ssa2 (SPCC1739.13)


Gene Standard Namessa2 Characterisation Statusbiological_role_inferred
Systematic IDSPCC1739.13 Feature Typeprotein coding
Synonyms Name Description
Productheat shock protein Ssa2 (predicted) Product Size647aa, 70.23 kDa
Genomic Location Chromosome III, 2057084-2059331 (2248nt); CDS:2057243-2059186 (1944nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0016887ATPase activityISOSGD:S000000004GO_REF:0000024233
GO:0051082unfolded protein bindingISOSGD:S000000004GO_REF:000002442
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0034605cellular response to heatIEPPMID:1252943843
GO:0061077chaperone-mediated protein foldingNASGO_REF:000000111
GO:0006457protein foldingISOSGD:S000000004GO_REF:0000024112
GO:0042026protein refoldingISOSGD:S000000004GO_REF:00000246
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyssa2ΔNullPECO:0000005, PECO:0000137PMID:236978061309
FYPO:0002060viable vegetative cell populationMicroscopyssa2ΔNullPMID:204732893755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable sporeMicroscopyssa2ΔNullPECO:0000005, PECO:0000137PMID:23697806447
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120570842059331
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00012 Pfam IPR013126 Heat shock protein 70 family 5 610 8
PS01036 Prosite Patterns IPR018181 Heat shock protein 70 family 332 346 7
PS00329 Prosite Patterns IPR018181 Heat shock protein 70 family 195 208 6
PS00297 Prosite Patterns IPR018181 Heat shock protein 70 family 7 14 5
PTHR19375 HMMPANTHER 1 645 8
G3DSA:3.30.420.40 Gene3D 121 197 24
G3DSA:3.30.420.40 Gene3D 4 52 24
G3DSA:3.30.420.40 Gene3D 314 356 24
G3DSA:3.30.420.40 Gene3D 198 228 24
G3DSA:3.30.30.30 Gene3D 53 113 6
G3DSA:1.20.1270.10 Gene3D 517 621 6
G3DSA:2.60.34.10 Gene3D 390 516 7
G3DSA:3.90.640.10 Gene3D 229 309 16
SSF100934 SuperFamily 535 617 7
SSF100920 SuperFamily 384 541 7
SSF53067 SuperFamily 188 380 25
SSF53067 SuperFamily 1 185 25
Low complexity (SEG) seg 611 637
Low complexity (SEG) seg 366 377
Low complexity (SEG) seg 491 502
Low complexity (SEG) seg 518 530
PR00301 PRINTS IPR013126 Heat shock protein 70 family 388 407 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 31 43 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 361 381 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 329 345 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 53 61 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 140 160 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 201 211 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 469 485 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 3 16 8

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.55 Da
Charge -15.00
Isoelectric point 4.87
Molecular weight 70.23 kDa
Number of residues 647
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
364293.29during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
68852.31during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
19during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
240during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Miscellaneous Functional Group
DescriptionQualifierReferenceCount
chaperone12
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
cdk11serine/threonine protein kinase cdk11 Affinity Capture-MSPMID:23122962
rad52DNA recombination protein Rad52 (previously Rad22) Affinity Capture-MSPMID:23779158
ddb1damaged DNA binding protein Ddb1 Affinity Capture-MSPMID:18794354
rad2414-3-3 protein Rad24 Affinity Capture-WesternPMID:20231270
int6eIF3e subunit Int6 Affinity Capture-MSPMID:16278451
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
mas5DNAJ domain protein Mas5 (predicted) Affinity Capture-WesternPMID:24146635
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Affinity Capture-MSPMID:21504829
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
rec10meiotic recombination protein Rec10 Affinity Capture-MSPMID:19756689
External References
Database Identifier Description
NBRP SPCC1739.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC1739.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPCC1739.13 BioGRID Interaction Datasets
Expression Viewer SPCC1739.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPCC1739.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPCC1739.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPCC1739.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPCC1739.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPCC1739.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPCC1739.13 Cell Cycle Data
GEO SPCC1739.13 GEO profiles
PInt SPCC1739.13 Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539225heat shock protein Ssa2
WikiGene2539225heat shock protein Ssa2
SPD / RIKEN26/26H10Orfeome Localization Data
UniProtKB/SwissProtO59855Probable heat shock protein ssa2
ModBaseO59855Database of comparative protein structure models
StringO59855Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_588421heat shock protein Ssa2
RefSeq mRNANM_001023412972h- heat shock protein Ssa2 (ssa2), mRNA
European Nucleotide ArchiveBAA25322ENA Protein Mapping
European Nucleotide ArchiveCAA20787ENA Protein Mapping
UniParcUPI0000161F36UniProt Archive

Literature for ssa2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014