ght2 (SPBC4B4.08)


Gene Standard Nameght2 Characterisation Statuspublished
Systematic IDSPBC4B4.08 Feature Typeprotein coding
Synonyms Name Description
Producthexose transporter Ght2 Product Size531aa, 58.85 kDa
Genomic Location Chromosome II, 3427180-3429424 (2245nt); CDS:3427572-3429167 (1596nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0055054fructose:hydrogen symporter activityIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358573
GO:0005358high-affinity hydrogen:glucose symporter activityIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358573
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0032445fructose importIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358574
GO:0046323glucose importIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358574
GO:0035428hexose transmembrane transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:107358578
GO:0034220ion transmembrane transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:10735857187
GO:0015992proton transportIGISGD:S000001136, SGD:S000002753, SGD:S000004613, SGD:S000001138, SGD:S000001134, SGD:S000002750, SGD:S000002751PMID:1073585749
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
GO:0005887integral component of plasma membraneICGO:0055054PMID:1073585751
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyght2ΔNullPMID:204732893755
Microscopyght2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyght2ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134271803429424
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 General substrate transporter 15 471 15
TMhelix TMHMM 335 357 959
TMhelix TMHMM 407 429 959
TMhelix TMHMM 308 330 959
TMhelix TMHMM 149 171 959
TMhelix TMHMM 181 203 959
TMhelix TMHMM 372 394 959
TMhelix TMHMM 271 293 959
TMhelix TMHMM 114 136 959
TMhelix TMHMM 433 455 959
TMhelix TMHMM 91 110 959
TMhelix TMHMM 62 84 959
TMhelix TMHMM 9 31 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 13 460 55
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 322 339 15
PTHR24063 HMMPANTHER 4 496 11
PTHR24063:SF98 HMMPANTHER 4 496 8
G3DSA:1.20.1250.20 Gene3D 53 214 69
G3DSA:1.20.1250.20 Gene3D 267 466 69
SSF103473 SuperFamily IPR016196 17 218 76
SSF103473 SuperFamily IPR016196 249 469 76
SignalP-noTM signalp 1 25 212
PR00171 PRINTS IPR003663 Sugar/inositol transporter 21 31 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 396 408 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 280 290 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 373 394 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 118 137 10
TIGR00879 tigrfam IPR003663 Sugar/inositol transporter 9 467 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.82 Da
Charge 8.50
Isoelectric point 8.55
Molecular weight 58.85 kDa
Number of residues 531
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2313.77during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
10312.95during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
9.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
uge1UDP-glucose 4-epimerase Uge1 Synthetic Growth DefectPMID:23254763
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPBC4B4.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC4B4.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC4B4.08 BioGRID Interaction Datasets
Expression Viewer SPBC4B4.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC4B4.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC4B4.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC4B4.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC4B4.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC4B4.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC4B4.08 Cell Cycle Data
GEO SPBC4B4.08 GEO profiles
PInt SPBC4B4.08 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN40/40F03Orfeome Localization Data
EntrezGene2539977hexose transporter Ght2
WikiGene2539977hexose transporter Ght2
UniProtKB/SwissProtO74969High-affinity glucose transporter ght2
ModBaseO74969Database of comparative protein structure models
StringO74969Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596425hexose transporter Ght2
RefSeq mRNANM_001022344972h- hexose transporter Ght2 (ght2), mRNA
European Nucleotide ArchiveAAB70519ENA Protein Mapping
European Nucleotide ArchiveCAA19288ENA Protein Mapping
UniParcUPI000012B41FUniProt Archive

Literature for ght2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014