ntp1 (SPBC660.07)

Gene Standard Namentp1 ChromosomeII
Systematic IDSPBC660.07 Gene Start206580
Synonyms Gene End209641
Productalpha,alpha-trehalase Ntp1 Gene Length3062
Feature Typeprotein coding CDS Start207078
Name Description CDS End209285
Characterisation Statuspublished CDS Length2208

Ensembl Gene Location
  1. SPNCRNA.1324
  2. SPNCRNA.1326
  3. SPBC660.05
  4. SPBC660.06
  5. SPNCRNA.1327
  6. ntp1
  7. SPBC660.08
  8. SPNCRNA.1328
  9. mug168
  10. SPBC660.10
  11. tcg1
  12. SPBC660.12c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000579normal spore germinationCell growth assayntp1delta (deletion)deletionPMID:9495778
FYPO:0000852resistance to salt stressCell growth assayntp1delta (deletion)deletionPECO:0000102, PECO:0000166, PECO:0000137PMID:9495778
Cell growth assayntp1delta (deletion)deletionPECO:0000103, PECO:0000137, PECO:0000166PMID:9495778
FYPO:0001090resistance to heat shock during vegetative growthCell growth assayntp1delta (deletion)deletionPECO:0000103, PECO:0000126, PECO:0000117PMID:10223994
Cell growth assayntp1delta (deletion)deletionPECO:0000168PMID:9495778
FYPO:0001091normal cellular response to heat shockCell growth assayntp1delta (deletion)deletionPECO:0000004PMID:9495778
FYPO:0001147normal mating efficiencyCell growth assayntp1delta (deletion)deletionPMID:9495778
FYPO:0001315normal cell morphology during vegetative growthMicroscopyntp1delta (deletion)deletionPMID:9495778
FYPO:0001444increased cellular trehalose levelEnzyme assay datantp1delta (deletion)deletionPECO:0000137PMID:9495778
Enzyme assay datantp1delta (deletion)deletionPECO:0000125, PECO:0000126PMID:10223994
FYPO:0001445increased cellular trehalose level during heat shockEnzyme assay datantp1delta (deletion)deletionPMID:9495778
Enzyme assay datantp1delta (deletion)deletionPECO:0000125, PECO:0000126, PECO:0000117PMID:10223994
FYPO:0001452resistance to water deprivationCell growth assayntp1delta (deletion)deletionPECO:0000125, PECO:0000126, PECO:0000102PMID:10223994
FYPO:0001481alpha,alpha-trehalase activity increase abolished during cellular response to nutrientEnzyme assay datantp1delta (deletion)deletionPMID:9495778
FYPO:0001482alpha,alpha-trehalase activity increase abolished during cellular response to heatEnzyme assay datantp1delta (deletion)deletionPMID:9495778
FYPO:0001502increased cellular trehalose level during cellular response to osmotic stressEnzyme assay datantp1delta (deletion)deletionPECO:0000166, PECO:0000137PMID:9495778
FYPO:0002060viable vegetative cell populationMicroscopyntp1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004555alpha,alpha-trehalase activityIMPPMID:10223994
happens_during cellular response to glucose stimulusIMPPMID:9495778
happens_during cellular response to heatIMPPMID:9495778
GO:0005509calcium ion binding
residue 86468_59617_35195IDAPMID:12943532
GO:0005515protein bindingIPItpp1PMID:12383265
IPItps1PMID:12383265
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0009409response to cold
requiredIDAPMID:9974219
GO:0030437ascospore formationIMPPMID:11094289
GO:0034599cellular response to oxidative stress
requiredIDAPMID:9974219
GO:0034605cellular response to heat
requiredIDAPMID:9974219
GO:0071470cellular response to osmotic stress
requiredIDAPMID:9974219
GO:0090442trehalose catabolism in response to heat stressIMPPMID:10223994
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1206580209641

References

Region Start End Reference
three_prime_UTR209286209641PMID:21511999
five_prime_UTR206580207077PMID:21511999
three_prime_UTR209286209641PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01204 IPR001661 Pfam Glycoside hydrolase, family 37 146 699 1
PF07492 IPR011120 Pfam Neutral trehalase Ca2+ binding 89 118 1
PS00928 IPR018232 Prosite Patterns Glycoside hydrolase, family 37 601 610 1
PS00927 IPR018232 Prosite Patterns Glycoside hydrolase, family 37 280 293 1
SSF48208 IPR008928 SuperFamily 173 695 9
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 594 610 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 521 537 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 469 486 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 322 340 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 682 695 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 390 407 1
PR00744 IPR001661 PRINTS Glycoside hydrolase, family 37 445 462 1
PTHR23403:SF1 hmmpanther 55 735 1
PTHR23403 IPR001661 hmmpanther Glycoside hydrolase, family 37 55 735 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:15965654
PMID:19547744

Protein Properties

Ave. residue weight 115.11 Da
Charge -5.00
Isoelectric point 6.03
Molecular weight 84.60 kDa
Number of residues 735
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
promoter contains CRE element PMID:15164362
promoter contains HSE element PMID:15164362
protein levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide5621.36PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide12509.38PMID:23101633
RNA levelNorthern assay evidencecellular response to heatincreasedPMID:9729425
experimental evidencePECO:0000014,
PECO:0000005		population_wide4.4PMID:23101633
Northern assay evidencecellular response to salt stressincreasedPMID:9729425
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2.3PMID:23101633
Northern assay evidencecellular response to salt stressincreasedPMID:9495778
Northern assay evidencecellular response to heatincreasedPMID:9495778
Northern assay evidencepresentPMID:9495778
Misc
DescriptionQualifierReference
target of SAPK pathway PMID:15164362
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in bacteria
conserved in metazoa
conserved in vertebrates
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rhn1RNA polymerase II transcription termination factor homolog Positive GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Positive GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
SPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
rpt419S proteasome regulatory subunit Rpt4 (predicted) Positive GeneticPMID:22681890
SPAC56F8.02AMP binding enzyme (predicted) Negative GeneticPMID:22681890
csn71COP9/signalosome complex subunit 7a (predicted) Positive GeneticPMID:22681890
sec74guanyl-nucleotide exchange factor Sec74 (predicted) Negative GeneticPMID:22681890
SPBC25B2.08sequence orphan Negative GeneticPMID:22681890
SPBPB2B2.17cS. pombe specific 5Tm protein family Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
alp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:22681890
SPAC4A8.10lipase (predicted) Negative GeneticPMID:22681890
vrp1verprolin Positive GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Positive GeneticPMID:22681890
atf21transcription factor, Atf-CREB family Atf21 Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
SPAC212.02sequence orphan Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tpp1trehalose-6-phosphate phosphatase Tpp1 Affinity Capture-WesternPMID:12153582
Co-fractionation
tps1alpha,alpha-trehalose-phosphate synthase Affinity Capture-WesternPMID:12153582
Co-fractionation
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External References
Database Identifier Description
NBRP SPBC660.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC660.07 Retrieval of eukaryotic orthologs
BioGrid SPBC660.07 BioGRID Interaction Datasets
Bähler Lab SPBC660.07 Cell Cycle Expression Profile
Bähler Lab SPBC660.07 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC660.07 Pheromone response/mating expression profiles
Bähler Lab SPBC660.07 Environmental stress expression profiles
Bähler Lab SPBC660.07 Bähler Lab Transcriptome Viewer
Cyclebase SPBC660.07 Cell Cycle Data
PInt SPBC660.07 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC660.07 Entrez Gene
IntEnz3.2.1.28
EntrezGene2541115alpha,alpha-trehalase Ntp1
Uniprot_genenameNTP1
WikiGene2541115alpha,alpha-trehalase Ntp1
UniProtKB/SwissProtO42893Neutral trehalase
ModBaseO42893Database of comparative protein structure models
Pfam Protein DomainsO42893Pfam Domain Arrangement
RefSeq PeptideNP_595086alpha,alpha-trehalase Ntp1
RefSeq mRNANM_001020993972h- alpha,alpha-trehalase Ntp1 (ntp1), mRNA
European Nucleotide ArchiveBAA13934ENA Protein Mapping
European Nucleotide ArchiveBAA87141ENA Protein Mapping
European Nucleotide ArchiveCAA11904ENA Protein Mapping
European Nucleotide ArchiveCAA22527ENA Protein Mapping
SPD / RIKEN50/50A10Orfeome Localization Data
UniParcUPI000013734DUniProt Archive

Literature for ntp1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013