SPCC1739.06c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC1739.06c Feature Typeprotein coding
Synonyms Name Description
Producturoporphyrin methyltransferase (predicted) Product Size496aa, 54.71 kDa
Genomic Location Chromosome III, 2039988-2037670 (2319nt); CDS:2039442-2037952 (1491nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0043115precorrin-2 dehydrogenase activityIEAIPR003043GO_REF:00000022
GO:0004851uroporphyrin-III C-methyltransferase activityISOSGD:S000001777GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006783heme biosynthetic processISSUniProtKB:P36150GO_REF:000000113
GO:0009086methionine biosynthetic processISOSGD:S000001777GO_REF:000002430
GO:0019354siroheme biosynthetic processIEAIPR006367GO_REF:00000022
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000096sensitive to cadmium246
expressivity FYPO_EXT:0000002Cell growth assaySPCC1739.06cΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0000087sensitive to hydrogen peroxide124
expressivity FYPO_EXT:0000003Cell growth assaySPCC1739.06cΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0000271sensitive to salt stress82
expressivity FYPO_EXT:0000003Cell growth assaySPCC1739.06cΔNullPECO:0000207, PECO:0000137, PECO:0000102, PECO:0000005PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopySPCC1739.06cΔNullPECO:0000005, PECO:0000137PMID:236978063751
MicroscopySPCC1739.06cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001MicroscopySPCC1739.06cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120399882037670
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00590 Pfam IPR000878 Tetrapyrrole methylase 261 468 2
PF13241 Pfam IPR006367 Sirohaem synthase, N-terminal 4 131 2
PS00840 Prosite Patterns IPR003043 Uroporphiryn-III C-methyltransferase, conserved site 339 372 1
PTHR21091:SF16 HMMPANTHER 145 494 1
PTHR21091 HMMPANTHER 145 494 6
3.30.950.10 Gene3D IPR014776 Tetrapyrrole methylase, subdomain 2 375 493 2
3.40.1010.10 Gene3D IPR014777 Tetrapyrrole methylase, subdomain 1 258 374 2
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 2 128 100
SSF53790 SuperFamily IPR000878 Tetrapyrrole methylase 255 490 2
SSF75615 SuperFamily 124 216 2
PIRSF036555 PIRSF IPR012066 Uroporphyrin-III C-methyltransferase, yeast 1 496 1
TIGR01469 tigrfam IPR006366 Uroporphyrin-III C-methyltransferase 259 488 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.31 Da
Charge 3.00
Isoelectric point 6.94
Molecular weight 54.71 kDa
Number of residues 496
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased in presence of cadmium sulfate expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3183.36during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1109.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
SPCC16C4.106-phosphogluconolactonase (predicted) Positive GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
SPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
par2protein phosphatase regulatory subunit Par2 Positive GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
vrp1verprolin Positive GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
clu1translation initiation factor eIF3 alpha subunit (p135) (predicted) Negative GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
toe4transcription factor, zf-fungal binuclear cluster type(predicted) Positive GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1739.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1739.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1739.06c BioGRID Interaction Datasets
Expression Viewer SPCC1739.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1739.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1739.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1739.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1739.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1739.06c Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1739.06c Cell Cycle Data
GEO SPCC1739.06c GEO profiles
PInt SPCC1739.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1739.06c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN24/24A12Orfeome Localization Data
UniProtKB/SwissProtO74468Probable uroporphyrinogen-III C-methyltransferase
ModBaseO74468Database of comparative protein structure models
STRINGO74468Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588414uroporphyrin methyltransferase (predicted)
RefSeq mRNANM_001023405972h- uroporphyrin methyltransferase (predicted) (SPCC1739.06c), mRNA
European Nucleotide ArchiveAB009602ENA EMBL mapping
European Nucleotide ArchiveD89123ENA EMBL mapping
European Nucleotide ArchiveCAA20780.1ENA Protein Mapping
MetaCycPWY-5194Siroheme biosynthesis
MetaCycPWY-5507Adenosylcobalamin biosynthesis I (early cobalt insertion)
UniParcUPI0000136217UniProt Archive
UniPathwayUPA00148Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1
UniPathwayUPA00262Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1

Literature for SPCC1739.06c

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014