wis1 (SPBC409.07c)


Gene Standard Namewis1 Characterisation Statuspublished
Systematic IDSPBC409.07c Feature Typeprotein coding
Synonymssmf2, spc2, sty2 Name DescriptionWIn Suppressing
ProductMAP kinase kinase Wis1 Product Size605aa, 64.76 kDa
Genomic Location Chromosome II, 1146633-1143731 (2903nt); CDS:1145784-1143967 (1818nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
MAP kinase kinase activity3
Annotation ExtensionEvidenceWith/FromReference
non-membrane spanning protein tyrosine kinase activity1
Annotation ExtensionEvidenceWith/FromReference
protein binding859
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
activation of MAPK activity3
Annotation ExtensionEvidenceWith/FromReference
MAPK cascade26
Annotation ExtensionEvidenceWith/FromReference
MAPK cascade in response to starvation2
Annotation ExtensionEvidenceWith/FromReference
MAPK cascade involved in osmosensory signaling pathway3
Annotation ExtensionEvidenceWith/FromReference
mitotic cell cycle arrest in response to nitrogen starvation7
Annotation ExtensionEvidenceWith/FromReference
peptidyl-tyrosine phosphorylation12
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle14
Annotation ExtensionEvidenceWith/FromReference
positive regulation of transcription factor import into nucleus in response to oxidative stress2
Annotation ExtensionEvidenceWith/FromReference
protein autophosphorylation17
Annotation ExtensionEvidenceWith/FromReference
protein phosphorylation132
Annotation ExtensionEvidenceWith/FromReference
regulation of cytoplasmic translation in response to stress9
Annotation ExtensionEvidenceWith/FromReference
regulation of G2/M transition of mitotic cell cycle61
Annotation ExtensionEvidenceWith/FromReference
stress-activated MAPK cascade10
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
abolished cell population growth on glycerol carbon sourcewis1ΔNull67
decreased bipolar indexwis1ΔNull27
decreased cell population growth at high temperatureAA (S469A, T473A)Endogenous136
AAA (S469A, S471A, T473A)Endogenous
K349R (K349R)Overexpression
decreased cell population growth on glucose carbon sourcewis1ΔNull258
decreased conjugation frequencywis1ΔNull44
decreased mating efficiencyAA (S469A, T473A)Endogenous252
AAA (S469A, S471A, T473A)Endogenous
wis1-DD (S469D, T473D)Not specified
wis1ΔNull
decreased septation indexwis1ΔNull20
increased monopolar indexwis1ΔNull35
inviable vegetative cell populationwis1+ (wild type)Overexpression1438
loss of viability at high temperaturewis1ΔNull41
loss of viability in stationary phasewis1ΔNull49
loss of viability upon nitrogen starvationwis1-558 (G461D)Not specified46
wis1-982 (F307S)Not specified
normal cell population growth at high temperatureAAA (S469A, S471A, T473A)Overexpression47
normal growth on glucose carbon sourcewis1ΔNull207
normal vegetative cell population growth rateAA (S469A, T473A)Endogenous70
AAA (S469A, S471A, T473A)Endogenous
wis1ΔNull
resistance to caffeinewis1DDNot specified26
resistance to cobaltwis1ΔNull56
resistance to hydrogen peroxidewis1DDNot specified73
sensitive to arsenatewis1ΔNull2
sensitive to bleomycinwis1ΔNull75
sensitive to caffeine during vegetative growthwis1ΔNull106
sensitive to heat shockwis1ΔNull6
sensitive to high osmolarityAA (S469A, T473A)Endogenous11
AAA (S469A, S471A, T473A)Endogenous
wis1ΔNull
sensitive to hydrogen peroxidewis1ΔNull139
sensitive to ionizing radiationwis1ΔNull60
sensitive to miconazolewis1+ (wild type)Overexpression37
sensitive to non-ionic osmotic stresswis1ΔNull12
sensitive to osmotic stresswis1AA (S469A, T473A)Endogenous102
sensitive to salt stresswis1ΔNull91
sensitive to sorbitolAA (S469A, T473A)Endogenous11
AAA (S469A, S471A, T473A)Endogenous
wis1ΔNull
sensitive to tacrolimuswis1ΔNull81
sensitive to UV during vegetative growthwis1ΔNull142
viable vegetative cell populationwis1-DD (S469D, T473D)Endogenous3809
wis1ΔNull

Cell Phenotype

Term NameAlleleExpressionCount
abnormal cell cycle arrest in mitotic G2 phase during nitrogen starvationwis1-558 (G461D)Not specified9
wis1-982 (F307S)Not specified
abnormal microtubule cytoskeleton morphology during mitotic interphasewis1ΔNull186
abnormal mitotic cell cyclewis1ΔNull834
abnormal mitotic cell cycle arrest in response to nitrogen starvationwis1ΔNull30
abolished protein autophosphorylation during vegetative growth7
affecting wis1K349R (K349R)Not specified
abolished protein kinase activity20
affecting wis1K349R (K349R)Not specified
affecting sty1wis1ΔNull
abolished protein localization to nucleus during cellular response to salt stress4
affecting srk1wis1-DD (S469D, T473D)Not specified
affecting sty1wis1ΔNull
abolished protein phosphorylation during cellular response to arsenic-containing substance1
affecting sty1wis1ΔNull
abolished protein phosphorylation during vegetative growth33
affecting sty1K349R (K349R)Not specified
abolished protein tyrosine phosphorylation4
affecting sty1wis1ΔNull
abolished protein tyrosine phosphorylation during cellular response to heat1
affecting sty1AAA (S469A, S471A, T473A)Endogenous
affecting sty1wis1ΔNull
affecting sty1wis1AA (S469A, T473A)Endogenous
abolished protein tyrosine phosphorylation during cellular response to hydrogen peroxide1
affecting sty1wis1ΔNull
affecting sty1wis1AA (S469A, T473A)Endogenous
abolished protein tyrosine phosphorylation during cellular response to osmotic stress1
affecting sty1AAA (S469A, S471A, T473A)Endogenous
affecting sty1wis1ΔNull
affecting sty1wis1AA (S469A, T473A)Endogenous
alpha,alpha-trehalase activity increase abolished during cellular response to hydrogen peroxidewis1ΔNull4
decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvationwis1ΔNull10
decreased cellular glycerol level during cellular response to salt stresswis1ΔNull2
decreased glutathione disulfide oxidoreductase activitywis1ΔNull4
decreased protein level during cellular response to glucose starvation3
affecting fbp1wis1ΔNull
decreased protein level during cellular response to nitrogen starvation20
affecting rum1wis1-558 (G461D)Not specified
affecting cdc13wis1-558 (G461D)Not specified
affecting rum1wis1-982 (F307S)Not specified
affecting cdc13wis1-982 (F307S)Not specified
affecting mei2wis1ΔNull
decreased protein level during vegetative growth95
affecting trr1wis1ΔNull
decreased protein phosphorylation78
affecting wis1AA (S469A, T473A)Not specified
affecting wis1AAA (S469A, S471A, T473A)Not specified
decreased protein phosphorylation during salt stress7
affecting srk1wis1-DD (S469D, T473D)Not specified
decreased protein phosphorylation during vegetative growth74
affecting atf1wis1ΔNull
decreased protein tyrosine phosphorylation during cellular response to heat1
affecting sty1AAA (S469A, S471A, T473A)Overexpression
decreased protein tyrosine phosphorylation during cellular response to hydrogen peroxide1
affecting sty1AAA (S469A, S471A, T473A)Overexpression
decreased RNA level during cellular response to glucose stimulus4
affecting mae2wis1 mutantNot specified
decreased RNA level during cellular response to heat7
affecting pyp2AAA (S469A, S471A, T473A)Overexpression
affecting gpd1AAA (S469A, S471A, T473A)Overexpression
affecting ctt1AAA (S469A, S471A, T473A)Overexpression
affecting pyp2K349R (K349R)Overexpression
affecting gpd1K349R (K349R)Overexpression
affecting ctt1K349R (K349R)Overexpression
affecting SPAC1486.01wis1ΔNull
decreased RNA level during cellular response to hydrogen peroxide20
affecting pyp2AAA (S469A, S471A, T473A)Overexpression
affecting gpd1AAA (S469A, S471A, T473A)Overexpression
affecting ctt1AAA (S469A, S471A, T473A)Overexpression
affecting pyp2K349R (K349R)Not specified
affecting gpd1K349R (K349R)Not specified
affecting ctt1K349R (K349R)Not specified
affecting sod1wis1ΔNull
affecting ntp1wis1ΔNull
decreased RNA level during cellular response to hypoxia5
affecting mae2wis1 mutantNot specified
decreased RNA level during cellular response to menadione4
affecting SPAC1486.01wis1ΔNull
decreased RNA level during cellular response to non-ionic osmotic stress3
affecting cta3wis1ΔNull
decreased RNA level during cellular response to salt stress12
affecting SPAC1486.01wis1ΔNull
affecting gpd1wis1ΔNull
affecting cta3wis1ΔNull
decreased RNA level during cellular response to UV10
affecting uvi15wis1ΔNull
decreased RNA level during nitrogen starvation37
affecting ste11wis1ΔNull
decreased RNA level during vegetative growth150
affecting gpd1wis1ΔNull
elongated cell during nitrogen starvationwis1-558 (G461D)Not specified18
wis1-982 (F307S)Not specified
enlarged nucleus during nitrogen starvationwis1-558 (G461D)Not specified2
wis1-982 (F307S)Not specified
increased nuclear protein level during cellular response to hydrogen peroxide2
affecting pap1wis1+ (wild type)Overexpression
increased protein phosphorylation during vegetative growth35
affecting sty1wis1-DD (S469D, T473D)Endogenous
increased protein tyrosine phosphorylation during cellular response to heat1
affecting sty1wis1-DD (S469D, T473D)Endogenous
increased RNA level during vegetative growth200
affecting pyp2wis1+ (wild type)Overexpression
increased RNA level in stationary phase4
affecting sod1wis1ΔNull
normal protein kinase activity14
affecting wis1AAA (S469A, S471A, T473A)Not specified
normal protein level during vegetative growth60
affecting wis1AA (S469A, T473A)Endogenous
affecting wis1AAA (S469A, S471A, T473A)Endogenous
normal protein phosphorylation during cellular response to salt stress6
affecting pmk1wis1ΔNull
normal RNA level during cellular response to menadione4
affecting sod1wis1ΔNull
RNA absent from cell during nitrogen starvation15
affecting ste11wis1ΔNull
sterilewis1ΔNull55
swollen vegetative cellwis1+ (wild type)Overexpression8
vegetative cell lysiswis1+ (wild type)Overexpression83
viable elongated vegetative cellAA (S469A, T473A)Endogenous301
AAA (S469A, S471A, T473A)Endogenous
K349R (K349R)Overexpression
wis1ΔNull
wis1AA (S469A, T473A)Endogenous
viable small vegetative cellwis1+ (wild type)Overexpression46
wis1-DD (S469D, T473D)Endogenous
viable vegetative cell with abnormal cell shapewis1ΔNull482
viable vegetative cell with normal cell morphologyAA (S469A, T473A)Endogenous3094
AAA (S469A, S471A, T473A)Endogenous
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in mcs4 response regulator Mcs4
FYPO affected by mutation in win1 MAP kinase kinase kinase Win1
FYPO affected by mutation in wis1 MAP kinase kinase Wis1
GO regulated by win1 MAP kinase kinase kinase Win1
GO substrate of win1 MAP kinase kinase kinase Win1
GO substrate of wis4 MAP kinase kinase kinase Wis4
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1146633..1143731
mRNA1146633..1143731
5' UTR1146633..1145785PMID:21511999
CDS1145784..1143967
3' UTR1143966..1143731AU008776
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 322 579 109
SM00220 SMART IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain 320 579 107
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 437 449 97
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 326 349 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 320 579 110
PTHR24360 HMMPANTHER 139 605 3
PTHR24360:SF3 HMMPANTHER 139 605 1
1.10.510.10 Gene3D 384 586 112
3.30.200.20 Gene3D 315 383 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 318 585 127

View domain organization at Pfam

Protein Properties

Ave. residue weight 107.05 Da
Charge 13.50
Isoelectric point 9.40
Molecular weight 64.76 kDa
Number of residues 605
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS129 1672
added by wis4469
present during cellular response to thiabendazole, mitotic M phaseS129
present during mitotic M phaseS201
present during mitotic M phaseS197
Annotation ExtensionEvidenceResidueReference
added by wis4 IDA 469 PMID:9718372
experimental evidence S129 PMID:24763107
present during cellular response to thiabendazole IDA S129 PMID:18257517
present during mitotic M phase experimental evidence S129 PMID:21712547
present during mitotic M phase experimental evidence S197 PMID:21712547
present during mitotic M phase experimental evidence S201 PMID:21712547
O-phospho-L-threonineT132 698
added by wis4473
present during mitotic M phaseT132
Annotation ExtensionEvidenceResidueReference
added by wis4 IDA 473 PMID:9718372
experimental evidence T132 PMID:24763107
present during mitotic M phase experimental evidence T132 PMID:21712547
phosphorylated residue 1927
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresent during GO:0072690Northern assay evidencePMID:1756736

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10153during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12460during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12150during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12134during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12418during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4753.27during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
7210.96during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withmpr1histidine-containing response regulator phosphotransferase Mpr1 Two-hybridPMID:23695164
affinity capturessty1MAP kinase Sty1 Affinity Capture-WesternPMID:12181336
modifiessty1MAP kinase Sty1 Biochemical ActivityPMID:7501024
binds DNA-binding domain construct withsty1MAP kinase Sty1 Two-hybridPMID:23695164
modifiessty1MAP kinase Sty1 Biochemical ActivityPMID:9718372
modifiessty1MAP kinase Sty1 Biochemical ActivityPMID:10398679
affinity captured bysty1MAP kinase Sty1 Affinity Capture-WesternPMID:9585506
affinity captured bywin1MAP kinase kinase kinase Win1 Affinity Capture-WesternPMID:24255738
modified bywin1MAP kinase kinase kinase Win1 Biochemical ActivityPMID:9693384
affinity captureswin1MAP kinase kinase kinase Win1 Affinity Capture-WesternPMID:23389634
modifieswis1MAP kinase kinase Wis1 Biochemical ActivityPMID:9718372
modified bywis4MAP kinase kinase kinase Wis4 Biochemical ActivityPMID:9718372
modified bywis4MAP kinase kinase kinase Wis4 Biochemical ActivityPMID:9321395
affinity captureswis4MAP kinase kinase kinase Wis4 Affinity Capture-WesternPMID:23389634
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
synthetically rescued byatf1transcription factor, Atf-CREB family Atf1 Synthetic RescuePMID:8824587
rescued byatf1transcription factor, Atf-CREB family Atf1 Phenotypic SuppressionPMID:15870269
synthetic growth defect withbyr1MAP kinase kinase Byr1 Synthetic Growth DefectPMID:8557102
rescued bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:1756736
rescuescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:1756736
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:1756736
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:1756736
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:1756736
synthetic lethal withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic LethalityPMID:9843572
synthetic lethal withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic LethalityPMID:9136929
synthetic lethal withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic LethalityPMID:8824588
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:8557102
synthetically rescued bycdc37Hsp90 co-chaperone Cdc37 Synthetic RescuePMID:12861001
synthetically rescued bycmk2MAPK-activated protein kinase Cmk2 Synthetic RescuePMID:11886858
synthetically rescuescut1separase/separin Synthetic RescuePMID:16861909
synthetically rescuescyr1adenylate cyclase Synthetic RescuePMID:15189983
rescued by overexpression ofgpd1glycerol-3-phosphate dehydrogenase Gpd1 Dosage RescuePMID:7498541
rescued by overexpression ofgpd2glycerol-3-phosphate dehydrogenase Gpd2 Dosage RescuePMID:7498541
rescued bygti1gluconate transmembrane transporter inducer Gti1 Phenotypic SuppressionPMID:9372449
enhances phenotype ofisp6vacuolar serine protease Isp6 Phenotypic EnhancementPMID:16550352
rescuesleu13-isopropylmalate dehydrogenase Leu1 Phenotypic SuppressionPMID:15466417
rescued bylsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Phenotypic SuppressionPMID:22144909
synthetically rescued bymcs4response regulator Mcs4 Synthetic RescuePMID:9136929
synthetically rescuesmcs4response regulator Mcs4 Synthetic RescuePMID:9136929
overexpression rescuesmcs4response regulator Mcs4 Dosage RescuePMID:9136929
rescuesmkh1MEK kinase (MEKK) Mkh1 Phenotypic SuppressionPMID:9199286
enhances phenotype ofmkh1MEK kinase (MEKK) Mkh1 Phenotypic EnhancementPMID:9199286
rescued bynrd1RNA-binding protein Nrd1 Phenotypic SuppressionPMID:9671458
synthetically rescuespat1serine/threonine protein kinase Ran1/Pat1 Synthetic RescuePMID:8832415
synthetically rescuespat1serine/threonine protein kinase Ran1/Pat1 Synthetic RescuePMID:8824588
rescuespck2protein kinase C (PKC)-like Pck2 Phenotypic SuppressionPMID:9199286
synthetic growth defect withpka1cAMP-dependent protein kinase catalytic subunit Pka1 Synthetic Growth DefectPMID:23640764
rescued byppa1minor serine/threonine protein phosphatase Ppa1 Phenotypic SuppressionPMID:1756736
rescued byppa2serine/threonine protein phosphatase Ppa2 Phenotypic SuppressionPMID:1756736
synthetically rescuesptc1protein phosphatase 2C Ptc1 Synthetic RescuePMID:7859738
synthetically rescuesptc3protein phosphatase 2c homolog 3 Synthetic RescuePMID:7859738
phenotype enhanced byptc4protein phosphatase 2C Ptc4 Phenotypic EnhancementPMID:22139357
enhances phenotype ofpyp1tyrosine phosphatase Pyp1 Phenotypic EnhancementPMID:9321395
enhances phenotype ofrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Phenotypic EnhancementPMID:9447985
phenotype enhanced byrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Phenotypic EnhancementPMID:9447985
phenotype enhanced bysds23PP2A-type phosphatase inhibitor Sds23/Moc1 Phenotypic EnhancementPMID:23640764
inviable in presence of overexpressedsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Dosage LethalityPMID:23640764
synthetically rescued bysrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:12080074
synthetically rescuessts5RNB-like protein Synthetic RescuePMID:8886983
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9450957
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9136929
rescued bysty1MAP kinase Sty1 Phenotypic SuppressionPMID:7501024
rescued by overexpression ofsty1MAP kinase Sty1 Dosage RescuePMID:8557102
synthetic growth defect withtup11transcriptional corepressor Tup11 Synthetic Growth DefectPMID:11238405
rescuestup11transcriptional corepressor Tup11 Phenotypic SuppressionPMID:11238405
rescuestup12transcriptional corepressor Tup12 Phenotypic SuppressionPMID:11238405
synthetic growth defect withtup12transcriptional corepressor Tup12 Synthetic Growth DefectPMID:11238405
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:1756736
overexpression rescueswee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1756736
overexpression rescueswin1MAP kinase kinase kinase Win1 Dosage RescuePMID:1756736
synthetically rescued bywin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9450957
overexpression rescueswin1MAP kinase kinase kinase Win1 Dosage RescuePMID:9450957
synthetically rescued bywin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9321395
synthetically rescued bywin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9693384
synthetically rescueswin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9693384
synthetically rescued bywis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9450957
synthetically rescueswis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9718372
synthetically rescued bywis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9321395
synthetically rescueswis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9614178
synthetically rescued bywis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9693384
External References
Database Identifier Description
NBRP SPBC409.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC409.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC409.07c BioGRID Interaction Datasets
Expression Viewer SPBC409.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC409.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC409.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC409.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC409.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC409.07c Transcriptome Viewer (Bähler Lab)
GEO SPBC409.07c GEO profiles
PInt SPBC409.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC409.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC409.07c Fission yeast phenotypic data & analysis
Cyclebase SPBC409.07c.1 Cell Cycle Data
SPD / RIKEN33/33D12Orfeome Localization Data
PUBMED9135147
UniProtKB/SwissProtP33886Protein kinase wis1
ModBaseP33886Database of comparative protein structure models
STRINGP33886Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595457MAP kinase kinase Wis1
RefSeq mRNANM_001021367972h- MAP kinase kinase Wis1 (wis1), mRNA
European Nucleotide ArchiveCAA44499.1ENA Protein Mapping
European Nucleotide ArchiveCAB52609.1ENA Protein Mapping
UniParcUPI0000138F12UniProt Archive

Literature for wis1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015