psf2 (SPBC725.13c)

Gene Standard Namepsf2 ChromosomeII
Systematic IDSPBC725.13c Gene Start1229239
Synonymsbsh3, dre13 Gene End1228148
ProductGINS complex subunit Psf2 Gene Length1092
Feature Typeprotein coding CDS Start1229027
Name DescriptionDefect in REplication CDS End1228476
Characterisation Statuspublished CDS Length552

Ensembl Gene Location
  1. SPBC725.08
  2. hob3
  3. SPBC725.10
  4. SPNCRNA.342
  5. php2
  6. nbl1
  7. psf2
  8. arg6
  9. ura5
  10. res1
  11. rrn11
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001122elongated vegetative cellno_name (unrecorded)unrecordedPMID:15466421
FYPO:0001489inviable vegetative cellno_name (unrecorded)unrecordedPMID:16199877
Microscopypsf2delta (deletion)deletionPMID:20473289
GO Biological Process

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0006261DNA-dependent DNA replication
requiredIMPPMID:15466421
GO:0006270DNA replication initiationTASPMID:19109429
GO:0034613cellular protein localization
has_input bir1IMPGO_REF:0000001
GO:0045132meiotic chromosome segregationIMPPMID:15466421
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000811GINS complexTASPMID:15466421
GO:0005634nucleusIDAPMID:16199877
IDAPMID:19109429
IDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0031261DNA replication preinitiation complexICGO:0000811GO_REF:0000001
GO:0043596nuclear replication forkICGO:0000811GO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
112292391228148

References

Region Start End Reference
three_prime_UTR12284751228148PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF05916 IPR021151 Pfam GINS complex, subunit Sld5 53 159 4
SSF160059 SuperFamily 11 71 3
SSF158573 SuperFamily 72 176 4
PIRSF028998 IPR016906 PIRSF GINS complex, subunit Psf2, subgroup 1 183 1
PTHR12772 IPR007257 hmmpanther GINS complex, subunit Psf2 1 181 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 116.62 Da
Charge -13.50
Isoelectric point 4.30
Molecular weight 21.34 kDa
Number of residues 183
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide716.23PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.72PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide2.9PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
bir1survivin, Bir1 Dosage RescuePMID:16199877
swi1replication fork protection complex subunit Swi1 Synthetic LethalityPMID:20176980
rad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:15466421
chk1Chk1 protein kinase Synthetic Growth DefectPMID:15466421
swi3replication fork protection complex subunit Swi3 Synthetic Growth DefectPMID:20176980
psf3GINS complex subunit Psf3 Dosage RescuePMID:16990792
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rad4BRCT domain protein Rad4 Affinity Capture-WesternPMID:22718908
Co-localizationPMID:16990792
mcm4MCM complex subunit Mcm4/Cdc21 Affinity Capture-WesternPMID:22433840
sld5GINS complex subunit Sld5 Affinity Capture-WesternPMID:22718908
Affinity Capture-WesternPMID:16990792
sld3DNA replication pre-initiation complex subunit Sld3 Two-hybridPMID:21593208
Co-localizationPMID:16990792
psf3GINS complex subunit Psf3 Affinity Capture-WesternPMID:22718908
Affinity Capture-WesternPMID:16990792
mcm6MCM complex subunit Mcm6 Affinity Capture-WesternPMID:22718908
Affinity Capture-WesternPMID:22433840
hsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Co-localizationPMID:16990792
bir1survivin, Bir1 Co-localizationPMID:16199877
cdc23MCM-associated protein Mcm10 Two-hybridPMID:22433840
psf1GINS complex subunit Psf1 Affinity Capture-WesternPMID:22718908
Affinity Capture-WesternPMID:16990792
cdc45DNA replication pre-initiation complex subunit Cdc45 Affinity Capture-WesternPMID:22718908
Affinity Capture-WesternPMID:22433840
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External References
Database Identifier Description
NBRP SPBC725.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC725.13c Retrieval of eukaryotic orthologs
BioGrid SPBC725.13c BioGRID Interaction Datasets
Bähler Lab SPBC725.13c Cell Cycle Expression Profile
Bähler Lab SPBC725.13c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC725.13c Pheromone response/mating expression profiles
Bähler Lab SPBC725.13c Environmental stress expression profiles
Bähler Lab SPBC725.13c Bähler Lab Transcriptome Viewer
Cyclebase SPBC725.13c Cell Cycle Data
PInt SPBC725.13c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC725.13c Entrez Gene
WikiGene2541194GINS complex subunit Psf2
Uniprot_genenamePSF2
EntrezGene2541194GINS complex subunit Psf2
SPD / RIKEN05/05F08Orfeome Localization Data
UniProtKB/SwissProtO94329DNA replication complex GINS protein psf2
ModBaseO94329Database of comparative protein structure models
Pfam Protein DomainsO94329Pfam Domain Arrangement
RefSeq PeptideNP_595493GINS complex subunit Psf2
RefSeq mRNANM_001021404972h- GINS complex subunit Psf2 (psf2), mRNA
European Nucleotide ArchiveCAA22185ENA Protein Mapping
SPD / RIKEN05/05F08Orfeome Localization Data

Literature for psf2
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013