lub1 (SPBC887.04c)

Gene Standard Namelub1 ChromosomeII
Systematic IDSPBC887.04c Gene Start3548655
Synonyms Gene End3546128
ProductWD repeat protein Lub1 Gene Length2528
Feature Typeprotein coding CDS Start3548505
Name Description CDS End3546238
Characterisation Statuspublished CDS Length2268

Ensembl Gene Location
  1. cnp1
  2. SPBC1105.18c
  3. SPBC887.01
  4. SPBC887.02
  5. SPNCRNA.1613
  6. noc3
  7. lub1
  8. cwf29
  9. snx3
  10. SPNCRNA.1614
  11. mrpl38
  12. SPBC887.08
  13. lrp1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopylub1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIcdc48PMID:14993272
GO:0043130ubiquitin bindingISOSGD:S000001696GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006281DNA repairISSUniProtKB:P36037GO_REF:0000001
GO:0016574histone ubiquitinationNASGO_REF:0000001
GO:0043161proteasomal ubiquitin-dependent protein catabolic processIMPPMID:14993272
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:14993272
GO:0005737cytoplasmIDAPMID:14993272
GO:0043234protein complexNASGO_REF:0000051
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
135486553548458
235483913548220
335481743546128

References

Region Start End Reference
three_prime_UTR35462373546128PMID:21511999
five_prime_UTR35486553548506PMID:21511999
three_prime_UTR35462373546128PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00400 IPR001680 Pfam WD40 repeat 251 286 104
PF00400 IPR001680 Pfam WD40 repeat 51 83 104
PF00400 IPR001680 Pfam WD40 repeat 132 169 104
PF00400 IPR001680 Pfam WD40 repeat 6 41 104
PF00400 IPR001680 Pfam WD40 repeat 172 206 104
PF00400 IPR001680 Pfam WD40 repeat 211 248 104
PF00400 IPR001680 Pfam WD40 repeat 99 129 104
PF09070 IPR015155 Pfam PLAA family ubiquitin binding, PFU 332 443 1
PF08324 IPR013535 Pfam PUL 463 714 1
SM00320 IPR001680 SMART WD40 repeat 170 207 120
SM00320 IPR001680 SMART WD40 repeat 249 287 120
SM00320 IPR001680 SMART WD40 repeat 209 248 120
SM00320 IPR001680 SMART WD40 repeat 131 169 120
SM00320 IPR001680 SMART WD40 repeat 45 88 120
SM00320 IPR001680 SMART WD40 repeat 92 130 120
SM00320 IPR001680 SMART WD40 repeat 3 41 120
PS51394 IPR015155 Prosite Profiles PLAA family ubiquitin binding, PFU 353 448 1
PS50082 IPR001680 Prosite Profiles WD40 repeat 216 248 100
PS50082 IPR001680 Prosite Profiles WD40 repeat 99 129 100
PS50082 IPR001680 Prosite Profiles WD40 repeat 138 169 100
PS51396 IPR013535 Prosite Profiles PUL 462 717 1
PS50294 IPR017986 Prosite Profiles WD40-repeat-containing domain 10 257 104
G3DSA:2.130.10.10 IPR015943 Gene3D 6 314 144
SSF50978 IPR017986 SuperFamily 3 298 135
SSF48371 IPR016024 SuperFamily 477 679 130
PTHR19849 hmmpanther 1 718 1
PTHR19849:SF0 hmmpanther 1 718 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 110.34 Da
Charge -14.00
Isoelectric point 4.98
Molecular weight 79.22 kDa
Number of residues 718
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide4672.46PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide6745.07PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.57PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.1PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:21511999
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Synthetic Growth DefectPMID:18931302
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:22681890
yox1MBF complex negative regulatory component Yox1 Positive GeneticPMID:22681890
usp103U1 snRNP-associated protein Usp103 (predicted) Negative GeneticPMID:18818364
mfm3M-factor precursor Mfm3 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
SPAC1952.09cacetyl-CoA hydrolase (predicted) Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Positive GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:18818364
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
psk1serine/threonine protein kinase Psk1 Negative GeneticPMID:22681890
rpl190260S ribosomal protein L19 Negative GeneticPMID:22681890
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
erd1Erd1 homolog (predicted) Positive GeneticPMID:22681890
ubc13ubiquitin conjugating enzyme Ubc13 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:22681890
SPAC4G9.12gluconokinase Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rps280240S ribosomal protein S28, Rps2802 Negative GeneticPMID:22681890
SPBC17A3.06phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
otu1ubiquitin-specific cysteine protease, OTU family, Otu1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Positive GeneticPMID:22681890
SPAC24B11.05pyrimidine 5'-nucleotidase (predicted) Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
SPCC18B5.10cTREX complex subunit Tex1 (predicted) Negative GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Positive GeneticPMID:22681890
arb1argonaute binding protein 1 Negative GeneticPMID:22681890
gld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
sub1transcription coactivator PC4 Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
cmk2MAPK-activated protein kinase Cmk2 Positive GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
gyp1GTPase activating protein Gyp1 (predicted) Positive GeneticPMID:22681890
erf4palmitoyltransferase complex subunit Erf4 (predicted) Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Negative GeneticPMID:18818364
SPAC3G9.11cpyruvate decarboxylase (predicted) Positive GeneticPMID:22681890
SPBC15C4.04camino acid permease (predicted) Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Negative GeneticPMID:22681890
SPAC167.07cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rhp26SNF2 family helicase Rhp26 Positive GeneticPMID:22681890
SPAC343.06cphospholipid scramblase (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
mug123meiotically upregulated gene Mug123 Negative GeneticPMID:22681890
erg5C-22 sterol desaturase Erg5 Positive GeneticPMID:18818364
SPAC17A5.09cprotein phosphatase regulatory subunit Glc9 (predicted) Negative GeneticPMID:22681890
lag1sphingosine N-acyltransferase Lag1 Negative GeneticPMID:22681890
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC14C8.15triglyceride lipase-cholesterol esterase (predicted) Negative GeneticPMID:22681890
kap113karyopherin Kap113 Positive GeneticPMID:18818364
elp1elongator subunit Elp1 (predicted) Positive GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
SPCC569.04sequence orphan Negative GeneticPMID:22681890
SPAC9G1.05actin cortical patch component Aip1 (predicted) Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:18818364
bun107WD repeat protein, human WDR48 family Bun107 Positive GeneticPMID:22681890
SPCC338.14adenosine kinase (predicted) Negative GeneticPMID:22681890
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Positive GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:22681890
SPCC594.01DUF1769 family protein Negative GeneticPMID:22681890
kap114karyopherin Kap14 Positive GeneticPMID:18818364
ftp105Ubp5 interacting protein Ftp105 Positive GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
sft1SNARE Sft1 (predicted) Positive GeneticPMID:22681890
cip2RNA-binding protein Cip2 Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pds5cohesin-associated protein Pds5 Negative GeneticPMID:22681890
exo1exonuclease I Exo1 Negative GeneticPMID:22681890
SPAC227.05prefoldin subunit 4 (predicted) Positive GeneticPMID:18818364
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
SPBC2A9.03WD40/YVTN repeat-like Negative GeneticPMID:18818364
SPBC216.01cDNA damage response protein (predicted) Negative GeneticPMID:22681890
rpl240160S ribosomal protein L24 (predicted) Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
snt1Set3 complex subunit Snt1 Phenotypic EnhancementPMID:19547744
spn2septin Spn2 Negative GeneticPMID:22681890
SPAC11D3.155-oxoprolinase (ATP-hydrolizing) (predicted) Negative GeneticPMID:22681890
myo51myosin type V Negative GeneticPMID:18818364
tal1transaldolase (predicted) Negative GeneticPMID:22681890
SPAC4G9.19DNAJ domain protein DNAJB family (predicted) Negative GeneticPMID:22681890
rec14Ski complex subunit Rec14 Negative GeneticPMID:18818364
sts5RNB-like protein Negative GeneticPMID:22681890
SPAC926.06cleucine-rich repeat protein, unknown Negative GeneticPMID:22681890
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
SPBC25B2.10Usp (universal stress protein) family protein Positive GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Positive GeneticPMID:18818364
SPAC4D7.06csiroheme synthase (predicted) Negative GeneticPMID:22681890
moc3transcription factor Moc3 Positive GeneticPMID:22681890
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:18818364
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
rpl270160S ribosomal protein L27 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
mug65spore wall assembly protein (predicted) Negative GeneticPMID:22681890
ubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
SPAC1F5.03cFAD-dependent oxidoreductase involved in late endosome to Golgi transport (predicted) Negative GeneticPMID:22681890
nop10snoRNP pseudouridylase box H/ACA snoRNP complex protein (predicted) Negative GeneticPMID:22681890
atp14F1-ATPase subunit H (predicted) Negative GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mxr2peptide-methionine (R)-S-oxide reductase MsrB Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
vht1vitamin H transporter Vth1 Negative GeneticPMID:22681890
syn1synaptotagmin family C2 domain protein, Syn1 Negative GeneticPMID:22681890
adn2transcription factor (predicted) Negative GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:18818364
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
trk2potassium ion transporter Trk2 Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Positive GeneticPMID:22681890
SPAC23H4.13csequence orphan Negative GeneticPMID:22681890
fft3fun thirty related protein Fft3 Positive GeneticPMID:18818364
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
cid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
SPAC2G11.10cthiosulfate sulfurtransferase, URM1 activating enzyme (predicted) Positive GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC4G8.04GTPase activating protein (predicted) Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
ppk6serine/threonine protein kinase Ppk6 (predicted) Positive GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
gms1UDP-galactose transporter Gms1 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
ulp2SUMO deconjugating cysteine peptidase Ulp2 (predicted) Positive GeneticPMID:22681890
sec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
ryh1GTPase Ryh1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPAPB1E7.11csequence orphan Negative GeneticPMID:22681890
nsk1Clp1-interacting protein Nsk1 Positive GeneticPMID:22681890
SPAC56F8.02AMP binding enzyme (predicted) Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
tif213translation initiation factor eIF2 gamma subunit (predicted) Phenotypic SuppressionPMID:19547744
rfp2SUMO-targeted ubiquitin-protein ligase subunit Rfp2 Phenotypic EnhancementPMID:19547744
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
rds1conserved fungal protein Positive GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
uge1UDP-glucose 4-epimerase Uge1 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc48AAA family ATPase Cdc48 Affinity Capture-WesternPMID:14993272
Contact Curators
External References
Database Identifier Description
NBRP SPBC887.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC887.04c Retrieval of eukaryotic orthologs
BioGrid SPBC887.04c BioGRID Interaction Datasets
Bähler Lab SPBC887.04c Cell Cycle Expression Profile
Bähler Lab SPBC887.04c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC887.04c Pheromone response/mating expression profiles
Bähler Lab SPBC887.04c Environmental stress expression profiles
Bähler Lab SPBC887.04c Bähler Lab Transcriptome Viewer
Cyclebase SPBC887.04c Cell Cycle Data
PInt SPBC887.04c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC887.04c Entrez Gene
EntrezGene2541208WD repeat protein Lub1
Uniprot_genenameLUB1
WikiGene2541208WD repeat protein Lub1
SPD / RIKEN28/28B06Orfeome Localization Data
UniProtKB/SwissProtO94289Ubiquitin homeostasis protein lub1
ModBaseO94289Database of comparative protein structure models
Pfam Protein DomainsO94289Pfam Domain Arrangement
RefSeq PeptideNP_596478WD repeat protein Lub1
RefSeq mRNANM_001022398972h- WD repeat protein Lub1 (lub1), mRNA
European Nucleotide ArchiveCAA21889ENA Protein Mapping
UniParcUPI000228F3C3UniProt Archive

Literature for lub1
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013