stc1 (SPBP8B7.28c)

Gene Standard Namestc1 ChromosomeII
Systematic IDSPBP8B7.28c Gene Start3691942
Synonyms Gene End3691008
ProductLIM-like protein linking chromatin modification to RNAi, Stc1 Gene Length935
Feature Typeprotein coding CDS Start3691848
Name DescriptionSiRNA To Chromatin CDS End3691201
Characterisation Statuspublished CDS Length648

Ensembl Gene Location
  1. SPBP8B7.23
  2. atg8
  3. cyp4
  4. SPBP8B7.26
  5. SPNCRNA.1630
  6. mug30
  7. stc1
  8. SPBP8B7.29
  9. thi5
  10. SPBP8B7.31
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000029abnormal chromosome segregationno_name (unrecorded)unrecordedPMID:20211136
FYPO:0000085sensitive to camptothecincompetitive growth assay evidencestc1delta (deletion)deletionPMID:20537132
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidencestc1delta (deletion)deletionPMID:20537132
FYPO:0000220accumulation of centromeric outer repeat transcriptsno_name (unrecorded)unrecordedPMID:20211136
FYPO:0000228lagging mitotic chromosomesno_name (unrecorded)unrecordedPMID:20211136
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencestc1delta (deletion)deletionPMID:20537132
FYPO:0000269sensitive to microtubule depolymerizing drugsno_name (unrecorded)unrecordedPMID:20211136
competitive growth assay evidencestc1delta (deletion)deletionPMID:20537132
FYPO:0000273centromeric outer repeat transcripts absentno_name (unrecorded)unrecordedPMID:20211136
FYPO:0002060viable vegetative cell populationMicroscopystc1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIago1PMID:20211136
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000070mitotic sister chromatid segregationIMPPMID:20211136
GO:0007126meiosisIMPPMID:16169489
GO:0030702chromatin silencing at centromereIMPPMID:20211136
GO:0031048chromatin silencing by small RNAIMPPMID:20211136
GO:0035389establishment of chromatin silencing at silent mating-type cassetteIMPPMID:20211136
GO:0035390establishment of chromatin silencing at telomereIMPPMID:20211136
GO:0044382CLRC ubiquitin ligase complex localization to heterochromatin
has_input CLRC ubiquitin ligase complexIMPPMID:20211136
GO:0051570regulation of histone H3-K9 methylationIMPPMID:20211136
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005730nucleolusIDAPMID:16823372
GO:0031618nuclear centromeric heterochromatin
localization_dependent_on chromatin silencing by small RNAIDAPMID:20211136
GO:0043494CLRC ubiquitin ligase complexIDAPMID:20211136
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
136919423691008

References

Region Start End Reference
three_prime_UTR36912003691008PMID:21511999
three_prime_UTR36912003691008PMID:21511999
five_prime_UTR36919423691849PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF12898 IPR024630 Pfam Stc1 domain 41 122 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 116.63 Da
Charge -3.00
Isoelectric point 5.69
Molecular weight 25.07 kDa
Number of residues 215
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.2PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide0.67PMID:23101633
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
conserved in fungi only
conserved in fungi
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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
par2protein phosphatase regulatory subunit Par2 Positive GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
sir2Sir2 family histone deacetylase Sir2 Phenotypic SuppressionPMID:20211136
hhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
ers1RNA-silencing factor Ers1 Positive GeneticPMID:22681890
dsk1SR protein-specific kinase Dsk1 Positive GeneticPMID:22681890
nsk1Clp1-interacting protein Nsk1 Negative GeneticPMID:22681890
mst2histone acetyltransferase Mst2 Synthetic RescuePMID:21289066
fft3fun thirty related protein Fft3 Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
rik1silencing protein Rik1 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
cyp7cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 (predicted) Negative GeneticPMID:22681890
top1DNA topoisomerase I Positive GeneticPMID:22681890
trm10tRNA m(1)G methyltransferase Trm10 (predicted) Positive GeneticPMID:22681890
vrp1verprolin Positive GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Positive GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
SPAC343.04cWD repeat protein, human WDR26 family, ubiquitin ligase complex subunit (predicted) Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Phenotypic SuppressionPMID:20211136
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
Phenotypic SuppressionPMID:20211136
SPAC139.03transcription factor, zf-fungal binuclear cluster type (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ebp2rRNA processing protein Ebp2 (predicted) Affinity Capture-MSPMID:20211136
rik1silencing protein Rik1 Affinity Capture-WesternPMID:22319459
Affinity Capture-WesternPMID:20211136
Affinity Capture-MS
pcu4cullin 4 Affinity Capture-MSPMID:20211136
SPAC23G3.06U3 snoRNP protein Nop58 (predicted) Affinity Capture-MSPMID:20211136
ago1argonaute Reconstituted ComplexPMID:20211136
Affinity Capture-Western
ned8ubiquitin-like protein modifier Ned8 Affinity Capture-MSPMID:20211136
clr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:20211136
SPAC1F12.07phosphoserine aminotransferase (predicted) Affinity Capture-MSPMID:20211136
ers1RNA-silencing factor Ers1 Affinity Capture-WesternPMID:22733737
SPBC646.10cU3 snoRNP protein Nop56 (predicted) Affinity Capture-MSPMID:20211136
mas5DNAJ domain protein Mas5 (predicted) Affinity Capture-MSPMID:20211136
raf1Rik1-associated factor Raf1 Affinity Capture-MSPMID:20211136
Affinity Capture-Western
raf2Rik1-associated factor Raf2 Affinity Capture-MSPMID:20211136
Affinity Capture-Western
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External References
Database Identifier Description
NBRP SPBP8B7.28c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBP8B7.28c Retrieval of eukaryotic orthologs
BioGrid SPBP8B7.28c BioGRID Interaction Datasets
Bähler Lab SPBP8B7.28c Cell Cycle Expression Profile
Bähler Lab SPBP8B7.28c Meiosis/Sporulation Expression Profies
Bähler Lab SPBP8B7.28c Pheromone response/mating expression profiles
Bähler Lab SPBP8B7.28c Environmental stress expression profiles
Bähler Lab SPBP8B7.28c Bähler Lab Transcriptome Viewer
Cyclebase SPBP8B7.28c Cell Cycle Data
PInt SPBP8B7.28c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBP8B7.28c Entrez Gene
WikiGene2541372sequence orphan
EntrezGene2541372sequence orphan
SPD / RIKEN07/07D12Orfeome Localization Data
UniProtKB/SwissProtO94276Meiotic chromosome segregation protein P8B7.28c
ModBaseO94276Database of comparative protein structure models
Pfam Protein DomainsO94276Pfam Domain Arrangement
RefSeq PeptideNP_596535sequence orphan
RefSeq mRNANM_001022456972h- sequence orphan (SPBP8B7.28c), mRNA
European Nucleotide ArchiveCAA21813ENA Protein Mapping
UniParcUPI000006B57EUniProt Archive

Literature for stc1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013