fzr3 (SPCC1620.04c)

Gene Standard Namefzr3 Characterisation Statuspublished
Systematic IDSPCC1620.04c Feature Typeprotein coding
Synonymsmug55 Name DescriptionMeiotically Upregulated Gene
Productmeiotic fizzy-related APC coactivator Fzr3 Product Size509aa, 58.41 kDa
Genomic Location Chromosome III, 2150908-2149317 (1592nt); CDS:2150908-2149379 (1530nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
anaphase-promoting complex binding7
Annotation ExtensionEvidenceWith/FromReference
ubiquitin-protein transferase activator activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
protein complex1361
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationmug55Δ3850

Cell Phenotype

Term NameGenotypesCount
delayed exit from meiosisfzr3Δ3
increased protein level during meiosis II3
affecting mes1fzr3Δ
increased protein level during meiotic anaphase II3
affecting mes1fzr3Δ
viable vegetative cell with normal cell morphologymug55Δ3102
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
3' UTR2149378..2149317PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 282 317 88
PF12894 Pfam IPR024977 Anaphase-promoting complex subunit 4, WD40 domain 192 253 11
SM00320 SMART IPR001680 WD40 repeat 430 467 112
SM00320 SMART IPR001680 WD40 repeat 190 229 112
SM00320 SMART IPR001680 WD40 repeat 234 272 112
SM00320 SMART IPR001680 WD40 repeat 277 317 112
SM00320 SMART IPR001680 WD40 repeat 320 362 112
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 183 371 104
PS50082 Prosite Profiles IPR001680 WD40 repeat 285 326 100
PTHR19918:SF5 HMMPANTHER 50 503 2
PTHR19918 HMMPANTHER IPR033010 The WD repeat Cdc20/Fizzy family 50 503 5 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 444 472 145 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 165 386 145
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 159 467 135

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000189Cdc20/Fizzy subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000189
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 114.75 Da
Charge 13.00
Codon Adaptation Index 0.37
Isoelectric point 8.63
Molecular weight 58.41 kDa
Number of residues 509
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

View graphical display of gene expression data for fzr3 (SPCC1620.04c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.005during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
no apparent S. cerevisiae ortholog600
conserved in fungi4607
conserved in eukaryotes4517
conserved in eukaryotes only2502

Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPCC1620.04c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withmca1transcription factor, zf-fungal binuclear cluster type Mca1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withomh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
negative genetic interaction withspo20sec14 cytosolic factor family, glycerophospholipid-transfer protein Spo20/Sec14 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1620.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1620.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1620.04c BioGRID Interaction Datasets
Expression Viewer SPCC1620.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1620.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1620.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1620.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1620.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1620.04c Transcriptome Viewer (Bähler Lab)
GEO SPCC1620.04c GEO profiles
PInt SPCC1620.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1620.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1620.04c Fission yeast phenotypic data & analysis
Cyclebase SPCC1620.04c.1 Cell Cycle Data
SPD / RIKEN44/44H04Orfeome Localization Data
UniProtKB/SwissProtO94411Meiotic fizzy-related protein 2
ModBaseO94411Database of comparative protein structure models
STRINGO94411Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588462Cdc20/Fizzy subfamily WD repeat protein
RefSeq mRNANM_001023453972h- Cdc20/Fizzy subfamily WD repeat protein (mug55), mRNA
European Nucleotide ArchiveCAA22488.1ENA Protein Mapping
UniParcUPI000006B530UniProt Archive

Literature for fzr3

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016