gpi3 (SPBC3D6.07)

Gene Standard Namegpi3 Characterisation Statusbiological_role_inferred
Systematic IDSPBC3D6.07 Feature Typeprotein coding
Synonyms Name Description
Productpig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted) Product Size456aa, 51.78 kDa
Genomic Location Chromosome II, 1282754-1284325 (1572nt); CDS:1282754-1284325 (1572nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatidylinositol N-acetylglucosaminyltransferase activity5
Annotation ExtensionEvidenceWith/FromReference
UDP-glycosyltransferase activity27
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
GPI anchor biosynthetic process28
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationgpi3ΔNull1428

Cell Phenotype

Term NameAlleleExpressionCount
inviable after spore germination, single or double cell divisiongpi3ΔNull101
inviable after spore germination, without cell division, with abnormal germ tube morphologygpi3ΔNull151
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1282754..1282850, 1282911..1282990, 1283046..1283323, 1283367..1283482, 1283526..1284325
CDS1282754..1282850, 1282911..1282990, 1283046..1283323, 1283367..1283482, 1283526..1284325
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 186 333 8
PF08288 Pfam IPR013234 PIGA, GPI anchor biosynthesis 36 125 1
PTHR12526:SF232 HMMPANTHER 1 385 1
PTHR12526 HMMPANTHER 1 385 9 Gene3D 187 343 15
SSF53756 SuperFamily 1 366 15

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.55 Da
Charge 8.00
Isoelectric point 7.43
Molecular weight 51.78 kDa
Number of residues 456
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
464.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.6during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Disease Association
paroxysmal nocturnal haemoglobinuri1
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPBC3D6.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3D6.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3D6.07 BioGRID Interaction Datasets
Expression Viewer SPBC3D6.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3D6.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3D6.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3D6.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3D6.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3D6.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3D6.07 Cell Cycle Data
GEO SPBC3D6.07 GEO profiles
PInt SPBC3D6.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC3D6.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC3D6.07 Fission yeast phenotypic data & analysis
SPD / RIKEN25/25D03Orfeome Localization Data
IntEnz2.4.1.198Integrated relational Enzyme database
Rhea2.4.1.198Annotated reactions database
UniProtKB/SwissProtP87172Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
ModBaseP87172Database of comparative protein structure models
STRINGP87172Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595519pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted)
RefSeq mRNANM_001021428972h- pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted) (gpi3), mRNA
European Nucleotide ArchiveCAB09127.1ENA Protein Mapping
KEGG_Enzyme00563+ biosynthesis
UniParcUPI000006C267UniProt Archive
UniPathwayUPA00196Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Literature for gpi3

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015