spo13 (SPCC1183.12)

Gene Standard Namespo13 Characterisation Statuspublished
Systematic IDSPCC1183.12 Feature Typeprotein coding
SynonymsSPNCRNA.546, SPNGAF60 Name Description
Productsporulation specific guanyl-nucleotide exchange factor Spo13 Product Size138aa, 15.86 kDa
Genomic Location Chromosome III, 604961-604366 (596nt); CDS:604872-604405 (468nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
guanyl-nucleotide exchange factor activity38
Annotation ExtensionEvidenceWith/FromReference
protein binding900
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ascospore formation58
Annotation ExtensionEvidenceWith/FromReference
ascospore-type prospore membrane assembly13
Annotation ExtensionEvidenceWith/FromReference
ascospore-type prospore-specific spindle pole body remodeling9
Annotation ExtensionEvidenceWith/FromReference
protein localization to meiotic spindle pole body3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
meiotic spindle pole body24
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes

Population Phenotype

Term NameGenotypesCount
viable vegetative cell population3862

Cell Phenotype

Term NameGenotypesCount
abnormal sporulation185
abolished ascospore wall biogenesisspo135
abolished protein localization to meiotic spindle pole body6
affects localization of ypt3spo13Δ
affects localization of syb1spo13Δ
affects localization of ypt2spo13Δ
abolished sporulationspo13-B8256
normal meiosisspo13-B82151
normal protein localization to meiotic spindle pole body11
affecting syb1spo13Δ
Target Of
FYPO localization affected by mutation in cam1 calmodulin Cam1
GO localized by spo15 mitotic and mieotic spindle pole body protein Spo15
GO localized by spo2 sporulation specific protein Spo2
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons604961..604857, 604805..604366
5' UTR604961..604873PMID:21511999
CDS604872..604857, 604805..604405
3' UTR604404..604366PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06428 Pfam IPR009449 GDP/GTP exchange factor Sec2, N-terminal 48 117 2
PTHR14430 HMMPANTHER 44 120 2
0053574 SuperFamily 38 120 2
Coil ncoils Predicted coiled-coil protein (DUF2205) 84 104 1049
Coil ncoils Predicted coiled-coil protein (DUF2205) 41 75 1049

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.94 Da
Charge 2.00
Codon Adaptation Index 0.35
Isoelectric point 8.91
Molecular weight 15.86 kDa
Number of residues 138
Gene Expression

Qualitative Gene Expression

RNA levelexclusively during GO:0007127experimental evidencePMID:18367542

Quantitative Gene Expression

View graphical display of gene expression data for spo13 (SPCC1183.12)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.15during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.31during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
previously annotated as ncRNA22
Taxonomic Conservation
orthologs cannot be distinguished121

Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1183.12 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withspo7sporulation protein Spo7 Two-hybridPMID:21775631
binds DNA-binding domain construct withypt2GTPase Ypt2 Two-hybridPMID:27630265
affinity captured byypt3Rab11 family GTPase Ypt3 Affinity Capture-WesternPMID:27630265
External References
Database Identifier Description
NBRP SPCC1183.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1183.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1183.12 BioGRID Interaction Datasets
Expression Viewer SPCC1183.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1183.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1183.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1183.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1183.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1183.12 Transcriptome Viewer (Bähler Lab)
GEO SPCC1183.12 GEO profiles
PInt SPCC1183.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1183.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1183.12 Fission yeast phenotypic data & analysis
Cyclebase SPCC1183.12.1 Cell Cycle Data
UniProtKB/SwissProtC6Y4C9Sporulation-specific protein 13
ModBaseC6Y4C9Database of comparative protein structure models
STRINGC6Y4C9Network display of known and predicted interactions and functional associations
RefSeq mRNAXM_002788902972h- sporulation specific protein Spo13 (spo13), mRNA
RefSeq PeptideXP_002788948sporulation specific protein Spo13
European Nucleotide ArchiveCBA11516.1ENA Protein Mapping
UniParcUPI0001B0625AUniProt Archive

Literature for spo13

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017