hsp16 (SPBC3E7.02c)


Gene Standard Namehsp16 Characterisation Statuspublished
Systematic IDSPBC3E7.02c Feature Typeprotein coding
Synonyms Name Description
Productheat shock protein Hsp16 Product Size143aa, 15.97 kDa
Genomic Location Chromosome II, 2660992-2660139 (854nt); CDS:2660921-2660490 (432nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0042802identical protein bindingIPIhsp16PMID:2327342941
GO:0005515protein bindingIPIhsp16PMID:11452028887
GO:0051082unfolded protein bindingIDAPMID:1605543742
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0009267cellular response to starvationIEPPMID:11452028122
GO:0034620cellular response to unfolded proteinIDAPMID:1605543715
GO:0061077chaperone-mediated protein foldingNASGO_REF:000000111
GO:0031990mRNA export from nucleus in response to heat stressIMPPMID:158409443
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:114520284198
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:114520282730
IDAPMID:16823372
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyhsp16ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyhsp16ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyhsp16ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
126609922660139
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00011 Pfam IPR002068 Alpha crystallin/Hsp20 domain 40 142 2
PS01031 Prosite Profiles IPR002068 Alpha crystallin/Hsp20 domain 40 130 2
PTHR11527 HMMPANTHER 6 142 2
G3DSA:2.60.40.790 Gene3D 4 143 5
SSF49764 SuperFamily IPR008978 6 138 6

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.66 Da
Charge -1.00
Isoelectric point 5.80
Molecular weight 15.97 kDa
Number of residues 143
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased,
in presence of methyl methanesulfonate
expression microarray evidencePMID:12529438
increasedexpression microarray evidencePMID:12529438
during GO:0071470
increasedexpression microarray evidencePMID:12529438
during GO:0034605
increased,
in presence of cadmium sulfate
expression microarray evidencePMID:12529438
increasedexpression microarray evidencePMID:12529438
during GO:0034599

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8800.96during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
14144.36during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
11during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Subunit Composition
DescriptionQualifierReferenceCount
dimeric PMID:232734292
hexadecameric PMID:232734291
Miscellaneous Functional Group
DescriptionQualifierReferenceCount
chaperone12
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
cdc18MCM loader Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
pmt3SUMO Two-hybridPMID:11452028
tef3translation elongation factor eEF3 Two-hybridPMID:11452028
rhp18Rad18 homolog Rhp18 Two-hybridPMID:11452028
tup12transcriptional corepressor Tup12 Two-hybridPMID:11452028
rfp1SUMO-targeted ubiquitin-protein ligase subunit Rfp1 Two-hybridPMID:11452028
mug190C2 domain protein Two-hybridPMID:11452028
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
pfl5cell surface glycoprotein (predicted) Two-hybridPMID:11452028
pek1MAP kinase kinase Pek1 Two-hybridPMID:23695164
eft201translation elongation factor 2 (EF-2) Eft2,A Two-hybridPMID:11452028
External References
Database Identifier Description
NBRP SPBC3E7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC3E7.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC3E7.02c BioGRID Interaction Datasets
Expression Viewer SPBC3E7.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC3E7.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC3E7.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC3E7.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC3E7.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC3E7.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC3E7.02c Cell Cycle Data
GEO SPBC3E7.02c GEO profiles
PInt SPBC3E7.02c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN31/31D08Orfeome Localization Data
EntrezGene2540977heat shock protein Hsp16
WikiGene2540977heat shock protein Hsp16
UniProtKB/SwissProtO14368Heat shock protein 16
ModBaseO14368Database of comparative protein structure models
StringO14368Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596091heat shock protein Hsp16
RefSeq mRNANM_001022007972h- heat shock protein Hsp16 (hsp16), mRNA
European Nucleotide ArchiveBAA31521ENA Protein Mapping
European Nucleotide ArchiveCAA06031ENA Protein Mapping
European Nucleotide ArchiveCAA19006ENA Protein Mapping
UniParcUPI000012CBFDUniProt Archive

Literature for hsp16

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014