wis1 (SPBC409.07c)


Gene Standard Namewis1 Characterisation Statuspublished
Systematic IDSPBC409.07c Feature Typeprotein coding
Synonymssmf2, spc2, sty2 Name DescriptionWIn Suppressing
ProductMAP kinase kinase Wis1 Product Size605aa, 64.76 kDa
Genomic Location Chromosome II, 1146633-1143731 (2903nt); CDS:1145784-1143967 (1818nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding557
Annotation ExtensionEvidenceWith/FromReference
MAP kinase kinase activity3
Annotation ExtensionEvidenceWith/FromReference
non-membrane spanning protein tyrosine kinase activity1
Annotation ExtensionEvidenceWith/FromReference
protein binding887
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular response to sodium arsenite5
Annotation ExtensionEvidenceWith/FromReference
MAPK cascade in response to starvation2
Annotation ExtensionEvidenceWith/FromReference
MAPK cascade involved in osmosensory signaling pathway3
Annotation ExtensionEvidenceWith/FromReference
mitotic G1 cell cycle arrest in response to nitrogen starvation11
Annotation ExtensionEvidenceWith/FromReference
peptidyl-tyrosine phosphorylation10
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle19
Annotation ExtensionEvidenceWith/FromReference
positive regulation of transcription factor import into nucleus in response to oxidative stress2
Annotation ExtensionEvidenceWith/FromReference
protein autophosphorylation14
Annotation ExtensionEvidenceWith/FromReference
protein phosphorylation126
Annotation ExtensionEvidenceWith/FromReference
regulation of cytoplasmic translation in response to stress8
Annotation ExtensionEvidenceWith/FromReference
stress-activated MAPK cascade13
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
abolished cell population growth at high temperaturesty2-138
abolished cell population growth on glycerol carbon sourcewis1Δ68
decreased bipolar indexwis1Δ27
decreased cell population growth at high temperatureAA (S469A, T473A)178
AAA (S469A, S471A, T473A)
K349R (K349R)
decreased cell population growth on glucose carbon sourcewis1Δ380
decreased conjugation frequencywis1Δ52
decreased mating efficiencyAA (S469A, T473A)275
AAA (S469A, S471A, T473A)
wis1-DD (S469D, T473D)
wis1Δ
decreased septation indexwis1Δ21
increased monopolar indexwis1Δ38
increased viability in stationary phasewis1-DD (S469D, T473D)62
inviable vegetative cell populationwis1+ (wild type)1455
loss of viability at high temperaturewis1Δ59
loss of viability in stationary phasewis1Δ61
loss of viability upon nitrogen starvationwis1-558 (G461D)53
wis1-982 (F307S)
normal cell population growth at high temperatureAAA (S469A, S471A, T473A)69
normal growth on cell wall-degrading enzymeswis1Δ11
normal growth on glucose carbon sourcewis1Δ294
wis1-AA (S469A, T473A)
normal growth on micafunginwis1Δ5
normal vegetative cell population growth rateAA (S469A, T473A)80
AAA (S469A, S471A, T473A)
wis1Δ
sty2-1
normal viability in stationary phasewis1-DD (S469D, T473D)33
resistance to caffeinewis1DD26
resistance to cobaltwis1Δ56
resistance to hydrogen peroxidewis1DD75
sensitive to arsenatewis1Δ2
sensitive to arsenitewis1Δ5
sensitive to bleomycinwis1Δ92
sensitive to caffeine during vegetative growthwis1Δ110
sensitive to heat shockwis1Δ7
sensitive to high osmolaritywis1Δ17
AAA (S469A, S471A, T473A)
AA (S469A, T473A)
sensitive to hydrogen peroxidewis1-AA (S469A, T473A)155
wis1Δ
sensitive to ionizing radiation during vegetative growthwis1Δ74
sensitive to methyl methanesulfonatewis1Δ331
sensitive to miconazolewis1+ (wild type)40
sensitive to non-ionic osmotic stresswis1Δ4
sensitive to osmotic stresswis1AA (S469A, T473A)108
sensitive to salt stresswis1Δ99
sensitive to sorbitolAAA (S469A, S471A, T473A)13
AA (S469A, T473A)
wis1Δ
sensitive to tacrolimuswis1Δ81
sensitive to UV during vegetative growthwis1Δ161
viable vegetative cell populationwis1-DD (S469D, T473D)3850
wis1Δ

Cell Phenotype

Term NameGenotypesCount
abnormal cell cycle arrest in mitotic G2 phase during nitrogen starvationwis1-558 (G461D)9
wis1-982 (F307S)
abnormal microtubule cytoskeleton morphology during mitotic interphasewis1Δ186
abnormal mitotic cell cyclewis1Δ894
abnormal mitotic cell cycle arrest in response to nitrogen starvationwis1Δ44
abnormal mitotic cell cycle regulation during cellular response to heat stresswis1-DD (S469D, T473D)3
abnormal mitotic cell cycle regulation during cellular response to UVwis1Δ23
abolished protein autophosphorylation during vegetative growth7
affecting wis1K349R (K349R)
abolished protein kinase activity27
affecting sty1wis1Δ
affecting wis1K349R (K349R)
abolished protein localization to nucleus during cellular response to salt stress4
affects localization of sty1wis1Δ
affects localization of srk1wis1-DD (S469D, T473D)
abolished protein phosphorylation during cellular response to arsenic-containing substance1
affecting sty1wis1Δ
abolished protein phosphorylation during cellular response to arsenite ion1
affecting sty1wis1Δ
abolished protein phosphorylation during vegetative growth55
affecting sty1K349R (K349R)
abolished protein tyrosine phosphorylation4
affecting sty1wis1Δ
abolished protein tyrosine phosphorylation during cellular response to heat1
affecting sty1AAA (S469A, S471A, T473A)
affecting sty1wis1Δ
affecting sty1wis1AA (S469A, T473A)
abolished protein tyrosine phosphorylation during cellular response to hydrogen peroxide1
affecting sty1wis1Δ
affecting sty1wis1AA (S469A, T473A)
abolished protein tyrosine phosphorylation during cellular response to methyl methanesulfonate1
affecting sty1wis1Δ
abolished protein tyrosine phosphorylation during cellular response to osmotic stress2
affecting sty1wis1Δ
affecting sty1AAA (S469A, S471A, T473A)
affecting sty1wis1AA (S469A, T473A)
abolished protein tyrosine phosphorylation during cellular response to UV1
affecting sty1wis1Δ
alpha,alpha-trehalase activity increase abolished during cellular response to hydrogen peroxidewis1Δ4
decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvationwis1Δ16
decreased cellular glycerol level during cellular response to salt stresswis1Δ2
decreased glutathione disulfide oxidoreductase activitywis1Δ4
decreased protein level during cellular response to glucose starvation5
affecting fbp1wis1Δ
decreased protein level during cellular response to nitrogen starvation12
affecting mei2wis1Δ
affecting rum1wis1-558 (G461D)
affecting rum1wis1-982 (F307S)
affecting cdc13wis1-558 (G461D)
affecting cdc13wis1-982 (F307S)
decreased protein level during vegetative growth153
affecting trr1wis1Δ
decreased protein phosphorylation116
affecting wis1AAA (S469A, S471A, T473A)
affecting wis1AA (S469A, T473A)
decreased protein phosphorylation during cellular response to arsenite ion1
affecting sty1wis1-AA (S469A, T473A)
decreased protein phosphorylation during cellular response to heat7
affecting plo1wis1Δ
decreased protein phosphorylation during salt stress7
affecting srk1wis1-DD (S469D, T473D)
decreased protein phosphorylation during vegetative growth104
affecting atf1wis1Δ
decreased protein tyrosine phosphorylation during cellular response to heat1
affecting sty1AAA (S469A, S471A, T473A)
decreased protein tyrosine phosphorylation during cellular response to hydrogen peroxide1
affecting sty1AAA (S469A, S471A, T473A)
decreased RNA level during cellular response to glucose stimulus4
affecting mae2wis1 mutant
decreased RNA level during cellular response to heat7
affecting sod2wis1Δ
affecting pyp2AAA (S469A, S471A, T473A)
affecting pyp2K349R (K349R)
affecting gpd1AAA (S469A, S471A, T473A)
affecting gpd1K349R (K349R)
affecting ctt1K349R (K349R)
affecting ctt1AAA (S469A, S471A, T473A)
decreased RNA level during cellular response to hydrogen peroxide23
affecting pyp2AAA (S469A, S471A, T473A)
affecting pyp2K349R (K349R)
affecting sod1wis1Δ
affecting gpd1K349R (K349R)
affecting gpd1AAA (S469A, S471A, T473A)
affecting ntp1wis1Δ
affecting ctt1K349R (K349R)
affecting ctt1AAA (S469A, S471A, T473A)
decreased RNA level during cellular response to hypoxia7
affecting mae2wis1 mutant
decreased RNA level during cellular response to menadione4
affecting sod2wis1Δ
decreased RNA level during cellular response to non-ionic osmotic stress3
affecting cta3wis1Δ
decreased RNA level during cellular response to salt stress14
affecting sod2wis1Δ
affecting gpd1wis1Δ
affecting cta3wis1Δ
decreased RNA level during cellular response to UV11
affecting uvi15wis1Δ
decreased RNA level during nitrogen starvation43
affecting ste11wis1Δ
decreased RNA level during vegetative growth200
affecting gpd1wis1Δ
elongated cell during nitrogen starvationwis1-558 (G461D)23
wis1-982 (F307S)
enlarged nucleus during nitrogen starvationwis1-558 (G461D)2
wis1-982 (F307S)
increased nuclear protein level during cellular response to hydrogen peroxide2
affecting pap1wis1+ (wild type)
increased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth3
affecting rpb1wis1+ (wild type)
increased protein kinase activity19
affecting wis1wis1-DD (S469D, T473D)
increased protein localization to mitotic spindle pole body8
affects localization of plo1wis1-DD (S469D, T473D)
increased protein phosphorylation during vegetative growth65
affecting plo1wis1-DD (S469D, T473D)
affecting sty1wis1-DD (S469D, T473D)
increased protein tyrosine phosphorylation during cellular response to heat1
affecting sty1wis1-DD (S469D, T473D)
increased RNA level during vegetative growth342
affecting pyp2wis1+ (wild type)
increased RNA level in stationary phase4
affecting sod1wis1Δ
normal protein kinase activity23
affecting wis1AAA (S469A, S471A, T473A)
normal protein level during vegetative growth91
affecting wis1AAA (S469A, S471A, T473A)
affecting wis1AA (S469A, T473A)
normal protein phosphorylation during cellular response to salt stress10
affecting pmk1wis1Δ
normal RNA level during cellular response to menadione4
affecting sod1wis1Δ
RNA absent from cell during cellular response to salt stress5
affecting pyp2wis1Δ
RNA absent from cell during nitrogen starvation15
affecting ste11wis1Δ
sterilewis1Δ61
swollen vegetative cellwis1+ (wild type)70
vegetative cell lysiswis1+ (wild type)98
viable elongated vegetative cellsty2-1325
AA (S469A, T473A)
wis1AA (S469A, T473A)
K349R (K349R)
AAA (S469A, S471A, T473A)
wis1Δ
viable small vegetative cellwis1-DD (S469D, T473D)54
wis1+ (wild type)
viable vegetative cell with abnormal cell shapewis1Δ705
viable vegetative cell with normal cell morphologyAA (S469A, T473A)3102
AAA (S469A, S471A, T473A)

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
abolished cell population growth at high temperaturewis1-DD (S469D, T473D), cdc25-22 (C532Y), S402A (S402A)
decreased mating efficiencywis1Δ, nrd1Δ
inviable vegetative cell populationcdc25-22 (C532Y), wis1Δ
cdc2-3w (C67Y), wee1-50, wis1Δ
cdc25-22 (C532Y), sty2-1
viable vegetative cell populationpyp1Δ, sty2-1, pyp2Δ
pyp1Δ, pyp2Δ, wis1Δ
wis1+ (wild type), sty1Δ
srk1Δ, wis1+ (wild type)
wis4Δ, cdc25-22 (C532Y), wis1+ (wild type)
pat1-114, wis1Δ
wis1-DD (S469D, T473D), wis4 N-terminal deletion

Cell Phenotype

Term NameGenotypes
abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during nitrogen starvation
affecting rpb1wis1+ (wild type), lsk1Δ
decreased protein level in stationary phase
affecting mei2wis1Δ, cyr1Δ
affecting fbp1wis1Δ, cyr1Δ
decreased RNA level during glucose starvation
affecting ste11nrd1Δ, wis1Δ
increased protein phosphorylation during cellular response to hydrogen peroxide
affecting sty1wis1-DD (S469D, T473D), ptc4Δ
inviable after spore germination, single or double cell division, elongated cellcdc25-22 (C532Y), sty2-1
large vacuoles present in decreased numbers during salt stressypt4Δ, wis1Δ
RNA absent from cell during vegetative growth
affecting ste11nrd1Δ, wis1Δ
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1146633..1143731
mRNA1146633..1143731
5' UTR1146633..1145785PMID:21511999
CDS1145784..1143967
3' UTR1143966..1143731AU008776
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 322 579 108
SM00220 SMART IPR000719 Protein kinase domain 320 579 107
PS50011 Prosite Profiles IPR000719 Protein kinase domain 320 579 110
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 326 349 73
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 437 449 97
PTHR24361 HMMPANTHER 219 260 14
PTHR24361 HMMPANTHER 291 604 14
PTHR24361 HMMPANTHER 168 201 14
PTHR24361 HMMPANTHER 53 143 14
PTHR24361:SF302 HMMPANTHER 219 260 1
PTHR24361:SF302 HMMPANTHER 291 604 1
PTHR24361:SF302 HMMPANTHER 168 201 1
PTHR24361:SF302 HMMPANTHER 53 143 1
3.30.200.20 Gene3D Tyrosine-protein kinase, receptor class V, conserved site 315 383 111
1.10.510.10 Gene3D Aminoglycoside phosphotransferase 384 586 112
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 318 585 127

View domain organization at Pfam

Protein Properties

Ave. residue weight 107.05 Da
Charge 13.50
Codon Adaptation Index 0.42
Isoelectric point 9.40
Molecular weight 64.76 kDa
Number of residues 605
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
added by wis4S469
present during mitotic M phaseS197
present during mitotic M phaseS201
present during cellular response to thiabendazole, mitotic M phaseS129
S129, S169, S195, S197, S226
Annotation ExtensionEvidenceResidueReference
added by wis4 IDA S469 PMID:9718372
present during mitotic M phase experimental evidence S197 PMID:21712547
present during mitotic M phase experimental evidence S201 PMID:21712547
present during cellular response to thiabendazole IDA S129 PMID:18257517
present during mitotic M phase experimental evidence S129 PMID:21712547
IDA S129 PMID:25720772
IDA S197 PMID:25720772
experimental evidence S129 PMID:24763107
IDA S169 PMID:25720772
IDA S226 PMID:25720772
IDA S195 PMID:25720772
O-phospho-L-threonine 1085
added by wis4T473
present during mitotic M phaseT132
T132, T225
Annotation ExtensionEvidenceResidueReference
added by wis4 IDA T473 PMID:9718372
present during mitotic M phase experimental evidence T132 PMID:21712547
experimental evidence T132 PMID:24763107
IDA T225 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS195,S197, S195,S201, S197,S201, S244,S250, S244,T249, S246,S250, S246,T249 2457
Annotation ExtensionEvidenceResidueReference
IDA S246,T249 PMID:25720772
IDA S246,S250 PMID:25720772
IDA S244,T249 PMID:25720772
IDA S244,S250 PMID:25720772
IDA S197,S201 PMID:25720772
IDA S195,S201 PMID:25720772
IDA S195,S197 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresent during GO:0072690Northern assay evidencePMID:1756736

Quantitative Gene Expression

View graphical display of gene expression data for wis1 (SPBC409.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10153during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
12460during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
12150during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
12134during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
4753.27during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
12418during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7210.96during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC409.07c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withmpr1histidine-containing response regulator phosphotransferase Mpr1 Two-hybridPMID:23695164
modifiessty1MAP kinase Sty1 Biochemical ActivityPMID:10398679
modifieswis1MAP kinase kinase Wis1 Biochemical ActivityPMID:9718372
binds DNA-binding domain construct withsty1MAP kinase Sty1 Two-hybridPMID:26771498
modified bywis4MAP kinase kinase kinase Wis4 Biochemical ActivityPMID:9718372
modified bywin1MAP kinase kinase kinase Win1 Biochemical ActivityPMID:9693384
affinity captured bysty1MAP kinase Sty1 Affinity Capture-WesternPMID:26432170
affinity captured bywin1MAP kinase kinase kinase Win1 Affinity Capture-WesternPMID:24255738
affinity capturessty1MAP kinase Sty1 Affinity Capture-WesternPMID:12181336
affinity captureswis4MAP kinase kinase kinase Wis4 Affinity Capture-WesternPMID:23389634
affinity captureswin1MAP kinase kinase kinase Win1 Affinity Capture-WesternPMID:23389634
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC409.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetically rescueswin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9693384
synthetically rescueswis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9614178
synthetically rescuesmcs4response regulator Mcs4 Synthetic RescuePMID:9136929
synthetically rescuesplo1Polo kinase Plo1 Synthetic RescuePMID:15917811
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:15917811
synthetically rescuespat1serine/threonine protein kinase Ran1/Pat1 Synthetic RescuePMID:8824588
synthetically rescuescyr1adenylate cyclase Synthetic RescuePMID:15189983
synthetically rescuescut1separase/separin Synthetic RescuePMID:16861909
synthetically rescuesptc3protein phosphatase 2c homolog 3 Synthetic RescuePMID:7859738
synthetically rescuessts5RNB-like protein Synthetic RescuePMID:8886983
synthetically rescuesptc1protein phosphatase 2C Ptc1 Synthetic RescuePMID:7859738
synthetic lethal withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic LethalityPMID:9136929
rescuescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:1756736
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:1756736
rescuesmkh1MEK kinase (MEKK) Mkh1 Phenotypic SuppressionPMID:9199286
rescuesleu13-isopropylmalate dehydrogenase Leu1 Phenotypic SuppressionPMID:15466417
rescuespck2protein kinase C (PKC)-like Pck2 Phenotypic SuppressionPMID:9199286
rescuestup12transcriptional corepressor Tup12 Phenotypic SuppressionPMID:11238405
rescuestup11transcriptional corepressor Tup11 Phenotypic SuppressionPMID:11238405
synthetically rescued bywis4MAP kinase kinase kinase Wis4 Synthetic RescuePMID:9693384
synthetically rescued bywin1MAP kinase kinase kinase Win1 Synthetic RescuePMID:9693384
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9136929
synthetically rescued byatf1transcription factor, Atf-CREB family Atf1 Synthetic RescuePMID:8824587
synthetically rescued bycdc37Hsp90 co-chaperone Cdc37 Synthetic RescuePMID:12861001
synthetically rescued bymcs4response regulator Mcs4 Synthetic RescuePMID:9136929
synthetically rescued bycmk2MAPK-activated protein kinase Cmk2 Synthetic RescuePMID:11886858
synthetically rescued bysrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:12080074
synthetic growth defect withbyr1MAP kinase kinase Byr1 Synthetic Growth DefectPMID:8557102
synthetic growth defect withpka1cAMP-dependent protein kinase catalytic subunit Pka1 Synthetic Growth DefectPMID:23640764
synthetic growth defect withtup11transcriptional corepressor Tup11 Synthetic Growth DefectPMID:11238405
synthetic growth defect withtup12transcriptional corepressor Tup12 Synthetic Growth DefectPMID:11238405
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:8557102
overexpression rescueswee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1756736
overexpression rescueswin1MAP kinase kinase kinase Win1 Dosage RescuePMID:1756736
overexpression rescuesmcs4response regulator Mcs4 Dosage RescuePMID:9136929
rescued bynrd1RNA-binding protein Nrd1 Phenotypic SuppressionPMID:9671458
rescued bysty1MAP kinase Sty1 Phenotypic SuppressionPMID:20075862
rescued bylsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Phenotypic SuppressionPMID:22144909
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:1756736
rescued byatf1transcription factor, Atf-CREB family Atf1 Phenotypic SuppressionPMID:15870269
rescued byppa1minor serine/threonine protein phosphatase Ppa1 Phenotypic SuppressionPMID:1756736
rescued bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:1756736
rescued byppa2serine/threonine protein phosphatase Ppa2 Phenotypic SuppressionPMID:1756736
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:1756736
rescued bygti1gluconate transmembrane transporter inducer Gti1 Phenotypic SuppressionPMID:9372449
rescued by overexpression ofsty1MAP kinase Sty1 Dosage RescuePMID:8557102
rescued by overexpression ofgpd1glycerol-3-phosphate dehydrogenase Gpd1 Dosage RescuePMID:7498541
rescued by overexpression ofgpd2glycerol-3-phosphate dehydrogenase Gpd2 Dosage RescuePMID:7498541
phenotype enhanced byrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Phenotypic EnhancementPMID:9447985
phenotype enhanced bysds23PP2A-type phosphatase inhibitor Sds23/Moc1 Phenotypic EnhancementPMID:23640764
phenotype enhanced byptc4protein phosphatase 2C Ptc4 Phenotypic EnhancementPMID:22139357
enhances phenotype ofrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Phenotypic EnhancementPMID:9447985
enhances phenotype ofpyp1tyrosine phosphatase Pyp1 Phenotypic EnhancementPMID:9321395
enhances phenotype ofisp6vacuolar serine protease Isp6 Phenotypic EnhancementPMID:16550352
enhances phenotype ofmkh1MEK kinase (MEKK) Mkh1 Phenotypic EnhancementPMID:9199286
inviable in presence of overexpressedsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Dosage LethalityPMID:23640764
External References
Database Identifier Description
NBRP SPBC409.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC409.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC409.07c BioGRID Interaction Datasets
Expression Viewer SPBC409.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC409.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC409.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC409.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC409.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC409.07c Transcriptome Viewer (Bähler Lab)
GEO SPBC409.07c GEO profiles
PInt SPBC409.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC409.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC409.07c Fission yeast phenotypic data & analysis
Cyclebase SPBC409.07c.1 Cell Cycle Data
SPD / RIKEN33/33D12Orfeome Localization Data
UniProtKB/SwissProtP33886Protein kinase wis1
ModBaseP33886Database of comparative protein structure models
STRINGP33886Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595457MAP kinase kinase Wis1
RefSeq mRNANM_001021367972h- MAP kinase kinase Wis1 (wis1), mRNA
European Nucleotide ArchiveCAA44499.1ENA Protein Mapping
European Nucleotide ArchiveCAB52609.1ENA Protein Mapping
UniParcUPI0000138F12UniProt Archive

Literature for wis1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016