gnr1 (SPCC1020.09)

Gene Standard Namegnr1 ChromosomeIII
Systematic IDSPCC1020.09 Gene Start767541
Synonyms Gene End765936
Productheterotrimeric G protein beta subunit Gnr1 Gene Length1606
Feature Typeprotein coding CDS Start767369
Name DescriptionG protein Negative Regulator CDS End766170
Characterisation Statuspublished CDS Length1200

Ensembl Gene Location
  1. oca2
  2. SPNCRNA.1156
  3. SPNCRNA.1157
  4. SPNCRNA.1158
  5. gnr1
  6. SPCC1020.08
  7. SPCC1020.07
  8. SPNCRNA.1159
  9. tal1
Fission Yeast Phenotype Ontology

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000302abnormal response to pheromoneReporter gene assaygnr1-delta (deletion)deletionPMID:16884933
FYPO:0000685transcriptional response to pheromone at decreased pheromone levelReporter gene assaygnr1-delta (deletion)deletionPMID:16884933
FYPO:0000781decreased transcriptionReporter gene assaynot recorded (wild type)wild_typeOverexpressionPMID:16884933
FYPO:0000987decreased transcriptional response to pheromone at normal pheromone levelReporter gene assaygnr1+ (wild type)wild_typeOverexpressionPMID:16884933
FYPO:0002060viable vegetative cell populationMicroscopygnr1delta (deletion)deletionPMID:20473289
gnr1delta (deletion)deletionPMID:12618370
GO Molecular Function

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0004871signal transducer activity
contributes_toTASPMID:16884933
GO:0005515protein bindingIPIPMID:16884933
IPIgpa1PMID:16884933
GO Biological Process

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathwayIMPPMID:16884933
GO:0090029negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionIMPPMID:16884933
GO Cellular Component

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0005829cytosolIDAPMID:16823372
GO:0005834heterotrimeric G-protein complexIPIgpa1PMID:16884933
Transcript
Contact Curators
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1767541765936

References

Region Start End Reference
three_prime_UTR766169765936PMID:21511999
five_prime_UTR767541767370PMID:21511999
three_prime_UTR766169765936PMID:21511999
Protein Features
Contact Curators

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
SM00320 IPR001680 SMART WD40 repeat 139 182 120
SM00320 IPR001680 SMART WD40 repeat 39 74 120
SM00320 IPR001680 SMART WD40 repeat 287 328 120
SM00320 IPR001680 SMART WD40 repeat 244 283 120
SM00320 IPR001680 SMART WD40 repeat 100 136 120
SM00320 IPR001680 SMART WD40 repeat 201 238 120
G3DSA:2.130.10.10 IPR015943 Gene3D 49 371 144
SSF50978 IPR017986 SuperFamily 50 370 135
PTHR13211 hmmpanther 1 398 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 114.66 Da
Charge -2.00
Isoelectric point 6.24
Molecular weight 45.75 kDa
Number of residues 399
Sequence
Contact Curators
Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide360.11PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.34PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide0.93PMID:23101633
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

Contact Curators
Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC18G6.13sequence orphan Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
spf31DNAJ protein Spf31 (predicted) Negative GeneticPMID:22681890
rps40240S ribosomal protein S4 (predicted) Positive GeneticPMID:22681890
SPCC338.14adenosine kinase (predicted) Negative GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
ppk31serine/threonine protein kinase Ppk31 (predicted) Positive GeneticPMID:18818364
ryh1GTPase Ryh1 Positive GeneticPMID:18818364
get1GET complex subunit Get1 (predicted) Negative GeneticPMID:18818364
ptn1phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1 Positive GeneticPMID:18818364
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
uap2U2 snRNP-associated protein Uap2 Negative GeneticPMID:22681890
dsk1SR protein-specific kinase Dsk1 Negative GeneticPMID:22681890
csk1cyclin-dependent kinase activating kinase Csk1 Positive GeneticPMID:22681890
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
trp663TRP-like ion channel (predicted) Negative GeneticPMID:22681890
cmk1calcium/calmodulin-dependent protein kinase Cmk1 Positive GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
amo1nuclear rim protein Amo1 Positive GeneticPMID:18818364
cbp1CENP-B homolog Positive GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Positive GeneticPMID:18818364
pck1protein kinase C (PKC)-like Pck1 Positive GeneticPMID:22681890
SPAC17G6.03phosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Positive GeneticPMID:18818364
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
Contact Curators
External References
Database Identifier Description
NBRP SPCC1020.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1020.09 Retrieval of eukaryotic orthologs
BioGrid SPCC1020.09 BioGRID Interaction Datasets
Bähler Lab SPCC1020.09 Cell Cycle Expression Profile
Bähler Lab SPCC1020.09 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC1020.09 Pheromone response/mating expression profiles
Bähler Lab SPCC1020.09 Environmental stress expression profiles
Bähler Lab SPCC1020.09 Bähler Lab Transcriptome Viewer
Cyclebase SPCC1020.09 Cell Cycle Data
PInt SPCC1020.09 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC1020.09 Entrez Gene
WikiGene2539303heterotrimeric G protein beta subunit Gnr1
Uniprot_genenameGNR1
EntrezGene2539303heterotrimeric G protein beta subunit Gnr1
UniProtKB/SwissProtO59762Guanine nucleotide-binding protein negative regulator 1
ModBaseO59762Database of comparative protein structure models
Pfam Protein DomainsO59762Pfam Domain Arrangement
RefSeq PeptideNP_587950heterotrimeric G protein beta subunit Gnr1
RefSeq mRNANM_001022941972h- heterotrimeric G protein beta subunit Gnr1 (gnr1), mRNA
European Nucleotide ArchiveCAA18997ENA Protein Mapping
SPD / RIKEN44/44A05Orfeome Localization Data
UniParcUPI000006BDF2UniProt Archive

Literature for gnr1
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013