.14c)


Gene Standard Nameuge1 Characterisation Statuspublished
Systematic IDSPBC365.14c Feature Typeprotein coding
Synonymsgal10 Name Description
ProductUDP-glucose 4-epimerase Uge1 Product Size355aa, 39.23 kDa
Genomic Location Chromosome II, 2523067-2521123 (1945nt); CDS:2522925-2521623 (1303nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003978UDP-glucose 4-epimerase activity2
majorIDAPMID:19942659
GO:0050662coenzyme bindingIEAIPR001509GO_REF:000000291
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033499galactose catabolic process via UDP-galactoseISSUniProtKB:P04397GO_REF:00000014
GO:0042125protein galactosylationIMPPMID:1994265912
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolISOSGD:S000000223GO_REF:00000012317
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001098sensitive to 4-nitroquinoline N-oxideCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:19264558159
expressivity FYPO_EXT:0000003
FYPO:0000085sensitive to camptothecinCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:19264558200
expressivity FYPO_EXT:0000003
FYPO:0002640sensitive to clotrimazoleCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817105
expressivity FYPO_EXT:0000003
FYPO:0001245sensitive to cobaltCell growth assayuge1ΔNullPECO:0000201, PECO:0000005PMID:2280634456
expressivity FYPO_EXT:0000002
FYPO:0002641sensitive to micafunginCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817105
FYPO:0000086sensitive to tacrolimusCell growth assayuge1ΔNullPECO:0000201, PECO:0000005, PECO:0000142PMID:2185027179
expressivity FYPO_EXT:0000001
FYPO:0002328sensitive to terbinafineCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817101
expressivity FYPO_EXT:0000003
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidenceuge1ΔNullPMID:2053713292
FYPO:0002060viable vegetative cell populationMicroscopyuge1ΔNullPMID:204732893755
Microscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidenceuge1ΔNullPECO:0000015PMID:23950735222
FYPO:0002107inviable stubby vegetative cellMicroscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:2369780610
penetrance FYPO:0000003
FYPO:0002106viable stubby vegetative cellMicroscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:2369780649
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
125230672522923
225228552522793
325226242521123

UTRs

Region Start End Reference
three_prime_UTR25216222521123PMID:21511999
five_prime_UTR25230672522926PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01370 Pfam IPR001509 NAD-dependent epimerase/dehydratase 9 271 5
PF13950 Pfam IPR025308 UDP-glucose 4-epimerase C-terminal domain 285 346 2
PTHR10366 HMMPANTHER 8 347 7
PTHR10366:SF39 HMMPANTHER IPR005886 8 347 2
G3DSA:3.90.25.10 Gene3D 189 241 3
G3DSA:3.90.25.10 Gene3D 274 346 3
G3DSA:3.40.50.720 Gene3D IPR016040 5 188 99
SSF51735 SuperFamily 7 344 88
TIGR01179 tigrfam IPR005886 UDP-glucose 4-epimerase GalE 9 343 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.52 Da
Charge 3.50
Isoelectric point 7.08
Molecular weight 39.23 kDa
Number of residues 355
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
24438.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
34980.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
tps1alpha,alpha-trehalose-phosphate synthase Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
vps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
SPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
sts5RNB-like protein Positive GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
dis2serine/threonine protein phosphatase PP1 Synthetic Growth DefectPMID:21965289
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
pyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
ght2hexose transporter Ght2 Synthetic Growth DefectPMID:23254763
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC365.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC365.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC365.14c BioGRID Interaction Datasets
Expression Viewer SPBC365.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC365.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC365.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC365.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC365.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC365.14c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC365.14c Cell Cycle Data
GEO SPBC365.14c GEO profiles
PInt SPBC365.14c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540938UDP-glucose 4-epimerase (predicted)
EntrezGene2540938UDP-glucose 4-epimerase (predicted)
SPD / RIKEN22/22F08Orfeome Localization Data
UniProtKB/SwissProtQ9Y7X5Uncharacterized protein C365.14c
ModBaseQ9Y7X5Database of comparative protein structure models
StringQ9Y7X5Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596043UDP-glucose 4-epimerase (predicted)
RefSeq mRNANM_001021953972h- UDP-glucose 4-epimerase (predicted) (SPBC365.14c), mRNA
European Nucleotide ArchiveCAB44766ENA Protein Mapping
UniParcUPI0000069D49UniProt Archive

Literature for uge1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014