uge1 (SPBC365.14c)


Gene Standard Nameuge1 Characterisation Statuspublished
Systematic IDSPBC365.14c Feature Typeprotein coding
Synonymsgal10 Name Description
ProductUDP-glucose 4-epimerase Uge1 Product Size355aa, 39.23 kDa
Genomic Location Chromosome II, 2523067-2521123 (1945nt); CDS:2522925-2521623 (1303nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
coenzyme binding86
Annotation ExtensionEvidenceWith/FromReference
UDP-glucose 4-epimerase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
galactose catabolic process via UDP-galactose4
Annotation ExtensionEvidenceWith/FromReference
protein galactosylation11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001098sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000003Cell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000085sensitive to camptothecin211
expressivity FYPO_EXT:0000003Cell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0002640sensitive to clotrimazole105
expressivity FYPO_EXT:0000003Cell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817
FYPO:0001245sensitive to cobalt56
expressivity FYPO_EXT:0000002Cell growth assayuge1ΔNullPECO:0000201, PECO:0000005PMID:22806344
FYPO:0002641sensitive to micafunginCell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817116
FYPO:0000086sensitive to tacrolimus81
expressivity FYPO_EXT:0000001Cell growth assayuge1ΔNullPECO:0000201, PECO:0000005, PECO:0000142PMID:21850271
FYPO:0002328sensitive to terbinafine101
expressivity FYPO_EXT:0000003Cell growth assayuge1ΔNullPECO:0000137, PECO:0000005PMID:22252817
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidenceuge1ΔNullPMID:20537132176
FYPO:0002060viable vegetative cell populationMicroscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyuge1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidenceuge1ΔNullPECO:0000015PMID:23950735240
FYPO:0002107inviable stubby vegetative cell10
penetrance FYPO_EXT:0000003Microscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:23697806
FYPO:0002106viable stubby vegetative cell69
penetrance FYPO_EXT:0000001Microscopyuge1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
125230672522923
225228552522793
325226242521123

UTRs

Region Coordinates Reference
five_prime_UTR2523067..2522926PMID:21511999
three_prime_UTR2521622..2521123PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01370 Pfam IPR001509 NAD-dependent epimerase/dehydratase 9 271 5
PF13950 Pfam IPR025308 UDP-glucose 4-epimerase C-terminal domain 285 346 2
PTHR10366:SF39 HMMPANTHER IPR005886 UDP-glucose 4-epimerase GalE 8 347 2
PTHR10366 HMMPANTHER 8 347 7
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 5 188 100
3.90.25.10 Gene3D 189 241 3
3.90.25.10 Gene3D 274 346 3
SSF51735 SuperFamily 7 344 88
TIGR01179 tigrfam IPR005886 UDP-glucose 4-epimerase GalE 9 343 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.52 Da
Charge 3.50
Isoelectric point 7.08
Molecular weight 39.23 kDa
Number of residues 355
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
88741during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
87425during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
81624during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
84229during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
87471during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
34980.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
24438.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:22681890
sts5RNB-like protein Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
tps1alpha,alpha-trehalose-phosphate synthase Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Negative GeneticPMID:24463365
SPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
vps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
dis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Synthetic Growth DefectPMID:21965289
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
pyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
ght2hexose transporter Ght2 Synthetic Growth DefectPMID:23254763
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC365.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC365.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC365.14c BioGRID Interaction Datasets
Expression Viewer SPBC365.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC365.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC365.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC365.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC365.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC365.14c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC365.14c Cell Cycle Data
GEO SPBC365.14c GEO profiles
PInt SPBC365.14c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC365.14c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC365.14c Fission yeast phenotypic data & analysis
SPD / RIKEN22/22F08Orfeome Localization Data
UniProtKB/SwissProtQ9Y7X5UDP-glucose 4-epimerase uge1
ModBaseQ9Y7X5Database of comparative protein structure models
STRINGQ9Y7X5Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596043UDP-glucose 4-epimerase Uge1
RefSeq mRNANM_001021953972h- UDP-glucose 4-epimerase Uge1 (uge1), mRNA
European Nucleotide ArchiveCAB44766.1ENA Protein Mapping
UniParcUPI0000069D49UniProt Archive

Literature for uge1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014