gpi3 (SPBC3D6.07)

Gene Standard Namegpi3 Characterisation Statusbiological_role_inferred
Systematic IDSPBC3D6.07 Feature Typeprotein coding
Synonyms Name Description
Productpig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted) Product Size456aa, 51.78 kDa
Genomic Location Chromosome II, 1282754-1284325 (1572nt); CDS:1282754-1284325 (1572nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatidylinositol N-acetylglucosaminyltransferase activity5
Annotation ExtensionEvidenceWith/FromReference
UDP-glycosyltransferase activity27
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
GPI anchor biosynthetic process28
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopygpi3ΔNullPMID:204732891338
Microscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001042inviable after spore germination, single or double cell division97
penetrance FYPO_EXT:0000003Microscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:23697806
FYPO:0000313inviable after spore germination, without cell division, with abnormal germ tube morphology146
penetrance FYPO_EXT:0000001Microscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08288 Pfam IPR013234 PIGA, GPI anchor biosynthesis 36 125 1
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 186 333 8
PTHR12526 HMMPANTHER 1 434 8
PTHR12526:SF37 HMMPANTHER 1 434 1 Gene3D 187 343 15
SSF53756 SuperFamily 1 366 15

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.55 Da
Charge 8.00
Isoelectric point 7.43
Molecular weight 51.78 kDa
Number of residues 456
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
464.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Disease Association
paroxysmal nocturnal haemoglobinuri1
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPBC3D6.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3D6.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3D6.07 BioGRID Interaction Datasets
Expression Viewer SPBC3D6.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3D6.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3D6.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3D6.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3D6.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3D6.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3D6.07 Cell Cycle Data
GEO SPBC3D6.07 GEO profiles
PInt SPBC3D6.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC3D6.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC3D6.07 Fission yeast phenotypic data & analysis
SPD / RIKEN25/25D03Orfeome Localization Data
IntEnz2.4.1.198Integrated relational Enzyme database
Rhea2.4.1.198Annotated reactions database
UniProtKB/SwissProtP87172Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
ModBaseP87172Database of comparative protein structure models
STRINGP87172Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595519pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted)
RefSeq mRNANM_001021428972h- pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted) (gpi3), mRNA
European Nucleotide ArchiveCAB09127.1ENA Protein Mapping
UniParcUPI000006C267UniProt Archive

Literature for gpi3

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014