clr4 (SPBC428.08c)


Gene Standard Nameclr4 Characterisation Statuspublished
Systematic IDSPBC428.08c Feature Typeprotein coding
Synonyms Name DescriptionCryptic Loci Regulator
Producthistone H3 lysine methyltransferase Clr4 Product Size490aa, 55.92 kDa
Genomic Location Chromosome II, 458487-453996 (4492nt); CDS:458047-456575 (1473nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
double-stranded DNA binding26
Annotation ExtensionEvidenceWith/FromReference
histone methyltransferase activity (H3-K9 specific)1
Annotation ExtensionEvidenceWith/FromReference
methylated histone binding8
Annotation ExtensionEvidenceWith/FromReference
methyltransferase activity101
Annotation ExtensionEvidenceWith/FromReference
protein binding851
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA binding28
Annotation ExtensionEvidenceWith/FromReference
single-stranded RNA binding11
Annotation ExtensionEvidenceWith/FromReference
zinc ion binding248
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
attachment of mitotic spindle microtubules to kinetochore39
Annotation ExtensionEvidenceWith/FromReference
cellular protein localization553
Annotation ExtensionEvidenceWith/FromReference
chromatin remodeling157
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere61
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere outer repeat region25
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at rDNA10
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at silent mating-type cassette36
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at telomere23
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing by small RNA22
Annotation ExtensionEvidenceWith/FromReference
donor selection3
Annotation ExtensionEvidenceWith/FromReference
heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region2
Annotation ExtensionEvidenceWith/FromReference
histone H3-K9 methylation13
Annotation ExtensionEvidenceWith/FromReference
meiotic telomere clustering14
Annotation ExtensionEvidenceWith/FromReference
negative regulation of transcription from RNA polymerase II promoter80
Annotation ExtensionEvidenceWith/FromReference
regulation of production of siRNA involved in RNA interference1
Annotation ExtensionEvidenceWith/FromReference
regulation of Ran protein signal transduction6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
CLRC ubiquitin ligase complex6
Annotation ExtensionEvidenceWith/FromReference
mating-type region heterochromatin25
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nuclear pericentric heterochromatin36
Annotation ExtensionEvidenceWith/FromReference
nuclear telomeric heterochromatin25
Annotation ExtensionEvidenceWith/FromReference
nucleus2697
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased mating efficiencyclr4ΔNull247
increased number of cells with 1C DNA contentclr4ΔNull40
increased viability upon nitrogen starvationclr4ΔNull54
normal growth on glucose carbon sourceclr4ΔNull194
normal growth on hydroxyureaclr4ΔNull34
normal growth on methyl methanesulfonateclr4ΔNull27
normal vegetative cell population growthclr4ΔNull697
sensitive to 4-nitroquinoline N-oxideclr4ΔNull159
sensitive to 5-fluorouracilclr4ΔNull271
sensitive to bortezomibclr4ΔNull256
sensitive to hydroxyureaclr4ΔNull525
sensitive to methyl methanesulfonateclr4ΔNull227
sensitive to thiabendazoleclr4ΔNull191
slow vegetative cell population growthclr4ΔNull318
viable vegetative cell populationclr4ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
abnormal chromatin silencing at centromere outer repeat regionclr4 alpha mut (58KRRKR62 substituted with NEHG)Endogenous37
clr4ΔNull
abnormal mitotic cell cycle arrest with unreplicated DNAclr4ΔNull46
abolished histone H3-K9 dimethylation at telomereclr4ΔNull3
abolished histone H3-K9 methylation at centromere outer repeatclr4ΔNull1
abolished protein localization to centromere25
affecting swi6clr4ΔNull
abolished protein localization to heterochromatin4
affecting crb3clr4ΔNull
affecting las1clr4ΔNull
affecting ipi1clr4ΔNull
affecting rix1clr4ΔNull
affecting grc3clr4ΔNull
abolished protein localization to nuclear centromeric heterochromatin3
affecting swi6clr4ΔNull
abolished RNA binding10
affecting clr4clr4 alpha mut (58KRRKR62 substituted with NEHG)Not specified
decreased chromatin silencing at centromere outer repeat regionclr4ΔNull30
decreased chromatin silencing at silent mating-type cassetteclr4-642 (G378S)Not specified15
clr4-680 (W487*)
clr4-681 (G486D)Not specified
clr4-689 (R320H)Not specified
clr4-S5Not specified
clr4ΔNull
decreased chromatin silencing at telomereclr4ΔNull22
decreased heterochromatin assembly at protein coding gene2
affecting SPAC8C9.04clr4ΔNull
affecting mcp5clr4ΔNull
affecting mei4clr4ΔNull
decreased histone H2A phosphorylation at centromere outer repeatclr4ΔNull1
decreased histone H2A phosphorylation at subtelomere during mitotic S phaseclr4ΔNull2
decreased histone H3-K9 dimethylation at centromere outer repeatclr4ΔNull8
decreased histone H3-K9 methylation at centromere outer repeatclr4ΔNull16
decreased histone H3-K9 methylation at mating-type region heterochromatinclr4ΔNull5
decreased histone H3-K9 methylation at subtelomeric heterochromatinclr4ΔNull2
decreased protein localization to centromere32
affecting swi6clr4ΔNull
affecting rdp1clr4ΔNull
affecting brc1clr4ΔNull
decreased protein localization to heterochromatin at centromere outer repeat6
affecting swi6clr4ΔNull
decreased protein localization to mating-type region heterochromatin2
affecting swi6clr4ΔNull
decreased protein localization to telomeric heterochromatin2
affecting swi6clr4ΔNull
affecting brc1clr4ΔNull
decreased punctate nuclear protein localization11
affecting swi6clr4ΔNull
affecting brc1clr4ΔNull
heterochromatin assembly beyond boundary element IRC1Rclr4ΔNull3
increased centromeric outer repeat transcript levelclr4ΔNull19
increased histone H3-K14 acetylation at centromere outer repeatclr4ΔNull1
increased histone H3-K4 dimethylation at centromere outer repeatclr4ΔNull3
increased histone H3-K56 acetylation at centromere outer repeatclr4ΔNull3
increased histone H3-K9 acetylation at centromereclr4ΔNull5
increased histone H3-K9 and H3-K14 acetylation at centromere outer repeatclr4ΔNull3
increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeatclr4ΔNull3
increased level of heterochromatin-encoded proteinsclr4ΔNull3
increased meiotic recombinationclr4-681 (G486D)Not specified9
increased protein localization to heterochromatin at centromere outer repeat2
affecting rpb1clr4ΔNull
increased RNA level during vegetative growth173
affecting SO:0000286clr4ΔNull
affecting SO:0001898clr4ΔNull
lagging mitotic chromosomesclr4ΔNull22
normal centromeric outer repeat transcript-derived siRNA levelclr4ΔNull8
normal genetic imprinting at mating-type locusclr4ΔNull6
normal histone H2A phosphorylation at mating type locusclr4ΔNull2
normal protein localization to centromere22
affecting dcr1clr4ΔNull
normal protein localization to heterochromatin at centromere outer repeat3
affecting cnp1clr4ΔNull
normal protein localization to rDNA1
affecting brc1clr4ΔNull
normal S-phase DNA damage checkpointclr4ΔNull17
viable vegetative cell with normal cell morphologyclr4ΔNull3092
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:22727667
GO localized by chp1 chromodomain protein Chp1 PMID:14704433
GO localized by pcu4 cullin 4 PMID:16127433
GO localized by rdp1 RNA-directed RNA polymerase Rdp1 PMID:15615848
GO localized by rik1 silencing protein Rik1 PMID:15197176
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1458487453996

UTRs

Region Coordinates Reference
five_prime_UTR458487..458048PMID:21511999
three_prime_UTR456574..453996PMID:21511999
exon458047..456575
mRNA458487..453996
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00856 Pfam IPR001214 SET domain 339 451 12
PF00385 Pfam IPR023780 Chromo domain 8 60 7
PF05033 Pfam IPR007728 Pre-SET domain 214 320 1
SM00317 SMART IPR001214 SET domain 328 458 11
SM00468 SMART IPR003606 Pre-SET zinc-binding sub-group 209 312 1
SM00298 SMART IPR000953 Chromo/chromo shadow domain 7 62 9
SM00508 SMART IPR003616 Post-SET domain 473 489 3
PS00598 Prosite Patterns IPR023779 Chromo domain, conserved site 27 47 4
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 8 69 7
PS50868 Prosite Profiles IPR003616 Post-SET domain 473 489 3
PS50867 Prosite Profiles IPR007728 Pre-SET domain 258 325 1
PS50280 Prosite Profiles IPR001214 SET domain 328 452 13
PTHR22884 HMMPANTHER 5 490 3
2.40.50.40 Gene3D 2 64 7
2.170.270.10 Gene3D 217 488 8
SSF82199 SuperFamily 198 453 13
SSF54160 SuperFamily IPR016197 Chromo domain-like 3 63 9

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 114.12 Da
Charge 13.00
Isoelectric point 8.42
Molecular weight 55.92 kDa
Number of residues 490
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS462 1670
present during cellular response to thiabendazoleS458
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S458 PMID:18257517
experimental evidence S462 PMID:24763107
phosphorylated residue 1923
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
Sequence
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1563206178
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog597
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesago1argonaute Affinity Capture-WesternPMID:20211136
affinity captureschp1chromodomain protein Chp1 Affinity Capture-WesternPMID:18345014
(peptide) binds to proteinhht1histone H3 h3.1 Protein-peptidePMID:22727667
forms complex withhht1histone H3 h3.1 Reconstituted ComplexPMID:18345014
modifieshht1histone H3 h3.1 Biochemical ActivityPMID:23849629
forms complex withhht1histone H3 h3.1 Reconstituted ComplexPMID:16540522
modifieshht1histone H3 h3.1 Biochemical ActivityPMID:16540522
(peptide) binds to proteinhht2histone H3 h3.2 Protein-peptidePMID:22727667
(peptide) binds to proteinhht3histone H3 h3.3 Protein-peptidePMID:22727667
modifieshtb1histone H2B Htb1 Biochemical ActivityPMID:16024659
binds DNA-binding domain construct withhus5SUMO conjugating enzyme E2 Hus5 Two-hybridPMID:16168376
affinity captured byhus5SUMO conjugating enzyme E2 Hus5 Affinity Capture-WesternPMID:16168376
forms complex withmlo3RNA binding protein Mlo3 Reconstituted ComplexPMID:21436456
affinity captured bymlo3RNA binding protein Mlo3 Affinity Capture-WesternPMID:21436456
binds activation domain construct withmlo3RNA binding protein Mlo3 Two-hybridPMID:21436456
modifiesmlo3RNA binding protein Mlo3 Biochemical ActivityPMID:21436456
affinity capturespcu4cullin 4 Affinity Capture-WesternPMID:16127433
affinity captured byraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Affinity Capture-WesternPMID:22319459
affinity capturesred1RNA elimination defective protein Red1 Affinity Capture-WesternPMID:22144463
affinity captured byrik1silencing protein Rik1 Affinity Capture-MSPMID:17114925
affinity captured byrik1silencing protein Rik1 Affinity Capture-WesternPMID:22319459
affinity captured byrik1silencing protein Rik1 Affinity Capture-MSPMID:16024659
affinity captured bystc1LIM-like protein linking chromatin modification to RNAi, Stc1 Affinity Capture-WesternPMID:23613586
affinity captured bystc1LIM-like protein linking chromatin modification to RNAi, Stc1 Affinity Capture-WesternPMID:20211136
affinity captured byswi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
affinity capturesswi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
affinity captured bytas3RITS complex subunit 3 Affinity Capture-WesternPMID:20705239
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withabo2ATPase with bromodomain protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withadn2transcription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withadn3transcription factor (predicted) Negative GeneticPMID:22681890
positive genetic interaction withago1argonaute Positive GeneticPMID:18818364
positive genetic interaction withago1argonaute Positive GeneticPMID:22681890
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
positive genetic interaction withaps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Positive GeneticPMID:22681890
positive genetic interaction witharb1argonaute inhibitor protein 1 Positive GeneticPMID:22681890
negative genetic interaction withark1aurora-B kinase Ark1 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction witharp6actin-like protein Arp6 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withath1ataxin-2 homolog Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withbtf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
negative genetic interaction withbun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
positive genetic interaction withbyr3translational activator, zf-CCHC type zinc finger protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withbzz1diacylglycerol binding protein Bzz1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
negative genetic interaction withccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:18818364
enhances phenotype ofchp1chromodomain protein Chp1 Phenotypic EnhancementPMID:10835380
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:22681890
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:22681890
positive genetic interaction withckb2CK2 family regulatory subunit Ckb2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withckb2CK2 family regulatory subunit Ckb2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withclp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
negative genetic interaction withclp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
enhances phenotype ofclr3histone deacetylase (class II) Clr3 Phenotypic EnhancementPMID:11283354
phenotype enhanced byclr5Clr5 protein Phenotypic EnhancementPMID:21253571
negative genetic interaction withcmk2MAPK-activated protein kinase Cmk2 Negative GeneticPMID:22681890
negative genetic interaction withcmk2MAPK-activated protein kinase Cmk2 Negative GeneticPMID:22681890
negative genetic interaction withcpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
positive genetic interaction withcsi2mitotic chromosome segregation protein Csi2 Positive GeneticPMID:22681890
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
negative genetic interaction withctu1cytosolic thiouridylase subunit Ctu1 Negative GeneticPMID:22681890
negative genetic interaction withctu2cytosolic thiouridylase subunit Ctu2 Negative GeneticPMID:22681890
negative genetic interaction withcut14condensin complex subunit Cut14 Negative GeneticPMID:22681890
negative genetic interaction withcut3condensin complex subunit Cut3 Negative GeneticPMID:22681890
negative genetic interaction withcwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
negative genetic interaction withdam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
negative genetic interaction withdcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
negative genetic interaction withdcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
positive genetic interaction withdcd1deoxycytidylate deaminase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withdcr1dicer Positive GeneticPMID:18818364
positive genetic interaction withdcr1dicer Positive GeneticPMID:22681890
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
positive genetic interaction withdlc1dynein light chain Dlc1 Positive GeneticPMID:22681890
positive genetic interaction withdlc1dynein light chain Dlc1 Positive GeneticPMID:22681890
negative genetic interaction withdph3diphthamide biosynthesis protein Dph3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp4elongator complex subunit Elp4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
rescuesepe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:23388053
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:22681890
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:22681890
rescued by overexpression ofers1RNA-silencing factor Ers1 Dosage RescuePMID:22474355
positive genetic interaction withers1RNA-silencing factor Ers1 Positive GeneticPMID:18818364
positive genetic interaction withers1RNA-silencing factor Ers1 Positive GeneticPMID:22681890
positive genetic interaction withers1RNA-silencing factor Ers1 Positive GeneticPMID:22681890
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
positive genetic interaction withfta6Mis6-Sim4 complex Fta6 Positive GeneticPMID:22681890
positive genetic interaction withfta6Mis6-Sim4 complex Fta6 Positive GeneticPMID:22681890
negative genetic interaction withfus1formin Fus1 Negative GeneticPMID:22681890
negative genetic interaction withgar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
positive genetic interaction withgit5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
positive genetic interaction withgld1mitochondrial glycerol dehydrogenase Gld1 Positive GeneticPMID:22681890
positive genetic interaction withgud1guanine deaminase Gud1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withhem12uroporphyrinogen decarboxylase Hem12 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withhhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:22681890
positive genetic interaction withhhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:22681890
inviable in presence of overexpressedhht1histone H3 h3.1 Dosage LethalityPMID:16540522
negative genetic interaction withhif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
negative genetic interaction withhrk1haspin related kinase Hrk1 Negative GeneticPMID:22681890
positive genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Positive GeneticPMID:22681890
enhances phenotype ofhrp3ATP-dependent DNA helicase Hrp3 Phenotypic EnhancementPMID:22990236
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
positive genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:22681890
negative genetic interaction withist1MVB sorting pathway protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withkap113karyopherin Kap113 Positive GeneticPMID:22681890
positive genetic interaction withkap113karyopherin Kap113 Positive GeneticPMID:22681890
negative genetic interaction withlaf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
negative genetic interaction withlaf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
negative genetic interaction withlaf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
negative genetic interaction withlon1Lon protease homolog Lon1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withlsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
synthetically rescueslsd1histone demethylase SWIRM1 Synthetic RescuePMID:17434129
negative genetic interaction withlsg1Lsk1 complex gamma subunit Lsg1 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
negative genetic interaction withmad3mitotic spindle checkpoint protein Mad3 Negative GeneticPMID:22681890
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:22681890
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
positive genetic interaction withmed6mediator complex subunit Med6 Positive GeneticPMID:18818364
positive genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Positive GeneticPMID:22681890
positive genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Positive GeneticPMID:22681890
negative genetic interaction withmms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withmoc3transcription factor Moc3 Positive GeneticPMID:22681890
positive genetic interaction withmoe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withmsc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
negative genetic interaction withmsc1multi-copy suppressor of Chk1 Negative GeneticPMID:22681890
negative genetic interaction withmsc1multi-copy suppressor of Chk1 Negative GeneticPMID:22681890
negative genetic interaction withmsd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
negative genetic interaction withmsd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:18818364
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:22681890
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:22681890
negative genetic interaction withmsn5karyopherin (predicted) Negative GeneticPMID:18818364
synthetic growth defect withmst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
negative genetic interaction withmto1MT organizer Mto1 Negative GeneticPMID:22681890
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withmug73plasma membrane transmembrane transport regulator (predicted) Negative GeneticPMID:22681890
positive genetic interaction withmug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withmug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withmug81ATP-dependent RNA helicase Slh1, human ASCC3 ortholog (predicted) Negative GeneticPMID:18818364
synthetic growth defect withnda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
negative genetic interaction withnem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
negative genetic interaction withnht10Ino80 complex HMG box subunit Nhp10 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withnrl1NRDE-2 family protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withnup124nucleoporin Nup124 Negative GeneticPMID:22681890
positive genetic interaction withnup132nucleoporin Nup132 Positive GeneticPMID:22681890
positive genetic interaction withnup132nucleoporin Nup132 Positive GeneticPMID:22681890
negative genetic interaction withotu2ubiquitin specific cysteine protease, OTU family, Otu2 Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
phenotype enhanced bypab2poly(A) binding protein Pab2 Phenotypic EnhancementPMID:22144463
negative genetic interaction withpac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
positive genetic interaction withpek1MAP kinase kinase Pek1 Positive GeneticPMID:18818364
positive genetic interaction withpek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
positive genetic interaction withpek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
negative genetic interaction withpho24-nitrophenylphosphatase Negative GeneticPMID:18818364
negative genetic interaction withpho24-nitrophenylphosphatase Negative GeneticPMID:22681890
negative genetic interaction withpho24-nitrophenylphosphatase Negative GeneticPMID:22681890
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
positive genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
positive genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:22681890
positive genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:22681890
positive genetic interaction withpng3ING family homolog Png3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
negative genetic interaction withpom152nucleoporin Pom152 Negative GeneticPMID:22681890
negative genetic interaction withpop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
negative genetic interaction withpop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
negative genetic interaction withpph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Negative GeneticPMID:18818364
positive genetic interaction withppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
positive genetic interaction withprp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
positive genetic interaction withpsl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpsl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:18818364
negative genetic interaction withptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:22681890
positive genetic interaction withptl2triacylglycerol lipase ptl2 Positive GeneticPMID:22681890
negative genetic interaction withpxd1structure-specific DNA nuclease regulator Pxd1 Negative GeneticPMID:22681890
negative genetic interaction withpxd1structure-specific DNA nuclease regulator Pxd1 Negative GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
negative genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
negative genetic interaction withqcr6ubiquinol-cytochrome-c reductase complex subunit 8, hinge protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
negative genetic interaction withrad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
negative genetic interaction withrad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:22681890
negative genetic interaction withrad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:22681890
positive genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:18818364
rescued byraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Phenotypic SuppressionPMID:20211136
positive genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:22681890
positive genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:22681890
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:18818364
rescued byraf2Rik1-associated factor Raf2 Phenotypic SuppressionPMID:20211136
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
positive genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Positive GeneticPMID:18818364
positive genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Positive GeneticPMID:22681890
rescued byrec10meiotic recombination protein Rec10 Phenotypic SuppressionPMID:20421495
rescued byrec8meiotic cohesin complex subunit Rec8 Phenotypic SuppressionPMID:20421495
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
positive genetic interaction withres2MBF transcription factor complex subunit Res2 Positive GeneticPMID:22681890
positive genetic interaction withrho2Rho family GTPase Rho2 Positive GeneticPMID:22681890
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:18818364
rescued byrik1silencing protein Rik1 Phenotypic SuppressionPMID:20211136
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:22681890
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:22681890
overexpression rescuesrik1silencing protein Rik1 Dosage RescuePMID:20705239
negative genetic interaction withrmt3type I ribosomal protein arginine N-methyltransferase Rmt3 Negative GeneticPMID:22681890
synthetic lethal withrna1Ran GAP Rna1 Synthetic LethalityPMID:15317843
overexpression rescuesrna1Ran GAP Rna1 Dosage RescuePMID:15317843
positive genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
positive genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:18818364
positive genetic interaction withrox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:22681890
positive genetic interaction withrox3mediator complex subunit Med19/Rox3 Positive GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
positive genetic interaction withrpb7DNA-directed RNA polymerase complex II subunit Rpb7 Positive GeneticPMID:22681890
positive genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:18818364
positive genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
positive genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
positive genetic interaction withrpl10260S ribosomal protein L10a Positive GeneticPMID:22681890
negative genetic interaction withrpl90160S ribosomal protein L9 Negative GeneticPMID:22681890
negative genetic interaction withrps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrrp1ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrrp1ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
rescuesrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:23151475
enhances phenotype ofrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic EnhancementPMID:23151475
rescuesrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic SuppressionPMID:24493644
enhances phenotype ofrrp6exosome 3'-5' exoribonuclease subunit Rrp6 (predicted) Phenotypic EnhancementPMID:24210919
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:22681890
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:22681890
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
positive genetic interaction withsdc1Dpy-30 domain protein Sdc1 Positive GeneticPMID:22681890
positive genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
negative genetic interaction withsec63ER protein translocation subcomplex subunit Sec63 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withset11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
negative genetic interaction withset11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
synthetic growth defect withset2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
synthetic growth defect withset2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18216783
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withsgf73SAGA complex subunit Sgf73 Positive GeneticPMID:25076038
positive genetic interaction withsgf73SAGA complex subunit Sgf73 Positive GeneticPMID:22681890
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:22681890
positive genetic interaction withsif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
positive genetic interaction withsif2Sad1 interacting factor 2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsnu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
positive genetic interaction withSPAC1071.05S-adenosylmethionine-dependent methyltransferase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC22A12.14cBSD domain protein, unknown biological role Negative GeneticPMID:22681890
positive genetic interaction withSPAC23A1.09RNA-binding protein, human RBM8A ortholog (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC23H4.13cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC24H6.10cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC2E1P3.05cfungal cellulose binding domain protein Positive GeneticPMID:22681890
negative genetic interaction withSPAC328.04AAA family ATPase, unknown biological role Negative GeneticPMID:22681890
positive genetic interaction withSPAC6G9.01cconserved protein Positive GeneticPMID:22681890
negative genetic interaction withSPAC6G9.14RNA-binding protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC8C9.12cmitochondrial iron ion transmembrane transporter (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC9.07cGTPase Rbg1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC9E9.05Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAPB1E7.11cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC1347.09hexaprenyldihydroxybenzoate methyltransferase, Coq3 variant (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC13E7.07Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC215.01GTPase activating protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC25H2.15SSU-rRNA maturation protein Tsr4 homolog 1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPBC3B8.04csodium ion transmembrane transporter (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC3H7.05cmitochondrial Membrane Bound O-Acyl Transferase (MBOAT) family Negative GeneticPMID:22681890
positive genetic interaction withSPBC725.10mitochondrial transport protein, tspO homolog (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBPB2B2.09c2-dehydropantoate 2-reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
negative genetic interaction withSPCC126.01cconserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC188.10cPositive GeneticPMID:22681890
negative genetic interaction withSPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC320.03transcription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC417.11cglutamate-1-semialdehyde 2,1-aminomutase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC4F11.03cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
positive genetic interaction withSPCC550.11karyopherin (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPCC550.11karyopherin (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPCC594.04csteroid oxidoreductase superfamily protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC613.02transmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC622.15cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC622.15cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC736.13short chain dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspe1ornithine decarboxylase Spe1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspf38U5 snRNP complex subunit Spf38 Negative GeneticPMID:22681890
negative genetic interaction withspf38U5 snRNP complex subunit Spf38 Negative GeneticPMID:22681890
negative genetic interaction withspn2mitotic and meiotic (sporulation) septin Spn2 Negative GeneticPMID:22681890
negative genetic interaction withspn2mitotic and meiotic (sporulation) septin Spn2 Negative GeneticPMID:22681890
negative genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
negative genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
rescuesstc1LIM-like protein linking chromatin modification to RNAi, Stc1 Phenotypic SuppressionPMID:20211136
rescued bystc1LIM-like protein linking chromatin modification to RNAi, Stc1 Phenotypic SuppressionPMID:20211136
positive genetic interaction withstc1LIM-like protein linking chromatin modification to RNAi, Stc1 Positive GeneticPMID:22681890
negative genetic interaction withswc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
negative genetic interaction withswi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
positive genetic interaction withswi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
positive genetic interaction withswi6HP1 family chromodomain protein Swi6 Positive GeneticPMID:22681890
positive genetic interaction withtas3RITS complex subunit 3 Positive GeneticPMID:18818364
positive genetic interaction withtas3RITS complex subunit 3 Positive GeneticPMID:22681890
negative genetic interaction withtea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
negative genetic interaction withtea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
negative genetic interaction withtea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
positive genetic interaction withtfs1transcription elongation factor TFIIS Positive GeneticPMID:18818364
positive genetic interaction withtfs1transcription elongation factor TFIIS Positive GeneticPMID:22681890
positive genetic interaction withtfs1transcription elongation factor TFIIS Positive GeneticPMID:22681890
negative genetic interaction withtif38translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
negative genetic interaction withtip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
negative genetic interaction withtip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
positive genetic interaction withtps2trehalose-phosphate synthase Tps2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtps2trehalose-phosphate synthase Tps2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withtrs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withubc13ubiquitin conjugating enzyme E2 Ubc13 Positive GeneticPMID:22681890
positive genetic interaction withubc13ubiquitin conjugating enzyme E2 Ubc13 Positive GeneticPMID:22681890
negative genetic interaction withubc14ubiquitin conjugating enzyme E2 Ubc14 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
negative genetic interaction withubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
positive genetic interaction withubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:18818364
positive genetic interaction withubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:22681890
positive genetic interaction withubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:22681890
positive genetic interaction withubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:22681890
positive genetic interaction withubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:22681890
positive genetic interaction withuch2ubiquitin C-terminal hydrolase Uch2 Positive GeneticPMID:22681890
positive genetic interaction withuch2ubiquitin C-terminal hydrolase Uch2 Positive GeneticPMID:22681890
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withura3dihydroorotate dehydrogenase Ura3 Negative GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
negative genetic interaction withutp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withvms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withvps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
negative genetic interaction withwhi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withwhi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withwis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Positive GeneticPMID:22681890
negative genetic interaction withyar1ribosome biogenesis protein Yar1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withyih1IMPACT homolog, translational regulator Yih1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
positive genetic interaction withzfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
negative genetic interaction withzip1transcription factor Zip1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC428.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC428.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC428.08c BioGRID Interaction Datasets
Expression Viewer SPBC428.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC428.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC428.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC428.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC428.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC428.08c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC428.08c Cell Cycle Data
GEO SPBC428.08c GEO profiles
PInt SPBC428.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC428.08c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC428.08c Fission yeast phenotypic data & analysis
SPD / RIKEN23/23G02Orfeome Localization Data
UniProtKB/SwissProtO60016Histone-lysine N-methyltransferase, H3 lysine-9 specific
ModBaseO60016Database of comparative protein structure models
STRINGO60016Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595186histone H3 methyltransferase Clr4
RefSeq mRNANM_001021094972h- histone H3 methyltransferase Clr4 (clr4), mRNA
ePDB1G6ZThe European PDB
PDB1G6ZPDB
PDBsum1G6ZPDBsum
ePDB1MVHThe European PDB
PDB1MVHPDB
PDBsum1MVHPDBsum
ePDB1MVXThe European PDB
PDB1MVXPDB
PDBsum1MVXPDBsum
European Nucleotide ArchiveAAC18302.1ENA Protein Mapping
European Nucleotide ArchiveCAA07709.1ENA Protein Mapping
European Nucleotide ArchiveCAA22283.1ENA Protein Mapping
MetaCycPWY-642426,27-dehydrozymosterol metabolism
KEGG_Enzyme00310+2.1.1.43Lysine degradation
UniParcUPI0000127B94UniProt Archive

Literature for clr4

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Release Version: PomBase:25_49 - 02 Feb 2015