mge1 (SPBC3B9.19)

Gene Standard Namemge1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC3B9.19 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial GrpE domain chaperone protein (predicted) Product Size223aa, 25.33 kDa
Genomic Location Chromosome II, 4022474-4023772 (1299nt); CDS:4022547-4023218 (672nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
adenyl-nucleotide exchange factor activity5
Annotation ExtensionEvidenceWith/FromReference
chaperone binding8
Annotation ExtensionEvidenceWith/FromReference
unfolded protein binding42
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
protein folding106
Annotation ExtensionEvidenceWith/FromReference
protein import into mitochondrial matrix17
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
presequence translocase-associated import motor6
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymge1ΔNullPECO:0000005, PECO:0000137PMID:236978061338
Microscopymge1ΔNullPECO:0000006, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001991inviable after spore germination, without cell divisionMicroscopymge1ΔNullPECO:0000006, PECO:0000137PMID:23697806474
FYPO:0002207inviable swollen sporeMicroscopymge1ΔNullPECO:0000005, PECO:0000137PMID:236978063
Microscopymge1ΔNullPECO:0000006, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01025 Pfam IPR000740 GrpE nucleotide exchange factor 52 220 1
PS01071 Prosite Patterns IPR000740 GrpE nucleotide exchange factor 175 218 1
PTHR21237 HMMPANTHER IPR000740 GrpE nucleotide exchange factor 6 223 1
PTHR21237:SF12 HMMPANTHER 6 223 1
1dkgA02 Gene3D IPR009012 GrpE nucleotide exchange factor, head 164 222 1
1dkgA01 Gene3D IPR013805 GrpE nucleotide exchange factor, coiled-coil 56 162 1
0036470 SuperFamily IPR009012 GrpE nucleotide exchange factor, head 166 222 1
0053405 SuperFamily 59 164 1
Coil ncoils Rabaptin coiled-coil domain 46 102 968
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 172 187 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 82 98 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 199 218 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 110 125 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.61 Da
Charge 2.00
Isoelectric point 8.39
Molecular weight 25.33 kDa
Number of residues 223
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
40246during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
40400during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
31161during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
37536during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
31942during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
11366.36during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
12954.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8.9during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPBC3B9.19 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3B9.19 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3B9.19 BioGRID Interaction Datasets
Expression Viewer SPBC3B9.19 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3B9.19 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3B9.19 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3B9.19 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3B9.19 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3B9.19 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3B9.19 Cell Cycle Data
GEO SPBC3B9.19 GEO profiles
PInt SPBC3B9.19 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC3B9.19 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC3B9.19 Fission yeast phenotypic data & analysis
SPD / RIKEN07/07G03Orfeome Localization Data
UniProtKB/SwissProtO43047GrpE protein homolog, mitochondrial
ModBaseO43047Database of comparative protein structure models
STRINGO43047Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596677mitochondrial GrpE domain chaperone protein (predicted)
RefSeq mRNANM_001022599972h- mitochondrial GrpE domain chaperone protein (predicted) (mge1), mRNA
European Nucleotide ArchiveCAA17799.1ENA Protein Mapping
UniParcUPI000012BB38UniProt Archive

Literature for mge1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014