gyp10 (SPBC651.03c)


Gene Standard Namegyp10 Characterisation Statuspublished
Systematic IDSPBC651.03c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase activating protein Gyp10 Product Size373aa, 42.55 kDa
Genomic Location Chromosome II, 1243207-1241431 (1777nt); CDS:1242945-1241824 (1122nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005097Rab GTPase activator activityIEAIPR000195GO_REF:000000213
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:1902409mitotic cytokinetic cell separationIGIexo70PMID:1629172323
GO:0032313regulation of Rab GTPase activityIEAIPR000195GO_REF:000000220
GO:0035023regulation of Rho protein signal transductionIGIrgf3PMID:1629172319
GO:0016192vesicle-mediated transportIGIexo70PMID:16291723320
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0005783endoplasmic reticulumIDAPMID:16291723594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopygyp10ΔNullPMID:204732893759
Microscopygyp10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopynot recorded (unrecorded)PMID:16291723

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopygyp10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
GO localized by yop1 ER membrane protein DP1/Yop1 PMID:20434336
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
112432071241431

UTRs

Region Coordinates Reference
five_prime_UTR1243207..1242946PMID:21511999
three_prime_UTR1241823..1241431PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 39 235 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 38 243 13
TMhelix TMHMM 344 366 959
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 35 220 13
PTHR20913:SF7 HMMPANTHER 2 346 1
PTHR20913 HMMPANTHER 2 346 1
2qq8A02 Gene3D 37 143 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 157 271 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 38 179 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.07 Da
Charge 13.50
Isoelectric point 8.59
Molecular weight 42.55 kDa
Number of residues 373
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
exo70exocyst complex subunit Exo70 Synthetic Growth DefectPMID:16291723
rgf3RhoGEF Rgf3 Dosage RescuePMID:16291723
ppk31serine/threonine protein kinase Ppk31 (predicted) Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC651.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC651.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC651.03c BioGRID Interaction Datasets
Expression Viewer SPBC651.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC651.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC651.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC651.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC651.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC651.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC651.03c Cell Cycle Data
GEO SPBC651.03c GEO profiles
PInt SPBC651.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC651.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC651.03c Fission yeast phenotypic data & analysis
SPD / RIKEN17/17F07Orfeome Localization Data
UniProtKB/SwissProtO94661GTPase-activating protein gyp10
ModBaseO94661Database of comparative protein structure models
STRINGO94661Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595501GTPase activating protein Gyp10
RefSeq mRNANM_001021411972h- GTPase activating protein Gyp10 (gyp10), mRNA
European Nucleotide ArchiveCAB37599.1ENA Protein Mapping
UniParcUPI000006A1E8UniProt Archive

Literature for gyp10

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014