dis2 (SPBC776.02c)


Gene Standard Namedis2 Characterisation Statuspublished
Systematic IDSPBC776.02c Feature Typeprotein coding
Synonymsbws1, sds1 Name Descriptiondefective in sister chromatid disjoining
Productserine/threonine protein phosphatase PP1, Dis2 Product Size327aa, 37.64 kDa
Genomic Location Chromosome II, 3175376-3173165 (2212nt); CDS:3175098-3173719 (1380nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
metal ion binding742
Annotation ExtensionEvidenceWith/FromReference
protein binding900
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine phosphatase activity14
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
Term NameCount
cell cortex182
Annotation ExtensionEvidenceWith/FromReference
cell division site318
Annotation ExtensionEvidenceWith/FromReference
cell tip211
Annotation ExtensionEvidenceWith/FromReference
CENP-A containing chromatin6
Annotation ExtensionEvidenceWith/FromReference
cytoplasm4212
Annotation ExtensionEvidenceWith/FromReference
cytosol2298
Annotation ExtensionEvidenceWith/FromReference
DPS complex3
Annotation ExtensionEvidenceWith/FromReference
endocytic vesicle8
Annotation ExtensionEvidenceWith/FromReference
growing cell tip31
Annotation ExtensionEvidenceWith/FromReference
mRNA cleavage and polyadenylation specificity factor complex15
Annotation ExtensionEvidenceWith/FromReference
non-growing cell tip9
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin364
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
protein phosphatase type 1 complex4
Annotation ExtensionEvidenceWith/FromReference
PTW/PP1 phosphatase complex3
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at low temperaturedis2-1196
dis2cs (R245Q)
inviable vegetative cell populationdis2-SPPR (T316S)1468
dis2-11
dis2-APPR (T316A)
normal growth on glucose carbon sourcedis2-11318
normal growth on thiabendazoledis2-1126
normal vegetative cell population growthdis2+846
sensitive to caffeine during vegetative growthdis2-11110
slow vegetative cell population growthdis2+369
viable vegetative cell populationdis2Δ::ura4+3862
dis2Δ

Cell Phenotype

Term NameGenotypesCount
abnormal rDNA separationdis2-116
abolished deactivation of mitotic spindle assembly checkpointdis2Δ3
abolished mitotic sister chromatid separationdis2-1139
chromosome loss during mitotic chromosome segregationdis2Δ12
complete but unequal mitotic sister chromatid segregationdis2-1136
decreased protein level during vegetative growth164
affecting dis2 (T316D)
decreased protein phosphatase activitydis2::ura4+5
dis2Δ
dis2cs (R245Q)
dis2-11
affecting dis2dis2-APPR (T316A)
decreased protein phosphorylation120
affecting dis2dis2-APPR (T316A)
decreased protein threonine phosphorylation during vegetative growth9
affecting dis2dis2-APPR (T316A)
increased histone H3-S10 phosphorylation during vegetative growthdis2Δ1
increased minichromosome loss during vegetative growthdis2-1181
increased minichromosome loss upon segregation during meiotic cell cycledis2-111
increased protein level during vegetative growth121
affecting dis2dis2-APPR (T316A)
affecting sds21dis2Δ
increased protein phosphatase activitydis2+4
mitotic metaphase/anaphase transition delaydis2Δ20
normal mitotic G1/S phase transitiondis2-113
normal protein phosphorylation104
affecting dis2dis2-SPPR (T316S)
normal protein serine phosphorylation during vegetative growth12
affecting dis2dis2-APPR (T316A)
protein mislocalized to cell tip2
affects localization of sds21dis2Δ
viable vegetative celldis2-113680
viable vegetative cell with normal cell morphologydis2Δ3103
viable vegetative cell with normal cell shapedis2-APPR (T316A)31
dis2+

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased cell population growth on glucose carbon sourcedam1-S143D (S143D), dis2Δ
dam1-T136A (T136A), dis2Δ
dam1-T139A (T139A), dis2Δ
inviable cell populationdis3-54 (P509L), dis2-11
inviable vegetative cell populationdis2::ura4+, dis2cs (R245Q)
dis2+, cdc25-22 (C532Y), wee1-50
cdc2-3w (C67Y), cdc25-22 (C532Y), dis2+
dis3-54 (P509L), dis2Δ
mad3Δ, dam1-S143A (S143A), dis2Δ
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
mad3Δ, dam1Δ, dis2Δ
mad3Δ, dam1(1-127) (128-155), dis2Δ
plo1-ts35, dis2Δ
dis2+, cdc25-22 (C532Y), wee1-6
dam1(1-127) (128-155), dis2Δ
dam1-S143A (S143A), dis2Δ
dam1Δ, dis2Δ
normal growth on okadaic aciddis2-11, dis3-54 (P509L), sds21Δ, ppe1Δ, dis1-288, dis2Δ, ppa1Δ
slow vegetative cell population growthdis2cs (R245Q), dis2+
ppa2::ura4+, dis2cs (R245Q)
sds21::LEU2, dis2cs (R245Q)
ppa1::ura4+, dis2cs (R245Q)
ppe1Δ, dis2Δ
ppa2::ura4+, dis2::ura4+
viable vegetative cell populationcdc2-3w (C67Y), cdc25-22 (C532Y), dis2+
dis2+, cdc25-22 (C532Y), wee1-6
dis2+, cdc25-22 (C532Y), wee1-50
ppb1::ura4+, dis2Δ
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+

Cell Phenotype

Term NameGenotypes
abolished deactivation of mitotic spindle assembly checkpoint
affecting cdc13nda3-KM311, ark1-as3 (analog-sensitive), dis2Δ
cut following normal mitotic chromosome condensationcut8-563 (T601C), dis2-11
decreased protein degradation during vegetative growth
affecting cdc13nda3-KM311, ark1-as3 (analog-sensitive), dis2Δ
elongated multinucleate multiseptate vegetative cell, single septa between nucleippb1::ura4+, dis2Δ
increased activation of mitotic cell cycle spindle assembly checkpointnda3-KM311, dis2Δ
inviable after spore germination, without cell divisiondis3-54 (P509L), dis2Δ
inviable sporedis3-54 (P509L), dis2-11
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in brr2 U5 snRNP complex subunit Brr2
FYPO affected by mutation in dis2 serine/threonine protein phosphatase PP1, Dis2
FYPO affected by mutation in klp5 kinesin-8 family plus-end microtubule motor Klp5
FYPO affected by mutation in klp6 kinesin-8 family plus-end microtubule motor Klp6
FYPO affected by mutation in pab1 protein phosphatase PP2A regulatory subunit B-55 Pab1
FYPO affected by mutation in par1 protein phosphatase PP2A regulatory subunit B-56 Par1
FYPO affected by mutation in prp4 serine/threonine protein kinase Prp4
FYPO affected by mutation in rpn12 19S proteasome regulatory subunit Rpn12
FYPO affected by mutation in sds22 protein phosphatase regulatory subunit Sds22
FYPO affected by mutation in spp42 U5 snRNP complex subunit Spp42
FYPO affected by mutation in tea4 tip elongation aberrant protein Tea4
FYPO localization affected by mutation in mis6 kinetochore protein, CENP-I ortholog Mis6
FYPO localization affected by mutation in mph1 dual specificity protein kinase Mph1
FYPO localization affected by mutation in ppn1 mRNA cleavage and polyadenylation specificity factor complex associated protein
FYPO localization affected by mutation in swd22 mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22
FYPO localization affected by mutation in tea1 cell end marker Tea1
FYPO localization affected by mutation in tea4 tip elongation aberrant protein Tea4
GO substrate of cdc2 cyclin-dependent protein kinase Cdk1/Cdc2
GO substrate of dis2 serine/threonine protein phosphatase PP1, Dis2
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3175376..3175047, 3174650..3173165
Intron3175046..3174651
mRNA3175376..3173165
5' UTR3175376..3175099PMID:21511999
CDS3175098..3175047, 3174650..3173719
3' UTR3173718..3173165AU012156
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Calcineurin-like phosphoesterase domain, ApaH type 59 248 19
PF16891 Pfam IPR031675 Serine-threonine protein phosphatase, N-terminal 8 55 3
SM00156 SMART IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 29 299 10
PTHR11668 HMMPANTHER 1 319 11
PTHR11668:SF213 HMMPANTHER 1 319 1
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 9 306 23
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 19 312 22
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 57 84 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 182 209 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 119 143 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 86 113 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 153 179 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 261 277 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 239 259 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.10 Da
Charge -4.50
Codon Adaptation Index 0.47
Isoelectric point 5.44
Molecular weight 37.64 kDa
Number of residues 327
Modifications

Protein Modifications

Term NameResidueCount
phosphorylated residue 2515
added by cdc2, added during mitotic metaphaseT316
Annotation ExtensionEvidenceResidueReference
added by cdc2
added during mitotic metaphase
IDA T316 PMID:7957097
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelincreased during GO:0000090Western blot evidencePMID:25487150
increased during GO:0000089Western blot evidencePMID:25487150
decreased during GO:0000093Western blot evidencePMID:25487150
constant during GO:0000278Western blot evidencePMID:2170029

Quantitative Gene Expression

View graphical display of gene expression data for dis2 (SPBC776.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
25473during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
18066during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
35145during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
36382.83during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
13953.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by S. cerevisiae DIS2partial PMID:2544298
Subunit Composition
DescriptionQualifierReferenceCount
oligomeric PMID:21700294
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC776.02c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
co-purifies withtea4tip elongation aberrant protein Tea4 Co-purificationPMID:21703453
affinity capturessds22protein phosphatase regulatory subunit Sds22 Affinity Capture-WesternPMID:15335873
affinity capturestea4tip elongation aberrant protein Tea4 Affinity Capture-WesternPMID:26525038
affinity capturesrif1telomere length regulator protein Rif1 Affinity Capture-WesternPMID:24656819
affinity capturesucp3GTPase activating protein Ucp3 Affinity Capture-MSPMID:24945319
affinity capturesmsi2mRNA cleavage factor complex subunit Msi2 Affinity Capture-MSPMID:24945319
affinity capturescft2cleavage factor two Cft2/polyadenylation factor CPSF-73 (predicted) Affinity Capture-MSPMID:24945319
affinity capturesppn1mRNA cleavage and polyadenylation specificity factor complex associated protein Affinity Capture-WesternPMID:24945319
affinity capturescut12spindle pole body protein Cut12 Affinity Capture-MSPMID:24945319
affinity capturesrad2514-3-3 protein Rad25 Affinity Capture-MSPMID:24945319
affinity capturestpp1trehalose-6-phosphate phosphatase Tpp1 Affinity Capture-MSPMID:24945319
affinity capturesuri1unconventional prefoldin chaperone involved protein complex assembly Uri1 (predicted) Affinity Capture-MSPMID:24945319
affinity capturesssu72phosphoric ester hydrolase Ssu72 (predicted) Affinity Capture-MSPMID:24945319
affinity capturesswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Affinity Capture-MSPMID:24945319
affinity capturespla1poly(A) polymerase Pla1 Affinity Capture-MSPMID:24945319
affinity capturespabpmRNA export shuttling protein Affinity Capture-MSPMID:24945319
affinity captureslys9saccharopine dehydrogenase (predicted) Affinity Capture-MSPMID:24945319
affinity capturesyth1mRNA cleavage and polyadenylation specificity factor complex Yth1 Affinity Capture-MSPMID:24945319
affinity capturesreg1protein phosphatase regulatory subunit Reg1 (predicted) Affinity Capture-MSPMID:24945319
affinity capturespfs2WD repeat protein Pfs2 Affinity Capture-MSPMID:24945319
affinity capturesdef1RNAPII degradation factor Def1 (predicted) Affinity Capture-MSPMID:24945319
affinity capturespta1mRNA cleavage and polyadenylation specificity factor complex subunit Pta1 Affinity Capture-MSPMID:24945319
affinity capturesrad2414-3-3 protein Rad24 Affinity Capture-MSPMID:24945319
affinity capturesysh1mRNA cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 Affinity Capture-MSPMID:24945319
affinity capturesSPAC6B12.13protein phosphatase inhibitor (predicted) Affinity Capture-MSPMID:24945319
affinity capturescft1cleavage factor one Cft1 (predicted) Affinity Capture-MSPMID:24945319
affinity capturesglc8protein phosphatase regulatory subunit Glc8 (predicted) Affinity Capture-MSPMID:24945319
affinity capturesrpb1RNA polymerase II large subunit Rpb1 Affinity Capture-MSPMID:24945319
affinity capturesiss1mRNA cleavage and polyadenylation specificity factor complex subunit, Fip1 homolog (predicted) Affinity Capture-MSPMID:24945319
affinity captured bypab1protein phosphatase PP2A regulatory subunit B-55 Pab1 Affinity Capture-WesternPMID:25487150
affinity captured bysds22protein phosphatase regulatory subunit Sds22 Affinity Capture-WesternPMID:15335873
affinity captured bytea4tip elongation aberrant protein Tea4 Affinity Capture-WesternPMID:24554432
affinity captured bypar1protein phosphatase PP2A regulatory subunit B-56 Par1 Affinity Capture-WesternPMID:25487150
affinity captured byclp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
affinity captured byysh1mRNA cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 Affinity Capture-MSPMID:14617822
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity captured bycut12spindle pole body protein Cut12 Affinity Capture-WesternPMID:23333317
affinity captured byppn1mRNA cleavage and polyadenylation specificity factor complex associated protein Affinity Capture-MSPMID:24945319
affinity captured byswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Affinity Capture-MSPMID:14617822
affinity captured byred1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
affinity captured byyth1mRNA cleavage and polyadenylation specificity factor complex Yth1 Affinity Capture-MSPMID:24945319
affinity captured bymtl1TRAMP/MTREC complex subunit, ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
binds DNA-binding domain construct withpar1protein phosphatase PP2A regulatory subunit B-56 Par1 Two-hybridPMID:25487150
binds DNA-binding domain construct withspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Two-hybridPMID:21664573
binds DNA-binding domain construct withSPAC29A4.09rRNA exonuclease Rrp17 (predicted) Two-hybridPMID:26771498
binds DNA-binding domain construct withcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Two-hybridPMID:26771498
interacts withtea4tip elongation aberrant protein Tea4 PCAPMID:21703453
forms complex withklp6kinesin-8 family plus-end microtubule motor Klp6 Reconstituted ComplexPMID:21664573
forms complex withspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Reconstituted ComplexPMID:21664573
modified bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:16920624
binds activation domain construct withcut12spindle pole body protein Cut12 Two-hybridPMID:23333317
fluorescence resonance energy donor topom1DYRK family protein kinase Pom1 FRETPMID:21703453
fluorescence resonance energy acceptor fromtea4tip elongation aberrant protein Tea4 FRETPMID:21703453
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC776.02c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
overexpression rescuescdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:16079915
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:1944266
overexpression rescueswee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1944266
synthetic lethal withspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Synthetic LethalityPMID:22521786
synthetic lethal withdis1TOG/XMAP14 microtubule-associated protein Dis1 Synthetic LethalityPMID:7628693
synthetic lethal withend4Huntingtin-interacting protein homolog Synthetic LethalityPMID:17895368
synthetic lethal withcut9anaphase-promoting complex, TPR lobe subcomplex subunit Cut9/Apc6 Synthetic LethalityPMID:9264466
synthetic lethal withsds21serine/threonine protein phosphatase PP1 subfamily, Sds21 Synthetic LethalityPMID:2170029
synthetic lethal withdis33'-5' exoribonuclease subunit Dis3 Synthetic LethalityPMID:1944266
synthetic lethal withcut8tethering factor for nuclear proteasome Cut8 Synthetic LethalityPMID:11084332
synthetic growth defect withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withrad51RecA family recombinase Rad51/Rhp51 Synthetic Growth DefectPMID:14765108
synthetic growth defect withcoq5C-methyltransferase (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withhtb1histone H2B Htb1 Synthetic Growth DefectPMID:16688222
synthetic growth defect withSPCC1494.08cvariant C2 domain protein, human FAM102A and FAM102B ortholog Synthetic Growth DefectPMID:21965289
synthetic growth defect withctf18RFC-like complex subunit Ctf18 Synthetic Growth DefectPMID:21965289
synthetic growth defect witharp8Ino80 complex actin-like protein Arp8 Synthetic Growth DefectPMID:21965289
synthetic growth defect withnut2mediator complex subunit Med10 Synthetic Growth DefectPMID:21965289
synthetic growth defect withnsk1Clp1-interacting, microtubule plus-end binding Nsk1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withcuf1nutritional copper sensing transcription factor Cuf1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withcho2phosphatidylethanolamine N-methyltransferase Cho2 Synthetic Growth DefectPMID:21965289
synthetic growth defect withrsc1RSC complex subunit Rsc1 Synthetic Growth DefectPMID:21965289
synthetic growth defect witharb2argonaute binding protein 2 Synthetic Growth DefectPMID:21965289
synthetic growth defect withrad2414-3-3 protein Rad24 Synthetic Growth DefectPMID:21965289
synthetic growth defect withubr1N-end-recognizing protein, UBR ubiquitin-protein ligase E3 Ubr1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withcwf21complexed with Cdc5 protein Cwf21 Synthetic Growth DefectPMID:21965289
synthetic growth defect withvps32ESCRT III complex subunit Vps32 Synthetic Growth DefectPMID:21965289
synthetic growth defect withppt1para-hydroxybenzoate--polyprenyltransferase Ppt1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withrad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:14765108
synthetic growth defect withatp10mitochondrial F1-F0 ATPase assembly protein (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withdam1DASH complex subunit Dam1 Synthetic Growth DefectPMID:22375062
synthetic growth defect withsmd3Sm snRNP core protein Smd3 Synthetic Growth DefectPMID:21965289
synthetic growth defect withsaf1splicing associated factor Saf1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withalp14TOG/XMAP14 family protein Alp14 Synthetic Growth DefectPMID:21965289
synthetic growth defect withalp31tubulin specific chaperone cofactor A, Alp31 Synthetic Growth DefectPMID:21965289
synthetic growth defect withSPBC557.02cconserved fungal protein Synthetic Growth DefectPMID:21965289
synthetic growth defect withcho1phosphatidyl-N-dimethylethanolamine N-methyltransferase Synthetic Growth DefectPMID:21965289
synthetic growth defect withrpm1mitochondrial 3'-5' exonuclease for RNA 3' ss-tail Synthetic Growth DefectPMID:21965289
synthetic growth defect withuge1UDP-glucose 4-epimerase Uge1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withnse6Smc5-6 complex non-SMC subunit Nse6 Synthetic Growth DefectPMID:21965289
synthetic growth defect withmmp2mitochondrial inner membrane peptidase complex catalytic subunit 2 (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withmss116mitochondrial ATP-dependent RNA helicase Mss116 (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withcox6cytochrome c oxidase subunit VI (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withned1lipin, phosphatidate phosphatase Ned1 Synthetic Growth DefectPMID:12376568
synthetic growth defect withrhp18Rad18 homolog ubiquitin protein ligase E3, Rhp18 Synthetic Growth DefectPMID:14765108
synthetic growth defect withplo1Polo kinase Plo1 Synthetic Growth DefectPMID:22375062
synthetic growth defect withhip1hira protein, histone chaperone Hip1 Synthetic Growth DefectPMID:21965289
synthetic growth defect withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Synthetic Growth DefectPMID:21965289
synthetic growth defect withnse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:21965289
synthetic growth defect withbst1GPI inositol deacylase Bst1 (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withSPBC25D12.06ATP-dependent RNA helicase (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withrhp41DNA repair protein Rhp41 Synthetic Growth DefectPMID:21965289
synthetic growth defect withprf1RNA polymerase II associated Paf1 complex (predicted) Synthetic Growth DefectPMID:21965289
synthetic growth defect withsft1SNARE Sft1 (predicted) Synthetic Growth DefectPMID:21965289
phenotype enhanced bynsk1Clp1-interacting, microtubule plus-end binding Nsk1 Phenotypic EnhancementPMID:21965289
phenotype enhanced byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:21965289
rescued bysds22protein phosphatase regulatory subunit Sds22 Phenotypic SuppressionPMID:1846086
synthetically rescuesmis3rRNA processing protein Mis3 Synthetic RescuePMID:10947840
synthetically rescuesark1aurora-B kinase Ark1 Synthetic RescuePMID:21965289
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:23333317
synthetically rescuescut3condensin complex SMC subunit Smc4 Synthetic RescuePMID:24945319
rescuescut12spindle pole body protein Cut12 Phenotypic SuppressionPMID:2245912
rescuesark1aurora-B kinase Ark1 Phenotypic SuppressionPMID:23438755
External References
Database Identifier Description
NBRP SPBC776.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC776.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC776.02c BioGRID Interaction Datasets
Expression Viewer SPBC776.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC776.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC776.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC776.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC776.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC776.02c Transcriptome Viewer (Bähler Lab)
GEO SPBC776.02c GEO profiles
PInt SPBC776.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC776.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC776.02c Fission yeast phenotypic data & analysis
Cyclebase SPBC776.02c.1 Cell Cycle Data
IntEnz3.1.3.16Integrated relational Enzyme database
Rhea3.1.3.16Annotated reactions database
SPD / RIKEN40/40E03Orfeome Localization Data
UniProtKB/SwissProtP13681Serine/threonine-protein phosphatase PP1-1
ModBaseP13681Database of comparative protein structure models
STRINGP13681Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596317serine/threonine protein phosphatase PP1
RefSeq mRNANM_001022239972h- serine/threonine protein phosphatase PP1 (dis2), mRNA
European Nucleotide ArchiveAAA74731.1ENA Protein Mapping
European Nucleotide ArchiveAAA89197.1ENA Protein Mapping
European Nucleotide ArchiveCAA22875.1ENA Protein Mapping
KEGG04660+3.1.3.16T cell receptor signaling pathway
UniParcUPI0000131FABUniProt Archive

Literature for dis2

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017