prp18 (SPCC126.14)

Gene Standard Nameprp18 Characterisation Statusbiological role inferred
Systematic IDSPCC126.14 Feature Typeprotein coding
Synonyms Name Description
ProductU5 snRNP-associated protein Prp18 (predicted) Product Size343aa, 40.30 kDa
Genomic Location Chromosome III, 2140983-2143550 (2568nt); CDS:2141190-2142266 (1077nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
mRNA cis splicing, via spliceosome119
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
spliceosomal complex117
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationprp18Δ1468

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cycleprp18Δ903
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellsprp18Δ88
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2140983..2142146, 2142192..2143550
5' UTR2140983..2141189PMID:21511999
CDS2141190..2142146, 2142192..2142266
3' UTR2142267..2143550PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08799 Pfam IPR014906 Pre-mRNA processing factor 4 (PRP4)-like 129 157 2
PF02840 Pfam IPR004098 Prp18 196 335 1
SM00500 SMART IPR014906 Pre-mRNA processing factor 4 (PRP4)-like 124 173 2
PTHR13007:SF19 HMMPANTHER 1 62 1
PTHR13007:SF19 HMMPANTHER 78 340 1
PTHR13007 HMMPANTHER 78 340 1
1dvkA00 Gene3D 176 337 1
0053824 SuperFamily IPR014906 Pre-mRNA processing factor 4 (PRP4)-like 111 159 2
0036629 SuperFamily 165 335 1
Coil ncoils Predicted coiled-coil protein (DUF2205) 41 78 1049
Coil ncoils Predicted coiled-coil protein (DUF2205) 1 21 1049

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.48 Da
Charge 7.50
Codon Adaptation Index 0.40
Isoelectric point 9.17
Molecular weight 40.30 kDa
Number of residues 343

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS115 2293
Annotation ExtensionEvidenceResidueReference
experimental evidence S115 PMID:24763107
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for prp18 (SPCC126.14)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
236.25during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
926.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.5during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPCC126.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.14 BioGRID Interaction Datasets
Expression Viewer SPCC126.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.14 Transcriptome Viewer (Bähler Lab)
GEO SPCC126.14 GEO profiles
PInt SPCC126.14 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC126.14 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC126.14 Fission yeast phenotypic data & analysis
Cyclebase SPCC126.14.1 Cell Cycle Data
SPD / RIKEN16/16F08Orfeome Localization Data
UniProtKB/SwissProtO94406Pre-mRNA-splicing factor 18
ModBaseO94406Database of comparative protein structure models
STRINGO94406Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588457U5 snRNP-associated protein Prp18 (predicted)
RefSeq mRNANM_001023448972h- U5 snRNP-associated protein Prp18 (predicted) (prp18), mRNA
European Nucleotide ArchiveBAA87243.1ENA Protein Mapping
European Nucleotide ArchiveCAA22483.1ENA Protein Mapping
UniParcUPI000006A369UniProt Archive

Literature for prp18

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017