SPCC16C4.10


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC16C4.10 Feature Typeprotein coding
Synonyms Name Description
Product6-phosphogluconolactonase (predicted) Product Size257aa, 28.35 kDa
Genomic Location Chromosome III, 685848-687406 (1559nt); CDS:685901-686792 (892nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00170576-phosphogluconolactonase activityISSUniProtKB:O95336GO_REF:00000011
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0009051pentose-phosphate shunt, oxidative branchICGO:0017057GO_REF:00000016
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722319
GO:0005634nucleusIDAPMID:168233722737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000096sensitive to cadmium246
expressivity FYPO_EXT:0000002Cell growth assaySPCC16C4.10ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0000087sensitive to hydrogen peroxide124
expressivity FYPO_EXT:0000003Cell growth assaySPCC16C4.10ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopySPCC16C4.10ΔNullPECO:0000005, PECO:0000137PMID:236978063751
MicroscopySPCC16C4.10ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001MicroscopySPCC16C4.10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1685848686085
2686204687406
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01182 Pfam IPR006148 Glucosamine/galactosamine-6-phosphate isomerase 13 211 1
PTHR11054 HMMPANTHER 3 253 1
3.40.50.1360 Gene3D 2 247 2
SSF100950 SuperFamily 1 251 8
TIGR01198 tigrfam IPR005900 6-phosphogluconolactonase, DevB-type 7 246 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.32 Da
Charge -5.00
Isoelectric point 5.17
Molecular weight 28.35 kDa
Number of residues 257
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
138987during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
135907during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
133096during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
143036during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
138255during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
15578.82during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
22997.26during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002
conserved in metazoa3428
conserved in vertebrates3402
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAP27G11.12human HID1 ortholog 1 Negative GeneticPMID:22681890
csn1COP9/signalosome complex subunit Csn1 Positive GeneticPMID:22681890
SPAC6G10.10chuman hmmtag2 homolog Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
SPAC6F6.04cmembrane transporter (predicted) Negative GeneticPMID:22681890
SPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
hnt1adenosine 5'-monophosphoramidase (predicted) Negative GeneticPMID:22681890
pmp3plasma membrane proteolipid Pmp3 Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
SPBC646.08coxysterol binding protein (predicted) Negative GeneticPMID:22681890
SPAC56E4.03aromatic aminotransferase (predicted) Negative GeneticPMID:22681890
ptf1Mst2 histone acetytransferase acytyltransferase complex, predicted phosphoric monoester hydrolase Ptf1 Negative GeneticPMID:22681890
sgf73SAGA complex subunit Sgf73 Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
rtn1reticulon-like protein Rtn1 Positive GeneticPMID:22681890
SPBC25B2.03zf-C3HC4 type zinc finger Positive GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
SPAC977.02S. pombe specific 5Tm protein family Positive GeneticPMID:22681890
rga8Rho-type GTPase activating protein Rga8 Negative GeneticPMID:22681890
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:22681890
mde3serine/threonine protein kinase, meiotic Mde3 Negative GeneticPMID:22681890
abc4glutathione S-conjugate-exporting ATPase Abc4 Positive GeneticPMID:22681890
SPBP16F5.05cribosome biogenesis protein Nop8 (predicted) Negative GeneticPMID:22681890
psd3phosphatidylserine decarboxylase Psd3 Negative GeneticPMID:22681890
SPBC1198.03cconserved fungal protein Negative GeneticPMID:22681890
nse6Smc5-6 complex non-SMC subunit Nse6 Positive GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
byr3translational activator, zf-CCHC type zinc finger protein (predicted) Positive GeneticPMID:22681890
btb2BTB/POZ domain protein Btb2 Negative GeneticPMID:22681890
SPAC806.04cDUF89 family protein Positive GeneticPMID:22681890
SPCC1739.06curoporphyrin methyltransferase (predicted) Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
fsv1SNARE Fsv1 Positive GeneticPMID:22681890
SPAPB24D3.05cNegative GeneticPMID:22681890
mug113T5orf172 family protein Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
fra2transcriptional repressor protein BolA domain (predicted) Negative GeneticPMID:22681890
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
trm12tRNA methyltransferase Trm12 (predicted) Positive GeneticPMID:22681890
mug82mitochondrial translation release factor (predicted) Negative GeneticPMID:22681890
SPAC1610.02cmitochondrial ribosomal protein subunit L1 (predicted) Positive GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
hsp104heat shock protein Hsp104 (predicted) Positive GeneticPMID:22681890
SPAC22H10.09Schizosaccharomyces specific protein Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:22681890
rec14Ski complex subunit Rec14 Negative GeneticPMID:22681890
SPAC3A11.10cdipeptidyl peptidase (predicted) Negative GeneticPMID:22681890
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
gut2glycerol-3-phosphate dehydrogenase Gut2 (predicted) Negative GeneticPMID:22681890
SPCC1442.02central kinetochore associated family protein (predicted) Negative GeneticPMID:22681890
SPAC5H10.04NADPH dehydrogenase (predicted) Negative GeneticPMID:22681890
elp1elongator subunit Elp1 (predicted) Negative GeneticPMID:22681890
cys11cysteine synthase Negative GeneticPMID:22681890
gmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:22681890
cta3P-type ATPase, potassium exporting Cta3 Positive GeneticPMID:22681890
elp6elongator complex subunit Elp6 (predicted) Negative GeneticPMID:22681890
far8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
SPAC26A3.14cDUF1748 family protein Negative GeneticPMID:22681890
pof10F-box protein Pof10 Negative GeneticPMID:22681890
adh4alcohol dehydrogenase Adh4 Positive GeneticPMID:22681890
SPCC777.04amino acid transporter (predicted) Negative GeneticPMID:22681890
rkr1RQC complex ubiquitin-protein ligase E3 Rkr1 (predicted) Negative GeneticPMID:22681890
psy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
SPBC18H10.07WW domain-binding protein 4 (predicted) Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
vms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted) Negative GeneticPMID:22681890
iss9conserved eukaryotic protein Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
med13mediator complex subunit Srb9 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
SPCC70.02cmitochondrial ATPase inhibitor (predicted) Negative GeneticPMID:22681890
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
SPBC31F10.02acyl-CoA hydrolase (predicted) Negative GeneticPMID:22681890
atp10F1-F0 ATPase assembly protein (predicted) Negative GeneticPMID:22681890
SPAC19A8.11crecombination protein Irc6 (predicted) Positive GeneticPMID:22681890
ptl1triacylglycerol lipase ptl1 Negative GeneticPMID:22681890
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
SPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
rho4Rho family GTPase Rho4 Negative GeneticPMID:22681890
omh5alpha-1,2-mannosyltransferase Omh5 (predicted) Negative GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
SPAPJ691.03mitochondrial inner membrane organizing system protein (predicted) Negative GeneticPMID:22681890
ppk9serine/threonine protein kinase Ppk9 (predicted) Positive GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
SPAC644.08methionine salvage haloacid dehalogenase-like hydrolase (predicted) Negative GeneticPMID:22681890
dlc1dynein light chain Dlc1 Positive GeneticPMID:22681890
SPBC31F10.17cSchizosaccharomyces pombe specific protein Negative GeneticPMID:22681890
png2ING family homolog Png2 Positive GeneticPMID:22681890
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
ctu1cytosolic thiouridylase subunit Ctu1 Negative GeneticPMID:22681890
nup97nucleoporin Nic96 homolog Negative GeneticPMID:22681890
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
ppk29Ark1/Prk1 family protein kinase Ppk29 Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
cut3condensin complex subunit Cut3 Negative GeneticPMID:22681890
SPCC4F11.03cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
nas6proteasome regulatory particle, gankyrin (predicted) Negative GeneticPMID:22681890
SPAC4H3.03cglucan 1,4-alpha-glucosidase (predicted) Positive GeneticPMID:22681890
plh1phospholipid-diacylglycerol acyltransferase Plh1 Positive GeneticPMID:22681890
SPAC27F1.05caminotransferase class-III, unknown specificty Negative GeneticPMID:22681890
SPAC1687.21phosphoglycerate mutase family (predicted) Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
SPAC4H3.06human C19orf60 homolog Negative GeneticPMID:22681890
pdi3ER associated protein disulfide isomerase Pdi3 Negative GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
get1GET complex subunit Get1 (predicted) Negative GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:22681890
rgf2RhoGEF Rgf2 Positive GeneticPMID:22681890
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Positive GeneticPMID:22681890
mak3histidine kinase Mak3 Negative GeneticPMID:22681890
SPBC21C3.14csSchizosaccharomyces specific protein Positive GeneticPMID:22681890
SPAC5H10.09c3-methyl-2-oxobutanoatehydroxymethyltransferase (predicted) Negative GeneticPMID:22681890
SPAC8C9.12cmitochondrial iron ion transporter (predicted) Positive GeneticPMID:22681890
rho5Rho family GTPase Rho5 Negative GeneticPMID:22681890
SPAC22F8.03cSchizosaccharomyces pombe specific protein Negative GeneticPMID:22681890
sep1forkhead transcription factor Sep1 Negative GeneticPMID:22681890
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Positive GeneticPMID:22681890
SPAC56E4.07N-acetyltransferase (predicted) Positive GeneticPMID:22681890
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:22681890
rnf10ubiquitin-protein ligase E3 implicated in transcription (predicted) Negative GeneticPMID:22681890
SPCC1223.01ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
SPAC1B3.15cvitamin H transporter (predicted) Positive GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
SPAC4A8.10lipase (predicted) Negative GeneticPMID:22681890
wtf15wtf element Wtf15 Positive GeneticPMID:22681890
gpx1glutathione peroxidase Gpx1 Negative GeneticPMID:22681890
SPAPJ695.01cS. pombe specific UPF0321 family protein 3 Negative GeneticPMID:22681890
SPBC725.01aspartate aminotransferase (predicted) Negative GeneticPMID:22681890
rqc1ribosome quality control complex (RQC) complex subunit Rqc1 (predicted) Negative GeneticPMID:22681890
SPBC1861.05pseudouridine-metabolizing bifunctional protein (predicted) Positive GeneticPMID:22681890
SPBC16H5.12cconserved fungal protein Positive GeneticPMID:22681890
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
mug58GLYK family kinase of unknown specificity (predicted) Negative GeneticPMID:22681890
SPAPB24D3.03agmatinase (predicted) Negative GeneticPMID:22681890
SPBC725.05cnucleotide pyrophosphatase (predicted) Negative GeneticPMID:22681890
tsf1mitochondrial translation elongation factor EF-Ts Tsf1 Negative GeneticPMID:22681890
bun62WD repeat protein, human WDR20 family, Bun62 Negative GeneticPMID:22681890
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
SPAC227.06Rab GTPase binding (predicted) Positive GeneticPMID:22681890
upf3up-frameshift suppressor 3 family protein (predicted) Positive GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Negative GeneticPMID:22681890
SPAC24B11.12cP-type ATPase (predicted) Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
top1DNA topoisomerase I Negative GeneticPMID:22681890
hmt2sulfide-quinone oxidoreductase Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
SPBC1348.01S. pombe specific DUF999 protein family 5 Positive GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
SPAC24B11.14dubious Negative GeneticPMID:22681890
SPBC725.10tspO homolog, involved in the cytoplasmic to mitochondrial transport of haem (predicted) Positive GeneticPMID:22681890
etf2electron transfer flavoprotein beta subunit EtfB (predicted) Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
SPBC12C2.03cmethionine synthase reductase (predicted) Positive GeneticPMID:22681890
SPAC3A12.09curease accessory protein UreD (predicted) Positive GeneticPMID:22681890
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
tfs1transcription elongation factor TFIIS Negative GeneticPMID:22681890
mlo2ubiquitin protein ligase E3 component human N-recognin 7 homolog Mlo2 Positive GeneticPMID:22681890
SPCC126.12GTP cyclohydrolase I involved in 7,8-dihydroneopterin 3'-triphosphate biosynthesis (predicted) Negative GeneticPMID:22681890
alo1D-arabinono-1,4-lactone oxidase (predicted) Negative GeneticPMID:22681890
SPBC418.02NatA N-acetyltransferase complex subunit (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC16C4.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC16C4.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC16C4.10 BioGRID Interaction Datasets
Expression Viewer SPCC16C4.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC16C4.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC16C4.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC16C4.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC16C4.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC16C4.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC16C4.10 Cell Cycle Data
GEO SPCC16C4.10 GEO profiles
PInt SPCC16C4.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC16C4.10 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN12/12B06Orfeome Localization Data
IntEnz3.1.1.31Integrated relational Enzyme database
Rhea3.1.1.31Annotated reactions database
UniProtKB/SwissProtO74455Probable 6-phosphogluconolactonase
ModBaseO74455Database of comparative protein structure models
STRINGO74455Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5879206-phosphogluconolactonase (predicted)
RefSeq mRNANM_001022911972h- 6-phosphogluconolactonase (predicted) (SPCC16C4.10), mRNA
European Nucleotide ArchiveCAA20749.1ENA Protein Mapping
MetaCycPWY-5514UDP-N-acetyl-D-galactosamine biosynthesis II
MetaCycPWY-6517N-acetylglucosamine degradation II
MetaCycPWY-6855Chitin degradation I (archaea)
MetaCycPWY-6906Chitin derivatives degradation
UniParcUPI0000124F92UniProt Archive
UniPathwayUPA00115Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3

Literature for SPCC16C4.10

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014