tim23 (SPCC16A11.09c)


Gene Standard Nametim23 Characterisation Statusbiological_role_inferred
Systematic IDSPCC16A11.09c Feature Typeprotein coding
Synonyms Name Description
ProductTIM23 translocase complex subunit Tim23 (predicted) Product Size210aa, 22.62 kDa
Genomic Location Chromosome III, 886972-885686 (1287nt); CDS:886733-886101 (633nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activityISOSGD:S000005300GO_REF:000002411
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030150protein import into mitochondrial matrixISOSGD:S000005300GO_REF:000002418
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
GO:0005744mitochondrial inner membrane presequence translocase complexISOSGD:S000005300GO_REF:000002411
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopytim23ΔNullPMID:204732891331
Microscopytim23ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002429inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell sizeMicroscopytim23ΔNullPECO:0000005, PECO:0000137PMID:2369780617
FYPO:0000310inviable after spore germination, without cell division, with normal germ tube morphologyMicroscopytim23ΔNullPECO:0000005, PECO:0000137PMID:23697806303
FYPO:0002151inviable sporeMicroscopytim23ΔNullPECO:0000005, PECO:0000137PMID:23697806459
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1886972885686

UTRs

Region Coordinates Reference
five_prime_UTR886972..886734PMID:21511999
three_prime_UTR886100..885686PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02466 Pfam IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24 79 204 3
PTHR15371:SF0 HMMPANTHER 2 209 1
PTHR15371 HMMPANTHER 2 209 1
TIGR00983 tigrfam IPR005681 Mitochondrial inner membrane translocase complex, subunit Tim23 47 198 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 107.72 Da
Charge 3.00
Isoelectric point 8.96
Molecular weight 22.62 kDa
Number of residues 210
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
35798during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
39154during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
33007during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
32992during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15636.33during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
33606during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
5008.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
6.4during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC16A11.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC16A11.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC16A11.09c BioGRID Interaction Datasets
Expression Viewer SPCC16A11.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC16A11.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC16A11.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC16A11.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC16A11.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC16A11.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC16A11.09c Cell Cycle Data
GEO SPCC16A11.09c GEO profiles
PInt SPCC16A11.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC16A11.09c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2538784TIM23 translocase complex subunit Tim23
EntrezGene2538784TIM23 translocase complex subunit Tim23
SPD / RIKEN42/42F01Orfeome Localization Data
UniProtKB/SwissProtQ9USM7Mitochondrial import inner membrane translocase subunit tim23
ModBaseQ9USM7Database of comparative protein structure models
STRINGQ9USM7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587996TIM23 translocase complex subunit Tim23
RefSeq mRNANM_001022987972h- TIM23 translocase complex subunit Tim23 (tim23), mRNA
European Nucleotide ArchiveCAB53081ENA Protein Mapping
European Nucleotide ArchiveCAB53081.1ENA Protein Mapping
UniParcUPI000012D5DDUniProt Archive

Literature for tim23

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014