clr4 (SPBC428.08c)

Gene Standard Nameclr4 ChromosomeII
Systematic IDSPBC428.08c Gene Start458487
Synonyms Gene End453996
Producthistone H3 lysine methyltransferase Clr4 Gene Length4492
Feature Typeprotein coding CDS Start458047
Name DescriptionCryptic Loci Regulator CDS End456575
Characterisation Statuspublished CDS Length1473

Ensembl Gene Location
  1. apq12
  2. arg12
  3. SPNCRNA.1360
  4. rxt2
  5. clr4
  6. meu6
  7. SPNCRNA.1361
  8. SPNCRNA.1362
  9. SPNCRNA.534
  10. SPBC428.10
Fission Yeast Phenotype Ontology

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidenceclr4delta (deletion)deletionPMID:20537132
Cell growth assayclr4delta (deletion)deletionPMID:18923422
FYPO:0000220accumulation of centromeric outer repeat transcriptsno_name (unrecorded)unrecordedPMID:20211136
FYPO:0000269sensitive to microtubule depolymerizing drugscompetitive growth assay evidenceclr4delta (deletion)deletionPMID:20537132
FYPO:0000957normal cell population growth on methyl methanesulfonateCell growth assayclr4delta (deletion)deletionPMID:18923422
FYPO:0000963normal cell population growth on hydroxyureaCell growth assayclr4delta (deletion)deletionPMID:18923422
FYPO:0001132abolished protein localization to heterochromatinMicroscopyclr4delta (deletion)deletionPMID:21385875
assayed_using las1
assayed_using grc3Microscopyclr4delta (deletion)deletionPMID:21385875
assayed_using rix1Microscopyclr4delta (deletion)deletionPMID:21385875
assayed_using SPCC1393.06Microscopyclr4delta (deletion)deletionPMID:21385875
assayed_using crb3Microscopyclr4delta (deletion)deletionPMID:21385875
FYPO:0001164normal cell population growth on glucose carbon sourceCell growth assayclr4delta (deletion)deletionPMID:18923422
FYPO:0001491viable vegetative cellclr4delta (deletion)deletionPMID:12618370
Microscopyclr4delta (deletion)deletionPMID:20473289
GO Molecular Function

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIhus5PMID:16168376
GO:0008168methyltransferase activityIDAPMID:10949293
GO:0008270zinc ion bindingIEAIPR003606, IPR007728GO_REF:0000002
GO:0046974histone methyltransferase activity (H3-K9 specific)IDAPMID:10949293
IDAPMID:10949293
GO Biological Process

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0000122negative regulation of transcription from RNA polymerase II promoter
has_regulation_target tlh2IMPPMID:16407326
has_regulation_target tlh1IMPPMID:16407326
GO:0000183chromatin silencing at rDNA
requiredIMPPMID:10835380
GO:0006348chromatin silencing at telomereTASPMID:15197176
GO:0007535donor selectionIMPPMID:9620780
GO:0030466chromatin silencing at silent mating-type cassette
requiredIMPPMID:8138176
GO:0030702chromatin silencing at centromereIMPPMID:7851795
GO:0030989dynein-driven meiotic oscillatory nuclear movementIGIrik1PMID:15197176
GO:0031048chromatin silencing by small RNAIMPPMID:12869699
GO:0031507heterochromatin assemblyNASGO_REF:0000001
GO:0032015regulation of Ran protein signal transductionTASPMID:18422602
GO:0034613cellular protein localization
has_input swi6IMPPMID:11283354
has_input chp2IMPPMID:15372076
has_input chp1IMPPMID:15372076
has_input rdp1IMPPMID:15372076
GO:0045141meiotic telomere clusteringIMPPMID:15197176
GO:0051315attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregationIMPPMID:17627824
GO:0051567histone H3-K9 methylationIDAPMID:10949293
GO:0090065regulation of production of siRNA involved in RNA interferenceIMPPMID:12869699
GO Cellular Component

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005724nuclear telomeric heterochromatinNASGO_REF:0000001
GO:0005737cytoplasmIEAUniProtKB:KW-0963GO_REF:0000037
GO:0031618nuclear centromeric heterochromatinTASPMID:16127433
GO:0031934mating-type region heterochromatinNASGO_REF:0000001
GO:0043494CLRC ubiquitin ligase complexIDAPMID:16127433
GO:0044732mitotic spindle pole bodyIDAPMID:16823372
Transcript
Contact Curators
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1458487453996

References

Region Start End Reference
three_prime_UTR456574453996PMID:21511999
Protein Features
Contact Curators

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF05033 IPR007728 Pfam Pre-SET domain 214 320 1
PF00385 IPR023780 Pfam Chromo domain/shadow 8 60 7
PF00856 IPR001214 Pfam SET domain 339 451 12
SM00317 IPR001214 SMART SET domain 328 458 11
SM00298 IPR000953 SMART Chromo domain/shadow 7 62 9
SM00468 IPR003606 SMART Pre-SET zinc-binding sub-group 209 312 1
SM00508 IPR003616 SMART Post-SET domain 473 489 3
PS50868 IPR003616 Prosite Profiles Post-SET domain 473 489 3
PS50013 IPR000953 Prosite Profiles Chromo domain/shadow 8 69 7
PS50867 IPR007728 Prosite Profiles Pre-SET domain 258 325 1
PS50280 IPR001214 Prosite Profiles SET domain 327 456 8
PS00598 IPR023779 Prosite Patterns Chromo domain/shadow 27 47 4
G3DSA:2.170.270.10 Gene3D 217 488 8
G3DSA:2.40.50.40 Gene3D 2 64 7
SSF54160 IPR016197 SuperFamily 3 63 9
SSF82199 SuperFamily 198 453 13
PTHR22884 hmmpanther 202 490 3
PTHR22884:SF39 hmmpanther 202 490 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 114.12 Da
Charge 13.00
Isoelectric point 8.42
Molecular weight 55.92 kDa
Number of residues 490
Sequence
Contact Curators
Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
deletion mutant expression profiling PMID:15632061
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.5PMID:23101633
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

Contact Curators
Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ctu1cytosolic thiouridylase subunit Ctu1 Negative GeneticPMID:22681890
rrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
SPCC736.13short chain dehydrogenase (predicted) Negative GeneticPMID:22681890
SPBC725.10tspO homolog/ peripheral benzodiazepine receptor homolog, involved in the transport cytoplas/mitochondrial of haem (predicted) Positive GeneticPMID:22681890
spf38splicing factor Spf38 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPCC417.11cglutamate-1-semialdehyde 2,1-aminomutase (predicted) Negative GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC1786.01ctriacylglycerol lipase (predicted) Positive GeneticPMID:22681890
ura3dihydroorotate dehydrogenase Ura3 Negative GeneticPMID:22681890
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
nda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
nup132nucleoporin Nup132 Positive GeneticPMID:22681890
SPAC9E9.05sequence orphan Negative GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
rps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
qcr6ubiquinol-cytochrome-c reductase complex subunit 8, hinge protein (predicted) Negative GeneticPMID:22681890
ist1MVB sorting pathway protein (predicted) Negative GeneticPMID:22681890
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
gld1mitochondrial glycerol dehydrogenase Gld1 Positive GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPBC13E7.07sequence orphan Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:18818364
epe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:23388053
Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPAC16E8.12cING family homolog Png3 (predicted) Positive GeneticPMID:22681890
sec63ER protein translocation subcomplex subunit Sec63 (predicted) Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
pho24-nitrophenylphosphatase Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
bzz1diacylglycerol binding protein Bzz1 (predicted) Negative GeneticPMID:18818364
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC23A1.09RNA-binding protein (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
tps2trehalose-phosphate synthase Tps2 (predicted) Positive GeneticPMID:22681890
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPCC188.10cpseudogene Positive GeneticPMID:22681890
rdp1RNA-directed RNA polymerase Rdp1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
SPBP16F5.05cribosome biogenesis protein Nop8 (predicted) Negative GeneticPMID:22681890
rrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:23151475
Phenotypic Enhancement
pom152nucleoporin Pom152 Negative GeneticPMID:22681890
SPBC21B10.03cataxin-2 homolog (predicted) Negative GeneticPMID:22681890
trs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
bub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
moe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:18818364
aps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Positive GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
SPAC1071.05S-adenosylmethionine-dependent methyltransferase (predicted) Positive GeneticPMID:22681890
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
pds5cohesin-associated protein Pds5 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC1347.09hexaprenyldihydroxybenzoate methyltransferase, Coq3 variant (predicted) Negative GeneticPMID:22681890
sif2Sad1 interacting factor 2 (predicted) Positive GeneticPMID:22681890
msh6MutS protein homolog Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cut3condensin complex subunit Cut3 Negative GeneticPMID:22681890
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
SPCC4F11.03csequence orphan Positive GeneticPMID:22681890
SPAC27E2.02IMPACT homolog, translational regulator (predicted) Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Positive GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:18818364
mto1MT organizer Mto1 Negative GeneticPMID:22681890
ctu2cytosolic thiouridylase subunit Ctu2 Negative GeneticPMID:22681890
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hht1histone H3 h3.1 Dosage LethalityPMID:16540522
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
SPCC594.04csteroid oxidoreductase superfamily protein (predicted) Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
ctp1CtIP-related endonuclease Negative GeneticPMID:22681890
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
SPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
SPCC320.03transcription factor (predicted) Negative GeneticPMID:22681890
moc3transcription factor Moc3 Positive GeneticPMID:22681890
rps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
SPAC2E1P3.05cfungal cellulose binding domain protein Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
ers1RNA-silencing factor Ers1 Dosage RescuePMID:22474355
Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
chp1chromodomain protein Chp1 Phenotypic EnhancementPMID:10835380
Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
hrk1haspin related kinase Hrk1 Negative GeneticPMID:22681890
SPBC215.01GTPase activating protein (predicted) Negative GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:22681890
SPAC4D7.07csequence orphan Positive GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Positive GeneticPMID:22681890
byr3zinc finger protein Byr3 Positive GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
SPAC23H4.13csequence orphan Negative GeneticPMID:22681890
mst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
pac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
hem12uroporphyrinogen decarboxylase Hem12 (predicted) Negative GeneticPMID:22681890
SPBC25H2.15SSU-rRNA maturation protein Tsr4 homolog 1 (predicted) Negative GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
SPAC10F6.08cHMG box protein Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
elp4elongator complex subunit Elp4 (predicted) Negative GeneticPMID:18818364
SPAC22A12.14cBSD domain protein, unknown biological role Negative GeneticPMID:22681890
sgf73SAGA complex subunit Sgf73 Positive GeneticPMID:22681890
ubc14ubiquitin conjugating enzyme Ubc14 (predicted) Negative GeneticPMID:22681890
otu2ubiquitin specific cysteine protease, OTU family, Otu2 Negative GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC328.04AAA family ATPase, unknown biological role Negative GeneticPMID:22681890
dcr1dicer Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPBPB2B2.09c2-dehydropantoate 2-reductase (predicted) Negative GeneticPMID:22681890
tip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
SPCC550.11karyopherin (predicted) Positive GeneticPMID:22681890
btf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC26H8.05cserine/threonine protein phosphatase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:22681890
dlc1dynein light chain Dlc1 Positive GeneticPMID:22681890
lsd1histone demethylase SWIRM1 Synthetic RescuePMID:17434129
pmc5mediator complex subunit Pmc5 Positive GeneticPMID:18818364
tip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Phenotypic EnhancementPMID:11283354
mug154conserved fungal protein Negative GeneticPMID:18818364
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
ago1argonaute Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
elp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ubc13ubiquitin conjugating enzyme Ubc13 Positive GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
stc1LIM-like protein linking chromatin modification to RNAi, Stc1 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
mug81ATP-dependent RNA helicase Slh1 (predicted) Negative GeneticPMID:18818364
arb1argonaute binding protein 1 Positive GeneticPMID:22681890
ark1aurora-B kinase Ark1 Negative GeneticPMID:22681890
psl1cyclin pho85 family (predicted) Positive GeneticPMID:22681890
snu66U4/U6 x U5 tri-snRNP complex subunit Snu66 (predicted) Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
cmk2MAPK-activated protein kinase Cmk2 Negative GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
tas3RITS complex subunit 3 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
lsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Phenotypic EnhancementPMID:22990236
rpl90160S ribosomal protein L9 Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
set2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
Synthetic Growth DefectPMID:18216783
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
kap113karyopherin Kap113 Positive GeneticPMID:22681890
cut14condensin complex subunit Cut14 Negative GeneticPMID:22681890
SPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
SPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
SPCC613.02membrane transporter (predicted) Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:18818364
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
SPBP8B7.10cU3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
dph3diphthamide biosynthesis protein Dph3 (predicted) Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
adn3transcription factor (predicted) Negative GeneticPMID:22681890
SPAC6G9.01cconserved protein Positive GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Positive GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
mug73membrane transporter (predicted) Negative GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
spf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
mal3EB1 family Mal3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rrp1ATP-dependent DNA helicase (predicted) Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
SPCC126.01cconserved fungal protein Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
SPAC6G9.14RNA-binding protein (predicted) Negative GeneticPMID:22681890
SPCC1672.03cguanine deaminase (predicted) Positive GeneticPMID:22681890
spn2septin Spn2 Negative GeneticPMID:22681890
rna1Ran GAP Rna1 Dosage RescuePMID:15317843
Synthetic Lethality
nup124nucleoporin Nup124 Negative GeneticPMID:22681890
SPAC24H6.10cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit (predicted) Negative GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rmt3type I ribosomal protein arginine N-methyltransferase Rmt3 Negative GeneticPMID:22681890
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
nrl1NRDE-2 family protein (predicted) Negative GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
dcd1deoxycytidylate deaminase (predicted) Positive GeneticPMID:22681890
rec8meiotic cohesin complex subunit Rec8 Phenotypic SuppressionPMID:20421495
mad2spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
lon1Lon protease homolog Lon1 (predicted) Negative GeneticPMID:22681890
SPAC328.01ckaryopherin (predicted) Negative GeneticPMID:18818364
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spe1ornithine decarboxylase Spe1 (predicted) Negative GeneticPMID:22681890
fus1formin Fus1 Negative GeneticPMID:22681890
ppk30Ark1/Prk1 family protein kinase Ppk30 Negative GeneticPMID:18818364
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
clr5Clr5 protein Phenotypic EnhancementPMID:21253571
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
rec10meiotic recombination protein Rec10 Phenotypic SuppressionPMID:20421495
adn2transcription factor (predicted) Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
fta6Sim4 and Mal2 associated (4 and 2 associated) protein 6 Positive GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC18G6.13sequence orphan Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPBC3H7.05cmitochondrial Membrane Bound O-Acyl Transferase (MBOAT) family Negative GeneticPMID:22681890
cwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
msd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
zip1transcription factor Zip1 Negative GeneticPMID:22681890
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
uch2ubiquitin C-terminal hydrolase Uch2 Positive GeneticPMID:22681890
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
abo2ATPase with bromodomain protein (predicted) Negative GeneticPMID:18818364
SPCC1322.02sequence orphan Negative GeneticPMID:22681890
SPBC3B8.04cmembrane transporter (predicted) Positive GeneticPMID:22681890
SPCC622.15csequence orphan Negative GeneticPMID:22681890
SPCC1827.04ankyrin repeat protein, unknown biological role Positive GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
rpl10260S ribosomal protein L10a Positive GeneticPMID:22681890
ckb2CK2 family regulatory subunit (predicted) Positive GeneticPMID:22681890
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
rho2Rho family GTPase Rho2 Positive GeneticPMID:22681890
mad3mitotic spindle checkpoint protein Mad3 Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAPB1E7.11csequence orphan Negative GeneticPMID:22681890
rpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
SPAC9.07cGTPase Rbg1 (predicted) Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC8C9.12cmitochondrial iron ion transporter (predicted) Positive GeneticPMID:22681890
chl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rik1silencing protein Rik1 Dosage RescuePMID:20705239
Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:18818364
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Phenotypic EnhancementPMID:22144463
Positive GeneticPMID:22681890
Negative GeneticPMID:18818364
mkh1MEK kinase (MEKK) Mkh1 Positive GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
sgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hrp1ATP-dependent DNA helicase Hrp1 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Co-localizationPMID:16762840
dsh1RNAi protein, Dsh1 Co-localizationPMID:22895252
hht2histone H3 h3.2 Protein-peptidePMID:22727667
Co-localizationPMID:15976807
chp1chromodomain protein Chp1 Co-localizationPMID:15372076
Affinity Capture-WesternPMID:18345014
hht1histone H3 h3.1 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:18345014
Biochemical ActivityPMID:16540522
Reconstituted Complex
Co-localizationPMID:15976807
stc1LIM-like protein linking chromatin modification to RNAi, Stc1 Affinity Capture-WesternPMID:20211136
hht3histone H3 h3.3 Protein-peptidePMID:22727667
rik1silencing protein Rik1 Affinity Capture-WesternPMID:22319459
Affinity Capture-MSPMID:16024659
Affinity Capture-MSPMID:17114925
pcu4cullin 4 Affinity Capture-WesternPMID:16127433
Co-localization
chp2HP1 family chromodomain protein 2 Co-localizationPMID:15372076
htb1histone H2B Htb1 Biochemical ActivityPMID:16024659
ago1argonaute Affinity Capture-WesternPMID:20211136
red1RNA elimination defective protein Red1 Affinity Capture-WesternPMID:22144463
rdp1RNA-directed RNA polymerase Rdp1 Co-localizationPMID:22895252
swi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
Co-localizationPMID:11283354
Co-localizationPMID:15976807
hus5SUMO conjugating enzyme Hus5 Affinity Capture-WesternPMID:16168376
Two-hybrid
raf1Rik1-associated factor Raf1 Affinity Capture-WesternPMID:22319459
mlo3RNA binding protein Mlo3 Two-hybridPMID:21436456
Biochemical Activity
Reconstituted Complex
Affinity Capture-Western
tas3RITS complex subunit 3 Affinity Capture-WesternPMID:20705239
Contact Curators
External References
Database Identifier Description
NBRP SPBC428.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC428.08c Retrieval of eukaryotic orthologs
BioGrid SPBC428.08c BioGRID Interaction Datasets
Bähler Lab SPBC428.08c Cell Cycle Expression Profile
Bähler Lab SPBC428.08c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC428.08c Pheromone response/mating expression profiles
Bähler Lab SPBC428.08c Environmental stress expression profiles
Bähler Lab SPBC428.08c Bähler Lab Transcriptome Viewer
Cyclebase SPBC428.08c Cell Cycle Data
PInt SPBC428.08c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC428.08c Entrez Gene
WikiGene2540825histone H3 methyltransferase Clr4
Uniprot_genenameCLR4
EntrezGene2540825histone H3 methyltransferase Clr4
SPD / RIKEN23/23G02Orfeome Localization Data
UniProtKB/SwissProtO60016Histone-lysine N-methyltransferase, H3 lysine-9 specific
ModBaseO60016Database of comparative protein structure models
Pfam Protein DomainsO60016Pfam Domain Arrangement
RefSeq PeptideNP_595186histone H3 methyltransferase Clr4
RefSeq mRNANM_001021094972h- histone H3 methyltransferase Clr4 (clr4), mRNA
European Nucleotide ArchiveAAC18302ENA Protein Mapping
European Nucleotide ArchiveCAA07709ENA Protein Mapping
European Nucleotide ArchiveCAA22283ENA Protein Mapping
SPD / RIKEN23/23G02Orfeome Localization Data

Literature for clr4
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013