SPCC1620.05


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC1620.05 Feature Typeprotein coding
Synonyms Name Description
ProductRab geranylgeranyltransferase alpha subunit (predicted) Product Size344aa, 41.19 kDa
Genomic Location Chromosome III, 2152135-2157975 (5841nt); CDS:2152189-2153637 (1449nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0017137Rab GTPase bindingISSUniProtKB:Q08602GO_REF:00000248
GO:0004663Rab geranylgeranyltransferase activityISSUniProtKB:Q08602GO_REF:00000244
ISOSGD:S000003568GO_REF:0000024
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006888ER to Golgi vesicle-mediated transportISOSGD:S000003568GO_REF:000002475
GO:0018344protein geranylgeranylationISOSGD:S000003568GO_REF:00000244
ISSUniProtKB:Q08602GO_REF:0000024
GO:0072661protein targeting to plasma membraneICGO:0018342GO_REF:00000017
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005968Rab-protein geranylgeranyltransferase complexISOSGD:S000003568GO_REF:00000242
ISSUniProtKB:Q08602GO_REF:0000024
GO:0032153cell division siteIDAPMID:16823372295
GO:0005829cytosolIDAPMID:168233722316
GO:0044732mitotic spindle pole bodyIDAPMID:16823372214
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPCC1620.05ΔNullPMID:204732891315
FYPO:0002060viable vegetative cell populationMicroscopySPCC1620.05ΔNullPECO:0000005, PECO:0000137PMID:236978063760

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001511inviable vegetative cell, abnormal cell shape, normal cell size199
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
MicroscopySPCC1620.05ΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121521352152191
221522342152344
321523912152518
421525612152748
521528692153090
621531642153367
721534592157975

UTRs

Region Coordinates Reference
five_prime_UTR2152135..2152188PMID:21511999
three_prime_UTR2153638..2157975PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01239 Pfam IPR002088 Protein prenyltransferase, alpha subunit 49 73 2
PF01239 Pfam IPR002088 Protein prenyltransferase, alpha subunit 92 121 2
PF01239 Pfam IPR002088 Protein prenyltransferase, alpha subunit 217 245 2
PF01239 Pfam IPR002088 Protein prenyltransferase, alpha subunit 168 196 2
PF01239 Pfam IPR002088 Protein prenyltransferase, alpha subunit 129 157 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 165 199 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 214 248 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 44 78 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 266 293 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 125 159 2
PS51147 Prosite Profiles IPR002088 Protein prenyltransferase, alpha subunit 89 123 2
PTHR11129 HMMPANTHER 1 339 2
PTHR11129:SF2 HMMPANTHER 1 339 1
1.25.40.120 Gene3D 1 338 3
SSF48439 SuperFamily 1 338 2
Coil ncoils Rabaptin coiled-coil domain 6 39 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 119.75 Da
Charge 7.50
Isoelectric point 8.33
Molecular weight 41.19 kDa
Number of residues 344
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1219.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
389.16during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
9008during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
9956during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8131during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8572during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8368during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.61during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancer141
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC1620.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1620.05 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1620.05 BioGRID Interaction Datasets
Expression Viewer SPCC1620.05 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1620.05 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1620.05 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1620.05 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1620.05 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1620.05 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1620.05 Cell Cycle Data
GEO SPCC1620.05 GEO profiles
PInt SPCC1620.05 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN44/44F11Orfeome Localization Data
EntrezGene2539343Rab geranylgeranyltransferase alpha subunit (predicted)
WikiGene2539343Rab geranylgeranyltransferase alpha subunit (predicted)
UniProtKB/SwissProtO94412Geranylgeranyl transferase type-2 subunit alpha
ModBaseO94412Database of comparative protein structure models
STRINGO94412Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588463Rab geranylgeranyltransferase alpha subunit (predicted)
RefSeq mRNANM_001023454972h- Rab geranylgeranyltransferase alpha subunit (predicted) (SPCC1620.05), mRNA
European Nucleotide ArchiveCAA22489ENA Protein Mapping
European Nucleotide ArchiveCAA22489.1ENA Protein Mapping
UniParcUPI000006981CUniProt Archive

Literature for SPCC1620.05

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014