nde1 (SPBC947.15c)


Gene Standard Namende1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC947.15c Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial NADH dehydrogenase (ubiquinone) Nde1 (predicted) Product Size551aa, 60.78 kDa
Genomic Location Chromosome II, 641285-643906 (2622nt); CDS:641686-643341 (1656nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
NADH dehydrogenase (ubiquinone) activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitochondrial ATP synthesis coupled electron transport24
Annotation ExtensionEvidenceWith/FromReference
NADH oxidation6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
mitochondrial inner membrane166
Annotation ExtensionEvidenceWith/FromReference
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
slow vegetative cell population growthnde1ΔNull328
viable vegetative cell populationnde1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable tapered vegetative cellnde1ΔNull5
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons641285..643906
mRNA641285..643906
5' UTR641285..641685PMID:21511999
CDS641686..643341
3' UTR643342..643906PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07992 Pfam IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain 93 232 9
PF00070 Pfam IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain 256 339 6
PTHR22915 HMMPANTHER 35 546 2
PTHR22915:SF28 HMMPANTHER 35 546 2
3.50.50.60 Gene3D 90 221 29
3.50.50.60 Gene3D 256 436 29
SSF51905 SuperFamily 90 307 26
SSF51905 SuperFamily 249 433 26
PR00368 PRINTS 194 212 7
PR00368 PRINTS 389 411 7
PR00368 PRINTS 256 274 7
PR00368 PRINTS 93 112 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.31 Da
Charge 22.00
Isoelectric point 10.04
Molecular weight 60.78 kDa
Number of residues 551
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
32146during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
34582during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
34681during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
31538during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12057.29during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
33005during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
20485.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.9during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withbmt2rRNA (adenine) methyltransferase activity Bmt2 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withcdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
negative genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBPB10D8.02carylsulfatase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtoe4transcription factor, zf-fungal binuclear cluster type(predicted) Negative GeneticPMID:22681890
positive genetic interaction withubp2ubiquitin C-terminal hydrolase Ubp2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC947.15c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC947.15c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC947.15c BioGRID Interaction Datasets
Expression Viewer SPBC947.15c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC947.15c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC947.15c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC947.15c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC947.15c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC947.15c Transcriptome Viewer (Bähler Lab)
GEO SPBC947.15c GEO profiles
PInt SPBC947.15c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC947.15c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC947.15c Fission yeast phenotypic data & analysis
Cyclebase SPBC947.15c.1 Cell Cycle Data
SPD / RIKEN34/34G02Orfeome Localization Data
UniProtKB/SwissProtO43090Probable NADH-ubiquinone oxidoreductase C947.15c, mitochondrial
ModBaseO43090Database of comparative protein structure models
STRINGO43090Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595261mitochondrial NADH dehydrogenase (predicted)
RefSeq mRNANM_001021168972h- mitochondrial NADH dehydrogenase (predicted) (SPBC947.15c), mRNA
European Nucleotide ArchiveCAA17043.1ENA Protein Mapping
UniParcUPI000006B282UniProt Archive

Literature for nde1

Search: Europe PMC or PubMed

Release Version: PomBase:26_53 - 27 May 2015