gal10 (SPBPB2B2.12c)


Gene Standard Namegal10 Characterisation Statuspublished
Systematic IDSPBPB2B2.12c Feature Typeprotein coding
Synonyms Name Description
ProductUDP-glucose 4-epimerase/aldose 1-epimerase Gal10 Product Size713aa, 80.67 kDa
Genomic Location Chromosome II, 4487569-4484023 (3547nt); CDS:4487418-4485277 (2142nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
aldose 1-epimerase activity1
Annotation ExtensionEvidenceWith/FromReference
carbohydrate binding16
Annotation ExtensionEvidenceWith/FromReference
UDP-glucose 4-epimerase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
galactose metabolic process6
Annotation ExtensionEvidenceWith/FromReference
protein galactosylation10
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
nucleus2691
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationgal10Δ3844

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologygal10Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4487569..4484023
mRNA4487569..4484023
5' UTR4487569..4487419PMID:21511999
CDS4487418..4485277
3' UTR4485276..4484023PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF16363 Pfam IPR016040 NAD(P)-binding domain 9 336 3
PF01263 Pfam IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase 372 688 1
PS00545 Prosite Patterns IPR018052 Aldose 1-epimerase, conserved site 528 537 1
PTHR10366:SF433 HMMPANTHER 7 365 2
PTHR10366 HMMPANTHER 7 365 7
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 3 187 100
3.90.25.10 Gene3D Bifunctional polymyxin resistance protein, ArnA 276 349 3
3.90.25.10 Gene3D Bifunctional polymyxin resistance protein, ArnA 188 240 3
2.70.98.10 Gene3D IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup 371 691 1
SSF51735 SuperFamily IPR016040 NAD(P)-binding domain 6 346 88
SSF74650 SuperFamily IPR011013 Galactose mutarotase-like domain 365 689 6
TIGR01179 TIGRFAM IPR005886 UDP-glucose 4-epimerase GalE 8 344 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.14 Da
Charge 2.00
Codon Adaptation Index 0.37
Isoelectric point 6.72
Molecular weight 80.67 kDa
Number of residues 713
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1677
present during mitotic M phaseS709
present during mitotic M phaseS704
present during mitotic M phaseS706
S539, S561, S706
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S709 PMID:21712547
present during mitotic M phase experimental evidence S704 PMID:21712547
present during mitotic M phase experimental evidence S706 PMID:21712547
experimental evidence S539 PMID:24763107
experimental evidence S561 PMID:24763107
experimental evidence S706 PMID:24763107
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased in presence of purvalanol A expression microarray evidencePMID:22840777

Quantitative Gene Expression

View graphical display of gene expression data for gal10 (SPBPB2B2.12c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
21545during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
20561during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
20597during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
23816during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
125.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
22364during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.14during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.14during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
metabolic disorders143
carbohydrate metabolism disorders11
galactosemia3
Genome Organisation
DescriptionQualifierReferenceCount
divergently orientated to functionally related gene10
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in bacteria1002
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBPB2B2.12c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBPB2B2.12c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc4 Negative GeneticPMID:21504829
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
positive genetic interaction withsgf73SAGA complex subunit Sgf73 Positive GeneticPMID:25076038
External References
Database Identifier Description
NBRP SPBPB2B2.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBPB2B2.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBPB2B2.12c BioGRID Interaction Datasets
Expression Viewer SPBPB2B2.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBPB2B2.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBPB2B2.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBPB2B2.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBPB2B2.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBPB2B2.12c Transcriptome Viewer (Bähler Lab)
GEO SPBPB2B2.12c GEO profiles
PInt SPBPB2B2.12c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBPB2B2.12c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBPB2B2.12c Fission yeast phenotypic data & analysis
Cyclebase SPBPB2B2.12c.1 Cell Cycle Data
SPD / RIKEN49/49D07Orfeome Localization Data
IntEnz5.1.3.3Integrated relational Enzyme database
Rhea5.1.3.3Annotated reactions database
IntEnz5.1.3.2Integrated relational Enzyme database
Rhea5.1.3.2Annotated reactions database
UniProtKB/SwissProtQ9HDU3Bifunctional protein gal10 UDP-glucose 4-epimerase Aldose 1-epimerase
ModBaseQ9HDU3Database of comparative protein structure models
STRINGQ9HDU3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596858UDP-glucose 4-epimerase/aldose 1-epimerase Gal10
RefSeq mRNANM_001023881972h- UDP-glucose 4-epimerase/aldose 1-epimerase Gal10 (gal10), mRNA
European Nucleotide ArchiveCAC21414.1ENA Protein Mapping
MetaCycPWY-3821D-galactose degradation III
MetaCycPWY-6317D-galactose degradation I (Leloir pathway)
MetaCycPWY-6397Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
MetaCycPWY-6527Stachyose degradation
MetaCycPWY-7328Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis
MetaCycPWY-7344UDP-D-galactose biosynthesis
KEGG00010+5.1.3.3Glycolysis / Gluconeogenesis
KEGG00052+5.1.3.2Galactose metabolism
KEGG00052+5.1.3.3Galactose metabolism
KEGG00520+5.1.3.2Amino sugar and nucleotide sugar metabolism
UniParcUPI000012B0C8UniProt Archive
UniPathwayUPA00214Carbohydrate metabolism; galactose metabolism
UniPathwayUPA00242Carbohydrate metabolism; hexose metabolism

Literature for gal10

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016