srp68 (SPCC1682.05c)


Gene Standard Namesrp68 Characterisation Statusbiological role inferred
Systematic IDSPCC1682.05c Feature Typeprotein coding
Synonyms Name Description
Productsignal recognition particle subunit (predicted) Product Size597aa, 67.86 kDa
Genomic Location Chromosome III, 381034-378099 (2936nt); CDS:381034-379065 (1970nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
7S RNA binding4
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum signal peptide binding2
Annotation ExtensionEvidenceWith/FromReference
signal recognition particle binding3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
Term NameCount
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
signal recognition particle, endoplasmic reticulum targeting7
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationsrp68Δ1453

Cell Phenotype

Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons381034..380969, 380922..380660, 380604..379728, 379652..378189, 378132..378099
Intron380968..380923, 380659..380605, 379727..379653, 378188..378133
3' UTR379064..378189, 378132..378099PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF16969 Pfam IPR026258 Signal recognition particle subunit SRP68 77 558 1
PTHR12860 HMMPANTHER 15 597 1
PIRSF038995 PIRSF IPR026258 Signal recognition particle subunit SRP68 64 594 1

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000245TPR repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000245

Protein Properties

Ave. residue weight 113.67 Da
Charge 6.00
Codon Adaptation Index 0.41
Isoelectric point 7.61
Molecular weight 67.86 kDa
Number of residues 597
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for srp68 (SPCC1682.05c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
23391during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
24327during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
26524during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
24955during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
22233during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8033.87during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2847.86during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.9during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPCC1682.05c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPCC1682.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1682.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1682.05c BioGRID Interaction Datasets
Expression Viewer SPCC1682.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1682.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1682.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1682.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1682.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1682.05c Transcriptome Viewer (Bähler Lab)
GEO SPCC1682.05c GEO profiles
PInt SPCC1682.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1682.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1682.05c Fission yeast phenotypic data & analysis
Cyclebase SPCC1682.05c.1 Cell Cycle Data
SPD / RIKEN27/27B11Orfeome Localization Data
UniProtKB/SwissProtO74436Signal recognition particle subunit srp68
ModBaseO74436Database of comparative protein structure models
STRINGO74436Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587798signal recognition particle subunit (predicted)
RefSeq mRNANM_001022791972h- signal recognition particle subunit (predicted) (srp68), mRNA

Literature for srp68

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016