nup131 (SPBP35G2.06c)

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Gene Standard Name	nup131	Characterisation Status	published
Systematic ID	SPBP35G2.06c	Feature Type	protein coding
Synonyms	Nup133a	Name Description
Product	nucleoporin Nup131	Product Size	1142aa, 131.44 kDa
Genomic Location	Chromosome II, 976901-973022 (3880nt); CDS:976632-973049 (3584nt)

GO Molecular Function

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Term Name

Count

protein binding

900

Annotation Extension	Evidence	With/From	Reference
binds nup107	IPI		PMID:15226438

binds nup107

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0005515	protein binding				900
binds nup107	IPI		PMID:15226438

GO Biological Process

GO Slim Terms

nucleocytoplasmic transport

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Term Name

Count

nucleocytoplasmic transport

109

Annotation Extension	Evidence	With/From	Reference
	ISO	SGD:S000001790	GO_REF:0000024

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0006913	nucleocytoplasmic transport	ISO	SGD:S000001790	GO_REF:0000024	109

GO Cellular Component

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Term Name

Count

cell division site

318

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

cytosol

2298

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

nuclear envelope

130

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

nuclear pore

Annotation Extension	Evidence	Reference
	IDA	PMID:15226438
	IDA	PMID:24637836
during mitotic cell cycle	IDA	PMID:20970342
during meiotic cell cycle	IDA	PMID:20970342

during meiotic cell cycle, mitotic cell cycle

nuclear pore outer ring

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:15226438

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0032153	cell division site	IDA		PMID:16823372	318
GO:0005829	cytosol	IDA		PMID:16823372	2298
GO:0005635	nuclear envelope	IDA		PMID:16823372	130
GO:0005643	nuclear pore	IDA		PMID:24637836	51
during meiotic cell cycle	IDA		PMID:20970342
	IDA		PMID:15226438
during mitotic cell cycle	IDA		PMID:20970342
GO:0031080	nuclear pore outer ring	IDA		PMID:15226438	7

FYPO Single-Allele Phenotypes

Gene Deletion Viability: Viable

Population Phenotype

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Term Name

Genotypes

Count

decreased spore germination frequency

nup131Δ

viable vegetative cell population

3862

nup131Δ

Term ID	Term Name	Evidence	Genotype	Condition	Reference	Count
FYPO:0000581	decreased spore germination frequency	70
	Cell growth assay	nup131Δ	Null	PECO:0000005, PECO:0000137	PMID:24637836
FYPO:0002060	viable vegetative cell population	3862
	Microscopy				PMID:15226438
	Microscopy	nup131Δ	Null	PECO:0000137, PECO:0000005	PMID:23697806
	Microscopy	nup131Δ	Null		PMID:20473289

Cell Phenotype

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Term Name

Genotypes

Count

normal RNA level during vegetative growth

137

affecting rec8

nup131Δ

affecting mei4

nup131Δ

viable vegetative cell with normal cell morphology

nup131Δ

3103

Term ID	Term Name	Evidence	Genotype	Condition	Reference	Count
FYPO:0001317	normal RNA level during vegetative growth	137
affecting rec8	Transcript expression level evidence	nup131Δ	Null		PMID:23658229
affecting mei4	Transcript expression level evidence	nup131Δ	Null		PMID:23658229
FYPO:0002177	viable vegetative cell with normal cell morphology	3103
penetrance FYPO_EXT:0000001	Microscopy	nup131Δ	Null	PECO:0000005, PECO:0000137	PMID:23697806

Transcript

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Transcript Structure

Region	Coordinates	Reference
Exons	976901..975172, 975137..975044, 975002..974617, 974577..974223, 974181..973022
Intron	975171..975138, 975043..975003, 974616..974578, 974222..974182
mRNA	976901..973022
5' UTR	976901..976633	PMID:21511999
CDS	976632..975172, 975137..975044, 975002..974617, 974577..974223, 974181..973049
3' UTR	973048..973022	PMID:21511999

Protein Features

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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID	Database	InterPro	Description	Start	End	Count
PF08801	Pfam	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	44	454	3
PF03177	Pfam	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal	581	1049	3
PTHR13405	HMMPANTHER			12	1118	2
2.130.10.10	Gene3D	IPR015943	WD40/YVTN repeat-like-containing domain	146	458	145
SSF117289	SuperFamily			115	458	4

View domain organization at Pfam

Term ID	Term Name	Reference	Count
PBO:0000190	WD repeat protein

Protein Properties

Ave. residue weight	115.10 Da
Charge	-22.00
Codon Adaptation Index	0.39
Isoelectric point	5.28
Molecular weight	131.44 kDa
Number of residues	1142

Sequence

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Gene Expression

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Quantitative Gene Expression

View graphical display of gene expression data for nup131 (SPBP35G2.06c)

Protein Level

Molecules/Cell (average)	Extension	Condition	Scale	Evidence	Reference
233.66	during GO:0072690	PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633

RNA Level

Molecules/Cell (average)	Extension	Condition	Scale	Evidence	Reference
0.77	during GO:0072690	PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633
0.3	during cell quiescence following G1 arrest due to nitrogen limitation	PECO:0000127, PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633

Warning

Description	Qualifier	Reference	Count
gene structure updated		PMID:21511999	435

Taxonomic Conservation

Description	Qualifier	Reference	Count
predominantly single copy (one to one)			3087
conserved in fungi			4608
conserved in eukaryotes			4516
conserved in metazoa			3498
conserved in vertebrates			3473
conserved in eukaryotes only			2525

Orthologs

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Manually curated orthologous groups

Species	Gene	Description	Links	Count

Orthologs in Compara

Physical Interactions

Source: BioGRID

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View the HCPIN interactions in esyN

	Gene	Product	Evidence	Reference
affinity captured by	nup107	nucleoporin Nup107	Affinity Capture-Western	PMID:15226438

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBP35G2.06c into the Query Builder
View these interactions in esyN View network in esyN

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	Gene	Product	Evidence	Reference
positive genetic interaction with	sec28	coatomer epsilon subunit (predicted)	Positive Genetic	PMID:18818364
positive genetic interaction with	med6	mediator complex subunit Med6	Positive Genetic	PMID:18818364
positive genetic interaction with	med20	mediator complex subunit Med20	Positive Genetic	PMID:18818364
positive genetic interaction with	ask1	DASH complex subunit Ask1	Positive Genetic	PMID:18818364
positive genetic interaction with	rpa12	DNA-directed RNA polymerase complex I subunit Rpa12	Positive Genetic	PMID:18818364
positive genetic interaction with	hip1	hira protein, histone chaperone Hip1	Positive Genetic	PMID:18818364
positive genetic interaction with	scs7	sphingosine hydroxylase Scs7	Positive Genetic	PMID:18818364
negative genetic interaction with	ryh1	GTPase Ryh1	Negative Genetic	PMID:22681890
negative genetic interaction with	mtg1	mitochondrial GTPase involved in translation Mtg1 (predicted)	Negative Genetic	PMID:22681890
negative genetic interaction with	epe1	Jmjc domain chromatin associated protein Epe1	Negative Genetic	PMID:22681890
negative genetic interaction with	SPCP1E11.10	ankyrin repeat protein, unknown biological role	Negative Genetic	PMID:22681890
negative genetic interaction with	amo1	nuclear rim protein Amo1	Negative Genetic	PMID:18818364
negative genetic interaction with	emc1	ER membrane protein complex subunit Emc1 (predicted)	Negative Genetic	PMID:22681890
negative genetic interaction with	SPAC3H5.08c	WD repeat protein, human WDR44 family	Negative Genetic	PMID:22681890
synthetic growth defect with	nup132	nucleoporin Nup132	Synthetic Growth Defect	PMID:24637836

External References

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Database	Identifier	Description
NBRP	SPBP35G2.06c	Fission yeast strain database, National BioResource Project (Japan)
YOGY	SPBP35G2.06c	Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid	SPBP35G2.06c	BioGRID Interaction Datasets
Expression Viewer	SPBP35G2.06c	Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer	SPBP35G2.06c	Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer	SPBP35G2.06c	Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer	SPBP35G2.06c	Environmental stress expression profiles (Bähler Lab)
Pomb(A)	SPBP35G2.06c	Polyadenylation Viewer (Gullerova lab)
pombeTV	SPBP35G2.06c	Transcriptome Viewer (Bähler Lab)
GEO	SPBP35G2.06c	GEO profiles
PInt	SPBP35G2.06c	Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas	SPBP35G2.06c	Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO	SPBP35G2.06c	Fission yeast phenotypic data & analysis
Cyclebase	SPBP35G2.06c.1	Cell Cycle Data
SPD / RIKEN	48/48D11	Orfeome Localization Data
UniProtKB/SwissProt	Q9P797	Nucleoporin nup131
ModBase	Q9P797	Database of comparative protein structure models
STRING	Q9P797	Network display of known and predicted interactions and functional associations
RefSeq Peptide	NP_595381	nucleoporin Nup131
RefSeq mRNA	NM_001021288	972h- nucleoporin Nup131 (nup131), mRNA
European Nucleotide Archive	CAB87368.3	ENA Protein Mapping
UniParc	UPI00000696FA	UniProt Archive

Literature for nup131

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Release Version: PomBase:30_62 - 30 Jan 2017

nup131 (SPBP35G2.06c)

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GO Slim Terms

Population Phenotype

Cell Phenotype

Transcript Structure

Graphical View

Protein Families and Domains

Protein Properties

Quantitative Gene Expression

Protein Level

RNA Level

Manually curated orthologous groups

Orthologs in Compara

Source: BioGRID

Source: BioGRID