rpp201 (SPBP8B7.06)


Gene Standard Namerpp201 Characterisation Statuspublished
Systematic IDSPBP8B7.06 Feature Typeprotein coding
Synonymsrpa2, rpp2, rpp2-1 Name Description
Product60S acidic ribosomal protein A2 Product Size110aa, 11.16 kDa
Genomic Location Chromosome II, 3643177-3643653 (477nt); CDS:3643189-3643584 (396nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
structural constituent of ribosome255
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cytoplasmic translational elongation193
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2316
Annotation ExtensionEvidenceWith/FromReference
cytosolic large ribosomal subunit83
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
slow vegetative cell population growthrpa2-Not specified318
viable vegetative cell populationrpp201ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cellrpa2-Not specified3615
viable vegetative cell with normal cell morphologyrpp201ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
136431773643497
236435613643653

UTRs

Region Coordinates Reference
five_prime_UTR3643177..3643188PMID:21511999
three_prime_UTR3643585..3643653PMID:21511999
mRNA3643177..3643653
exon3643189..3643497,3643561..3643584
intron3643498..3643560
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00428 Pfam IPR001813 Ribosomal protein L10/L12 17 109 7
PTHR21141 HMMPANTHER 1 110 8
MF_01478 hamap IPR027534 Ribosomal protein L12 family 2 110 6
PR00456 PRINTS IPR001859 Trypanosoma cruzi ribosomal protein P2-like 97 108 3
PR00456 PRINTS IPR001859 Trypanosoma cruzi ribosomal protein P2-like 36 47 3
PR00456 PRINTS IPR001859 Trypanosoma cruzi ribosomal protein P2-like 82 96 3
PR00456 PRINTS IPR001859 Trypanosoma cruzi ribosomal protein P2-like 21 32 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 101.44 Da
Charge -17.00
Isoelectric point 3.69
Molecular weight 11.16 kDa
Number of residues 110
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
present during mitotic M phaseS100
present during mitotic M phaseS28
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S28 PMID:21712547
present during mitotic M phase experimental evidence S100 PMID:21712547
phosphorylated residue 1923
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
513386during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
532063during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
633373during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
566086during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
494436during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
147874.99during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
78738.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
95during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
8.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byhhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
affinity captured byhhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
positive genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Positive GeneticPMID:22681890
positive genetic interaction withatg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withclr1SHREC complex subunit Clr1 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
negative genetic interaction withdsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withgma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
negative genetic interaction withgst1glutathione S-transferase Gst1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
positive genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withnro1negative regulator of Ofd1, Nro1 Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
negative genetic interaction withpek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
negative genetic interaction withppk9serine/threonine protein kinase Ppk9 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withpub3HECT-type ubiquitin-protein ligase E3 Pub3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withsnu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
positive genetic interaction withSPAC343.04cWD repeat protein, human WDR26 family, ubiquitin ligase complex subunit (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC513.07flavonol reductase/cinnamoyl-CoA reductase family Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withtps1alpha,alpha-trehalose-phosphate synthase Negative GeneticPMID:22681890
positive genetic interaction withtps2trehalose-phosphate synthase Tps2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withvps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBP8B7.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBP8B7.06 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBP8B7.06 BioGRID Interaction Datasets
Expression Viewer SPBP8B7.06 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBP8B7.06 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBP8B7.06 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBP8B7.06 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBP8B7.06 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBP8B7.06 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBP8B7.06 Cell Cycle Data
GEO SPBP8B7.06 GEO profiles
PInt SPBP8B7.06 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBP8B7.06 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBP8B7.06 Fission yeast phenotypic data & analysis
SPD / RIKEN31/31D03Orfeome Localization Data
UniProtKB/SwissProtP0809460S acidic ribosomal protein P2-alpha
ModBaseP08094Database of comparative protein structure models
STRINGP08094Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59651360S acidic ribosomal protein P2A
RefSeq mRNANM_001022434972h- 60S acidic ribosomal protein P2A (rpp201), mRNA
European Nucleotide ArchiveY00466ENA EMBL mapping
European Nucleotide ArchiveAAA35335.1ENA Protein Mapping
European Nucleotide ArchiveCAA21791.1ENA Protein Mapping
UniParcUPI0000134260UniProt Archive

Literature for rpp201

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015