SPCC126.13c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC126.13c Feature Typeprotein coding
Synonyms Name Description
Producthistone deacetylase complex subunit, SAP128 family (predicted) Product Size145aa, 16.85 kDa
Genomic Location Chromosome III, 2141364-2139883 (1482nt); CDS:2141174-2140570 (605nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016575histone deacetylationICGO:0000118GO_REF:000000125
GO:0006351transcription, DNA-templatedISSUniProtKB:O00422GO_REF:0000001186
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0000118histone deacetylase complexISSUniProtKB:O00422GO_REF:000000126
GO:0000790nuclear chromatinICGO:0000118GO_REF:0000001247
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002643normal cell population growth on clotrimazoleCell growth assaySPCC126.13cΔNullPECO:0000137, PECO:0000005PMID:222528176
FYPO:0002619normal cell population growth on sodium butyrateCell growth assaySPCC126.13cΔNullPECO:0000005, PECO:0000201, PECO:0000142PMID:2386193755
FYPO:0002620normal cell population growth on trichostatin ACell growth assaySPCC126.13cΔNullPECO:0000005, PECO:0000201, PECO:0000142PMID:23861937110
FYPO:0001098sensitive to 4-nitroquinoline N-oxideCell growth assaySPCC126.13cΔNullPECO:0000137, PECO:0000005PMID:19264558159
expressivity FYPO_EXT:0000003
FYPO:0000085sensitive to camptothecinCell growth assaySPCC126.13cΔNullPECO:0000137, PECO:0000005PMID:19264558200
expressivity FYPO_EXT:0000003
FYPO:0002641sensitive to micafunginCell growth assaySPCC126.13cΔNullPECO:0000137, PECO:0000005PMID:22252817105
FYPO:0002328sensitive to terbinafineCell growth assaySPCC126.13cΔNullPECO:0000137, PECO:0000005PMID:22252817101
expressivity FYPO_EXT:0000003
FYPO:0000115sensitive to valproic acidCell growth assaySPCC126.13cΔNullPECO:0000201, PECO:0000005, PECO:0000142PMID:23861937154
expressivity FYPO_EXT:0000003
FYPO:0002060viable vegetative cell populationMicroscopySPCC126.13cΔNullPMID:204732893755
MicroscopySPCC126.13cΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPCC126.13cΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121413642141011
221408432139883

UTRs

Region Start End Reference
five_prime_UTR21413642141175PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06487 Pfam IPR010516 Sin3 associated polypeptide p18 21 136 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 116.20 Da
Charge 2.00
Isoelectric point 7.50
Molecular weight 16.85 kDa
Number of residues 145
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
2132.81during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.23during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog579
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ctp1CtIP-related endonuclease Positive GeneticPMID:22681890
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
mca1transcription factor, zf-fungal binuclear cluster type Mca1 (predicted) Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:18818364
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
SPCC306.07cU3 snoRNP-associated protein Cic1/Utp30 family (predicted) Positive GeneticPMID:18818364
tbf1DNA binding factor Trf1 Positive GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
ago1argonaute Positive GeneticPMID:18818364
SPCC417.09ctranscription factor (predicted) Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
get1GET complex subunit Get1 (predicted) Negative GeneticPMID:18818364
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
hmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
can1arginine transporter Can1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC126.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.13c BioGRID Interaction Datasets
Expression Viewer SPCC126.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.13c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC126.13c Cell Cycle Data
GEO SPCC126.13c GEO profiles
PInt SPCC126.13c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539066histone deacetylase complex subunit, SAP128 family (predicted)
EntrezGene2539066histone deacetylase complex subunit, SAP128 family (predicted)
SPD / RIKEN42/42D07Orfeome Localization Data
UniProtKB/SwissProtO94405Uncharacterized protein C126.13c
ModBaseO94405Database of comparative protein structure models
StringO94405Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588456histone deacetylase complex subunit, SAP128 family (predicted)
RefSeq mRNANM_001023447972h- histone deacetylase complex subunit, SAP128 family (predicted) (SPCC126.13c), mRNA
European Nucleotide ArchiveCAA22482ENA Protein Mapping
UniParcUPI00000699E2UniProt Archive

Literature for SPCC126.13c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014