mug55 (SPCC1620.04c)

Gene Standard Namemug55 Characterisation Statusconserved_unknown
Systematic IDSPCC1620.04c Feature Typeprotein coding
Synonyms Name DescriptionMeiotically Upregulated Gene
ProductCdc20/Fizzy subfamily WD repeat protein Product Size509aa, 58.41 kDa
Genomic Location Chromosome III, 2150908-2149317 (1592nt); CDS:2150908-2149379 (1530nt)

Ensembl Gene Location
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0043234protein complexNASGO_REF:00000511468
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopymug55ΔNullPECO:0000005, PECO:0000137PMID:236978063755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopymug55ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 242 271 104
PF00400 Pfam IPR001680 WD40 repeat 283 317 104
SM00320 SMART IPR001680 WD40 repeat 430 467 121
SM00320 SMART IPR001680 WD40 repeat 320 362 121
SM00320 SMART IPR001680 WD40 repeat 190 229 121
SM00320 SMART IPR001680 WD40 repeat 234 272 121
SM00320 SMART IPR001680 WD40 repeat 277 317 121
PS50082 Prosite Profiles IPR001680 WD40 repeat 285 326 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 183 371 104
PTHR19918:SF0 HMMPANTHER 1 508 5
PTHR19918 HMMPANTHER 1 508 5
G3DSA: Gene3D IPR015943 444 472 143
G3DSA: Gene3D IPR015943 165 386 143
SSF50978 SuperFamily IPR017986 159 467 135

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000189Cdc20/Fizzy subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000189
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 114.75 Da
Charge 13.00
Isoelectric point 8.63
Molecular weight 58.41 kDa
Number of residues 509
Gene Expression

Qualitative Gene Expression

RNA levelincreasedexperimental evidencePMID:16303567
during GO:0007126

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.005during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
orthologs cannot be distinguished132
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
mca1transcription factor, zf-fungal binuclear cluster type Mca1 (predicted) Negative GeneticPMID:22681890
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1620.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1620.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1620.04c BioGRID Interaction Datasets
Expression Viewer SPCC1620.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1620.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1620.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1620.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1620.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1620.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1620.04c Cell Cycle Data
GEO SPCC1620.04c GEO profiles
PInt SPCC1620.04c Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539258Cdc20/Fizzy family WD repeat protein
WikiGene2539258Cdc20/Fizzy family WD repeat protein
SPD / RIKEN44/44H04Orfeome Localization Data
UniProtKB/SwissProtO94411Meiotic fizzy-related protein 2
ModBaseO94411Database of comparative protein structure models
StringO94411Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588462Cdc20/Fizzy family WD repeat protein
RefSeq mRNANM_001023453972h- Cdc20/Fizzy family WD repeat protein (mug55), mRNA
European Nucleotide ArchiveCAA22488ENA Protein Mapping
UniParcUPI000006B530UniProt Archive

Literature for mug55

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014