whi5 (SPBC800.02)

Gene Standard Namewhi5 ChromosomeII
Systematic IDSPBC800.02 Gene Start253148
Synonymsmug54 Gene End253984
Productcell cycle transcriptional repressor Whi5 (predicted) Gene Length837
Feature Typeprotein coding CDS Start253148
Name DescriptionMeiotically Upregulated Gene,
WHIskey		 CDS End253984
Characterisation Statusbiological_role_inferred CDS Length837

Ensembl Gene Location
  1. pep12
  2. gle1
  3. bms1
  4. whi5
  5. SPNCRNA.1331
  6. clr3
  7. SPBTRNAGLN.01
  8. SPBTRNAGLN.02
  9. SPBTRNAGLN.03
  10. rpl4301
  11. atb2
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopywhi5delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0001135RNA polymerase II transcription factor recruiting transcription factor activityISOSGD:S000005609GO_REF:0000024
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionISOSGD:S000005609GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000083regulation of transcription involved in G1/S phase of mitotic cell cycleISOSGD:S000005609GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
ISOSGD:S000005609GO_REF:0000024
GO:0005737cytoplasmISOSGD:S000005609GO_REF:0000024
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1253148253231
2253310253984
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF08528 IPR013734 Pfam Transcription factor Nrm1/Whi5 46 70 2

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residueevidenceInferred from Sequence or Structural Similarity
PMID:19547744

Protein Properties

Ave. residue weight 112.81 Da
Charge 16.00
Isoelectric point 10.22
Molecular weight 28.43 kDa
Number of residues 252
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
expressed during meiosis PMID:16303567
protein levelexperimental evidencePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.93PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:21511999
Species Distribution
DescriptionQualifierReference
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC977.02S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
cfr1Chs five related protein Cfr1 Negative GeneticPMID:22681890
SPAC9E9.04bcap family homolog (predicted) Negative GeneticPMID:22681890
SPAC12G12.07cconserved fungal protein Negative GeneticPMID:22681890
arf6ADP-ribosylation factor, Arf family Arf6 Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
agn2glucan endo-1,3-alpha-glucosidase Agn2 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
yps1aspartic protease, yapsin Yps1 Negative GeneticPMID:22681890
SPAC750.04cS. pombe specific 5Tm protein family Negative GeneticPMID:22681890
SPAC11G7.01sequence orphan Negative GeneticPMID:22681890
idh2isocitrate dehydrogenase (NAD+) subunit 2 Negative GeneticPMID:22681890
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:22681890
SPAC1565.03sequence orphan Positive GeneticPMID:22681890
fft3fun thirty related protein Fft3 Positive GeneticPMID:22681890
rpl35b60S ribosomal protein L35a (predicted) Positive GeneticPMID:22681890
cuf2middle-meiotic transcription factor Cuf2 Negative GeneticPMID:22681890
rlp1RecA family ATPase Rlp1 Negative GeneticPMID:22681890
SPCC594.04csteroid oxidoreductase superfamily protein (predicted) Positive GeneticPMID:22681890
SPCC1672.04cmitochondrial copper chaperone (predicted) Negative GeneticPMID:22681890
iqw1WD repeat protein, Iqw1 Negative GeneticPMID:22681890
meu6meiotic chromosome segregation protein Meu6 Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
SPAC6C3.02cmitochondrial CHCH domain protein (predicted) Negative GeneticPMID:22681890
pex5peroxisomal targeting signal receptor Pex5 Negative GeneticPMID:22681890
SPAC24H6.11csulfate transporter (predicted) Negative GeneticPMID:22681890
SPAC14C4.07membrane transporter (predicted) Negative GeneticPMID:22681890
SPAC10F6.04RCC domain protein Ats1 (predicted) Negative GeneticPMID:22681890
SPAC15A10.06CPA1 sodium ion/proton antiporter (predicted) Negative GeneticPMID:22681890
cho2phosphatidylethanolamine N-methyltransferase Cho2 Negative GeneticPMID:22681890
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
SPAC17A2.14CorA family magnesium ion transporter Negative GeneticPMID:22681890
rhp23Rad23 homolog Rhp23 Negative GeneticPMID:22681890
SPAC212.04cS. pombe specific DUF999 family protein 1 Positive GeneticPMID:22681890
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Positive GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Positive GeneticPMID:22681890
ely5nuclear pore protein Ely5 Negative GeneticPMID:22681890
str3siderophore-iron transporter Str3 Negative GeneticPMID:22681890
SPAC1687.21phosphoglycerate mutase family (predicted) Negative GeneticPMID:22681890
SPBC18H10.20cendocytosis regulator (predicted) Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Negative GeneticPMID:22681890
SPBC16G5.06sequence orphan Negative GeneticPMID:22681890
SPCC16C4.106-phosphogluconolactonase (predicted) Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
SPAC8C9.04sequence orphan Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
nrm1negative regulator of MBF Negative GeneticPMID:22681890
mug117meiotically upregulated gene Mug117 Negative GeneticPMID:22681890
tim21TIM23 translocase complex subunit Tim21 (predicted) Negative GeneticPMID:22681890
mni1Mago Nashi interacting protein (predicted) Negative GeneticPMID:22681890
mug150sequence orphan Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
SPCC1450.09cphospholipase (predicted) Negative GeneticPMID:22681890
mei2RNA-binding protein involved in meiosis Mei2 Negative GeneticPMID:22681890
mdm31mitochondrial inner membrane protein Mdm31 (predicted) Negative GeneticPMID:22681890
SPBC1348.02S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
SPAC19A8.11crecombination protein Irc6 (predicted) Positive GeneticPMID:22681890
SPAC212.02sequence orphan Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPBC800.02 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC800.02 Retrieval of eukaryotic orthologs
BioGrid SPBC800.02 BioGRID Interaction Datasets
Bähler Lab SPBC800.02 Cell Cycle Expression Profile
Bähler Lab SPBC800.02 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC800.02 Pheromone response/mating expression profiles
Bähler Lab SPBC800.02 Environmental stress expression profiles
Bähler Lab SPBC800.02 Bähler Lab Transcriptome Viewer
Cyclebase SPBC800.02 Cell Cycle Data
PInt SPBC800.02 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC800.02 Entrez Gene
WikiGene2540918cell cycle transcriptional repressor Whi5
Uniprot_genenameWHI5
EntrezGene2540918cell cycle transcriptional repressor Whi5
UniProtKB/SwissProtQ9HGL9Cell cycle transcriptional repressor whi5
ModBaseQ9HGL9Database of comparative protein structure models
Pfam Protein DomainsQ9HGL9Pfam Domain Arrangement
RefSeq PeptideNP_595103cell cycle transcriptional repressor Whi5
RefSeq mRNANM_001021010972h- cell cycle transcriptional repressor Whi5 (whi5), mRNA
European Nucleotide ArchiveCAC01517ENA Protein Mapping
SPD / RIKEN10/10H07Orfeome Localization Data
UniParcUPI000006BE20UniProt Archive

Literature for whi5
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013