mpc1 (SPCC1235.11)


Gene Standard Namempc1 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1235.11 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial pyruvate transmembrane transporter subunit Mpc1 (predicted) Product Size141aa, 16.06 kDa
Genomic Location Chromosome III, 200020-201625 (1606nt); CDS:200130-200987 (858nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0050833pyruvate transmembrane transporter activity2
contributes_toISOSGD:S000003048GO_REF:0000024
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:1902361mitochondrial pyruvate transmembrane transportISOSGD:S000003048GO_REF:00000012
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031305integral component of mitochondrial inner membraneISOSGD:S000003048GO_REF:000002414
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assaympc1ΔNullPMID:24463365147
FYPO:0000245loss of viability in stationary phaseCell growth assaympc1ΔNullPECO:0000137PMID:2446336541
FYPO:0000067resistance to brefeldin ACell growth assaympc1ΔNullPECO:0000137PMID:2446336519
FYPO:0003824resistance to caffeine and rapamycinCell growth assaympc1ΔNullPECO:0000137PMID:2446336533
FYPO:0001701sensitive to bortezomib256
expressivity FYPO_EXT:0000003Cell growth assaympc1ΔNullPECO:0000005, PECO:0000137PMID:21760946
FYPO:0002060viable vegetative cell populationMicroscopympc1ΔNullPMID:204732893759
Microscopympc1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002019elongated telomeres158
expressivity FYPO_EXT:0000001Gel electrophoresis evidencempc1ΔNullPMID:20625380
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopympc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1200020200131
2200172200276
3200365200459
4200643200683
5200750200844
6200900201625

UTRs

Region Coordinates Reference
three_prime_UTR200988..201625PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03650 Pfam IPR005336 Mitochondrial pyruvate carrier 30 132 2
TMhelix TMHMM 60 82 959
PTHR14154 HMMPANTHER 17 134 2
PTHR14154:SF3 HMMPANTHER 17 134 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.87 Da
Charge 13.50
Isoelectric point 10.76
Molecular weight 16.06 kDa
Number of residues 141
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
67792during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
65519during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
12271.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
60885during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2753.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.76during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
lactic acidosis and hyperpyruvatemia1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
rik1silencing protein Rik1 Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
tip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
jmj2histone demethylase Jmj2 Positive GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
pmk1MAP kinase Pmk1 Negative GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
clr1cryptic loci regulator Clr1 Negative GeneticPMID:22681890
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
psl1cyclin pho85 family Psl1 (predicted) Negative GeneticPMID:22681890
SPCC70.06nuclear export factor (predicted) Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
cdc37Hsp90 co-chaperone Cdc37 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
atg13autophagy associated protein kinase regulatory subunit Atg13 Negative GeneticPMID:22681890
cxr1mRNA processing factor Positive GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
dsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
lsc1Lsk1 associated cyclin Positive GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPCC1235.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1235.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1235.11 BioGRID Interaction Datasets
Expression Viewer SPCC1235.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1235.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1235.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1235.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1235.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1235.11 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1235.11 Cell Cycle Data
GEO SPCC1235.11 GEO profiles
PInt SPCC1235.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1235.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1235.11 Fission yeast phenotypic data & analysis
SPD / RIKEN11/11D08Orfeome Localization Data
UniProtKB/SwissProtO74847Probable mitochondrial pyruvate carrier 2
ModBaseO74847Database of comparative protein structure models
STRINGO74847Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587737hypothetical protein SPCC1235.11
RefSeq mRNANM_001022732972h- hypothetical protein (SPCC1235.11), mRNA
European Nucleotide ArchiveCAA21115.2ENA Protein Mapping
UniParcUPI0000069729UniProt Archive

Literature for mpc1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014