anc1 (SPBC530.10c)


Gene Standard Nameanc1 Characterisation Statuspublished
Systematic IDSPBC530.10c Feature Typeprotein coding
Synonyms Name DescriptionAdenine Nucleotide Carrier
Productmitochondrial adenine nucleotide carrier Anc1 Product Size322aa, 35.02 kDa
Genomic Location Chromosome II, 812897-811060 (1838nt); CDS:812381-811413 (969nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP:ADP antiporter activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ADP transport1
Annotation ExtensionEvidenceWith/FromReference
ATP transport1
Annotation ExtensionEvidenceWith/FromReference
ion transmembrane transport200
Annotation ExtensionEvidenceWith/FromReference
mitochondrial transport94
Annotation ExtensionEvidenceWith/FromReference
nucleotide transmembrane transport16
Annotation ExtensionEvidenceWith/FromReference
purine nucleoside transmembrane transport5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
mitochondrial inner membrane158
Annotation ExtensionEvidenceWith/FromReference
mitochondrion758
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001934abolished cell population growth on glycerol carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000139PMID:1008278961
FYPO:0003690abolished cell population growth on glycerol/ethanol carbon sourceCell growth assayanc1ΔNullPECO:0000139, PECO:0000102PMID:206218435
FYPO:0003502abolished cell population growth on raffinose carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000136PMID:100827891
FYPO:0003238decreased anaerobic cell population growthCell growth assayanc1ΔNullPECO:0000135, PECO:0000137, PECO:0000103PMID:100827892
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000137PMID:20621843147
Cell growth assayanc1ΔNullPECO:0000137, PECO:0000103PMID:10082789
Cell growth assayanc1ΔNullPECO:0000102, PECO:0000137PMID:10082789
FYPO:0001162decreased cell population growth on raffinose carbon sourceCell growth assayanc1ΔNullPECO:0000103, PECO:0000136PMID:100827891
FYPO:0000440sensitive to antimycin ACell growth assayanc1ΔNullPECO:0000137PMID:100827896
FYPO:0002060viable vegetative cell populationMicroscopyanc1ΔNullPMID:204732893759
Microscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001165inviable cell following anaerobic growthCell growth assayanc1ΔNullPECO:0000137, PECO:0000102PMID:100827891
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1812897811060

UTRs

Region Coordinates Reference
five_prime_UTR812897..812382PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 25 121 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 231 319 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 131 222 23
TMhelix TMHMM 194 216 959
TMhelix TMHMM 231 253 959
TMhelix TMHMM 131 153 959
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 25 118 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 230 316 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 130 222 24
PTHR24089 HMMPANTHER 31 317 23
PTHR24089:SF31 HMMPANTHER 31 317 1
1okcA00 Gene3D IPR023395 Mitochondrial carrier domain 24 314 24
0048588 SuperFamily IPR023395 Mitochondrial carrier domain 25 313 24
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 43 57 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 239 261 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 30 43 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 93 113 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 145 163 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 195 213 11
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 71 92 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 235 251 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 27 39 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 130 143 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 104 116 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000409mitochondrial carrierTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000409

Protein Properties

Ave. residue weight 108.76 Da
Charge 21.50
Isoelectric point 10.49
Molecular weight 35.02 kDa
Number of residues 322
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreased during GO:0071456Northern assay evidencePMID:10082789
increased during GO:0006071Northern assay evidencePMID:10082789
increased during GO:0033530Northern assay evidencePMID:10082789
present during GO:0072690Northern assay evidencePMID:10082789

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
220040during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
227978during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
230907during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
228138during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
229347during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
27770.59during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
57822.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
48during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complements S. cerevisiae ANC1 and ANC2full PMID:8675018
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:24634168
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
slm9hira protein Slm9 Affinity Capture-MSPMID:20976105
External References
Database Identifier Description
NBRP SPBC530.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC530.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC530.10c BioGRID Interaction Datasets
Expression Viewer SPBC530.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC530.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC530.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC530.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC530.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC530.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC530.10c Cell Cycle Data
GEO SPBC530.10c GEO profiles
PInt SPBC530.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC530.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC530.10c Fission yeast phenotypic data & analysis
SPD / RIKEN32/32B08Orfeome Localization Data
UniProtKB/SwissProtQ09188ADP,ATP carrier protein
ModBaseQ09188Database of comparative protein structure models
STRINGQ09188Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595323mitochondrial adenine nucleotide carrier Anc1
RefSeq mRNANM_001021230972h- mitochondrial adenine nucleotide carrier Anc1 (anc1), mRNA
European Nucleotide ArchiveD89102ENA EMBL mapping
European Nucleotide ArchiveCAA19176.1ENA Protein Mapping
European Nucleotide ArchiveCAA90275.1ENA Protein Mapping
UniParcUPI0000125627UniProt Archive

Literature for anc1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014