mpc1 (SPCC1235.11)


Gene Standard Namempc1 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1235.11 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial pyruvate transmembrane transporter subunit Mpc1 (predicted) Product Size141aa, 16.06 kDa
Genomic Location Chromosome III, 200020-201625 (1606nt); CDS:200130-200987 (858nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
pyruvate transmembrane transporter activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitochondrial pyruvate transmembrane transport2
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of mitochondrial inner membrane17
Annotation ExtensionEvidenceWith/FromReference
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourcempc1ΔNull250
loss of viability in stationary phasempc1ΔNull46
resistance to brefeldin Ampc1ΔNull19
resistance to caffeine and rapamycinmpc1ΔNull33
sensitive to bortezomibmpc1ΔNull256
viable vegetative cell populationmpc1ΔNull3795

Cell Phenotype

Term NameAlleleExpressionCount
elongated telomeresmpc1ΔNull167
viable vegetative cell with normal cell morphologympc1ΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons200020..200131, 200172..200276, 200365..200459, 200643..200683, 200750..200844, 200900..201625
Introns200132..200171, 200277..200364, 200460..200642, 200684..200749
mRNA200020..201625
5' UTR200020..200129AU006727
CDS200130..200131, 200172..200276, 200365..200459, 200643..200683, 200750..200844, 200900..200987
3' UTR200988..201625PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03650 Pfam IPR005336 Mitochondrial pyruvate carrier 30 132 2
TMhelix TMHMM 60 82 959
PTHR14154:SF3 HMMPANTHER 24 128 1
PTHR14154 HMMPANTHER 24 128 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.87 Da
Charge 13.50
Isoelectric point 10.76
Molecular weight 16.06 kDa
Number of residues 141
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
67792during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
65519during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12271.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
60885during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2753.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.76during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
lactic acidosis and hyperpyruvatemia1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withatg13autophagy associated protein kinase regulatory subunit Atg13 Negative GeneticPMID:22681890
negative genetic interaction withcdc37Hsp90 co-chaperone Cdc37 Negative GeneticPMID:22681890
negative genetic interaction withclr1SHREC complex subunit Clr1 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
positive genetic interaction withcxr1mRNA processing factor Positive GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:22681890
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
negative genetic interaction withdsc5UBX domain containing protein required for Sre1 cleavage Negative GeneticPMID:22681890
negative genetic interaction witheif21translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
positive genetic interaction withjmj2histone demethylase Jmj2 Positive GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
positive genetic interaction withlsc1Lsk1 associated cyclin Positive GeneticPMID:22681890
positive genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
negative genetic interaction withmcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
negative genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
negative genetic interaction withmpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
positive genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
negative genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
negative genetic interaction withpmk1MAP kinase Pmk1 Negative GeneticPMID:22681890
positive genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpsl1cyclin pho85 family Psl1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:22681890
negative genetic interaction withrpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
negative genetic interaction withsap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC70.06nuclear export factor (predicted) Negative GeneticPMID:22681890
positive genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:22681890
negative genetic interaction withtip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withtsc1hamartin Negative GeneticPMID:22681890
negative genetic interaction withtsc2tuberin Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1235.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1235.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1235.11 BioGRID Interaction Datasets
Expression Viewer SPCC1235.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1235.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1235.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1235.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1235.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1235.11 Transcriptome Viewer (Bähler Lab)
GEO SPCC1235.11 GEO profiles
PInt SPCC1235.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1235.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1235.11 Fission yeast phenotypic data & analysis
Cyclebase SPCC1235.11.1 Cell Cycle Data
SPD / RIKEN11/11D08Orfeome Localization Data
UniProtKB/SwissProtO74847Probable mitochondrial pyruvate carrier 2
ModBaseO74847Database of comparative protein structure models
STRINGO74847Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587737hypothetical protein SPCC1235.11
RefSeq mRNANM_001022732972h- hypothetical protein (SPCC1235.11), mRNA
European Nucleotide ArchiveCAA21115.2ENA Protein Mapping
UniParcUPI0000069729UniProt Archive

Literature for mpc1

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015