clr4 (SPBC428.08c)

Gene Standard Nameclr4 Characterisation Statuspublished
Systematic IDSPBC428.08c Feature Typeprotein coding
Synonyms Name DescriptionCryptic Loci Regulator
Producthistone H3 lysine methyltransferase Clr4 Product Size490aa, 55.92 kDa
Genomic Location Chromosome II, 458487-453996 (4492nt); CDS:458047-456575 (1473nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
double-stranded DNA binding26
Annotation ExtensionEvidenceWith/FromReference
histone methyltransferase activity (H3-K9 specific)1
Annotation ExtensionEvidenceWith/FromReference
methylated histone binding8
Annotation ExtensionEvidenceWith/FromReference
methyltransferase activity101
Annotation ExtensionEvidenceWith/FromReference
protein binding848
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA binding28
Annotation ExtensionEvidenceWith/FromReference
single-stranded RNA binding11
Annotation ExtensionEvidenceWith/FromReference
zinc ion binding248
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
attachment of mitotic spindle microtubules to kinetochore38
Annotation ExtensionEvidenceWith/FromReference
cellular protein localization555
Annotation ExtensionEvidenceWith/FromReference
chromatin remodeling159
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere63
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere outer repeat region25
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at rDNA10
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at silent mating-type cassette36
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at telomere23
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing by small RNA22
Annotation ExtensionEvidenceWith/FromReference
donor selection3
Annotation ExtensionEvidenceWith/FromReference
heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region2
Annotation ExtensionEvidenceWith/FromReference
histone H3-K9 methylation14
Annotation ExtensionEvidenceWith/FromReference
meiotic telomere clustering14
Annotation ExtensionEvidenceWith/FromReference
negative regulation of transcription from RNA polymerase II promoter79
Annotation ExtensionEvidenceWith/FromReference
peptidyl-lysine methylation34
Annotation ExtensionEvidenceWith/FromReference
regulation of production of siRNA involved in RNA interference1
Annotation ExtensionEvidenceWith/FromReference
regulation of Ran protein signal transduction6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
CLRC ubiquitin ligase complex6
Annotation ExtensionEvidenceWith/FromReference
mating-type region heterochromatin25
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nuclear pericentric heterochromatin36
Annotation ExtensionEvidenceWith/FromReference
nuclear telomeric heterochromatin25
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased mating efficiencyclr4ΔNull247
increased number of cells with 1C DNA contentclr4ΔNull39
normal growth on glucose carbon sourceclr4ΔNull189
normal growth on hydroxyureaclr4ΔNull31
normal growth on methyl methanesulfonateclr4ΔNull25
normal vegetative cell population growthclr4ΔNull685
sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000003clr4ΔNull
sensitive to bortezomib256
expressivity FYPO_EXT:0000002clr4ΔNull
sensitive to hydroxyureaclr4ΔNull518
sensitive to methyl methanesulfonateclr4ΔNull227
sensitive to thiabendazoleclr4ΔNull185
viable vegetative cell populationclr4ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal heterochromatin silencing at centromere outer repeat regionclr4 alpha mut (58KRRKR62 substituted with NEHG)Endogenous10
abnormal mitotic cell cycle arrest with unreplicated DNAclr4ΔNull45
abolished histone H3-K9 dimethylation at telomereclr4ΔNull3
abolished histone H3-K9 methylation at centromere outer repeatclr4ΔNull1
abolished protein localization to centromere21
affecting swi6clr4ΔNull
abolished protein localization to heterochromatin3
affecting crb3clr4ΔNull
affecting las1clr4ΔNull
affecting ipi1clr4ΔNull
affecting rix1clr4ΔNull
affecting grc3clr4ΔNull
abolished RNA binding10
affecting clr4clr4 alpha mut (58KRRKR62 substituted with NEHG)Not specified
decreased chromatin silencing at centromere outer repeat regionclr4ΔNull30
decreased chromatin silencing at silent mating-type cassetteclr4-642 (G378S)Not specified15
clr4-680 (W487*)
clr4-681 (G486D)Not specified
clr4-689 (R320H)Not specified
clr4-S5Not specified
decreased chromatin silencing at telomere22
expressivity FYPO_EXT:0000001clr4ΔNull
decreased heterochromatin assembly at protein coding gene2
affecting SPAC8C9.04clr4ΔNull
affecting mcp5clr4ΔNull
affecting mei4clr4ΔNull
decreased histone H2A phosphorylation at centromere outer repeatclr4ΔNull1
decreased histone H2A phosphorylation at subtelomere during mitotic S phaseclr4ΔNull2
decreased histone H3-K9 dimethylation at centromere outer repeatclr4ΔNull8
decreased histone H3-K9 methylation at centromere outer repeatclr4ΔNull16
decreased histone H3-K9 methylation at mating-type region heterochromatinclr4ΔNull5
decreased histone H3-K9 methylation at subtelomeric heterochromatinclr4ΔNull2
decreased protein localization to centromere31
affecting swi6clr4ΔNull
affecting rdp1clr4ΔNull
affecting brc1clr4ΔNull
decreased protein localization to heterochromatin at centromere outer repeat6
affecting swi6clr4ΔNull
decreased protein localization to mating-type region heterochromatin2
affecting swi6clr4ΔNull
decreased protein localization to telomeric heterochromatin2
affecting swi6clr4ΔNull
affecting brc1clr4ΔNull
decreased punctate nuclear protein localization11
affecting swi6clr4ΔNull
affecting brc1clr4ΔNull
heterochromatin assembly beyond boundary element IRC1Rclr4ΔNull3
increased centromeric outer repeat transcript level19
expressivity FYPO_EXT:0000001clr4ΔNull
increased histone H3-K14 acetylation at centromere outer repeatclr4ΔNull1
increased histone H3-K4 dimethylation at centromere outer repeatclr4ΔNull3
increased histone H3-K56 acetylation at centromere outer repeatclr4ΔNull3
increased histone H3-K9 acetylation at centromereclr4ΔNull5
increased histone H3-K9 and H3-K14 acetylation at centromere outer repeatclr4ΔNull3
increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeatclr4ΔNull3
increased level of heterochromatin-encoded proteinsclr4ΔNull3
increased meiotic recombinationclr4-681 (G486D)Not specified9
increased protein localization to heterochromatin at centromere outer repeat2
affecting rpb1clr4ΔNull
increased RNA level during vegetative growth171
affecting SO:0000286clr4ΔNull
affecting SO:0001898clr4ΔNull
lagging mitotic chromosomesclr4ΔNull19
normal centromeric outer repeat transcript-derived siRNA levelclr4ΔNull8
normal genetic imprinting at mating-type locusclr4ΔNull6
normal histone H2A phosphorylation at mating type locusclr4ΔNull2
normal protein localization to centromere18
affecting dcr1clr4ΔNull
normal protein localization to heterochromatin at centromere outer repeat3
affecting cnp1clr4ΔNull
normal protein localization to rDNA1
affecting brc1clr4ΔNull
normal S-phase DNA damage checkpointclr4ΔNull17
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001clr4ΔNull
Target Of
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:22727667
GO localized by chp1 chromodomain protein Chp1 PMID:14704433
GO localized by pcu4 cullin 4 PMID:16127433
GO localized by rdp1 RNA-directed RNA polymerase Rdp1 PMID:15615848
GO localized by rik1 silencing protein Rik1 PMID:15197176
GO localized by rik1 silencing protein Rik1 PMID:10766735
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00385 Pfam IPR023780 Chromo domain 8 60 7
PF00856 Pfam IPR001214 SET domain 339 451 12
PF05033 Pfam IPR007728 Pre-SET domain 214 320 1
SM00317 SMART IPR001214 SET domain 328 458 11
SM00298 SMART IPR000953 Chromo/chromo shadow domain 7 62 9
SM00468 SMART IPR003606 Pre-SET zinc-binding sub-group 209 312 1
SM00508 SMART IPR003616 Post-SET domain 473 489 3
PS00598 Prosite Patterns IPR023779 Chromo domain, conserved site 27 47 4
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 8 69 7
PS50868 Prosite Profiles IPR003616 Post-SET domain 473 489 3
PS50867 Prosite Profiles IPR007728 Pre-SET domain 258 325 1
PS50280 Prosite Profiles IPR001214 SET domain 328 452 13
PTHR22884 HMMPANTHER 5 490 3 Gene3D 2 64 7 Gene3D 217 488 8
SSF82199 SuperFamily 198 453 13
SSF54160 SuperFamily IPR016197 Chromo domain-like 3 63 9

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 114.12 Da
Charge 13.00
Isoelectric point 8.42
Molecular weight 55.92 kDa
Number of residues 490

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS462 1670
present during cellular response to thiabendazoleS458
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S458 PMID:18257517
experimental evidence S462 PMID:24763107
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
deletion mutant expression profiling PMID:1563206178
Species Distribution
no apparent S. cerevisiae ortholog597
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
htb1histone H2B Htb1 Biochemical ActivityPMID:16024659
hus5SUMO conjugating enzyme E2 Hus5 Affinity Capture-WesternPMID:16168376
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Affinity Capture-WesternPMID:22319459
rik1silencing protein Rik1 Affinity Capture-MSPMID:17114925
Affinity Capture-WesternPMID:22319459
Affinity Capture-MSPMID:16024659
swi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
stc1LIM-like protein linking chromatin modification to RNAi, Stc1 Affinity Capture-WesternPMID:23613586
Affinity Capture-WesternPMID:20211136
ago1argonaute Affinity Capture-WesternPMID:20211136
tas3RITS complex subunit 3 Affinity Capture-WesternPMID:20705239
hht1histone H3 h3.1 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:18345014
Biochemical ActivityPMID:23849629
Biochemical ActivityPMID:16540522
Reconstituted Complex
hht3histone H3 h3.3 Protein-peptidePMID:22727667
chp1chromodomain protein Chp1 Affinity Capture-WesternPMID:18345014
red1RNA elimination defective protein Red1 Affinity Capture-WesternPMID:22144463
hht2histone H3 h3.2 Protein-peptidePMID:22727667
pcu4cullin 4 Affinity Capture-WesternPMID:16127433
mlo3RNA binding protein Mlo3 Reconstituted ComplexPMID:21436456
Biochemical Activity
Affinity Capture-Western
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
yih1IMPACT homolog, translational regulator Yih1 (predicted) Negative GeneticPMID:22681890
SPBPB2B2.09c2-dehydropantoate 2-reductase (predicted) Negative GeneticPMID:22681890
snu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
rik1silencing protein Rik1 Positive GeneticPMID:18818364
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:22681890
Dosage RescuePMID:20705239
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
sgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hem12uroporphyrinogen decarboxylase Hem12 (predicted) Negative GeneticPMID:22681890
mug73plasma membrane transmembrane transport regulator (predicted) Negative GeneticPMID:22681890
msh6MutS protein homolog Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
fta6Sim4 and Mal2 associated (4 and 2 associated) protein 6 Positive GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spe1ornithine decarboxylase Spe1 (predicted) Negative GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
ubc14ubiquitin conjugating enzyme E2 Ubc14 (predicted) Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
spn2septin Spn2 Negative GeneticPMID:22681890
rpl10260S ribosomal protein L10a Positive GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC3B8.04ctransmembrane transporter (predicted) Positive GeneticPMID:22681890
clr5Clr5 protein Phenotypic EnhancementPMID:21253571
cwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
sgf73SAGA complex subunit Sgf73 Positive GeneticPMID:25076038
Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
otu2ubiquitin specific cysteine protease, OTU family, Otu2 Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
med6mediator complex subunit Med6 Positive GeneticPMID:18818364
SPAC1071.05S-adenosylmethionine-dependent methyltransferase (predicted) Positive GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rec8meiotic cohesin complex subunit Rec8 Phenotypic SuppressionPMID:20421495
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
psl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
yar1ribosome biogenesis protein Yar1 (predicted) Negative GeneticPMID:22681890
sif2Sad1 interacting factor 2 (predicted) Positive GeneticPMID:22681890
utp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
zip1transcription factor Zip1 Negative GeneticPMID:22681890
pac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
SPBC215.01GTPase activating protein (predicted) Negative GeneticPMID:22681890
bzz1diacylglycerol binding protein Bzz1 (predicted) Negative GeneticPMID:18818364
rrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
byr3translational activator, zf-CCHC type zinc finger protein (predicted) Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1347.09hexaprenyldihydroxybenzoate methyltransferase, Coq3 variant (predicted) Negative GeneticPMID:22681890
SPAC9.07cGTPase Rbg1 (predicted) Negative GeneticPMID:22681890
lsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
sec63ER protein translocation subcomplex subunit Sec63 (predicted) Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
fus1formin Fus1 Negative GeneticPMID:22681890
pom152nucleoporin Pom152 Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
ago1argonaute Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
Positive GeneticPMID:22681890
Phenotypic EnhancementPMID:22144463
SPCC736.13short chain dehydrogenase (predicted) Negative GeneticPMID:22681890
mad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ura3dihydroorotate dehydrogenase Ura3 Negative GeneticPMID:22681890
SPCC613.02transmembrane transporter (predicted) Negative GeneticPMID:22681890
SPAC8C9.12cmitochondrial iron ion transmembrane transporter (predicted) Positive GeneticPMID:22681890
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
spf38U5 snRNP complex subunit Spf38 Negative GeneticPMID:22681890
ath1ataxin-2 homolog Negative GeneticPMID:22681890
rec10meiotic recombination protein Rec10 Phenotypic SuppressionPMID:20421495
mal3EB1 family Mal3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ctp1CtIP-related endonuclease Negative GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
SPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:18818364
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:22681890
btf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
rmt3type I ribosomal protein arginine N-methyltransferase Rmt3 Negative GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
arb1argonaute inhibitor protein 1 Positive GeneticPMID:22681890
dcd1deoxycytidylate deaminase (predicted) Positive GeneticPMID:22681890
pds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
elp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
set2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
Synthetic Growth DefectPMID:18216783
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPAC9E9.05Schizosaccharomyces specific protein Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
rrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:23151475
Phenotypic Enhancement
Phenotypic SuppressionPMID:24493644
Phenotypic EnhancementPMID:24210919
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
uch2ubiquitin C-terminal hydrolase Uch2 Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
stc1LIM-like protein linking chromatin modification to RNAi, Stc1 Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:22681890
nup124nucleoporin Nup124 Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
pxd1structure-specific DNA nuclease regulator Pxd1 Negative GeneticPMID:22681890
SPBC13E7.07Schizosaccharomyces specific protein Negative GeneticPMID:22681890
nht10Ino80 complex HMG box subunit Nhp10 (predicted) Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Phenotypic EnhancementPMID:22990236
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Phenotypic EnhancementPMID:11283354
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
rps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
SPAC22A12.14cBSD domain protein, unknown biological role Negative GeneticPMID:22681890
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
ark1aurora-B kinase Ark1 Negative GeneticPMID:22681890
tip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:18818364
arp6actin-like protein Arp6 Negative GeneticPMID:18818364
kap113karyopherin Kap113 Positive GeneticPMID:22681890
SPCC550.11karyopherin (predicted) Positive GeneticPMID:22681890
SPAC6G9.01cconserved protein Positive GeneticPMID:22681890
rna1Ran GAP Rna1 Dosage RescuePMID:15317843
Synthetic Lethality
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
SPAC328.04AAA family ATPase, unknown biological role Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
SPAC2E1P3.05cfungal cellulose binding domain protein Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
csi2mitotic chromosome segregation protein Csi2 Positive GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
cmk2MAPK-activated protein kinase Cmk2 Negative GeneticPMID:22681890
SPCC594.04csteroid oxidoreductase superfamily protein (predicted) Negative GeneticPMID:22681890
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
nup132nucleoporin Nup132 Positive GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
dlc1dynein light chain Dlc1 Positive GeneticPMID:22681890
ctu1cytosolic thiouridylase subunit Ctu1 Negative GeneticPMID:22681890
dph3diphthamide biosynthesis protein Dph3 (predicted) Negative GeneticPMID:22681890
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
mad3mitotic spindle checkpoint protein Mad3 Negative GeneticPMID:22681890
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ers1RNA-silencing factor Ers1 Dosage RescuePMID:22474355
Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
hrp1ATP-dependent DNA helicase Hrp1 Positive GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC188.10cPositive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC3H7.05cmitochondrial Membrane Bound O-Acyl Transferase (MBOAT) family Negative GeneticPMID:22681890
cut3condensin complex subunit Cut3 Negative GeneticPMID:22681890
ppk30Ark1/Prk1 family protein kinase Ppk30 Negative GeneticPMID:18818364
SPCC4F11.03cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:23388053
Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
aps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Positive GeneticPMID:22681890
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
msn5karyopherin (predicted) Negative GeneticPMID:18818364
pmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC6G9.14RNA-binding protein (predicted) Negative GeneticPMID:22681890
ubc13ubiquitin conjugating enzyme E2 Ubc13 Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit Lsg1 Negative GeneticPMID:22681890
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
SPBC25H2.15SSU-rRNA maturation protein Tsr4 homolog 1 (predicted) Negative GeneticPMID:22681890
rps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
chp1chromodomain protein Chp1 Positive GeneticPMID:18818364
Phenotypic EnhancementPMID:10835380
Positive GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
elp4elongator complex subunit Elp4 (predicted) Negative GeneticPMID:18818364
trs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:22681890
abo2ATPase with bromodomain protein (predicted) Negative GeneticPMID:18818364
SPCC320.03transcription factor (predicted) Negative GeneticPMID:22681890
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:18818364
Phenotypic SuppressionPMID:20211136
Positive GeneticPMID:22681890
tps2trehalose-phosphate synthase Tps2 (predicted) Positive GeneticPMID:22681890
SPCC622.15cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
SPAC24H6.10cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
adn3transcription factor (predicted) Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
ptl2triacylglycerol lipase ptl2 Positive GeneticPMID:22681890
nrl1NRDE-2 family protein (predicted) Negative GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
SPAPB1E7.11cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
pho24-nitrophenylphosphatase Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:22681890
rrp1ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
vms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted) Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
lon1Lon protease homolog Lon1 (predicted) Negative GeneticPMID:22681890
nda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
mug81ATP-dependent RNA helicase Slh1, human ASCC3 ortholog (predicted) Negative GeneticPMID:18818364
lsd1histone demethylase SWIRM1 Synthetic RescuePMID:17434129
msd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
qcr6ubiquinol-cytochrome-c reductase complex subunit 8, hinge protein (predicted) Negative GeneticPMID:22681890
ctu2cytosolic thiouridylase subunit Ctu2 Negative GeneticPMID:22681890
tip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
adn2transcription factor (predicted) Negative GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
chl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
png3ING family homolog Png3 (predicted) Positive GeneticPMID:22681890
rho2Rho family GTPase Rho2 Positive GeneticPMID:22681890
cut14condensin complex subunit Cut14 Negative GeneticPMID:22681890
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
bub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
moc3transcription factor Moc3 Positive GeneticPMID:22681890
hht1histone H3 h3.1 Dosage LethalityPMID:16540522
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Positive GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
gld1mitochondrial glycerol dehydrogenase Gld1 Positive GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
SPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
rdp1RNA-directed RNA polymerase Rdp1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
hrk1haspin related kinase Hrk1 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:18818364
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
ist1MVB sorting pathway protein (predicted) Negative GeneticPMID:22681890
SPCC126.01cconserved fungal protein Negative GeneticPMID:22681890
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:22681890
mst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
tas3RITS complex subunit 3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
rpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Positive GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
SPAC23A1.09RNA-binding protein, human RBM8A ortholog (predicted) Positive GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Positive GeneticPMID:22681890
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
spf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
SPBC725.10mitochondrial transport protein, tspO homolog (predicted) Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
rpl90160S ribosomal protein L9 Negative GeneticPMID:22681890
gud1guanine deaminase Gud1 (predicted) Positive GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Positive GeneticPMID:22681890
dcr1dicer Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPCC417.11cglutamate-1-semialdehyde 2,1-aminomutase (predicted) Negative GeneticPMID:22681890
SPAC23H4.13cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
ckb2CK2 family regulatory subunit Ckb2 (predicted) Positive GeneticPMID:22681890
SPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC428.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC428.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC428.08c BioGRID Interaction Datasets
Expression Viewer SPBC428.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC428.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC428.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC428.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC428.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC428.08c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC428.08c Cell Cycle Data
GEO SPBC428.08c GEO profiles
PInt SPBC428.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC428.08c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC428.08c Fission yeast phenotypic data & analysis
SPD / RIKEN23/23G02Orfeome Localization Data
UniProtKB/SwissProtO60016Histone-lysine N-methyltransferase, H3 lysine-9 specific
ModBaseO60016Database of comparative protein structure models
STRINGO60016Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595186histone H3 methyltransferase Clr4
RefSeq mRNANM_001021094972h- histone H3 methyltransferase Clr4 (clr4), mRNA
ePDB1G6ZThe European PDB
ePDB1MVHThe European PDB
ePDB1MVXThe European PDB
European Nucleotide ArchiveAAC18302.1ENA Protein Mapping
European Nucleotide ArchiveCAA07709.1ENA Protein Mapping
European Nucleotide ArchiveCAA22283.1ENA Protein Mapping
MetaCycPWY-642426,27-dehydrozymosterol metabolism
KEGG_Enzyme00310+ degradation
UniParcUPI0000127B94UniProt Archive

Literature for clr4

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015