eaf1 (SPCC1223.10c)

Gene Standard Nameeaf1 ChromosomeIII
Systematic IDSPCC1223.10c Gene Start1862041
Synonyms Gene End1860094
ProductRNA polymerase II transcription elongation factor SpEAF Gene Length1948
Feature Typeprotein coding CDS Start1861913
Name DescriptionELL Associated Factor CDS End1860767
Characterisation Statuspublished CDS Length1147

Ensembl Gene Location
  1. drs1
  2. dfr1
  3. SPCC1223.09
  4. SPNCRNA.1236
  5. eaf1
  6. SPCTRNAGLN.05
  7. ptc2
  8. SPNCRNA.586
  9. meu10
  10. SPNCRNA.1237
  11. SPNCRNA.1238
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationno_name (unrecorded)unrecordedPMID:17150956
Microscopyeaf1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIell1PMID:17150956
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006368transcription elongation from RNA polymerase II promoterIDAPMID:17150956
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoterICGO:0045944, GO:0006368GO_REF:0000001
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDAPMID:17150956
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0032783ELL-EAF complexIDAPMID:17150956
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
118620411861829
218617261861635
318614691861383
418612581860094

References

Region Start End Reference
intron18618281861727PMID:17150956
intron18613821861260PMID:17150956
intron18618281861727PMID:17150956
intron18616341861470PMID:17150956
three_prime_UTR18607661860094PMID:21511999
five_prime_UTR18620411861914PMID:21511999
three_prime_UTR18607661860094PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF09816 IPR019194 Pfam Transcription elognation factor Eaf, N-terminal 9 107 1
PTHR15970 hmmpanther EAF family 1 250 1
PTHR15970:SF9 hmmpanther 1 250 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.19 Da
Charge -6.00
Isoelectric point 4.84
Molecular weight 27.66 kDa
Number of residues 251
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide431.48PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.4PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.46PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:17150956
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog PMID:17150956
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
yox1MBF complex negative regulatory component Yox1 Negative GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
ubr11UBR ubiquitin ligase Ubr11 Positive GeneticPMID:18818364
rpl270160S ribosomal protein L27 Negative GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
sec72Sec7 domain protein, ARF GEF Sec72 Positive GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
amt2ammonium transporter Amt2 Positive GeneticPMID:22681890
msh1mitochondrial MutS protein Msh1 (predicted) Positive GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Positive GeneticPMID:18818364
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Positive GeneticPMID:18818364
cbp1CENP-B homolog Positive GeneticPMID:18818364
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Positive GeneticPMID:18818364
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
emc1ER membrane protein complex subunit Emc1 (predicted) Positive GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Positive GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Positive GeneticPMID:18818364
SPCC16C4.20cHMG box protein (predicted) Positive GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:22681890
SPAC1705.02human 4F5S homolog Positive GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPCC1223.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1223.10c Retrieval of eukaryotic orthologs
BioGrid SPCC1223.10c BioGRID Interaction Datasets
Bähler Lab SPCC1223.10c Cell Cycle Expression Profile
Bähler Lab SPCC1223.10c Meiosis/Sporulation Expression Profies
Bähler Lab SPCC1223.10c Pheromone response/mating expression profiles
Bähler Lab SPCC1223.10c Environmental stress expression profiles
Bähler Lab SPCC1223.10c Bähler Lab Transcriptome Viewer
Cyclebase SPCC1223.10c Cell Cycle Data
PInt SPCC1223.10c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC1223.10c Entrez Gene
European Nucleotide ArchiveEF192607ENA EMBL mapping
WikiGene2539104RNA polymerase II transcription elongation factor SpEAF
Uniprot_genenameEAF1
EntrezGene2539104RNA polymerase II transcription elongation factor SpEAF
SPD / RIKEN16/16H03Orfeome Localization Data
UniProtKB/SwissProtA0ZWU1Ell1-associated factor 1
ModBaseA0ZWU1Database of comparative protein structure models
Pfam Protein DomainsA0ZWU1Pfam Domain Arrangement
RefSeq_mRNA_predictedXM_001713119972h- RNA polymerase II transcription elongation factor SpEAF (eaf1), mRNA
RefSeq_peptide_predictedXP_001713171RNA polymerase II transcription elongation factor SpEAF
European Nucleotide ArchiveABM68355ENA Protein Mapping
European Nucleotide ArchiveCAL92194ENA Protein Mapping
UniParcUPI0000EA261CUniProt Archive

Literature for eaf1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013