trp1322 (SPCC1322.03)


Gene Standard Nametrp1322 Characterisation Statuspublished
Systematic IDSPCC1322.03 Feature Typeprotein coding
Synonyms Name Description
ProductTRP-like ion channel (predicted) Product Size862aa, 97.44 kDa
Genomic Location Chromosome III, 1287903-1291811 (3909nt); CDS:1288137-1290725 (2589nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
transmembrane transporter activity288
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
calcium ion transmembrane import into cytosol5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4212
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
resistance to tacrolimus during salt stresstrp1322Δ7
sensitive to amphotericin Btrp1322Δ69
sensitive to camptothecintrp1322Δ248
sensitive to micafungintrp1322Δ119
viable vegetative cell populationtrp1322Δ3844

Cell Phenotype

Term NameGenotypesCount
abnormal microtubule cytoskeleton morphology during mitotic interphasetrp1322Δ186
abnormal mitotic cell cycle phasetrp1322Δ159
increased cytosolic calcium leveltrp1322+6
increased transcription from CDRE promoter in response to calcium iontrp1322+6
short cytoplasmic microtubulestrp1322Δ20
viable vegetative cell with abnormal cell shapetrp1322Δ702
viable vegetative cell with normal cell morphologytrp1322Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1287903..1291811
mRNA1287903..1291811
5' UTR1287903..1288136PMID:21511999
CDS1288137..1290725
3' UTR1290726..1291811PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06011 Pfam IPR010308 TRP-like family 235 565 3
PF14558 Pfam IPR032800 ML-like domain 30 179 3
TMhelix TMHMM 187 209 953
TMhelix TMHMM 408 430 953
TMhelix TMHMM 484 503 953
TMhelix TMHMM 63 85 953
TMhelix TMHMM 371 393 953
TMhelix TMHMM 546 568 953
TMhelix TMHMM 7 29 953
TMhelix TMHMM 231 250 953
TMhelix TMHMM 320 351 953
TMhelix TMHMM 458 480 953
TMhelix TMHMM 262 281 953
PTHR31145:SF6 HMMPANTHER 1 857 1
PTHR31145 HMMPANTHER 1 857 3
SignalP-noTM signalp 1 25 207

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.04 Da
Charge 15.00
Codon Adaptation Index 0.39
Isoelectric point 8.77
Molecular weight 97.44 kDa
Number of residues 862
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for trp1322 (SPCC1322.03)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog601
conserved in fungi only618
conserved in fungi4606
conserved in eukaryotes4516
Orthologs

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1322.03 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
overexpression rescuesppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Dosage RescuePMID:21811607
overexpression rescuescis4cation diffusion family zinc transmembrane transporter Cis4 Dosage RescuePMID:22848669
overexpression rescuesapm1AP-1 adaptor complex mu subunit Apm1 Dosage RescuePMID:22848669
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc4 Negative GeneticPMID:21504829
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPCC1322.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1322.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1322.03 BioGRID Interaction Datasets
Expression Viewer SPCC1322.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1322.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1322.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1322.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1322.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1322.03 Transcriptome Viewer (Bähler Lab)
GEO SPCC1322.03 GEO profiles
PInt SPCC1322.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1322.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1322.03 Fission yeast phenotypic data & analysis
Cyclebase SPCC1322.03.1 Cell Cycle Data
SPD / RIKEN38/38E06Orfeome Localization Data
UniProtKB/SwissProtO94543Uncharacterized membrane protein C1322.03
ModBaseO94543Database of comparative protein structure models
STRINGO94543Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588131TRP-like ion channel (predicted)
RefSeq mRNANM_001023121972h- TRP-like ion channel (predicted) (SPCC1322.03), mRNA
European Nucleotide ArchiveCAA22856.1ENA Protein Mapping
UniParcUPI000006B86AUniProt Archive

Literature for trp1322

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016