gyp10 (SPBC651.03c)

Gene Standard Namegyp10 Characterisation Statuspublished
Systematic IDSPBC651.03c Feature Typeprotein coding
Synonyms Name DescriptionGap for YPt
ProductGTPase activating protein Gyp10 Product Size373aa, 42.55 kDa
Genomic Location Chromosome II, 1243207-1241431 (1777nt); CDS:1242945-1241824 (1122nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTPase activator activity43
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cell separation after cytokinesis15
Annotation ExtensionEvidenceWith/FromReference
regulation of Rho protein signal transduction12
Annotation ExtensionEvidenceWith/FromReference
vesicle-mediated transport315
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum602
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane969
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationgyp10Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologygyp10Δ3103
Target Of
GO localized by yop1 ER membrane protein DP1/Yop1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR1243207..1242946PMID:21511999
3' UTR1241823..1241431PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00566 Pfam IPR000195 Rab-GTPase-TBC domain 39 236 13
SM00164 SMART IPR000195 Rab-GTPase-TBC domain 38 243 13
TMhelix TMHMM 344 366 950
PS50086 Prosite Profiles IPR000195 Rab-GTPase-TBC domain 35 220 12
PTHR20913:SF7 HMMPANTHER 2 368 1
PTHR20913 HMMPANTHER 2 368 1
2qq8A02 Gene3D 37 143 12
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 157 271 13
SSF47923 SuperFamily IPR000195 Rab-GTPase-TBC domain 38 179 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.07 Da
Charge 13.50
Codon Adaptation Index 0.44
Isoelectric point 8.59
Molecular weight 42.55 kDa
Number of residues 373

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS65 2293
Annotation ExtensionEvidenceResidueReference
IDA S65 PMID:25720772
ubiquitinylated lysineK4 514
Annotation ExtensionEvidenceResidueReference
IDA PMID:26412298
mass spectrometry evidence K4 PMID:26412298
O-phosphorylated residueS65,S67, S65,S68 2461
Annotation ExtensionEvidenceResidueReference
IDA S65,S68 PMID:25720772
IDA S65,S67 PMID:25720772
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for gyp10 (SPBC651.03c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.1during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC651.03c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
overexpression lethal toypt3Rab11 family GTPase Ypt3 Dosage LethalityPMID:24350606
overexpression lethal toryh1GTPase Ryh1 Dosage LethalityPMID:24350606
positive genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
positive genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:22681890
positive genetic interaction withtim18TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
positive genetic interaction withccr4CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 Positive GeneticPMID:22681890
rescuesits31-phosphatidylinositol-4-phosphate 5-kinase Its3 Phenotypic SuppressionPMID:24350606
synthetic growth defect withexo70exocyst complex subunit Exo70 Synthetic Growth DefectPMID:16291723
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withppk31serine/threonine protein kinase Ppk31 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
negative genetic interaction withatg6autophagy associated beclin family protein Atg6 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase PP2A regulatory subunit B-56 Par1 Negative GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
overexpression rescuesrgf3RhoGEF Rgf3 Dosage RescuePMID:16291723
External References
Database Identifier Description
NBRP SPBC651.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC651.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC651.03c BioGRID Interaction Datasets
Expression Viewer SPBC651.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC651.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC651.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC651.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC651.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC651.03c Transcriptome Viewer (Bähler Lab)
GEO SPBC651.03c GEO profiles
PInt SPBC651.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC651.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC651.03c Fission yeast phenotypic data & analysis
Cyclebase SPBC651.03c.1 Cell Cycle Data
SPD / RIKEN17/17F07Orfeome Localization Data
UniProtKB/SwissProtO94661GTPase-activating protein gyp10
ModBaseO94661Database of comparative protein structure models
STRINGO94661Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595501GTPase activating protein Gyp10
RefSeq mRNANM_001021411972h- GTPase activating protein Gyp10 (gyp10), mRNA
European Nucleotide ArchiveCAB37599.1ENA Protein Mapping
UniParcUPI000006A1E8UniProt Archive

Literature for gyp10

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017