SPCC16C4.22


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC16C4.22 Feature Typeprotein coding
SynonymsSPNCRNA.470, SPNG2185 Name Description
ProductDNA polymerase epsilon Dpb3 (predicted) Product Size87aa, 10.11 kDa
Genomic Location Chromosome III, 684656-685496 (841nt); CDS:684828-685192 (365nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046982protein heterodimerization activityIEAIPR009072GO_REF:000000261
GO:0043565sequence-specific DNA bindingIEAIPR003958GO_REF:0000002141
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033260nuclear cell cycle DNA replicationICGO:0008622GO_REF:000000125
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008622epsilon DNA polymerase complexISOSGD:S000000482GO_REF:00000244
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1684656684947
2685049685496

UTRs

Region Start End Reference
mRNA684656685496PMID:18488015
exon685049685192PMID:18488015
exon684828684947PMID:18488015
five_prime_UTR684656684827PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00808 Pfam IPR003958 Transcription factor CBF/NF-Y/archaeal histone 10 71 7
PTHR10252:SF26 HMMPANTHER 2 83 1
PTHR10252 HMMPANTHER 2 83 3
G3DSA:1.10.20.10 Gene3D IPR009072 10 84 26
SSF47113 SuperFamily IPR009072 6 86 26

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Protein Properties

Ave. residue weight 116.24 Da
Charge 1.50
Isoelectric point 8.45
Molecular weight 10.11 kDa
Number of residues 87
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.34during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
previously annotated as ncRNA21
dpb3 was previously considered to be SPAC17G8.03c but this new gene product appears to be the true ortholog of DPB3/POLE4 see TreeFam:TF1030091
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPCC16C4.22 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC16C4.22 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC16C4.22 BioGRID Interaction Datasets
Expression Viewer SPCC16C4.22 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC16C4.22 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC16C4.22 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC16C4.22 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC16C4.22 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC16C4.22 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC16C4.22 Cell Cycle Data
GEO SPCC16C4.22 GEO profiles
PInt SPCC16C4.22 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene9406966histone-like transcription factor family (CBF/NF-Y)
EntrezGene9406966histone-like transcription factor family (CBF/NF-Y)
UniProtKB/SwissProtC6Y4D0Putative transcription factor C16C4.22
ModBaseC6Y4D0Database of comparative protein structure models
StringC6Y4D0Network display of known and predicted interactions and functional associations
RefSeq_mRNA_predictedXM_002788903972h- histone-like transcription factor family (CBF/NF-Y) (SPCC16C4.22), mRNA
RefSeq_peptide_predictedXP_002788949histone-like transcription factor family (CBF/NF-Y)
European Nucleotide ArchiveCBA11517ENA Protein Mapping
UniParcUPI0001B0626DUniProt Archive

Literature for SPCC16C4.22

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014