ght2 (SPBC4B4.08)


Gene Standard Nameght2 Characterisation Statuspublished
Systematic IDSPBC4B4.08 Feature Typeprotein coding
Synonyms Name Description
Producthexose transmembrane transporter Ght2 Product Size531aa, 58.85 kDa
Genomic Location Chromosome II, 3427180-3429424 (2245nt); CDS:3427572-3429167 (1596nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
GO Cellular Component
Term NameCount
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of plasma membrane49
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationght2ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001ght2ΔNull
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134271803429424
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 General substrate transporter 15 471 15
TMhelix TMHMM 181 203 959
TMhelix TMHMM 114 136 959
TMhelix TMHMM 372 394 959
TMhelix TMHMM 308 330 959
TMhelix TMHMM 62 84 959
TMhelix TMHMM 335 357 959
TMhelix TMHMM 271 293 959
TMhelix TMHMM 149 171 959
TMhelix TMHMM 433 455 959
TMhelix TMHMM 9 31 959
TMhelix TMHMM 407 429 959
TMhelix TMHMM 91 110 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 13 460 55
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 322 339 15
PTHR24063 HMMPANTHER 9 498 11
PTHR24063:SF337 HMMPANTHER 9 498 8
1.20.1250.20 Gene3D 267 466 72
1.20.1250.20 Gene3D 53 214 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 17 218 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 249 469 76
SignalP-noTM signalp 1 25 212
PR00171 PRINTS IPR003663 Sugar/inositol transporter 396 408 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 280 290 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 118 137 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 21 31 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 373 394 10
TIGR00879 tigrfam IPR003663 Sugar/inositol transporter 9 467 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.82 Da
Charge 8.50
Isoelectric point 8.55
Molecular weight 58.85 kDa
Number of residues 531
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS507, S515, S519, S524 1670
present during mitotic M phaseS507
Annotation ExtensionEvidenceResidueReference
experimental evidence S507 PMID:24763107
present during mitotic M phase experimental evidence S507 PMID:21712547
experimental evidence S515 PMID:24763107
experimental evidence S519 PMID:24763107
experimental evidence S524 PMID:24763107
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
20186during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
19517during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
20847during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
20914during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
10312.95during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
19792during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2313.77during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
uge1UDP-glucose 4-epimerase Uge1 Synthetic Growth DefectPMID:23254763
External References
Database Identifier Description
NBRP SPBC4B4.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC4B4.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC4B4.08 BioGRID Interaction Datasets
Expression Viewer SPBC4B4.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC4B4.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC4B4.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC4B4.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC4B4.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC4B4.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC4B4.08 Cell Cycle Data
GEO SPBC4B4.08 GEO profiles
PInt SPBC4B4.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC4B4.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC4B4.08 Fission yeast phenotypic data & analysis
SPD / RIKEN40/40F03Orfeome Localization Data
UniProtKB/SwissProtO74969High-affinity glucose transporter ght2
ModBaseO74969Database of comparative protein structure models
STRINGO74969Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596425hexose transporter Ght2
RefSeq mRNANM_001022344972h- hexose transporter Ght2 (ght2), mRNA
European Nucleotide ArchiveAF017180ENA EMBL mapping
European Nucleotide ArchiveCAA19288.1ENA Protein Mapping
UniParcUPI000012B41FUniProt Archive

Literature for ght2

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015