prp18 (SPCC126.14)


Gene Standard Nameprp18 Characterisation Statusbiological_role_inferred
Systematic IDSPCC126.14 Feature Typeprotein coding
Synonyms Name Description
ProductU5 snRNP-associated protein Prp18 (predicted) Product Size343aa, 40.30 kDa
Genomic Location Chromosome III, 2140983-2143550 (2568nt); CDS:2141190-2142266 (1077nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0045292mRNA cis splicing, via spliceosomeISOSGD:S000003238GO_REF:0000024110
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005634nucleusIDAPMID:168233722730
GO:0005681spliceosomal complexISOSGD:S000003238GO_REF:0000024107
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyprp18ΔNullPMID:204732891309
Microscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:23697806564
FYPO:0002262inviable after spore germination, multiple cell divisions, elongated cellMicroscopyprp18ΔNullPECO:0000005, PECO:0000137PMID:2369780687
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121409832142146
221421922143550

UTRs

Region Start End Reference
five_prime_UTR21409832141189PMID:21511999
three_prime_UTR21422672143550PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02840 Pfam IPR004098 Prp18 195 336 1
PF08799 Pfam IPR014906 Pre-mRNA processing factor 4 (PRP4)-like 129 158 2
SM00500 SMART IPR003648 Splicing factor motif 124 173 2
PTHR13007:SF4 HMMPANTHER 2 334 1
PTHR13007 HMMPANTHER 2 334 1
G3DSA:1.20.940.10 Gene3D IPR004098 176 337 1
SSF158230 SuperFamily 111 159 2
SSF47938 SuperFamily IPR004098 165 335 1
Coil ncoils Rabaptin coiled-coil domain 41 79 975
Coil ncoils Rabaptin coiled-coil domain 1 22 975
Low complexity (SEG) seg 210 222
Low complexity (SEG) seg 84 92
Low complexity (SEG) seg 41 71

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.48 Da
Charge 7.50
Isoelectric point 9.17
Molecular weight 40.30 kDa
Number of residues 343
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
926.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
236.25during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC126.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC126.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC126.14 BioGRID Interaction Datasets
Expression Viewer SPCC126.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC126.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC126.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC126.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC126.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC126.14 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC126.14 Cell Cycle Data
GEO SPCC126.14 GEO profiles
PInt SPCC126.14 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539357U5 snRNP-associated protein Prp18
EntrezGene2539357U5 snRNP-associated protein Prp18
SPD / RIKEN16/16F08Orfeome Localization Data
UniProtKB/SwissProtO94406Pre-mRNA-splicing factor 18
ModBaseO94406Database of comparative protein structure models
StringO94406Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588457U5 snRNP-associated protein Prp18
RefSeq mRNANM_001023448972h- U5 snRNP-associated protein Prp18 (prp18), mRNA
European Nucleotide ArchiveBAA87243ENA Protein Mapping
European Nucleotide ArchiveCAA22483ENA Protein Mapping
UniParcUPI000006A369UniProt Archive

Literature for prp18

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014