prp18 (SPCC126.14)

Gene Standard Nameprp18 Characterisation Statusbiological_role_inferred
Systematic IDSPCC126.14 Feature Typeprotein coding
Synonyms Name Description
ProductU5 snRNP-associated protein Prp18 (predicted) Product Size343aa, 40.30 kDa
Genomic Location Chromosome III, 2140983-2143550 (2568nt); CDS:2141190-2142266 (1077nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
mRNA cis splicing, via spliceosome116
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
spliceosomal complex107
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:236978061338

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:23697806686
FYPO:0003529inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells87
penetrance FYPO_EXT:0000001Microscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02840 Pfam IPR004098 Prp18 195 336 1
PF08799 Pfam IPR014906 Pre-mRNA processing factor 4 (PRP4)-like 129 158 2
SM00500 SMART IPR003648 Splicing factor motif 124 173 2
PTHR13007:SF4 HMMPANTHER 2 334 1
PTHR13007 HMMPANTHER 2 334 1
1dvkA00 Gene3D IPR004098 Prp18 176 337 1
0036629 SuperFamily IPR004098 Prp18 165 335 1
0053824 SuperFamily 111 159 2
Coil ncoils Rabaptin coiled-coil domain 1 22 968
Coil ncoils Rabaptin coiled-coil domain 41 79 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.48 Da
Charge 7.50
Isoelectric point 9.17
Molecular weight 40.30 kDa
Number of residues 343

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS115PMID:247631071670
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
236.25during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
926.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.5during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPCC126.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.14 BioGRID Interaction Datasets
Expression Viewer SPCC126.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.14 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC126.14 Cell Cycle Data
GEO SPCC126.14 GEO profiles
PInt SPCC126.14 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC126.14 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC126.14 Fission yeast phenotypic data & analysis
SPD / RIKEN16/16F08Orfeome Localization Data
UniProtKB/SwissProtO94406Pre-mRNA-splicing factor 18
ModBaseO94406Database of comparative protein structure models
STRINGO94406Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588457U5 snRNP-associated protein Prp18 (predicted)
RefSeq mRNANM_001023448972h- U5 snRNP-associated protein Prp18 (predicted) (prp18), mRNA
European Nucleotide ArchiveBAA87243.1ENA Protein Mapping
European Nucleotide ArchiveCAA22483.1ENA Protein Mapping
UniParcUPI000006A369UniProt Archive

Literature for prp18

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014