ypt7 (SPBC405.04c)

Gene Standard Nameypt7 Characterisation Statuspublished
Systematic IDSPBC405.04c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase Ypt7 Product Size205aa, 22.99 kDa
Genomic Location Chromosome II, 3148452-3147096 (1357nt); CDS:3148230-3147478 (753nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTP binding88
Annotation ExtensionEvidenceWith/FromReference
GTPase activity54
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
Golgi to vacuole transport19
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport373
Annotation ExtensionEvidenceWith/FromReference
positive regulation of vacuole fusion, non-autophagic2
Annotation ExtensionEvidenceWith/FromReference
regulation of endocytosis10
Annotation ExtensionEvidenceWith/FromReference
small GTPase mediated signal transduction97
Annotation ExtensionEvidenceWith/FromReference
vacuolar acidification17
Annotation ExtensionEvidenceWith/FromReference
vacuole fusion, non-autophagic20
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
vacuolar membrane109
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperatureypt7Δ186
decreased conjugation frequencyypt7Δ52
decreased spore germination frequencyypt7Δ70
decreased vegetative cell population growth during phosphate starvationypt7Δ1
sensitive to 5-fluorouracilypt7Δ307
sensitive to calciumypt7Δ29
sensitive to L-azetidine-2-carboxylic acidypt7Δ3
viable vegetative cell populationypt7Δ3862

Cell Phenotype

Term NameGenotypesCount
abnormal endocytosis during vegetative growthypt7Δ15
abnormal prospore membrane formationypt7Δ34
abnormal protein targeting to vacuoleypt7Δ7
abnormal spore morphologyypt7Δ45
abnormal sporulation resulting in formation of ascus containing anucleate sporesypt7Δ7
abnormal sporulation resulting in formation of ascus with fewer than four sporesypt7Δ82
abnormal vacuole fusion during cellular hypotonic responseypt7Δ3
small sporesypt7Δ9
small vacuoles during sporulationypt7Δ1
small vacuoles present in increased numbers during cellular hypotonic responseypt7Δ5
viable vegetative cell with normal cell morphologyypt7Δ3103
Target Of
FYPO localization affected by mutation in spo9 farnesyl pyrophosphate synthetase
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3148452..3148150, 3148076..3147753, 3147690..3147096
Intron3148149..3148077, 3147752..3147691
5' UTR3148452..3148231PMID:21511999
CDS3148230..3148150, 3148076..3147753, 3147690..3147478
3' UTR3147477..3147096PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00071 Pfam IPR001806 Small GTPase superfamily 10 175 19
SM00174 SMART 11 178 19
SM00176 SMART 14 200 13
SM00175 SMART 9 178 22
SM00173 SMART 6 178 19
PS51419 Prosite Profiles 4 205 9
PTHR24073:SF589 HMMPANTHER 1 205 1
PTHR24073 HMMPANTHER 1 205 9 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 3 185 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 4 180 294
PR00449 PRINTS 32 48 19
PR00449 PRINTS 50 72 19
PR00449 PRINTS 116 129 19
PR00449 PRINTS 153 175 19
PR00449 PRINTS 9 30 19
TIGR00231 TIGRFAM IPR005225 Small GTP-binding protein domain 9 172 35

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.17 Da
Charge -6.00
Codon Adaptation Index 0.41
Isoelectric point 4.72
Molecular weight 22.99 kDa
Number of residues 205

Protein Modifications

Term NameResidueCount
ubiquitinylated lysineK173 514
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K173 PMID:26412298
IDA PMID:26412298
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for ypt7 (SPBC405.04c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
62432during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
63646during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
58951during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
67228during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
4715.94during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
59964during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
14433.77during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.5during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC405.04c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescuesbtn1battenin CLN3 family protein Phenotypic SuppressionPMID:16291725
External References
Database Identifier Description
NBRP SPBC405.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC405.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC405.04c BioGRID Interaction Datasets
Expression Viewer SPBC405.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC405.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC405.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC405.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC405.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC405.04c Transcriptome Viewer (Bähler Lab)
GEO SPBC405.04c GEO profiles
PInt SPBC405.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC405.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC405.04c Fission yeast phenotypic data & analysis
Cyclebase SPBC405.04c.1 Cell Cycle Data
SPD / RIKEN31/31H05Orfeome Localization Data
UniProtKB/SwissProtO94655GTP-binding protein ypt7
ModBaseO94655Database of comparative protein structure models
STRINGO94655Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596307GTPase Ypt7
RefSeq mRNANM_001022229972h- GTPase Ypt7 (ypt7), mRNA
European Nucleotide ArchiveCAB38603.1ENA Protein Mapping
UniParcUPI000013BE48UniProt Archive

Literature for ypt7

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017