pof6 (SPCC18.04)

Gene Standard Namepof6 ChromosomeIII
Systematic IDSPCC18.04 Gene Start1960078
Synonyms Gene End1963015
ProductF-box protein Pof6 Gene Length2938
Feature Typeprotein coding CDS Start1960130
Name Description CDS End1962798
Characterisation Statuspublished CDS Length2669

Ensembl Gene Location
  1. SPCC18.02
  2. SPNCRNA.1247
  3. SPCC18.03
  4. pof6
  5. SPCC18.05c
  6. caf1
  7. ost5
  8. SPNCRNA.1248
  9. SPNCRNA.1249
  10. rpc53
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002061inviable vegetative cell populationno_name (unrecorded)unrecordedPMID:12511573
Microscopypof6delta (deletion)deletionPMID:20473289
pof6delta (deletion)deletionPMID:20519959
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIskp1PMID:12511573
IPIskp1PMID:19243310
IPIsip1PMID:19243310
GO:0030674protein binding, bridgingISMPFAM:PF00646GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000910cytokinesis
requiredIMPPMID:12511573
GO:0000920cytokinetic cell separationIMPPMID:12511573
GO:0006887exocytosisIEAIPR009976GO_REF:0000002
GO:0006897endocytosisISOSGD:S000003740GO_REF:0000024
GO:0048278vesicle dockingIEAIPR009976GO_REF:0000002
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000151ubiquitin ligase complexISMPFAM:PF00646GO_REF:0000001
GO:0000935barrier septumIDAPMID:12511573
GO:0005634nucleusIDAPMID:12511573
IDAPMID:16823372
NOT GO:0005730nucleolusIDAPMID:12511573
GO:0005737cytoplasmIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0030428cell septumIDAPMID:12511573
GO:0051286cell tipIDAPMID:12511573
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119600781962477
219625281963015

References

Region Start End Reference
three_prime_UTR19627991963015PMID:21511999
five_prime_UTR19600781960129PMID:21511999
three_prime_UTR19627991963015PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00646 IPR001810 Pfam F-box domain, cyclin-like 39 74 8
PF07393 IPR009976 Pfam Exocyst complex component Sec10-like 179 861 2
SM00256 IPR001810 SMART F-box domain, cyclin-like 33 73 10
G3DSA:1.20.1280.50 Gene3D 36 68 9
SSF81383 IPR001810 SuperFamily 30 82 12
PTHR12100 IPR009976 hmmpanther Exocyst complex component Sec10-like 1 872 2

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000933F-box proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000933

Protein Properties

Ave. residue weight 114.58 Da
Charge -8.00
Isoelectric point 5.99
Molecular weight 99.91 kDa
Number of residues 872
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide165.42PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.4PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.44PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ppm1leucine carboxyl methyltransferase Ppm1 (predicted) Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
skp1SCF ubiquitin ligase complex subunit Skp1 Two-hybridPMID:17016471
Two-hybridPMID:12511573
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External References
Database Identifier Description
NBRP SPCC18.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPCC18.04 Retrieval of eukaryotic orthologs
BioGrid SPCC18.04 BioGRID Interaction Datasets
Bähler Lab SPCC18.04 Cell Cycle Expression Profile
Bähler Lab SPCC18.04 Meiosis/Sporulation Expression Profies
Bähler Lab SPCC18.04 Pheromone response/mating expression profiles
Bähler Lab SPCC18.04 Environmental stress expression profiles
Bähler Lab SPCC18.04 Bähler Lab Transcriptome Viewer
Cyclebase SPCC18.04 Cell Cycle Data
PInt SPCC18.04 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPCC18.04 Entrez Gene
WikiGene2539324F-box protein Pof6
Uniprot_genenamePOF6
EntrezGene2539324F-box protein Pof6
SPD / RIKEN38/38H05Orfeome Localization Data
UniProtKB/SwissProtO74854F-box protein pof6
ModBaseO74854Database of comparative protein structure models
Pfam Protein DomainsO74854Pfam Domain Arrangement
RefSeq PeptideNP_588383F-box protein Pof6
RefSeq mRNANM_001023374972h- F-box protein Pof6 (pof6), mRNA
European Nucleotide ArchiveCAA21418ENA Protein Mapping
UniParcUPI0000131DBFUniProt Archive

Literature for pof6
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013