adn3 (SPCC1494.10)

Gene Standard Nameadn3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1494.10 Feature Typeprotein coding
SynonymsSPCC70.01 Name DescriptionADhesioN defective
Producttranscription factor (predicted) Product Size964aa, 104.59 kDa
Genomic Location Chromosome III, 2344694-2348598 (3905nt); CDS:2345367-2348261 (2895nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
GO Cellular Component
Term NameCount
cell division site301
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000096sensitive to cadmium246
expressivity FYPO_EXT:0000002Cell growth assayadn3ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopyadn3ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000010abolished cell-substrate adhesionadn3ΔNullPMID:195423129
FYPO:0000551pseudohyphal growth abolishedMicroscopyadn3ΔNullPMID:1954231212
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyadn3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08513 Pfam IPR013720 LisH dimerisation motif, subgroup 36 62 8
SM00667 SMART IPR006594 LisH dimerisation motif 34 66 10
PS50896 Prosite Profiles IPR006594 LisH dimerisation motif 34 66 11
PTHR12610:SF12 HMMPANTHER 35 205 2
PTHR12610 HMMPANTHER 35 205 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.50 Da
Charge 8.50
Isoelectric point 7.45
Molecular weight 104.59 kDa
Number of residues 964

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS840PMID:217125471670
present during mitotic M phase
present during mitotic M phaseexperimental evidenceS117PMID:21712547
present during mitotic M phaseexperimental evidenceS723PMID:21712547
present during mitotic M phaseexperimental evidenceS100PMID:21712547
present during mitotic M phaseexperimental evidenceS725PMID:21712547
present during mitotic M phaseexperimental evidenceS114PMID:21712547
present during mitotic M phaseexperimental evidenceS113PMID:21712547
present during mitotic M phaseexperimental evidenceS727PMID:21712547
present during mitotic M phaseexperimental evidenceS836PMID:21712547
present during mitotic M phaseexperimental evidenceS834PMID:21712547
present during mitotic M phaseexperimental evidenceS95PMID:21712547
present during mitotic M phaseexperimental evidenceS731PMID:21712547
level fluctuates during mitotic cell cycleexperimental evidenceS725PMID:24763107
experimental evidenceS727PMID:24763107
level fluctuates during mitotic cell cycleexperimental evidenceS840PMID:24763107
experimental evidenceS117PMID:24763107
experimental evidenceS84PMID:24763107
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2737during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2449during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2038.21during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2693during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
4146.82during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi only623
conserved in fungi4600
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Positive GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
gsf2galactose-specific flocculin Gsf2 Phenotypic SuppressionPMID:23236291
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
SPBC106.13ubiquitin ligase complex subunit, involved in proteasome-dependent catabolite inactivation of FBPase (predicted) Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
sap10splicing factor 3B Negative GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
slx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:22681890
SPAC144.17c6-phosphofructo-2-kinase (predicted) Negative GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1494.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1494.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1494.10 BioGRID Interaction Datasets
Expression Viewer SPCC1494.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1494.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1494.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1494.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1494.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1494.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1494.10 Cell Cycle Data
GEO SPCC1494.10 GEO profiles
PInt SPCC1494.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1494.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1494.10 Fission yeast phenotypic data & analysis
SPD / RIKEN47/47D07Orfeome Localization Data
UniProtKB/SwissProtO74522Adhesion defective protein 3
ModBaseO74522Database of comparative protein structure models
STRINGO74522Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588535transcription factor (predicted)
RefSeq mRNANM_001023523972h- transcription factor (predicted) (adn3), mRNA
European Nucleotide ArchiveBAA87256.1ENA Protein Mapping
European Nucleotide ArchiveCAA19308.1ENA Protein Mapping
UniParcUPI000006C3F3UniProt Archive

Literature for adn3

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014