ero12 (SPCC1450.14c)

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Gene Standard Nameero12 Characterisation Statuspublished
Systematic IDSPCC1450.14c Feature Typeprotein coding
Synonyms Name Description
ProductER protein folding oxidoreductin Ero1b Product Size567aa, 65.44 kDa
Genomic Location Chromosome III, 1763118-1758944 (4175nt); CDS:1760998-1759295 (1704nt)

Ensembl Gene Location
  1. SPCC1450.12
  2. rib5
  3. ero12
  4. SPCC1450.15
  5. ptl1
  6. ste6-antisense-1
  7. ste6
GO Molecular Function
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GO Biological Process

GO Slim Terms

protein folding


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GO Cellular Component
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FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

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Term NameGenotypesCount
inviable vegetative cell populationero12Δ1468

Cell Phenotype

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Term NameGenotypesCount
swollen septated spheroid vegetative cellero12Δ3
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1763118..1758944
mRNA1763118..1758944
5' UTR1763118..1760999PMID:21511999
CDS1760998..1759295
3' UTR1759294..1758944PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04137 Pfam IPR007266 Endoplasmic reticulum oxidoreductin 1 62 454 2
PTHR12613 HMMPANTHER IPR007266 Endoplasmic reticulum oxidoreductin 1 1 464 2
PTHR12613 HMMPANTHER IPR007266 Endoplasmic reticulum oxidoreductin 1 502 548 2
PTHR12613:SF0 HMMPANTHER 1 464 2
PTHR12613:SF0 HMMPANTHER 502 548 2
0043331 SuperFamily 242 464 2
0043331 SuperFamily 51 211 2
PIRSF017205 PIRSF IPR007266 Endoplasmic reticulum oxidoreductin 1 2 567 2
SignalP-noTM signalp 1 22 207

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279

Protein Properties

Ave. residue weight 115.41 Da
Charge 2.50
Codon Adaptation Index 0.42
Isoelectric point 6.78
Molecular weight 65.44 kDa
Number of residues 567
Modifications

Protein Modifications

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Term NameResidueCount
O-phospho-L-serineS450 2293
Annotation ExtensionEvidenceResidueReference
IDA S450 PMID:25720772
glycosylated residue 126
Annotation ExtensionEvidenceResidueReference
IDA PMID:15449306
Sequence
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Gene Expression
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Quantitative Gene Expression

View graphical display of gene expression data for ero12 (SPCC1450.14c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7055during GO:0000080PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7055during GO:0000080PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7055during GO:0000080PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7055during GO:0000080PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
8767during GO:0000084PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
8767during GO:0000084PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
8767during GO:0000084PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
8767during GO:0000084PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7948during GO:0000085PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7948during GO:0000085PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7948during GO:0000085PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7948during GO:0000085PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
9042during GO:0000087PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
9042during GO:0000087PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
9042during GO:0000087PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
9042during GO:0000087PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
4009.84during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
7455during GO:0072690PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
7455during GO:0072690PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
4009.84during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
7455during GO:0072690PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
4009.84during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
4009.84during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
7455during GO:0072690PECO:0000005,
PECO:0000126		single cellmass spectrometry evidencePMID:24763107
1108.83during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
1108.83during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
1108.83during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
1108.83during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.1during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
2.1during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
2.1during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
2.1during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.56during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complements S. cerevisiae ERO1 PMID:15449306
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs
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Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
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Database Identifier Description
NBRP SPCC1450.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1450.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1450.14c BioGRID Interaction Datasets
Expression Viewer SPCC1450.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1450.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1450.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1450.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1450.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1450.14c Transcriptome Viewer (Bähler Lab)
GEO SPCC1450.14c GEO profiles
PInt SPCC1450.14c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1450.14c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1450.14c Fission yeast phenotypic data & analysis
Cyclebase SPCC1450.14c.1 Cell Cycle Data
SPD / RIKEN36/36G03Orfeome Localization Data
UniProtKB/SwissProtQ9Y7P1ERO1-like protein 2
ModBaseQ9Y7P1Database of comparative protein structure models
STRINGQ9Y7P1Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588313ER protein folding oxidoreductin Ero1b
RefSeq mRNANM_001023303972h- ER protein folding oxidoreductin Ero1b (ero12), mRNA
European Nucleotide ArchiveCAB40181.2ENA Protein Mapping
UniParcUPI0001B06264UniProt Archive

Literature for ero12
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Release Version: PomBase:30_62 - 30 Jan 2017