cog6 (SPBC776.10c)

Gene Standard Namecog6 Characterisation Statusbiological role inferred
Systematic IDSPBC776.10c Feature Typeprotein coding
Synonyms Name Description
ProductGolgi transport complex peripheral subunit Cog6 (predicted) Product Size675aa, 77.33 kDa
Genomic Location Chromosome II, 3195791-3193253 (2539nt); CDS:3195569-3193434 (2136nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
intra-Golgi vesicle-mediated transport13
Annotation ExtensionEvidenceWith/FromReference
intracellular protein transport373
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell division site318
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Golgi transport complex7
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationcog6Δ1468

Cell Phenotype

Term NameGenotypesCount
inviable after spore germination, single or double cell divisioncog6Δ107
inviable after spore germination, without cell division, with abnormal germ tube morphologycog6Δ153
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3195791..3195309, 3195256..3194295, 3194238..3193253
Intron3195308..3195257, 3194294..3194239
5' UTR3195791..3195570PMID:21511999
CDS3195569..3195309, 3195256..3194295, 3194238..3193434
3' UTR3193433..3193253AU006769
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06419 Pfam Conserved oligomeric Golgi complex subunit 6 44 634 1
SM01087 SMART IPR010490 Conserved oligomeric Golgi complex subunit 6 43 650 1
PTHR21506 HMMPANTHER IPR010490 Conserved oligomeric Golgi complex subunit 6 1 667 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.56 Da
Charge -24.00
Codon Adaptation Index 0.37
Isoelectric point 4.60
Molecular weight 77.33 kDa
Number of residues 675
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for cog6 (SPBC776.10c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
722during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
315.42during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.1during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.64during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Disease Association
congenital disorders of glycosylation30
metabolic disorders143
carbohydrate metabolism disorders11
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC776.10c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withhhp2serine/threonine protein kinase Hhp2 Two-hybridPMID:26771498
binds DNA-binding domain construct withtrm13tRNA 2'-O-methyltransferase Trm13 (predicted) Two-hybridPMID:26771498
binds activation domain construct withcog6Golgi transport complex peripheral subunit Cog6 (predicted) Two-hybridPMID:26771498
External References
Database Identifier Description
NBRP SPBC776.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC776.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC776.10c BioGRID Interaction Datasets
Expression Viewer SPBC776.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC776.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC776.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC776.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC776.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC776.10c Transcriptome Viewer (Bähler Lab)
GEO SPBC776.10c GEO profiles
PInt SPBC776.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC776.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC776.10c Fission yeast phenotypic data & analysis
Cyclebase SPBC776.10c.1 Cell Cycle Data
SPD / RIKEN37/37E04Orfeome Localization Data
UniProtKB/SwissProtO94677Conserved oligomeric Golgi complex subunit 6
ModBaseO94677Database of comparative protein structure models
STRINGO94677Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596325Golgi transport complex peripheral subunit Cog6 (predicted)
RefSeq mRNANM_001022247972h- Golgi transport complex peripheral subunit Cog6 (predicted) (cog6), mRNA
European Nucleotide ArchiveCAA22883.1ENA Protein Mapping
UniParcUPI000006BB03UniProt Archive

Literature for cog6

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017