ypt7 (SPBC405.04c)


Gene Standard Nameypt7 Characterisation Statuspublished
Systematic IDSPBC405.04c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase Ypt7 Product Size205aa, 22.99 kDa
Genomic Location Chromosome II, 3148452-3147096 (1357nt); CDS:3148230-3147478 (753nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTP binding113
Annotation ExtensionEvidenceWith/FromReference
GTPase activity61
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
Golgi to vacuole transport18
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport338
Annotation ExtensionEvidenceWith/FromReference
positive regulation of vacuole fusion, non-autophagic2
Annotation ExtensionEvidenceWith/FromReference
regulation of endocytosis14
Annotation ExtensionEvidenceWith/FromReference
small GTPase mediated signal transduction139
Annotation ExtensionEvidenceWith/FromReference
vacuolar acidification22
Annotation ExtensionEvidenceWith/FromReference
vacuole fusion, non-autophagic21
Annotation ExtensionEvidenceWith/FromReference
vesicle fusion with vacuole1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
vacuolar membrane108
Annotation ExtensionEvidenceWith/FromReference
vacuole186
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyypt7ΔNullPMID:204732893759
Microscopyypt7ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001914abnormal forespore membrane formationMicroscopyypt7ΔNullPMID:1635744324
FYPO:0000581decreased spore germinationCell growth assayypt7ΔNullPMID:1635744321
FYPO:0000346small sporesMicroscopyypt7ΔNullPMID:163574434
FYPO:0003590small vacuoles during sporulationMicroscopyypt7ΔNullPMID:163574431
FYPO:0000281small vacuoles present in greater numbers during vegetative growthMicroscopynot recorded (unrecorded)PMID:944391321
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyypt7ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
131484523148150
231480763147753
331476903147096

UTRs

Region Coordinates Reference
five_prime_UTR3148452..3148231PMID:21511999
three_prime_UTR3147477..3147096PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00071 Pfam IPR001806 Small GTPase superfamily 10 175 18
SM00173 SMART IPR020849 Small GTPase superfamily, Ras type 6 178 19
SM00175 SMART IPR003579 Small GTPase superfamily, Rab type 9 178 22
SM00174 SMART IPR003578 Small GTPase superfamily, Rho type 11 178 19
SM00176 SMART IPR002041 Ran GTPase 14 200 13
PS51419 Prosite Profiles 4 205 9
PTHR24073:SF57 HMMPANTHER 2 205 2
PTHR24073 HMMPANTHER 2 205 9
3.40.50.300 Gene3D 3 185 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 4 180 294
PR00449 PRINTS IPR001806 Small GTPase superfamily 50 72 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 32 48 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 153 175 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 116 129 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 9 30 19
TIGR00231 tigrfam IPR005225 Small GTP-binding protein domain 9 172 35

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.17 Da
Charge -6.00
Isoelectric point 4.72
Molecular weight 22.99 kDa
Number of residues 205
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
62432during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
63646during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
58951during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
67228during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
59964during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
4715.94during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
14433.77during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
vps41HOPS complex subunit Vps41 (predicted) Affinity Capture-WesternPMID:21062894
vps26retromer complex subunit Vps26 Affinity Capture-WesternPMID:21062894
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
btn1battenin CLN3 family protein Phenotypic SuppressionPMID:16291725
External References
Database Identifier Description
NBRP SPBC405.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC405.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC405.04c BioGRID Interaction Datasets
Expression Viewer SPBC405.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC405.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC405.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC405.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC405.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC405.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC405.04c Cell Cycle Data
GEO SPBC405.04c GEO profiles
PInt SPBC405.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC405.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC405.04c Fission yeast phenotypic data & analysis
SPD / RIKEN31/31H05Orfeome Localization Data
UniProtKB/SwissProtO94655GTP-binding protein ypt7
ModBaseO94655Database of comparative protein structure models
STRINGO94655Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596307GTPase Ypt7
RefSeq mRNANM_001022229972h- GTPase Ypt7 (ypt7), mRNA
European Nucleotide ArchiveCAB38603.1ENA Protein Mapping
UniParcUPI000013BE48UniProt Archive

Literature for ypt7

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014