SPBC947.15c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC947.15c Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial NADH dehydrogenase (predicted) Product Size551aa, 60.78 kDa
Genomic Location Chromosome II, 641285-643906 (2622nt); CDS:641686-643341 (1656nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003954NADH dehydrogenase activityISSUniProtKB:Q07500GO_REF:00000013
GO:0050660flavin adenine dinucleotide bindingIEAIPR001327GO_REF:000000234
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006116NADH oxidationISSUniProtKB:Q07500GO_REF:00000017
GO:0006091generation of precursor metabolites and energyNASGO_REF:0000051115
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005743mitochondrial inner membraneISSUniProtKB:Q07500GO_REF:0000001155
GO:0005739mitochondrionIDAPMID:16823372756
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPBC947.15cΔNullPECO:0000005, PECO:0000137PMID:236978061309
FYPO:0002060viable vegetative cell populationMicroscopySPBC947.15cΔNullPMID:204732893755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002110viable bottle-shaped vegetative cellMicroscopySPBC947.15cΔNullPECO:0000005, PECO:0000137PMID:236978066
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1641285643906

UTRs

Region Start End Reference
three_prime_UTR643342643906PMID:21511999
five_prime_UTR641285641685PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00070 Pfam IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain 256 339 6
PF07992 Pfam IPR023753 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 93 232 9
PTHR22915:SF4 HMMPANTHER 29 551 2
PTHR22915 HMMPANTHER 29 551 2
G3DSA:3.50.50.60 Gene3D 90 221 29
G3DSA:3.50.50.60 Gene3D 256 436 29
SSF51905 SuperFamily 90 307 26
SSF51905 SuperFamily 249 433 26
Low complexity (SEG) seg 497 508
Low complexity (SEG) seg 80 91
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 93 112 7
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 194 212 7
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 256 274 7
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 389 411 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.31 Da
Charge 22.00
Isoelectric point 10.04
Molecular weight 60.78 kDa
Number of residues 551
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
20485.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
12057.29during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
4.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
toe4transcription factor, zf-fungal binuclear cluster type(predicted) Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
SPBPB10D8.02carylsulfatase (predicted) Negative GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
ubp2ubiquitin C-terminal hydrolase Ubp2 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
SPAC630.10conserved eukaryotic protein, DUF3321 family Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPBC947.15c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC947.15c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC947.15c BioGRID Interaction Datasets
Expression Viewer SPBC947.15c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC947.15c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC947.15c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC947.15c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC947.15c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC947.15c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC947.15c Cell Cycle Data
GEO SPBC947.15c GEO profiles
PInt SPBC947.15c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540211NADH dehydrogenase
EntrezGene2540211NADH dehydrogenase
SPD / RIKEN34/34G02Orfeome Localization Data
UniProtKB/SwissProtO43090Probable NADH-ubiquinone oxidoreductase C947.15c, mitochondrial
ModBaseO43090Database of comparative protein structure models
StringO43090Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595261NADH dehydrogenase
RefSeq mRNANM_001021168972h- NADH dehydrogenase (SPBC947.15c), mRNA
European Nucleotide ArchiveCAA17043ENA Protein Mapping
UniParcUPI000006B282UniProt Archive

Literature for SPBC947.15c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014