anc1 (SPBC530.10c)


Gene Standard Nameanc1 Characterisation Statuspublished
Systematic IDSPBC530.10c Feature Typeprotein coding
Synonyms Name DescriptionAdenine Nucleotide Carrier
Productmitochondrial adenine nucleotide carrier Anc1 Product Size322aa, 35.02 kDa
Genomic Location Chromosome II, 812897-811060 (1838nt); CDS:812381-811413 (969nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005471ATP:ADP antiporter activityIGIUniProtKB:P04710PMID:86750181
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015866ADP transportIGIUniProtKB:P04710PMID:86750181
GO:0015867ATP transportIGIUniProtKB:P04710PMID:86750181
GO:0019564aerobic glycerol catabolic processIMPPMID:100827892
GO:0009060aerobic respirationIMPPMID:1008278950
GO:0071456cellular response to hypoxiaIMPPMID:100827898
GO:0006007glucose catabolic processIMPPMID:1008278916
GO:0034220ion transmembrane transportIGIUniProtKB:P04710PMID:8675018187
GO:0006839mitochondrial transportIGIUniProtKB:P04710PMID:867501898
GO:1901003negative regulation of fermentationIMPPMID:100827891
GO:1901679nucleotide transmembrane transportIGIUniProtKB:P04710PMID:867501816
GO:0015860purine nucleoside transmembrane transportIGIUniProtKB:P04710PMID:86750185
GO:0034484raffinose catabolic processIMPPMID:100827893
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
GO:0005743mitochondrial inner membraneIGIUniProtKB:P04710PMID:8675018155
GO:0005739mitochondrionIDAPMID:16823372756
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000137PMID:1008278985
Cell growth assayanc1ΔNullPECO:0000135, PECO:0000137, PECO:0000103PMID:10082789
FYPO:0000442decreased cell population growth on glycerol/ethanol carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000139PMID:100827895
FYPO:0001162decreased cell population growth on raffinose carbon sourceCell growth assayanc1ΔNullPECO:0000102, PECO:0000136PMID:100827891
Cell growth assayanc1ΔNullPECO:0000103, PECO:0000136PMID:10082789
FYPO:0001164normal cell population growth on glucose carbon sourceCell growth assayanc1ΔNullPECO:0000137, PECO:0000103PMID:10082789101
FYPO:0000440sensitive to antimycin ACell growth assayanc1ΔNullPECO:0000137PMID:100827895
FYPO:0002060viable vegetative cell populationMicroscopyanc1ΔNullPMID:204732893755
Microscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001165inviable cell following anaerobic growthCell growth assayanc1ΔNullPECO:0000137, PECO:0000102PMID:100827891
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyanc1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1812897811060

UTRs

Region Start End Reference
five_prime_UTR812897812382PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 231 319 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 131 222 23
PF00153 Pfam IPR018108 Mitochondrial substrate/solute carrier 25 121 23
TMhelix TMHMM 131 153 959
TMhelix TMHMM 231 253 959
TMhelix TMHMM 194 216 959
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 130 222 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 230 316 24
PS50920 Prosite Profiles IPR018108 Mitochondrial substrate/solute carrier 25 118 24
PTHR24089:SF31 HMMPANTHER 31 317 1
PTHR24089 HMMPANTHER 31 317 23
G3DSA:1.50.40.10 Gene3D IPR023395 24 314 24
SSF103506 SuperFamily IPR023395 25 313 24
Low complexity (SEG) seg 2 12
Low complexity (SEG) seg 111 123
Low complexity (SEG) seg 133 148
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 145 163 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 30 43 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 239 261 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 93 113 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 195 213 11
PR00926 PRINTS IPR002067 Mitochondrial carrier protein 43 57 11
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 104 116 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 235 251 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 71 92 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 27 39 1
PR00927 PRINTS IPR002113 Adenine nucleotide translocator 1 130 143 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000409mitochondrial carrierTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000409

Protein Properties

Ave. residue weight 108.76 Da
Charge 21.50
Isoelectric point 10.49
Molecular weight 35.02 kDa
Number of residues 322
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreasedNorthern assay evidencePMID:10082789
during GO:0071456
increasedNorthern assay evidencePMID:10082789
during GO:0033530
increasedNorthern assay evidencePMID:10082789
during GO:0006071
presentNorthern assay evidencePMID:10082789
during GO:0072690

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
27770.59during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
57822.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
48during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
functionally complements S. cerevisiae ANC1 and ANC2full PMID:86750181
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
slm9hira protein Slm9 Affinity Capture-MSPMID:20976105
External References
Database Identifier Description
NBRP SPBC530.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC530.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC530.10c BioGRID Interaction Datasets
Expression Viewer SPBC530.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC530.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC530.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC530.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC530.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC530.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC530.10c Cell Cycle Data
GEO SPBC530.10c GEO profiles
PInt SPBC530.10c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540900mitochondrial adenine nucleotide carrier Anc1
EntrezGene2540900mitochondrial adenine nucleotide carrier Anc1
SPD / RIKEN32/32B08Orfeome Localization Data
UniProtKB/SwissProtQ09188ADP,ATP carrier protein
ModBaseQ09188Database of comparative protein structure models
StringQ09188Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595323mitochondrial adenine nucleotide carrier Anc1
RefSeq mRNANM_001021230972h- mitochondrial adenine nucleotide carrier Anc1 (anc1), mRNA
European Nucleotide ArchiveBAA13765ENA Protein Mapping
European Nucleotide ArchiveCAA19176ENA Protein Mapping
European Nucleotide ArchiveCAA90275ENA Protein Mapping
UniParcUPI0000125627UniProt Archive

Literature for anc1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014