mug33 (SPCC1739.10)

Gene Standard Namemug33 ChromosomeIII
Systematic IDSPCC1739.10 Gene Start2047508
Synonyms Gene End2049286
Productconserved fungal protein Gene Length1779
Feature Typeprotein coding CDS Start2047936
Name DescriptionMeiotically Upregulated Gene CDS End2048946
Characterisation Statusconserved_unknown CDS Length1011

Ensembl Gene Location
  1. cti1
  2. SPCC1739.08c
  3. SPNCRNA.549
  4. SPNCRNA.1256
  5. cox13
  6. mug33
  7. cdc11
  8. ppe1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000085sensitive to camptothecincompetitive growth assay evidencemug33delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencemug33delta (deletion)deletionPMID:20537132
competitive growth assay evidencemug33delta (deletion)deletionPMID:20537132
FYPO:0000268sensitive to UVcompetitive growth assay evidencemug33delta (deletion)deletionPMID:20537132
FYPO:0002060viable vegetative cell populationMicroscopymug33delta (deletion)deletionPMID:20473289
GO Biological Process

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0007127meiosis IIEPPMID:12161753
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005737cytoplasmIDAPMID:16823372
GO:0005886plasma membraneISOSGD:S000005379GO_REF:0000024
GO:0032153cell division siteIDAPMID:16823372
GO:0051286cell tipIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120475082049286

References

Region Start End Reference
three_prime_UTR20489472049286PMID:21511999
five_prime_UTR20475082047935PMID:21511999
three_prime_UTR20489472049286PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF06687 IPR009571 Pfam Actin cortical patch SUR7/pH-response regulator PalI 7 165 3
TMhelix TMHMM 118 140 955
TMhelix TMHMM 9 31 955
TMhelix TMHMM 89 111 955
TMhelix TMHMM 150 172 955
SignalP-TM signalp 1 23 16

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744

Sequence Ontology

Term IDTerm NameReference
SO:0000418signal_peptide
SO:0001812transmembrane_helix

Protein Properties

Ave. residue weight 110.34 Da
Charge 17.00
Isoelectric point 10.15
Molecular weight 37.07 kDa
Number of residues 336
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
expressed during meiosis PMID:16303567
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide653.94PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide4481.14PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide4.2PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide9.5PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
cwf19complexed with Cdc5 protein Cwf19 Negative GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:22681890
sre2membrane-tethered transcription factor (predicted) Negative GeneticPMID:21504829
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
erg5C-22 sterol desaturase Erg5 Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
SPAC23A1.07ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
nhp6High-mobility group non-histone chromatin protein (predicted) Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
pmk1MAP kinase Pmk1 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
rga2Rho-type GTPase activating protein Rga2 (predicted) Negative GeneticPMID:22681890
clr1cryptic loci regulator Clr1 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
rho3Rho family GTPase Rho3 Synthetic Growth DefectPMID:21652630
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
SPBC1347.08cribonuclease H2 complex subunit (predicted) Positive GeneticPMID:22681890
rad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:22681890
myo52myosin type V Synthetic LethalityPMID:21652630
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Positive GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Positive GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
taz1human TRF ortholog Taz1 Negative GeneticPMID:22681890
srk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
slm1cytoskeletal signaling protein Slm1 (predicted) Negative GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Negative GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
ies2Ino80 complex subunit Ies2 Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:21652630
Phenotypic Enhancement
hrp1ATP-dependent DNA helicase Hrp1 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tea1cell end marker Tea1 Affinity Capture-WesternPMID:21652630
Affinity Capture-MS
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External References
Database Identifier Description
NBRP SPCC1739.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1739.10 Retrieval of eukaryotic orthologs
BioGrid SPCC1739.10 BioGRID Interaction Datasets
Bähler Lab SPCC1739.10 Cell Cycle Expression Profile
Bähler Lab SPCC1739.10 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC1739.10 Pheromone response/mating expression profiles
Bähler Lab SPCC1739.10 Environmental stress expression profiles
Bähler Lab SPCC1739.10 Bähler Lab Transcriptome Viewer
Cyclebase SPCC1739.10 Cell Cycle Data
PInt SPCC1739.10 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC1739.10 Entrez Gene
WikiGene2539381conserved fungal protein
Uniprot_genenameMUG33
EntrezGene2539381conserved fungal protein
SPD / RIKEN15/15A08Orfeome Localization Data
UniProtKB/SwissProtO74472Meiotically up-regulated gene 33 protein
ModBaseO74472Database of comparative protein structure models
Pfam Protein DomainsO74472Pfam Domain Arrangement
RefSeq PeptideNP_588418conserved fungal protein
RefSeq mRNANM_001023409972h- conserved fungal protein (mug33), mRNA
European Nucleotide ArchiveCAA20784ENA Protein Mapping
UniParcUPI000006C37BUniProt Archive

Literature for mug33
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013