mpc1 (SPCC1235.11)

Gene Standard Namempc1 ChromosomeIII
Systematic IDSPCC1235.11 Gene Start200020
Synonyms Gene End201625
Productmitochondrial pyruvate transmembrane transporter subunit Mpc1 Gene Length1606
Feature Typeprotein coding CDS Start200130
Name Description CDS End200987
Characterisation Statusbiological_role_inferred CDS Length858

Ensembl Gene Location
  1. pdh1
  2. hif2
  3. sec6
  4. mpc1
  5. mug146
  6. SPNCRNA.1118
  7. ght6
  8. SPCC1235.17
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopympc1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0050833pyruvate transmembrane transporter activity
contributes_toISOSGD:S000003048GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006850mitochondrial pyruvate transportISOSGD:S000003048GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005739mitochondrionIDAPMID:16823372
GO:0031305integral to mitochondrial inner membraneISOSGD:S000003048GO_REF:0000024
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1200020200131
2200172200276
3200365200459
4200643200683
5200750200844
6200900201625

References

Region Start End Reference
three_prime_UTR200988201625PMID:21511999
three_prime_UTR200988201625PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF03650 IPR005336 Pfam Uncharacterised protein family UPF0041 30 132 2
TMhelix TMHMM 60 82 955
PTHR14154 hmmpanther 15 135 2
PTHR14154:SF3 hmmpanther 15 135 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.87 Da
Charge 13.50
Isoelectric point 10.76
Molecular weight 16.06 kDa
Number of residues 141
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2753.8PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide12271.2PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.76PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide5PMID:23101633
Disease Association
DescriptionQualifierReference
lactic acidosis and hyperpyruvatemia
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPCC70.06nuclear export factor (predicted) Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Negative GeneticPMID:22681890
lsc1Lsk1 associated cyclin Positive GeneticPMID:22681890
sre2membrane-tethered transcription factor (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
dsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
atg13autophagy associated protein kinase regulatory subunit Atg13 Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
cxr1mRNA processing factor Positive GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
pmk1MAP kinase Pmk1 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
clr1cryptic loci regulator Clr1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
cdc37Hsp90 co-chaperone Cdc37 Negative GeneticPMID:22681890
jmj2histone demethylase Jmj2 Positive GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
rik1silencing protein Rik1 Negative GeneticPMID:22681890
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
psl1cyclin pho85 family (predicted) Negative GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
tip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPCC1235.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1235.11 Retrieval of eukaryotic orthologs
BioGrid SPCC1235.11 BioGRID Interaction Datasets
Bähler Lab SPCC1235.11 Cell Cycle Expression Profile
Bähler Lab SPCC1235.11 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC1235.11 Pheromone response/mating expression profiles
Bähler Lab SPCC1235.11 Environmental stress expression profiles
Bähler Lab SPCC1235.11 Bähler Lab Transcriptome Viewer
Cyclebase SPCC1235.11 Cell Cycle Data
PInt SPCC1235.11 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC1235.11 Entrez Gene
SPD / RIKEN11/11D08Orfeome Localization Data
WikiGene2539169hypothetical protein
EntrezGene2539169hypothetical protein
UniProtKB/SwissProtO74847Probable mitochondrial pyruvate carrier 2
ModBaseO74847Database of comparative protein structure models
Pfam Protein DomainsO74847Pfam Domain Arrangement
RefSeq PeptideNP_587737hypothetical protein SPCC1235.11
RefSeq mRNANM_001022732972h- hypothetical protein (SPCC1235.11), mRNA
European Nucleotide ArchiveCAA21115ENA Protein Mapping
UniParcUPI0000069729UniProt Archive

Literature for mpc1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013