sap18 (SPCC126.13c)


Gene Standard Namesap18 Characterisation Statusbiological role inferred
Systematic IDSPCC126.13c Feature Typeprotein coding
Synonyms Name Description
Producthistone deacetylase complex subunit Sap18 (predicted) Product Size145aa, 16.85 kDa
Genomic Location Chromosome III, 2141364-2139883 (1482nt); CDS:2141174-2140570 (605nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
histone deacetylation26
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2298
Annotation ExtensionEvidenceWith/FromReference
histone deacetylase complex29
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin364
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal growth on clotrimazolesap18Δ13
normal growth on sodium butyratesap18Δ55
normal growth on trichostatin Asap18Δ114
sensitive to 4-nitroquinoline N-oxidesap18Δ159
sensitive to camptothecinsap18Δ259
sensitive to micafunginsap18Δ119
sensitive to terbinafinesap18Δ103
sensitive to valproic acidsap18Δ155
viable vegetative cell populationsap18Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologysap18Δ3103
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2141364..2141011, 2140843..2139883
Intron2141010..2140844
mRNA2141364..2139883
5' UTR2141364..2141175PMID:21511999
CDS2141174..2141011, 2140843..2140570
3' UTR2140569..2139883AU006812
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06487 Pfam IPR010516 Sin3 associated polypeptide p18 22 136 1
PTHR13082 HMMPANTHER IPR010516 Sin3 associated polypeptide p18 1 136 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 116.20 Da
Charge 2.00
Codon Adaptation Index 0.42
Isoelectric point 7.50
Molecular weight 16.85 kDa
Number of residues 145
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS10 2293
Annotation ExtensionEvidenceResidueReference
IDA S10 PMID:25720772
O-phosphorylated residueS8,S10 2461
Annotation ExtensionEvidenceResidueReference
IDA S8,S10 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for sap18 (SPCC126.13c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2132.81during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.23during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog600
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC126.13c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withcaf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC126.13c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withSPCC306.07cU3 snoRNP-associated protein Cic1/Utp30 family (predicted) Positive GeneticPMID:18818364
positive genetic interaction withurk1uridine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
positive genetic interaction withscs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
positive genetic interaction withtbf1DNA binding factor Trf1 Positive GeneticPMID:22681890
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
positive genetic interaction withryh1GTPase Ryh1 Positive GeneticPMID:22681890
positive genetic interaction withago1argonaute Positive GeneticPMID:18818364
positive genetic interaction withcan1arginine transmembrane transporter Can1 Positive GeneticPMID:22681890
negative genetic interaction withhmt2sulfide-quinone oxidoreductase Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withmca1transcription factor, zf-fungal binuclear cluster type Mca1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspo20sec14 cytosolic factor family, glycerophospholipid-transfer protein Spo20/Sec14 Negative GeneticPMID:22681890
negative genetic interaction withomh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withget1GET complex (ER membrane insertion) subunit Get1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withsft1SNARE Sft1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC417.09ctranscription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
negative genetic interaction withsde2silencing defective protein Sde2 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPCC126.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.13c BioGRID Interaction Datasets
Expression Viewer SPCC126.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.13c Transcriptome Viewer (Bähler Lab)
GEO SPCC126.13c GEO profiles
PInt SPCC126.13c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC126.13c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC126.13c Fission yeast phenotypic data & analysis
Cyclebase SPCC126.13c.1 Cell Cycle Data
SPD / RIKEN42/42D07Orfeome Localization Data
UniProtKB/SwissProtO94405Uncharacterized protein C126.13c
ModBaseO94405Database of comparative protein structure models
STRINGO94405Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588456histone deacetylase complex subunit, SAP128 family (predicted)
RefSeq mRNANM_001023447972h- histone deacetylase complex subunit, SAP128 family (predicted) (SPCC126.13c), mRNA
European Nucleotide ArchiveCAA22482.1ENA Protein Mapping
UniParcUPI00000699E2UniProt Archive

Literature for sap18

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017