ptc2 (SPCC1223.11)


Gene Standard Nameptc2 Characterisation Statuspublished
Systematic IDSPCC1223.11 Feature Typeprotein coding
Synonyms Name DescriptionProtein Phosphatase 2C homolog
Productprotein phosphatase 2C Ptc2 Product Size370aa, 40.88 kDa
Genomic Location Chromosome III, 1863661-1866637 (2977nt); CDS:1863757-1864869 (1113nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
metal ion binding746
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine phosphatase activity16
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

signaling


Term NameCount
cellular response to osmotic stress35
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum unfolded protein response9
Annotation ExtensionEvidenceWith/FromReference
inactivation of MAPK activity involved in osmosensory signaling pathway3
Annotation ExtensionEvidenceWith/FromReference
protein dephosphorylation32
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2316
Annotation ExtensionEvidenceWith/FromReference
nucleus2697
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
slow vegetative cell population growthptc2ΔNull318
viable vegetative cell populationptc2ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyptc2ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
118636611866637

UTRs

Region Coordinates Reference
five_prime_UTR1863661..1863756PMID:21511999
three_prime_UTR1864870..1866637PMID:21511999
mRNA1863661..1866637
exon1863757..1864869
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00481 Pfam IPR001932 Protein phosphatase 2C (PP2C)-like domain 23 276 6
SM00332 SMART IPR001932 Protein phosphatase 2C (PP2C)-like domain 13 289 7
PS01032 Prosite Patterns IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site 58 66 4
PTHR13832 HMMPANTHER IPR015655 Protein phosphatase 2C 1 351 5
3.60.40.10 Gene3D IPR001932 Protein phosphatase 2C (PP2C)-like domain 13 294 7
SSF81606 SuperFamily IPR001932 Protein phosphatase 2C (PP2C)-like domain 3 291 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.48 Da
Charge -17.50
Isoelectric point 4.57
Molecular weight 40.88 kDa
Number of residues 370
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
25806during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
25541during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
27237during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
38832during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8405.51during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
26563during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
824.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.4during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.64during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withapt1adenine phosphoribosyltransferase (APRT) (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
positive genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Positive GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withatd1aldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withbun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:18818364
negative genetic interaction withcbs2protein kinase activator (predicted) Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withcox19mitochondrial respiratory chain complex IV assembly protein Cox19 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcsk1cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1 Negative GeneticPMID:22681890
negative genetic interaction withcys11cysteine synthase Negative GeneticPMID:22681890
negative genetic interaction withdeg1tRNA-pseudouridine synthase Deg1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp1elongator subunit Elp1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
negative genetic interaction withhmt2sulfide-quinone oxidoreductase Negative GeneticPMID:22681890
negative genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
positive genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Positive GeneticPMID:22681890
negative genetic interaction withmed13mediator complex subunit Srb9 Negative GeneticPMID:18818364
negative genetic interaction withmgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withmid1medial ring protein Mid1 Positive GeneticPMID:22681890
negative genetic interaction withmms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
negative genetic interaction withmrf1mitochondrial peptide chain release factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmrpl1mitochondrial ribosomal protein subunit L1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmrpl39mitochondrial ribosomal protein subunit L39 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmso1endocytic docking protein Mso1 Negative GeneticPMID:22681890
negative genetic interaction withmug123Schizosaccharomyces specific protein Mug123 Negative GeneticPMID:22681890
positive genetic interaction withnas226S proteasome regulatory particle assembly protein Nas2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withnro1negative regulator of Ofd1, Nro1 Negative GeneticPMID:22681890
negative genetic interaction withotu2ubiquitin specific cysteine protease, OTU family, Otu2 Negative GeneticPMID:22681890
negative genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:18818364
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
negative genetic interaction withppr2mitochondrial PPR repeat protein Ppr2 Negative GeneticPMID:22681890
negative genetic interaction withppr8mitochondrial PPR repeat protein Ppr8 Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
synthetic growth defect withptc1protein phosphatase 2C Ptc1 Synthetic Growth DefectPMID:7859738
synthetic growth defect withptc3protein phosphatase 2c homolog 3 Synthetic Growth DefectPMID:7859738
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
negative genetic interaction withrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
negative genetic interaction withrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:22681890
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
negative genetic interaction withres2MBF transcription factor complex subunit Res2 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:22681890
negative genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:18818364
negative genetic interaction withrpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withscs7sphingosine hydroxylase Scs7 Positive GeneticPMID:22681890
negative genetic interaction withsdh3succinate dehydrogenase (ubiquinone) cytochrome b subunit (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:22681890
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:18818364
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
positive genetic interaction withsnz1pyridoxine biosynthesis protein Positive GeneticPMID:22681890
negative genetic interaction withsol1SWI/SNF complex subunit Sol1 Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC22H10.09Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC25B8.08conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC30.02celongator complex associated protein Kti2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC7D4.12cDUF1212 family protein Negative GeneticPMID:22681890
negative genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1683.03ctransmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC28E12.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC30B4.06cmitochondrial GIDA family tRNA uridine 5-carboxymethylaminomethyl modification enzyme (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC336.13cmitochondrial inner membrane peptidase complex catalytic subunit 2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC839.02arrestin Aly1 related, implicated in endocytosis Negative GeneticPMID:22681890
negative genetic interaction withSPBPB7E8.01Schizosaccharomyces specific protein, predicted GPI anchor Negative GeneticPMID:22681890
negative genetic interaction withSPCC132.03Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withtip1CLIP170 family protein Tip1 Negative GeneticPMID:22681890
positive genetic interaction withtls1splicing factor Tls1 Positive GeneticPMID:22681890
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtrx2mitochondrial thioredoxin Trx2 Negative GeneticPMID:22681890
negative genetic interaction withtsc1hamartin Negative GeneticPMID:22681890
positive genetic interaction withubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:18818364
negative genetic interaction withubp7ubiquitin C-terminal hydrolase Ubp7 Negative GeneticPMID:18818364
negative genetic interaction withubr11UBR ubiquitin-protein ligase E3 Ubr11 Negative GeneticPMID:18818364
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPCC1223.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1223.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1223.11 BioGRID Interaction Datasets
Expression Viewer SPCC1223.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1223.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1223.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1223.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1223.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1223.11 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1223.11 Cell Cycle Data
GEO SPCC1223.11 GEO profiles
PInt SPCC1223.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1223.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1223.11 Fission yeast phenotypic data & analysis
SPD / RIKEN17/17E08Orfeome Localization Data
IntEnz3.1.3.16Integrated relational Enzyme database
Rhea3.1.3.16Annotated reactions database
UniProtKB/SwissProtQ09172Protein phosphatase 2C homolog 2
ModBaseQ09172Database of comparative protein structure models
STRINGQ09172Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588356protein phosphatase 2C Ptc2
RefSeq mRNANM_001023347972h- protein phosphatase 2C Ptc2 (ptc2), mRNA
European Nucleotide ArchiveAAA67320.1ENA Protein Mapping
European Nucleotide ArchiveCAA20880.1ENA Protein Mapping
UniParcUPI0000130FDFUniProt Archive

Literature for ptc2

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015