lub1 (SPBC887.04c)

Gene Standard Namelub1 Characterisation Statuspublished
Systematic IDSPBC887.04c Feature Typeprotein coding
Synonyms Name Description
ProductWD repeat protein Lub1 Product Size718aa, 79.22 kDa
Genomic Location Chromosome II, 3548655-3546128 (2528nt); CDS:3548505-3546238 (2268nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding831
Annotation ExtensionEvidenceWith/FromReference
ubiquitin binding23
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
DNA repair165
Annotation ExtensionEvidenceWith/FromReference
histone ubiquitination6
Annotation ExtensionEvidenceWith/FromReference
proteasome-mediated ubiquitin-dependent protein catabolic process137
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
protein complex1363
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001023normal growth on cisplatinCell growth assaylub1ΔNullPECO:0000137, PECO:0000103, PECO:0000005PMID:2124741636
FYPO:0001245sensitive to cobalt56
expressivity FYPO_EXT:0000003Cell growth assaylub1ΔNullPECO:0000201, PECO:0000005PMID:22806344
FYPO:0002060viable vegetative cell populationMicroscopylub1ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopylub1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 51 83 104
PF00400 Pfam IPR001680 WD40 repeat 172 206 104
PF00400 Pfam IPR001680 WD40 repeat 7 41 104
PF00400 Pfam IPR001680 WD40 repeat 99 129 104
PF00400 Pfam IPR001680 WD40 repeat 251 286 104
PF00400 Pfam IPR001680 WD40 repeat 132 169 104
PF00400 Pfam IPR001680 WD40 repeat 211 248 104
PF08324 Pfam IPR013535 PUL 463 714 1
PF09070 Pfam IPR015155 PLAA family ubiquitin binding, PFU 332 443 1
SM00320 SMART IPR001680 WD40 repeat 209 248 112
SM00320 SMART IPR001680 WD40 repeat 249 287 112
SM00320 SMART IPR001680 WD40 repeat 170 207 112
SM00320 SMART IPR001680 WD40 repeat 3 41 112
SM00320 SMART IPR001680 WD40 repeat 131 169 112
SM00320 SMART IPR001680 WD40 repeat 45 88 112
SM00320 SMART IPR001680 WD40 repeat 92 130 112
PS50082 Prosite Profiles IPR001680 WD40 repeat 138 169 100
PS51396 Prosite Profiles IPR013535 PUL 462 717 1
PS50082 Prosite Profiles IPR001680 WD40 repeat 216 248 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 99 129 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 10 257 104
PS51394 Prosite Profiles IPR015155 PLAA family ubiquitin binding, PFU 353 448 1
PTHR19849:SF0 HMMPANTHER 1 718 1
PTHR19849 HMMPANTHER 1 718 1 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 6 314 145
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 3 298 135
SSF48371 SuperFamily IPR016024 Armadillo-type fold 477 679 130

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 110.34 Da
Charge -14.00
Isoelectric point 4.98
Molecular weight 79.22 kDa
Number of residues 718
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
32525during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
34231during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
32757during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
34746during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
6745.07during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
34857during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
4672.46during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.1during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
gene structure updated PMID:21511999432
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
cdc48AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48 Affinity Capture-WesternPMID:14993272
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
tal1transaldolase (predicted) Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Positive GeneticPMID:22681890
SPAC3G9.11cpyruvate decarboxylase (predicted) Positive GeneticPMID:22681890
glc9protein phosphatase regulatory subunit Glc9 (predicted) Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
moc3transcription factor Moc3 Positive GeneticPMID:22681890
mug123Schizosaccharomyces specific protein Mug123 Negative GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
SPAC24B11.05pyrimidine 5'-nucleotidase (predicted) Negative GeneticPMID:22681890
spn2septin Spn2 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
rds1conserved fungal protein Positive GeneticPMID:22681890
gyp1GTPase activating protein Gyp1 (predicted) Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
git3G-protein coupled receptor Git3 Positive GeneticPMID:22681890
sft1SNARE Sft1 (predicted) Positive GeneticPMID:22681890
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Negative GeneticPMID:18818364
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Positive GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
SPBC15C4.04camino acid permease (predicted) Negative GeneticPMID:22681890
SPAC4G9.12gluconokinase Positive GeneticPMID:22681890
vht1vitamin H transporter Vht1 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
myo51myosin type V Negative GeneticPMID:18818364
SPBC2A9.03WD40/YVTN repeat-like Negative GeneticPMID:18818364
mug65spore wall assembly protein (predicted) Negative GeneticPMID:22681890
SPAC4G9.19DNAJ domain protein DNAJB family (predicted) Negative GeneticPMID:22681890
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:18818364
otu1ubiquitin-specific cysteine protease, OTU family, Otu1 Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
ado1adenosine kinase (predicted) Negative GeneticPMID:22681890
rhp26SNF2 family helicase Rhp26 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:18818364
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Positive GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
exo1exonuclease I Exo1 Negative GeneticPMID:22681890
cip2RNA-binding protein Cip2 Negative GeneticPMID:22681890
SPAC56F8.02AMP binding enzyme (predicted) Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:22681890
SPAC227.05prefoldin subunit 4 (predicted) Positive GeneticPMID:18818364
rec14Ski complex subunit Rec14 Negative GeneticPMID:18818364
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC4G8.04GTPase activating protein (predicted) Negative GeneticPMID:22681890
atp14F1-ATPase subunit H (predicted) Negative GeneticPMID:22681890
elp1elongator subunit Elp1 (predicted) Positive GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
arb1argonaute inhibitor protein 1 Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
pds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
SPAC11D3.155-oxoprolinase (ATP-hydrolizing) (predicted) Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Positive GeneticPMID:18818364
psy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
erf4palmitoyltransferase complex subunit Erf4 Negative GeneticPMID:22681890
gms1UDP-galactose transporter Gms1 Negative GeneticPMID:22681890
kap113karyopherin Kap113 Positive GeneticPMID:18818364
rps280240S ribosomal protein S28, Rps2802 Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
trk2potassium ion transporter Trk2 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Positive GeneticPMID:22681890
SPAC1F5.03cFAD-dependent oxidoreductase involved in late endosome to Golgi transport (predicted) Negative GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rpl240160S ribosomal protein L24 (predicted) Negative GeneticPMID:22681890
SPAPB1E7.11cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
lag1sphingosine N-acyltransferase Lag1 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
rpl270160S ribosomal protein L27 Negative GeneticPMID:22681890
hul5HECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
set1histone lysine methyltransferase Set1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC343.06cphospholipid scramblase (predicted) Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC926.06cleucine-rich repeat protein, unknown Negative GeneticPMID:22681890
mxr2peptide-methionine (R)-S-oxide reductase MsrB Negative GeneticPMID:22681890
SPCC18B5.10cTREX complex subunit Tex1 (predicted) Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
SPBC14C8.15triglyceride lipase-cholesterol esterase (predicted) Negative GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:22681890
rfp2SUMO-targeted ubiquitin-protein ligase subunit Rfp2 Phenotypic EnhancementPMID:19547744
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
aip1actin cortical patch component Aip1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC4D7.06csiroheme synthase (predicted) Negative GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Positive GeneticPMID:18818364
erg5C-22 sterol desaturase Erg5 Positive GeneticPMID:18818364
ubc13ubiquitin conjugating enzyme Ubc13 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
uge1UDP-glucose 4-epimerase Uge1 Positive GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Positive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
sec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:22681890
SPAC2G11.10cthiosulfate sulfurtransferase, URM1 activating enzyme (predicted) Positive GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
yox1MBF complex corepressor Yox1 Positive GeneticPMID:22681890
SPCC569.04Schizosaccharomyces pombe specific protein Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
ulp2SUMO deconjugating cysteine peptidase Ulp2 (predicted) Positive GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:22681890
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sub1transcription coactivator PC4 Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
ubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
mfm3M-factor precursor Mfm3 Positive GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPAC1952.09cacetyl-CoA hydrolase (predicted) Negative GeneticPMID:22681890
cmk2MAPK-activated protein kinase Cmk2 Positive GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Positive GeneticPMID:22681890
SPCC594.01DUF1769 family protein Negative GeneticPMID:22681890
kap114karyopherin Kap14 Positive GeneticPMID:18818364
ppk6serine/threonine protein kinase Ppk6 (predicted) Positive GeneticPMID:22681890
cid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
usp103U1 snRNP-associated protein Usp103 Negative GeneticPMID:18818364
erd1Erd1 homolog (predicted) Positive GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
adn2transcription factor (predicted) Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
tif213translation initiation factor eIF2 gamma subunit Phenotypic SuppressionPMID:19547744
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Synthetic Growth DefectPMID:18931302
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
gld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:18818364
nop10snoRNP pseudouridylase box H/ACA snoRNP complex protein (predicted) Negative GeneticPMID:22681890
syn1synaptotagmin family C2 domain protein, Syn1 Negative GeneticPMID:22681890
SPBC17A3.06phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:18818364
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
rpl190260S ribosomal protein L19 Negative GeneticPMID:22681890
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
SPAC23H4.13cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
snt1Set3 complex subunit Snt1 Phenotypic EnhancementPMID:19547744
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
nsk1Clp1-interacting, microtubule plus-end binding Nsk1 Positive GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Positive GeneticPMID:22681890
psk1serine/threonine protein kinase Psk1 Negative GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
SPBC25B2.10Usp (universal stress protein) family protein Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC887.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC887.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC887.04c BioGRID Interaction Datasets
Expression Viewer SPBC887.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC887.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC887.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC887.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC887.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC887.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC887.04c Cell Cycle Data
GEO SPBC887.04c GEO profiles
PInt SPBC887.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC887.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC887.04c Fission yeast phenotypic data & analysis
SPD / RIKEN28/28B06Orfeome Localization Data
UniProtKB/SwissProtO94289Ubiquitin homeostasis protein lub1
ModBaseO94289Database of comparative protein structure models
STRINGO94289Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596478WD repeat protein Lub1
RefSeq mRNANM_001022398972h- WD repeat protein Lub1 (lub1), mRNA
European Nucleotide ArchiveCAA21889.2ENA Protein Mapping
UniParcUPI000228F3C3UniProt Archive

Literature for lub1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014