gyp10 (SPBC651.03c)


Gene Standard Namegyp10 Characterisation Statuspublished
Systematic IDSPBC651.03c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase activating protein Gyp10 Product Size373aa, 42.55 kDa
Genomic Location Chromosome II, 1243207-1241431 (1777nt); CDS:1242945-1241824 (1122nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTPase activator activity42
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cell separation after cytokinesis14
Annotation ExtensionEvidenceWith/FromReference
positive regulation of GTPase activity69
Annotation ExtensionEvidenceWith/FromReference
regulation of Rho protein signal transduction80
Annotation ExtensionEvidenceWith/FromReference
vesicle-mediated transport323
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationgyp10ΔNull3809
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologygyp10ΔNull3093
Target Of
OntologyRelationshipGeneProduct
GO localized by yop1 ER membrane protein DP1/Yop1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1243207..1241431
mRNA1243207..1241431
5' UTR1243207..1242946PMID:21511999
CDS1242945..1241824
3' UTR1241823..1241431PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 39 235 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 38 243 13
TMhelix TMHMM 344 366 959
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 35 220 13
PTHR20913:SF7 HMMPANTHER 2 361 1
PTHR20913 HMMPANTHER 2 361 1
2qq8A02 Gene3D 37 143 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 38 179 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 157 271 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.07 Da
Charge 13.50
Isoelectric point 8.59
Molecular weight 42.55 kDa
Number of residues 373
Sequence
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withatg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
positive genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
synthetic growth defect withexo70exocyst complex subunit Exo70 Synthetic Growth DefectPMID:16291723
positive genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:22681890
rescuesits31-phosphatidylinositol-4-phosphate 5-kinase Its3 Phenotypic SuppressionPMID:24350606
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
negative genetic interaction withppk31serine/threonine protein kinase Ppk31 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
overexpression rescuesrgf3RhoGEF Rgf3 Dosage RescuePMID:16291723
overexpression lethal toryh1GTPase Ryh1 Dosage LethalityPMID:24350606
positive genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
negative genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:22681890
overexpression lethal toypt3GTPase Ypt3 Dosage LethalityPMID:24350606
External References
Database Identifier Description
NBRP SPBC651.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC651.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC651.03c BioGRID Interaction Datasets
Expression Viewer SPBC651.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC651.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC651.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC651.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC651.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC651.03c Transcriptome Viewer (Bähler Lab)
GEO SPBC651.03c GEO profiles
PInt SPBC651.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC651.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC651.03c Fission yeast phenotypic data & analysis
Cyclebase SPBC651.03c.1 Cell Cycle Data
SPD / RIKEN17/17F07Orfeome Localization Data
UniProtKB/SwissProtO94661GTPase-activating protein gyp10
ModBaseO94661Database of comparative protein structure models
STRINGO94661Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595501GTPase activating protein Gyp10
RefSeq mRNANM_001021411972h- GTPase activating protein Gyp10 (gyp10), mRNA
European Nucleotide ArchiveCAB37599.1ENA Protein Mapping
UniParcUPI000006A1E8UniProt Archive

Literature for gyp10

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015