mge1 (SPBC3B9.19)

Gene Standard Namemge1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC3B9.19 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial GrpE domain chaperone protein (predicted) Product Size223aa, 25.33 kDa
Genomic Location Chromosome II, 4022474-4023772 (1299nt); CDS:4022547-4023218 (672nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000774adenyl-nucleotide exchange factor activityISOSGD:S000005758GO_REF:00000244
GO:0051087chaperone bindingIEAIPR000740GO_REF:00000028
GO:0042803protein homodimerization activityIEAIPR000740GO_REF:000000234
GO:0051082unfolded protein bindingISSUniProtKB:P38523GO_REF:000000142
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006457protein foldingISOSGD:S000005758GO_REF:0000024112
GO:0030150protein import into mitochondrial matrixISOSGD:S000005758GO_REF:000002419
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0001405presequence translocase-associated import motorISOSGD:S000005758GO_REF:00000246
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymge1ΔNullPECO:0000006, PECO:0000137PMID:236978061309
Microscopymge1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001991inviable after spore germination, without cell divisionMicroscopymge1ΔNullPECO:0000006, PECO:0000137PMID:23697806463
FYPO:0002207inviable swollen sporeMicroscopymge1ΔNullPECO:0000006, PECO:0000137PMID:236978063
Microscopymge1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01025 Pfam IPR000740 GrpE nucleotide exchange factor 52 220 1
PS01071 Prosite Patterns IPR000740 GrpE nucleotide exchange factor 175 218 1
PTHR21237:SF12 HMMPANTHER 6 223 1
PTHR21237 HMMPANTHER IPR000740 GrpE nucleotide exchange factor 6 223 1
G3DSA: Gene3D IPR013805 56 162 1
G3DSA: Gene3D IPR009012 164 222 1
SSF51064 SuperFamily IPR009012 166 222 1
SSF58014 SuperFamily 59 164 1
Coil ncoils Rabaptin coiled-coil domain 46 102 975
Low complexity (SEG) seg 33 49
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 82 98 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 110 125 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 199 218 1
PR00773 PRINTS IPR000740 GrpE nucleotide exchange factor 172 187 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.61 Da
Charge 2.00
Isoelectric point 8.39
Molecular weight 25.33 kDa
Number of residues 223
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
12954.12during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
11366.36during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
8.9during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
External References
Database Identifier Description
NBRP SPBC3B9.19 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3B9.19 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3B9.19 BioGRID Interaction Datasets
Expression Viewer SPBC3B9.19 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3B9.19 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3B9.19 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3B9.19 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3B9.19 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3B9.19 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3B9.19 Cell Cycle Data
GEO SPBC3B9.19 GEO profiles
PInt SPBC3B9.19 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2541039mitochondrial GrpE domain chaperone protein
EntrezGene2541039mitochondrial GrpE domain chaperone protein
SPD / RIKEN07/07G03Orfeome Localization Data
UniProtKB/SwissProtO43047GrpE protein homolog, mitochondrial
ModBaseO43047Database of comparative protein structure models
StringO43047Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596677mitochondrial GrpE domain chaperone protein
RefSeq mRNANM_001022599972h- mitochondrial GrpE domain chaperone protein (mge1), mRNA
European Nucleotide ArchiveCAA17799ENA Protein Mapping
UniParcUPI000012BB38UniProt Archive

Literature for mge1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014