SPCC1183.02


Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPCC1183.02 Feature Typeprotein coding
Synonyms Name Description
Productglutathione S-transferase, translational elongation factor eEF1 (predicted) Product Size220aa, 25.50 kDa
Genomic Location Chromosome III, 594963-596054 (1092nt); CDS:595060-596002 (943nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
glutathione transferase activity8
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cytoplasmic translation469
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationSPCC1183.02Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologySPCC1183.02Δ3102
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons594963..595212, 595493..596054
Intron595213..595492
mRNA594963..596054
5' UTR594963..595059PMID:21511999
CDS595060..595212, 595493..596002
3' UTR596003..596054AU013839
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00043 Pfam IPR004046 Glutathione S-transferase, C-terminal 127 200 6
PF02798 Pfam IPR004045 Glutathione S-transferase, N-terminal 4 72 6
PS50405 Prosite Profiles IPR010987 Glutathione S-transferase, C-terminal-like 89 216 7
PS50404 Prosite Profiles IPR004045 Glutathione S-transferase, N-terminal 2 81 5
PTHR11260 HMMPANTHER 4 200 6
PTHR11260:SF143 HMMPANTHER 4 200 3
1.20.1050.10 Gene3D IPR010987 Glutathione S-transferase, C-terminal-like 82 208 11
3.40.30.10 Gene3D IPR012336 Thioredoxin-like fold 1 79 36
SSF47616 SuperFamily IPR010987 Glutathione S-transferase, C-terminal-like 80 208 12
SSF52833 SuperFamily IPR012336 Thioredoxin-like fold 1 76 38

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000261thioredoxin familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000261

Protein Properties

Ave. residue weight 115.93 Da
Charge 1.00
Codon Adaptation Index 0.59
Isoelectric point 6.95
Molecular weight 25.50 kDa
Number of residues 220
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPCC1183.02

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
364335during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
375194during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
349326during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
357052during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
42479.74during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
355634during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
14170.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.6during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
faster evolving duplicate23
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1183.02 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withtef5translation elongation factor EF-1 beta subunit, guanyl-nucleotide exchange factor (eEF1B) Two-hybridPMID:26771498
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
affinity captured bypmt3SUMO Affinity Capture-MSPMID:22730331
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1183.02 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1183.02 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1183.02 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1183.02 BioGRID Interaction Datasets
Expression Viewer SPCC1183.02 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1183.02 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1183.02 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1183.02 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1183.02 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1183.02 Transcriptome Viewer (Bähler Lab)
GEO SPCC1183.02 GEO profiles
PInt SPCC1183.02 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1183.02 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1183.02 Fission yeast phenotypic data & analysis
Cyclebase SPCC1183.02.1 Cell Cycle Data
SPD / RIKEN13/13C03Orfeome Localization Data
UniProtKB/SwissProtO74830Putative glutathione S-transferase C1183.02
ModBaseO74830Database of comparative protein structure models
STRINGO74830Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587885glutathione S-transferase (predicted)
RefSeq mRNANM_001022877972h- glutathione S-transferase (predicted) (SPCC1183.02), mRNA
European Nucleotide ArchiveCAA21082.1ENA Protein Mapping
UniParcUPI000006A908UniProt Archive

Literature for SPCC1183.02

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016