str1 (SPBC4F6.09)


Gene Standard Namestr1 Characterisation Statuspublished
Systematic IDSPBC4F6.09 Feature Typeprotein coding
SynonymsSPNCRNA.106 Name Description
Productsiderophore-iron transmembrane transporter Str1 Product Size612aa, 68.16 kDa
Genomic Location Chromosome II, 2704645-2707648 (3004nt); CDS:2705523-2707361 (1839nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
siderophore transmembrane transporter activity3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
iron assimilation by chelation and transport4
Annotation ExtensionEvidenceWith/FromReference
iron ion transmembrane transport12
Annotation ExtensionEvidenceWith/FromReference
siderophore transmembrane transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
increased cell population growth ratestr1ΔNull246
viable vegetative cell populationstr1ΔNull3795

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologystr1ΔNull3093
Target Of
OntologyRelationshipGeneProductReference
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2704645..2707648
mRNA2704645..2707648AU008311
5' UTR2704645..2705522PMID:21511999
CDS2705523..2707361AU008311
3' UTR2707362..2707648PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06609 Pfam IPR010573 Fungal trichothecene efflux pump 128 547 1
TMhelix TMHMM 463 485 959
TMhelix TMHMM 366 385 959
TMhelix TMHMM 573 592 959
TMhelix TMHMM 299 321 959
TMhelix TMHMM 184 206 959
TMhelix TMHMM 119 141 959
TMhelix TMHMM 218 235 959
TMhelix TMHMM 250 272 959
TMhelix TMHMM 434 453 959
TMhelix TMHMM 498 520 959
TMhelix TMHMM 405 427 959
TMhelix TMHMM 331 353 959
TMhelix TMHMM 91 109 959
TMhelix TMHMM 161 180 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 92 596 55
PTHR24003:SF443 HMMPANTHER 3 528 1
PTHR24003 HMMPANTHER 3 528 17
1.20.1250.20 Gene3D 93 249 72
1.20.1250.20 Gene3D 333 348 72
1.20.1250.20 Gene3D 364 523 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 321 522 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 93 316 76
Coil ncoils Rabaptin coiled-coil domain 10 31 968

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 111.37 Da
Charge 4.50
Isoelectric point 7.94
Molecular weight 68.16 kDa
Number of residues 612
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS62
present during mitotic M phaseS64
present during mitotic M phaseS607
present during mitotic M phaseS48
present during mitotic M phaseS36
S48, S62, S607, S610
present during mitotic M phaseS41
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S36 PMID:21712547
present during mitotic M phase experimental evidence S41 PMID:21712547
experimental evidence S48 PMID:24763107
present during mitotic M phase experimental evidence S48 PMID:21712547
experimental evidence S62 PMID:24763107
present during mitotic M phase experimental evidence S62 PMID:21712547
present during mitotic M phase experimental evidence S64 PMID:21712547
experimental evidence S607 PMID:24763107
present during mitotic M phase experimental evidence S607 PMID:21712547
experimental evidence S610 PMID:24763107
O-phospho-L-threonine 698
present during mitotic M phaseT35
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T35 PMID:21712547
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5060during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4692during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4534during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3398.74during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.39during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
merged with ncRNA SPNCRNA.1061
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPBC4F6.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC4F6.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC4F6.09 BioGRID Interaction Datasets
Expression Viewer SPBC4F6.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC4F6.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC4F6.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC4F6.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC4F6.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC4F6.09 Transcriptome Viewer (Bähler Lab)
GEO SPBC4F6.09 GEO profiles
PInt SPBC4F6.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC4F6.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC4F6.09 Fission yeast phenotypic data & analysis
Cyclebase SPBC4F6.09.1 Cell Cycle Data
SPD / RIKEN36/36G10Orfeome Localization Data
UniProtKB/SwissProtO74395Siderophore iron transporter 1
ModBaseO74395Database of comparative protein structure models
STRINGO74395Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596109siderophore-iron transporter Str1
RefSeq mRNANM_001022026972h- siderophore-iron transporter Str1 (str1), mRNA
European Nucleotide ArchiveCAA20729.1ENA Protein Mapping
UniParcUPI0000069A5DUniProt Archive

Literature for str1

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015