ght6 (SPCC1235.13)


Gene Standard Nameght6 Characterisation Statuspublished
Systematic IDSPCC1235.13 Feature Typeprotein coding
Synonymsmeu12 Name DescriptionMeiotic Expression Upregulated
Producthexose transmembrane transporter Ght6 Product Size535aa, 59.40 kDa
Genomic Location Chromosome III, 204706-206717 (2012nt); CDS:204733-206340 (1608nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
fructose transmembrane transporter activity4
Annotation ExtensionEvidenceWith/FromReference
glucose transmembrane transporter activity4
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
fructose import across plasma membrane4
Annotation ExtensionEvidenceWith/FromReference
glucose import across plasma membrane4
Annotation ExtensionEvidenceWith/FromReference
meiotic cell cycle437
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell division site300
Annotation ExtensionEvidenceWith/FromReference
cell tip191
Annotation ExtensionEvidenceWith/FromReference
integral component of plasma membrane49
Annotation ExtensionEvidenceWith/FromReference
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
vacuole185
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationght6ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyght6ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1204706206717

UTRs

Region Coordinates Reference
five_prime_UTR204706..204732PMID:21511999
mRNA204706..206717
exon204733..206340
three_prime_UTR206341..206717AB054532
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 General substrate transporter 11 468 15
TMhelix TMHMM 331 350 959
TMhelix TMHMM 118 135 959
TMhelix TMHMM 145 167 959
TMhelix TMHMM 370 392 959
TMhelix TMHMM 302 324 959
TMhelix TMHMM 89 111 959
TMhelix TMHMM 7 29 959
TMhelix TMHMM 431 453 959
TMhelix TMHMM 405 427 959
TMhelix TMHMM 180 202 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 458 55
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 320 337 15
PTHR24063 HMMPANTHER 1 495 11
PTHR24063:SF337 HMMPANTHER 1 495 8
1.20.1250.20 Gene3D 265 464 72
1.20.1250.20 Gene3D 48 206 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 15 216 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 247 466 76
SignalP-noTM signalp 1 21 212
PR00171 PRINTS IPR003663 Sugar/inositol transporter 394 406 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 371 392 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 278 288 10
TIGR00879 tigrfam IPR003663 Sugar/inositol transporter 6 465 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.04 Da
Charge 10.00
Isoelectric point 8.43
Molecular weight 59.40 kDa
Number of residues 535
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0051321experimental evidencePMID:11376151

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.67during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Genome Organisation
DescriptionQualifierReferenceCount
tandem duplication30
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
positive genetic interaction withatg13autophagy associated protein kinase regulatory subunit Atg13 Positive GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
negative genetic interaction withfbp1fructose-1,6-bisphosphatase Fbp1 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
negative genetic interaction withsap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
positive genetic interaction withswd2Set1C complex subunit Swd2.1 Positive GeneticPMID:22681890
positive genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1235.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1235.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1235.13 BioGRID Interaction Datasets
Expression Viewer SPCC1235.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1235.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1235.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1235.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1235.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1235.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1235.13 Cell Cycle Data
GEO SPCC1235.13 GEO profiles
PInt SPCC1235.13 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1235.13 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1235.13 Fission yeast phenotypic data & analysis
SPD / RIKEN25/25G09Orfeome Localization Data
UniProtKB/SwissProtO74849High-affinity fructose transporter ght6
ModBaseO74849Database of comparative protein structure models
STRINGO74849Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587739hexose transporter Ght6
RefSeq mRNANM_001022734972h- hexose transporter Ght6 (ght6), mRNA
European Nucleotide ArchiveAB054532ENA EMBL mapping
European Nucleotide ArchiveAAC64976.1ENA Protein Mapping
European Nucleotide ArchiveCAA21117.1ENA Protein Mapping
UniParcUPI000012B423UniProt Archive

Literature for ght6

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015