SPCC1739.06c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPCC1739.06c Feature Typeprotein coding
Synonyms Name Description
Producturoporphyrin methyltransferase (predicted) Product Size496aa, 54.71 kDa
Genomic Location Chromosome III, 2039988-2037670 (2319nt); CDS:2039442-2037952 (1491nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
precorrin-2 dehydrogenase activity2
Annotation ExtensionEvidenceWith/FromReference
uroporphyrin-III C-methyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
heme biosynthetic process13
Annotation ExtensionEvidenceWith/FromReference
methionine biosynthetic process30
Annotation ExtensionEvidenceWith/FromReference
siroheme biosynthetic process2
Annotation ExtensionEvidenceWith/FromReference
sulfate assimilation9
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to cadmiumSPCC1739.06cΔNull246
sensitive to hydrogen peroxideSPCC1739.06cΔNull139
sensitive to salt stressSPCC1739.06cΔNull91
viable vegetative cell populationSPCC1739.06cΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologySPCC1739.06cΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2039988..2037670
mRNA2039988..2037670
5' UTR2039988..2039443PMID:21511999
CDS2039442..2037952
3' UTR2037951..2037670AB009602
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13241 Pfam IPR006367 Sirohaem synthase, N-terminal 4 131 2
PF00590 Pfam IPR000878 Tetrapyrrole methylase 261 468 2
PS00840 Prosite Patterns IPR003043 Uroporphiryn-III C-methyltransferase, conserved site 339 372 1
PTHR21091 HMMPANTHER 257 494 6
PTHR21091:SF96 HMMPANTHER IPR012066 Uroporphyrin-III C-methyltransferase, yeast 257 494 1
3.30.950.10 Gene3D IPR014776 Tetrapyrrole methylase, subdomain 2 375 493 2
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 2 128 100
3.40.1010.10 Gene3D IPR014777 Tetrapyrrole methylase, subdomain 1 258 374 2
SSF75615 SuperFamily 124 216 2
SSF53790 SuperFamily IPR000878 Tetrapyrrole methylase 255 490 2
TIGR01469 tigrfam IPR006366 Uroporphyrin-III C-methyltransferase 259 488 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.31 Da
Charge 3.00
Isoelectric point 6.94
Molecular weight 54.71 kDa
Number of residues 496
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased in presence of cadmium sulfate expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3183.36during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1109.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withclu1clustered mitochondria (cluA/CLU1) homolog Clu1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
positive genetic interaction withelp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
positive genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
positive genetic interaction withhus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withmcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
negative genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
positive genetic interaction withmug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpar2protein phosphatase regulatory subunit Par2 Positive GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
positive genetic interaction withSPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC16C4.106-phosphogluconolactonase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
positive genetic interaction withtoe4transcription factor, zf-fungal binuclear cluster type(predicted) Positive GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withvrp1verprolin Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPCC1739.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1739.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1739.06c BioGRID Interaction Datasets
Expression Viewer SPCC1739.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1739.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1739.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1739.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1739.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1739.06c Transcriptome Viewer (Bähler Lab)
GEO SPCC1739.06c GEO profiles
PInt SPCC1739.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPCC1739.06c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPCC1739.06c Fission yeast phenotypic data & analysis
Cyclebase SPCC1739.06c.1 Cell Cycle Data
SPD / RIKEN24/24A12Orfeome Localization Data
UniProtKB/SwissProtO74468Probable uroporphyrinogen-III C-methyltransferase
ModBaseO74468Database of comparative protein structure models
STRINGO74468Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588414uroporphyrin methyltransferase (predicted)
RefSeq mRNANM_001023405972h- uroporphyrin methyltransferase (predicted) (SPCC1739.06c), mRNA
European Nucleotide ArchiveAB009602ENA EMBL mapping
European Nucleotide ArchiveD89123ENA EMBL mapping
European Nucleotide ArchiveCAA20780.1ENA Protein Mapping
MetaCycPWY-5194Siroheme biosynthesis
MetaCycPWY-7377Cob(ii)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
KEGG_Enzyme00860+4.99.1.4+1.3.1.76+2.1.1.107Porphyrin and chlorophyll metabolism
UniParcUPI0000136217UniProt Archive
UniPathwayUPA00148Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1
UniPathwayUPA00262Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1

Literature for SPCC1739.06c

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015