adn3 (SPCC1494.10)


Gene Standard Nameadn3 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1494.10 Feature Typeprotein coding
SynonymsSPCC70.01 Name DescriptionADhesioN defective
Producttranscription factor (predicted) Product Size964aa, 104.59 kDa
Genomic Location Chromosome III, 2344694-2348598 (3905nt); CDS:2345367-2348261 (2895nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
GO Cellular Component
Term NameCount
cell division site300
Annotation ExtensionEvidenceWith/FromReference
nucleus2697
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to cadmiumadn3ΔNull246
viable vegetative cell populationadn3ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
abolished cell-substrate adhesionadn3ΔNull9
pseudohyphal growth abolishedadn3ΔNull12
viable vegetative cell with normal cell morphologyadn3ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
123446942348598

UTRs

Region Coordinates Reference
five_prime_UTR2344694..2345366PMID:21511999
three_prime_UTR2348262..2348598PMID:21511999
mRNA2344694..2348598
exon2345367..2348261
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08513 Pfam IPR013720 LisH dimerisation motif, subgroup 36 62 8
SM00667 SMART IPR006594 LisH dimerisation motif 34 66 10
PS50896 Prosite Profiles IPR006594 LisH dimerisation motif 34 66 11
PTHR12610 HMMPANTHER 1 251 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.50 Da
Charge 8.50
Isoelectric point 7.45
Molecular weight 104.59 kDa
Number of residues 964
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
present during mitotic M phaseS731
present during mitotic M phaseS113
present during mitotic M phaseS840
present during mitotic M phaseS100
level fluctuates during mitotic cell cycleS840
present during mitotic M phaseS725
present during mitotic M phaseS834
present during mitotic M phaseS723
present during mitotic M phaseS114
present during mitotic M phaseS117
S84, S117, S727
present during mitotic M phaseS727
present during mitotic M phaseS95
present during mitotic M phaseS836
level fluctuates during mitotic cell cycleS725
Annotation ExtensionEvidenceResidueReference
experimental evidence S84 PMID:24763107
present during mitotic M phase experimental evidence S95 PMID:21712547
present during mitotic M phase experimental evidence S100 PMID:21712547
present during mitotic M phase experimental evidence S113 PMID:21712547
present during mitotic M phase experimental evidence S114 PMID:21712547
experimental evidence S117 PMID:24763107
present during mitotic M phase experimental evidence S117 PMID:21712547
present during mitotic M phase experimental evidence S723 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S725 PMID:24763107
present during mitotic M phase experimental evidence S725 PMID:21712547
experimental evidence S727 PMID:24763107
present during mitotic M phase experimental evidence S727 PMID:21712547
present during mitotic M phase experimental evidence S731 PMID:21712547
present during mitotic M phase experimental evidence S834 PMID:21712547
present during mitotic M phase experimental evidence S836 PMID:21712547
present during mitotic M phase experimental evidence S840 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S840 PMID:24763107
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2737during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2449during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2693during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2038.21during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
4146.82during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.6during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi only619
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
positive genetic interaction withatg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
negative genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
negative genetic interaction withbun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
positive genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
rescued bygsf2galactose-specific flocculin Gsf2 Phenotypic SuppressionPMID:23236291
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
negative genetic interaction withrpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
negative genetic interaction withsap10splicing factor 3B Negative GeneticPMID:22681890
positive genetic interaction withsap114U2 snRNP subunit Sap114 Positive GeneticPMID:22681890
positive genetic interaction withslx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withSPAC144.17c6-phosphofructo-2-kinase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC106.13ubiquitin ligase complex subunit, involved in proteasome-dependent catabolite inactivation of FBPase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
positive genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsts5RNB-like protein Negative GeneticPMID:22681890
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtsc1hamartin Negative GeneticPMID:22681890
negative genetic interaction withtsc2tuberin Negative GeneticPMID:22681890
positive genetic interaction withusp102U1 snRNP-associated protein Usp102 Positive GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1494.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1494.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1494.10 BioGRID Interaction Datasets
Expression Viewer SPCC1494.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1494.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1494.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1494.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1494.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1494.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1494.10 Cell Cycle Data
GEO SPCC1494.10 GEO profiles
PInt SPCC1494.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1494.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1494.10 Fission yeast phenotypic data & analysis
SPD / RIKEN47/47D07Orfeome Localization Data
UniProtKB/SwissProtO74522Adhesion defective protein 3
ModBaseO74522Database of comparative protein structure models
STRINGO74522Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588535transcription factor (predicted)
RefSeq mRNANM_001023523972h- transcription factor (predicted) (adn3), mRNA
European Nucleotide ArchiveBAA87256.1ENA Protein Mapping
European Nucleotide ArchiveCAA19308.1ENA Protein Mapping
UniParcUPI000006C3F3UniProt Archive

Literature for adn3

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015