srp68 (SPCC1682.05c)


Gene Standard Namesrp68 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1682.05c Feature Typeprotein coding
Synonyms Name Description
Productsignal recognition particle subunit (predicted) Product Size597aa, 67.86 kDa
Genomic Location Chromosome III, 381034-378099 (2936nt); CDS:381034-379065 (1970nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00083127S RNA bindingIEAIPR026258GO_REF:00000024
GO:0030942endoplasmic reticulum signal peptide binding2
contributes_toISOSGD:S000006164GO_REF:0000024
GO:0005047signal recognition particle bindingIEAIPR026258GO_REF:00000023
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006617SRP-dependent cotranslational protein targeting to membrane, signal sequence recognitionISOSGD:S000006164GO_REF:00000243
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0005786signal recognition particle, endoplasmic reticulum targetingISOSGD:S000006164GO_REF:00000247
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopysrp68ΔNullPMID:205199591331
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1381034380969
2380922380660
3380604379728
4379652378189
5378132378099

UTRs

Region Coordinates Reference
three_prime_UTR379064..378189,378132..378099PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PTHR12860 HMMPANTHER 35 597 1
PIRSF038995 PIRSF IPR026258 Signal recognition particle subunit SRP68 13 593 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000245TPR repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000245

Protein Properties

Ave. residue weight 113.67 Da
Charge 6.00
Isoelectric point 7.61
Molecular weight 67.86 kDa
Number of residues 597
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
23391during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
24327during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
26524during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
24955during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
22233during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8033.87during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
2847.86during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.9during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPCC1682.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1682.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1682.05c BioGRID Interaction Datasets
Expression Viewer SPCC1682.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1682.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1682.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1682.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1682.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1682.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1682.05c Cell Cycle Data
GEO SPCC1682.05c GEO profiles
PInt SPCC1682.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1682.05c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN27/27B11Orfeome Localization Data
WikiGene2539391signal recognition particle subunit (predicted)
EntrezGene2539391signal recognition particle subunit (predicted)
UniProtKB/SwissProtO74436Signal recognition particle subunit srp68
ModBaseO74436Database of comparative protein structure models
STRINGO74436Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587798signal recognition particle subunit (predicted)
RefSeq mRNANM_001022791972h- signal recognition particle subunit (predicted) (srp68), mRNA
European Nucleotide ArchiveCAA20671ENA Protein Mapping
European Nucleotide ArchiveCAA20671.1ENA Protein Mapping
ReactomeREACT_188294
UniParcUPI000006BB74UniProt Archive

Literature for srp68

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014