anc1 (SPBC530.10c)


Gene Standard Nameanc1 Characterisation Statuspublished
Systematic IDSPBC530.10c Feature Typeprotein coding
Synonyms Name DescriptionAdenine Nucleotide Carrier
Productmitochondrial adenine nucleotide carrier Anc1 Product Size322aa, 35.02 kDa
Genomic Location Chromosome II, 812897-811060 (1838nt); CDS:812381-811413 (969nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005471ATP:ADP antiporter activityIGIUniProtKB:P04710PMID:86750181
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015866ADP transportIGIUniProtKB:P04710PMID:86750181
GO:0015867ATP transportIGIUniProtKB:P04710PMID:86750181
GO:0034220ion transmembrane transportIGIUniProtKB:P04710PMID:8675018189
GO:0006839mitochondrial transportIGIUniProtKB:P04710PMID:867501897
GO:1901679nucleotide transmembrane transportIGIUniProtKB:P04710PMID:867501816
GO:0015860purine nucleoside transmembrane transportIGIUniProtKB:P04710PMID:86750185
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
GO:0005743mitochondrial inner membraneIGIUniProtKB:P04710PMID:8675018155
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001934abolished cell population growth on glycerol carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000139PMID:1008278961
FYPO:0003502abolished cell population growth on raffinose carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000136PMID:100827891
FYPO:0003238decreased anaerobic cell population growthCell growth assayanc1ΔNullPECO:0000135, PECO:0000137, PECO:0000103PMID:100827892
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assayanc1ΔNullPECO:0000137, PECO:0000103PMID:1008278999
Cell growth assayanc1ΔNullPECO:0000102, PECO:0000137PMID:10082789
FYPO:0001162decreased cell population growth on raffinose carbon sourceCell growth assayanc1ΔNullPECO:0000103, PECO:0000136PMID:100827891
FYPO:0000440sensitive to antimycin ACell growth assayanc1ΔNullPECO:0000137PMID:100827895
FYPO:0002060viable vegetative cell populationMicroscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyanc1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001165inviable cell following anaerobic growthCell growth assayanc1ΔNullPECO:0000137, PECO:0000102PMID:100827891
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1812897811060

UTRs

Region Coordinates Reference
five_prime_UTR812897..812382PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 231 319 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 131 222 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 25 121 23
TMhelix TMHMM 194 216 959
TMhelix TMHMM 231 253 959
TMhelix TMHMM 131 153 959
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 130 222 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 230 316 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 25 118 24
PTHR24089:SF156 HMMPANTHER 17 321 1
PTHR24089 HMMPANTHER 17 321 24
1okcA00 Gene3D IPR023395 Mitochondrial carrier domain 24 314 24
0048588 SuperFamily IPR023395 Mitochondrial carrier domain 25 313 24
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 145 163 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 30 43 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 239 261 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 93 113 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 195 213 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 43 57 11
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 104 116 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 235 251 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 71 92 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 27 39 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 130 143 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000409mitochondrial carrierTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000409

Protein Properties

Ave. residue weight 108.76 Da
Charge 21.50
Isoelectric point 10.49
Molecular weight 35.02 kDa
Number of residues 322
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresent during GO:0072690Northern assay evidencePMID:10082789
increased during GO:0006071Northern assay evidencePMID:10082789
increased during GO:0033530Northern assay evidencePMID:10082789
decreased during GO:0071456Northern assay evidencePMID:10082789

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
27770.59during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
229347during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
57822.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
230907during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
228138during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
220040during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
227978during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
48during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complements S. cerevisiae ANC1 and ANC2full PMID:8675018
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
slm9hira protein Slm9 Affinity Capture-MSPMID:20976105
External References
Database Identifier Description
NBRP SPBC530.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC530.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC530.10c BioGRID Interaction Datasets
Expression Viewer SPBC530.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC530.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC530.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC530.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC530.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC530.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC530.10c Cell Cycle Data
GEO SPBC530.10c GEO profiles
PInt SPBC530.10c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540900mitochondrial adenine nucleotide carrier Anc1
EntrezGene2540900mitochondrial adenine nucleotide carrier Anc1
SPD / RIKEN32/32B08Orfeome Localization Data
UniProtKB/SwissProtQ09188ADP,ATP carrier protein
ModBaseQ09188Database of comparative protein structure models
STRINGQ09188Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595323mitochondrial adenine nucleotide carrier Anc1
RefSeq mRNANM_001021230972h- mitochondrial adenine nucleotide carrier Anc1 (anc1), mRNA
European Nucleotide ArchiveD89102ENA EMBL mapping
European Nucleotide ArchiveBAA13765ENA Protein Mapping
European Nucleotide ArchiveCAA19176ENA Protein Mapping
European Nucleotide ArchiveCAA19176.1ENA Protein Mapping
European Nucleotide ArchiveCAA90275ENA Protein Mapping
European Nucleotide ArchiveCAA90275.1ENA Protein Mapping
UniParcUPI0000125627UniProt Archive

Literature for anc1

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014