tim23 (SPCC16A11.09c)


Gene Standard Nametim23 Characterisation Statusbiological role inferred
Systematic IDSPCC16A11.09c Feature Typeprotein coding
Synonyms Name Description
ProductTIM23 translocase complex subunit Tim23 (predicted) Product Size210aa, 22.62 kDa
Genomic Location Chromosome III, 886972-885686 (1287nt); CDS:886733-886101 (633nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
P-P-bond-hydrolysis-driven protein transmembrane transporter activity11
Annotation ExtensionEvidenceWith/FromReference
protein channel activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
protein import into mitochondrial matrix20
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of membrane963
Annotation ExtensionEvidenceWith/FromReference
mitochondrial inner membrane presequence translocase complex12
Annotation ExtensionEvidenceWith/FromReference
mitochondrion752
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationtim23Δ1453

Cell Phenotype

Term NameGenotypesCount
inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell sizetim23Δ17
inviable after spore germination, without cell division, with normal germ tube morphologytim23Δ303
inviable sporetim23Δ476
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons886972..885686
5' UTR886972..886734PMID:21511999
3' UTR886100..885686PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02466 Pfam IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24 83 202 3
PTHR15371:SF0 HMMPANTHER 1 209 1
PTHR15371 HMMPANTHER 1 209 1
TIGR00983 TIGRFAM IPR005681 Mitochondrial inner membrane translocase complex, subunit Tim23 47 198 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 107.72 Da
Charge 3.00
Codon Adaptation Index 0.50
Isoelectric point 8.96
Molecular weight 22.62 kDa
Number of residues 210
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for tim23 (SPCC16A11.09c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
35798during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
39154during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
33007during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
32992during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15636.33during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
33606during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5008.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC16A11.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC16A11.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC16A11.09c BioGRID Interaction Datasets
Expression Viewer SPCC16A11.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC16A11.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC16A11.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC16A11.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC16A11.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC16A11.09c Transcriptome Viewer (Bähler Lab)
GEO SPCC16A11.09c GEO profiles
PInt SPCC16A11.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC16A11.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC16A11.09c Fission yeast phenotypic data & analysis
Cyclebase SPCC16A11.09c.1 Cell Cycle Data
SPD / RIKEN42/42F01Orfeome Localization Data
UniProtKB/SwissProtQ9USM7Mitochondrial import inner membrane translocase subunit tim23
ModBaseQ9USM7Database of comparative protein structure models
STRINGQ9USM7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_587996TIM23 translocase complex subunit Tim23 (predicted)
RefSeq mRNANM_001022987972h- TIM23 translocase complex subunit Tim23 (predicted) (tim23), mRNA

Literature for tim23

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016