tal1 (SPCC1020.06c)


Gene Standard Nametal1 Characterisation Statusbiological role inferred
Systematic IDSPCC1020.06c Feature Typeprotein coding
Synonyms Name Description
Producttransaldolase (predicted) Product Size322aa, 35.24 kDa
Genomic Location Chromosome III, 773329-774834 (1506nt); CDS:773498-774466 (969nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
pentose-phosphate shunt, non-oxidative branch4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4213
Annotation ExtensionEvidenceWith/FromReference
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationtal1Δ3837

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologytal1Δ3100
Target Of
OntologyRelationshipGeneProduct
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons773329..773410, 773488..774834
Intron773411..773487
5' UTR773329..773410, 773488..773497PMID:21511999
3' UTR774467..774834PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00923 Pfam IPR001585 Transaldolase/Fructose-6-phosphate aldolase 14 313 1
PS00958 Prosite Patterns IPR018225 Transaldolase, active site 129 146 1
PS01054 Prosite Patterns IPR018225 Transaldolase, active site 31 39 1
PTHR10683:SF18 HMMPANTHER 1 320 1
PTHR10683 HMMPANTHER IPR001585 Transaldolase/Fructose-6-phosphate aldolase 1 320 1
3.20.20.70 Gene3D IPR013785 Aldolase-type TIM barrel 1 319 35
SSF51569 SuperFamily 1 320 9
MF_00492 HAMAP IPR004730 Transaldolase type 1 1 320 1
TIGR00874 TIGRFAM IPR004730 Transaldolase type 1 3 320 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.44 Da
Charge -2.00
Codon Adaptation Index 0.76
Isoelectric point 5.54
Molecular weight 35.24 kDa
Number of residues 322
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during cellular response to thiabendazoleS225
present during cellular response to thiabendazoleS68
present during cellular response to thiabendazoleS269
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S225 PMID:18257517
present during cellular response to thiabendazole IDA S68 PMID:18257517
present during cellular response to thiabendazole IDA S269 PMID:18257517
mannosylated residue 89
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence PMID:26644575
phosphorylated residue 1930
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
ubiquitinylated lysineK28, K266 512
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K266 PMID:26412298
mass spectrometry evidence K28 PMID:26412298
IDA PMID:26412298
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for tal1 (SPCC1020.06c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
766740during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
800152during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
732986during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
840616during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
747526during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
150632.97during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
70615.78during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
62during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
6.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in bacteria1001
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1020.06c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
affinity captured bycwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
affinity captured byfar8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
affinity captured bycrp79poly(A) binding protein Crp79 Affinity Capture-RNAPMID:20531409
binds activation domain construct withtal1transaldolase (predicted) Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1020.06c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withcut1separase/separin Negative GeneticPMID:22681890
negative genetic interaction withpsl1cyclin pho85 family Psl1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1B3.02ctranscription elongation factor, Elf1 family (predicted) Negative GeneticPMID:22681890
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withlub1WD repeat protein Lub1 Negative GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withfml2ATP-dependent 3' to 5' DNA helicase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
negative genetic interaction withsrp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
negative genetic interaction withppm1leucine carboxyl methyltransferase, involved in regulation of autophagy Ppm1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withdsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
negative genetic interaction withplb1phospholipase B homolog Plb1 Negative GeneticPMID:22681890
negative genetic interaction withint6eIF3e subunit Int6 Negative GeneticPMID:22681890
positive genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Positive GeneticPMID:22681890
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:22681890
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
positive genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtps1alpha,alpha-trehalose-phosphate synthase [UDP-forming] Positive GeneticPMID:22681890
positive genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Positive GeneticPMID:22681890
positive genetic interaction withlsc1Lsk1 associated cyclin Positive GeneticPMID:22681890
positive genetic interaction withres2MBF transcription factor complex subunit Res2 Positive GeneticPMID:22681890
positive genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Positive GeneticPMID:22681890
positive genetic interaction withdsk1SR protein-specific kinase Dsk1 Positive GeneticPMID:22681890
positive genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
positive genetic interaction withcdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
positive genetic interaction withrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1020.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1020.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1020.06c BioGRID Interaction Datasets
Expression Viewer SPCC1020.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1020.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1020.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1020.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1020.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1020.06c Transcriptome Viewer (Bähler Lab)
GEO SPCC1020.06c GEO profiles
PInt SPCC1020.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1020.06c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1020.06c Fission yeast phenotypic data & analysis
Cyclebase SPCC1020.06c.1 Cell Cycle Data
IntEnz2.2.1.2Integrated relational Enzyme database
Rhea2.2.1.2Annotated reactions database
SPD / RIKEN13/13G10Orfeome Localization Data
UniProtKB/SwissProtO42700Transaldolase
ModBaseO42700Database of comparative protein structure models
STRINGO42700Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587953transaldolase (predicted)
MetaCycPWY-1861Formaldehyde assimilation II (RuMP Cycle)
MetaCycPWY-5723Rubisco shunt
KEGG00030+2.2.1.2Pentose phosphate pathway
UniPathwayUPA00115Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3

Literature for tal1

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016