str1 (SPBC4F6.09)


Gene Standard Namestr1 Characterisation Statuspublished
Systematic IDSPBC4F6.09 Feature Typeprotein coding
SynonymsSPNCRNA.106 Name DescriptionSiderophore TRansporter
Productsiderophore-iron transmembrane transporter Str1 Product Size612aa, 68.16 kDa
Genomic Location Chromosome II, 2704645-2707648 (3004nt); CDS:2705523-2707361 (1839nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
cellular iron ion homeostasis19
Annotation ExtensionEvidenceWith/FromReference
iron assimilation by chelation and transport4
Annotation ExtensionEvidenceWith/FromReference
siderophore transmembrane transport1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
increased cell population growth ratestr1Δ256
viable vegetative cell populationstr1Δ3840

Cell Phenotype

Term NameGenotypesCount
increased transcription during cellular response to iron2
affecting str1GATA promoter mutant CYC1-lacZ (-870AGATAA-865 ->GCCGTC)
viable vegetative cell with normal cell morphologystr1Δ3100
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in ark1 aurora-B kinase Ark1
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1
FYPO affected by mutation in ofd2 histone H2A dioxygenase Ofd2
FYPO affected by mutation in str1 siderophore-iron transmembrane transporter Str1
GO regulated by fep1 iron-sensing transcription factor Fep1
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2704645..2707648
mRNA2704645..2707648AU008311
5' UTR2704645..2705522PMID:21511999
CDS2705523..2707361AU008311
3' UTR2707362..2707648PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06609 Pfam IPR010573 Fungal trichothecene efflux pump 128 547 1
TMhelix TMHMM 184 206 953
TMhelix TMHMM 463 485 953
TMhelix TMHMM 434 453 953
TMhelix TMHMM 91 109 953
TMhelix TMHMM 573 592 953
TMhelix TMHMM 299 321 953
TMhelix TMHMM 218 235 953
TMhelix TMHMM 366 385 953
TMhelix TMHMM 161 180 953
TMhelix TMHMM 331 353 953
TMhelix TMHMM 119 141 953
TMhelix TMHMM 250 272 953
TMhelix TMHMM 498 520 953
TMhelix TMHMM 405 427 953
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 92 596 55
PTHR23501 HMMPANTHER 25 280 10
PTHR23501 HMMPANTHER 296 611 10
PTHR23501:SF87 HMMPANTHER 25 280 2
PTHR23501:SF87 HMMPANTHER 296 611 2
1.20.1250.20 Gene3D Major facilitator superfamily domain 364 523 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 333 348 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 93 249 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 321 522 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 93 316 76
Coil ncoils Predicted coiled-coil protein (DUF2205) 10 30 1057

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 111.37 Da
Charge 4.50
Codon Adaptation Index 0.53
Isoelectric point 7.94
Molecular weight 68.16 kDa
Number of residues 612
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS41
present during mitotic M phaseS64
present during mitotic M phaseS62
present during mitotic M phaseS48
present during mitotic M phaseS36
present during mitotic M phaseS607
S48, S62, S607, S610
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S41 PMID:21712547
present during mitotic M phase experimental evidence S64 PMID:21712547
present during mitotic M phase experimental evidence S62 PMID:21712547
present during mitotic M phase experimental evidence S48 PMID:21712547
present during mitotic M phase experimental evidence S36 PMID:21712547
present during mitotic M phase experimental evidence S607 PMID:21712547
experimental evidence S48 PMID:24763107
experimental evidence S62 PMID:24763107
experimental evidence S610 PMID:24763107
experimental evidence S607 PMID:24763107
O-phospho-L-threonine 701
present during mitotic M phaseT35
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T35 PMID:21712547
phosphorylated residue 1931
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
ubiquitinylated lysineK608 512
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K608 PMID:26412298
IDA PMID:26412298
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresent during GO:0072690Northern assay evidencePMID:12888492
present during GO:0071281Northern assay evidencePMID:12888492
increased during GO:0010106Northern assay evidencePMID:12888492

Quantitative Gene Expression

View graphical display of gene expression data for str1 (SPBC4F6.09)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5060during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
4692during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
3398.74during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4534during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.39during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
merged with ncRNA SPNCRNA.1061
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4606
conserved in eukaryotes4516
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC4F6.09 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
External References
Database Identifier Description
NBRP SPBC4F6.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC4F6.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC4F6.09 BioGRID Interaction Datasets
Expression Viewer SPBC4F6.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC4F6.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC4F6.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC4F6.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC4F6.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC4F6.09 Transcriptome Viewer (Bähler Lab)
GEO SPBC4F6.09 GEO profiles
PInt SPBC4F6.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC4F6.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC4F6.09 Fission yeast phenotypic data & analysis
Cyclebase SPBC4F6.09.1 Cell Cycle Data
SPD / RIKEN36/36G10Orfeome Localization Data
UniProtKB/SwissProtO74395Siderophore iron transporter 1
ModBaseO74395Database of comparative protein structure models
STRINGO74395Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596109siderophore-iron transporter Str1
RefSeq mRNANM_001022026972h- siderophore-iron transporter Str1 (str1), mRNA

Literature for str1

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016