SPCC126.12


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC126.12 Feature Typeprotein coding
Synonyms Name Description
ProductGTP cyclohydrolase I involved in 7,8-dihydroneopterin 3'-triphosphate biosynthesis (predicted) Product Size278aa, 29.85 kDa
Genomic Location Chromosome III, 2137595-2139203 (1609nt); CDS:2138121-2139127 (1007nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003934GTP cyclohydrolase I activityIEA EC:3.5.4.16GO_REF:00000032
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037748
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00359987,8-dihydroneopterin 3'-triphosphate biosynthetic processIEA UniPathway:UPA00848GO_REF:00000412
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmISOSGD:S000003189GO_REF:00000244204
GO:0005829cytosolIDAPMID:168233722319
GO:0005739mitochondrionISOSGD:S000003189GO_REF:0000024758
GO:0005634nucleusIDAPMID:168233722737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000089sensitive to methyl methanesulfonateCell growth assaySPCC126.12ΔNullPECO:0000137, PECO:0000005PMID:23173672214
FYPO:0002060viable vegetative cell populationMicroscopySPCC126.12ΔNullPMID:204732893751
MicroscopySPCC126.12ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001MicroscopySPCC126.12ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121375952138334
221383882138702
321387552138925
421389912139203
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01784 Pfam IPR002678 Ngg1p interacting factor 3, NIF3 10 256 1
PTHR13799 HMMPANTHER IPR002678 Ngg1p interacting factor 3, NIF3 1 278 1
PTHR13799:SF13 HMMPANTHER 1 278 1
3.40.1390.30 Gene3D 9 115 1
3.40.1390.30 Gene3D 116 235 1
SSF102705 SuperFamily IPR002678 Ngg1p interacting factor 3, NIF3 9 276 1
TIGR00486 tigrfam IPR002678 Ngg1p interacting factor 3, NIF3 9 274 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 107.38 Da
Charge 0.00
Isoelectric point 6.51
Molecular weight 29.85 kDa
Number of residues 278
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
35039during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
20900during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
18019during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
23645during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
23306during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3958.45during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2265.03during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002
conserved in metazoa3428
conserved in vertebrates3402
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
SPCC16C4.106-phosphogluconolactonase (predicted) Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Positive GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPCC126.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.12 BioGRID Interaction Datasets
Expression Viewer SPCC126.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC126.12 Cell Cycle Data
GEO SPCC126.12 GEO profiles
PInt SPCC126.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC126.12 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN14/14H02Orfeome Localization Data
UniProtKB/SwissProtO94404Putative GTP cyclohydrolase 1 type 2
ModBaseO94404Database of comparative protein structure models
STRINGO94404Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588455NGG1 interacting factor 3 family protein
RefSeq mRNANM_001023446972h- NGG1 interacting factor 3 family protein (SPCC126.12), mRNA
European Nucleotide ArchiveCAA22481.1ENA Protein Mapping
MetaCycPWY-5663Tetrahydrobiopterin biosynthesis I
MetaCycPWY-5664Tetrahydrobiopterin biosynthesis II
MetaCycPWY-61476-hydroxymethyl-dihydropterin diphosphate biosynthesis I
MetaCycPWY-6703Preq0 biosynthesis
MetaCycPWY-6983Tetrahydrobiopterin biosynthesis III
UniParcUPI000013B4B4UniProt Archive
UniPathwayUPA00848Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1

Literature for SPCC126.12

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014