gpi3 (SPBC3D6.07)


Gene Standard Namegpi3 Characterisation Statusbiological_role_inferred
Systematic IDSPBC3D6.07 Feature Typeprotein coding
Synonyms Name Description
Productpig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted) Product Size456aa, 51.78 kDa
Genomic Location Chromosome II, 1282754-1284325 (1572nt); CDS:1282754-1284325 (1572nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008194UDP-glycosyltransferase activityISOSGD:S000006096GO_REF:000002427
GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activityIEA EC:2.4.1.198GO_REF:00000035
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006506GPI anchor biosynthetic processISOSGD:S000006096GO_REF:000002428
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumISOSGD:S000006096GO_REF:0000024594
GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complexISOSGD:S000006096GO_REF:00000243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopygpi3ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001042inviable after spore germination, single or double cell divisionMicroscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:2369780691
penetrance FYPO_EXT:0000003
FYPO:0000313inviable after spore germination, without cell division, with abnormal germ tube morphologyMicroscopygpi3ΔNullPECO:0000005, PECO:0000137PMID:23697806144
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
112827541282850
212829111282990
312830461283323
412833671283482
512835261284325
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08288 Pfam IPR013234 PIGA, GPI anchor biosynthesis 36 125 1
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 186 333 8
PTHR12526:SF37 HMMPANTHER 1 434 1
PTHR12526 HMMPANTHER 1 434 8
G3DSA:3.40.50.2000 Gene3D 187 343 15
SSF53756 SuperFamily 1 366 15
Low complexity (SEG) seg 67 77
Low complexity (SEG) seg 442 449

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.55 Da
Charge 8.00
Isoelectric point 7.43
Molecular weight 51.78 kDa
Number of residues 456
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
464.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
0.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
paroxysmal nocturnal haemoglobinuri1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPBC3D6.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3D6.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3D6.07 BioGRID Interaction Datasets
Expression Viewer SPBC3D6.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3D6.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3D6.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3D6.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3D6.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3D6.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3D6.07 Cell Cycle Data
GEO SPBC3D6.07 GEO profiles
PInt SPBC3D6.07 Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.4.1.198Integrated relational Enzyme database
Rhea2.4.1.198Annotated reactions database
EntrezGene2540986pig-A
WikiGene2540986pig-A
SPD / RIKEN25/25D03Orfeome Localization Data
UniProtKB/SwissProtP87172Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
ModBaseP87172Database of comparative protein structure models
StringP87172Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595519pig-A
RefSeq mRNANM_001021428972h- pig-A (gpi3), mRNA
European Nucleotide ArchiveCAB09127ENA Protein Mapping
UniParcUPI000006C267UniProt Archive

Literature for gpi3

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014